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4/2/13 Chromosome 1. Chromatid 2. Centromere 3. Short Arm 4. Long Arm Chromosome - DNA tightly coiled Chromatid - two exact copies of DNA that make up each chromosome Centromere - attaches the chromatids Haploid vs Diploid Somatic Cells - “regular” cells – Contain two sets of chromosomes: diploid Gametes - eggs and sperm – Contain one set of chromosomes: haploid 1 4/2/13 Why divide? Cells can only get so large before diffusion will not work properly to bring in nutrients or remove waste. Allows organisms to grow and replace damaged tissue Cell Cycle Phases 1. Interphase – G1, S, G2 2. Mitosis – – – – 3. Prophase Metaphase Anaphase Telophase Cytokinesis 1) Interphase Includes G1, S and G2 phases Chromosomes are not visible Cell performs regular functions 90% of cell’s life spent in Interphase 2 4/2/13 G1 phase Cell grows rapidly Synthesis (S) phase Cell’s DNA is copied – Each chromosome has two chromatids (X shaped now) G2 phase Cell grows more Prepares to divide 2) Mitosis A sequence of cellular division In the lifetime of a cell, it is very short – Prophase – Metaphase – Anaphase – Telophase Prophase Centrioles start forming spindles Chromosomes coil up and become visible Nuclear envelope dissolves 3 4/2/13 Metaphase Chromosomes move to equator (middle) of cell Line up in single file Spindle fibers pull them there Anaphase Chromosomes are pulled apart by spindles Chromatids move to opposite poles Telophase Nuclear envelop forms around chromosomes at each pole Chromosomes uncoil Spindles dissolve 4 4/2/13 3) Cytokinesis The cytoplasm and cell membrane are separated by a belt of proteins Resulting in two new identical cells Cell Cycle Summary The nucleus divides The two new cells have the same number of chromosomes as the original cell Allows for growth and repair Cells That Don’t Divide Muscle and nerve cells do not divide They are in G1 phase forever If they die, the body cannot replace them 5 4/2/13 Control of the Cell Cycle The cell cycle has inspection points which allow the next phase to take place The cycle can be slowed or stopped, or the cell can be killed if necessary When Control is Lost Cancer is the uncontrolled growth of cells Cancer cells do not respond to signals to stop growing or signals to die They keep dividing and invading surrounding tissue 6