Download BY2208 SF Genetics Central Dogma McConnell_1.1

Genetics module
Lectures
!! DNA Structure, Replication
!!Transcription and Translation: Genetic Code
!! Principles of Heredity: Gene Mapping
!! Controlling Gene Expression
!! Mutation and Cancer
Textbook: Introduction to Genetic Analysis, Griffiths et al., 9th Ed.
The Central Dogma
Smurfit Institute of Genetics!
DNA structure 1.1 and 1.2
4500 square metres !
DNA replication 1.3 and 2
RNA Synthesis 3
Protein synthesis 4
Prof. David McConnell
>100 researchers!
25 countries!
"7 m research income (2007) !
Half of the Trinity papers in Nature/Science!
1990-2004!
Smurfit Institute of Genetics
The Central Dogma
The role and flow of genetic information
Genetic information flows from nucleic acid to
nucleic acid
The Central Dogma
States how genetic information is
stored, replicated and read.
DNA makes DNA:
DNA replication
Genetic information flows from nucleic acid to
protein
DNA makes RNA:
transcription
RNA makes protein:
translation
Genetic information does NOT flow from protein to
nucleic acid
RNA makes RNA:
RNA replication and RNA
transcription
RNA makes DNA:
reverse transcription
Textbooks
Griffiths, Wessler, Lewontin and Carroll
Websites
Open University
Introduction to Genetic Analysis
Hartl & Jones
Genetics: Analysis of Genes and Genomes,
Klug & Cummings
Essentials of Genetics
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Lectures www.tcd.ie/Genetics -> Undergraduates
SCHROEDINGER!
ON CHROMSOMES!
(preDNA)!
Erwin Schroedinger!
Genes must contain
information!
Genes must replicate!
1943!
! !
Three lectures in Trinity!
!“What is life?”!
Erwin Schroedinger and the Origins of
Molecular Biology "
Aperiodic crystal!
Friedrich Miescher!
(b Basel)!
Krishna R. Dronamraju "
U. Tubingen!
Genetics 153: 1071-1076 (November 1999)"
http://www.genetics.org/cgi/reprint/
153/3/1071.pdf!
1869!
Purified phosphate rich
chemical from nuclei of
white blood cells !
DNA is the Genetic Material
Avery McCarty and MacLeod 1944
Bacterial genes are made of DNA
Therefore it must
(1)! Replicate faithfully.
(2)! Have the coding capacity to generate
proteins and other products for all
cellular functions.
Maclyn
McCarty
1911-2005
Oswald Avery
Colin MacLeod
1977-1955
1909-72
CHROMOSOME!
NOTE DOUBLENESS!
•! “A genetic material must carry out two jobs:
duplicate itself and control the development of the
rest of the cell in a specific way.”
•! -Francis Crick