Download PHT 415 HomeWork

Home Work
Lab 1
1. How many half-lives (t 1/2) would it take for 99.9% of any initial concentration of a drug
to decompose? Assume first-order kinetics.
2. If the half-life for decomposition of a drug is 12 hours, how long will it take for 125 mg
of the drug to decompose by 30%? Assume first-order kinetics and constant temperature.
Lab 2
1. Determine the total body clearance for a drug in a 70-kg male patient.
The drug follows the kinetics of a first order one-compartment model and
has an elimination half-life of 3 hours with an apparent volume of
distribution of 100 mL/kg.
2. A 170 mg dose of cinoxin was given to a group of patients and the
following data was obtained.
Time, hr
Conc., mg/L
0.5 1
1.33
36.9 24.7 19
2
11.1
3
5
4
2.2
6
0.42
8
0.09
a. Calculate C0, slope, k, t1/2, VD, Cl, AUC.
b. What is the time for the drug to reach 5 % of the dose?
Lab 6
Problem 4
Given the data in Table 1 and 2, calculate ka, F, kel, and V? Assume a one compartment
linear model.
Table 1. Plasma Concentrations Measured after a 100 mg I.V. Bolus Dose of Drug X to Subject Y
Time (hr)
Concentration (mg/L)
1
5.72
3
4.14
6
2.56
Table 2. Plasma Concentrations Measured after a 300 mg Oral Dose of Drug X to Subject Y
Time (hr)
Concentration (mg/L)
0.25
2.28
0.5
4.33
0.75
5.67
1
6.89
1.5
8.81
2
9.31
3
9.68
4
10.25
6
7.51
9
4.98
12
3.25