Download Mathematical Tools for Understanding Genome Rearrangements

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Transcript
Office of Research &
Sponsored Programs
Faculty / Academic Staff
FORUM
Fall 2012 Series
Mathematical Tools for
Understanding
Genome Rearrangements
presented by
Manda Riehl
Mathematics
Wednesday
September 19, 2012
12:10 - 12:50 p.m.
*CETL (OL 1142)*
The diversity of life is a direct result of inaccuracy in DNA replication. At some point in the past,
humans and mice had a common ancestor, and many "mistakes" later, we have two apparently
very different species. At the level of DNA, the evolutionary distance between organisms can be
estimated by calculating the degree of disorder between the genes in different genomes. I will
discuss a few of the ways that mathematicians have approached the problem of finding out how
"different" different genomes are, and I will also describe a new model for mutations that I am
researching that was developed for understanding mutations that cause human diseases.
Feel free to bring your own lunch.