Download Quiz #2

BEFORE YOU START:
PLEASE NOTE THESE IMPORTANT ITEMS
USING #2 PENCIL, MAKE SURE THAT BOTH YOUR NAME AND UW AND SOM
(Test ID) SCHOOL STUDENT NUMBERS ARE CODED ON THE ANSWER SHEET
AND WRITTEN
ON THE SHORT-ANSWER PAGE
NOW - BEFORE YOU BEGIN.
SCORES WITHOUT STUDENT NAME AND NUMBERS
MAY NOT BE RECORDED.
THIS IS A TIMED QUIZ.
PUT ANSWERS ON ANSWER SHEET USING #2 PENCIL
ANSWER SHEETS TURNED IN LATE WILL NOT BE GRADED.
THIS QUIZ CONTAINS 33 ITEMS ON 7 PAGES (100 POINTS TOTAL).
THERE ARE 32 MULTIPLE CHOICE QUESTIONS AND ONE (3-part)
SHORT ANSWER/ESSAY QUESTION.
MAKE SURE ALL PAGES ARE PRESENT.
YOU MAY KEEP YOUR COPY OF THE QUIZ.
PLEASE NOTE THAT THE QUESTIONS ARE NUMBERED X01X33;USE THE CORRECT SIDE OF YOUR ANSWER SHEET
I.
SELECT ONE BEST (3 points each). Each numbered item or incomplete statement
in this section is followed by answers or completions of the statement. For items X01-X11
select the ONE lettered answer or statement that is BEST. MAKE SURE THAT FOR
THIS SECTION YOU USE THE APPROPRIATE NUMBERS ON THE ANSWER
SHEET BEGINNING WITH THE NUMBER X01.
X01. Tissue(s) with predominantly parasympathetic tone include:
A. ciliary muscle of the eye
B. salivary glands
C. sino-atrial node
D. urinary tract
E. all of the above
X02. Enzyme(s) involved in the biosynthesis of dopamine:
A. only dopa decarboxylase
B. only tyrosine hydroxylase
C. only dopamine-beta-hydroxylase
D. both tyrosine hydroxylase and dopa decarboxylase
E. all three enzymes are involved
Hu Bio 543
Quiz 2
October 17, 203
Page 1
X03. A beta-adrenergic antagonist is indicated for treatment of all of the following EXCEPT:
A. anxiety
B. asthma
C. glaucoma
D. hypertension
E. pheochromocytoma
X04. Indicated in the treatment of hypertension:
A. alpha-methyldopa
B. labetalol
C. prazosin
D. propranolol
E. all of the above
X05. Can activate nicotinic receptors in sympathetic ganglia
A. bethanechol
B. neostigmine
C. N-methylatropine
D. scopolamine
E. none of the above
X06. A drug which does NOT act on the central nervous system after systemic administration:
A. clonidine
B. guanethidine
C. physostigmine
D. pilocarpine
E. propranolol
X07. Likely to cause reflex tachycardia:
A. acetylcholine
B. ephedrine
C. norepinephrine
D. phenylephrine
E. all of the above
X08. Botulinun toxin:
A. blocks the uptake of choline into the nerve terminal
B. blocks the transport of acetylcholine into the synaptic vesicle
C. is indicated in the treatment of radiation-induced xerostomia
D. is indicated in the treatment of myasthenia gravis
E. none of the above
Hu Bio 543
Quiz 2
October 17, 203
Page 2
X09. Your annoying lab partner hands you a vial labeled “Drug X.” When you intravenously
administer it to him, you observe no change in total peripheral resistance (TPR). He then hands
you a vial marked “Drug Y”. When you inject first Y, followed by X, there is a decrease in TPR.
You then inject propranolol, followed by Y and then X. TPR does not change in response to X.
What were X and Y?
A. Drug X was acetylcholine; Drug Y was neostigmine
B. Drug X was carbachol; Drug Y was atropine
C. Drug X was epinephrine; Drug Y was imipramine
D. Drug X was isoproterenol; Drug Y was atenolol
E. Drug X was norepinephrine; Drug Y was cocaine
X10. Ipratropium is indicated in the treatment of respiratory disorders because:
A. it acts in the autonomic ganglia to produce bronchodilation
B. it blocks alpha-adrenergic mediated bronchoconstriction
C. it does not decrease bronchial secretions
D. it acts in the central nervous system to produce bronchodilation
E. none of the above
X11. A drug which (at therapeutic doses) can block both alpha1 and beta1-adrenergic receptors:
A. esmolol
B. fenoldopam
C. labetolol
D..phenoxybenzamine
E. prazosin
II. A, B, BOTH, NEITHER (2 points each).
For items X12 through X22 select:
A)
B)
C)
D)
if A is correct
if B is correct
if BOTH A AND B are correct
if NEITHER A NOR B is correct
X12. Indicated in a patient experiencing malignant hyperthermia:
A. dantrolene
B. succinylcholine
C . both A and B are correct
D. neither A nor B is correct
X13. Indicated in a patient experiencing premature labor:
A. ephedrine
B. ritodrine
C. both A and B are correct
D. neither A nor B is correct
Hu Bio 543
Quiz 2
October 17, 203
Page 3
X14. Acetylcholine receptors are normally diffusely distributed over the entire surface of:
A. cardiac muscle cells
B. skeletal muscle fibers
C. both A and B are correct
D. neither A nor B is correct
X15. Can cause cycloplegia:
A. atropine
B. mecamylamine
C. both A and B are correct
D. neither A nor B is correct
X16. Can act on the adrenal medulla after systemic administration:
A. amphetamine
B. bretylium
C. both A and B are correct
D. neither A nor B is correct
X17. Drug(s) whose adverse effects include dry mouth:
A. alpha-methyldopa
B. atropine
C. both A and B are correct
D. neither A nor B is correct
X18. Causes fasiculations prior to paralysis:
A. mivacurium
B. succinylcholine
C. both A and B are correct
D. neither A nor B is correct
X19. Dobutamine can act as an agonist at:
A. alpha1-adrenergic receptors
B. beta1-adrenergic receptors
C. both A and B are correct
D. neither A nor B is correct
X20. Drug(s) which form a covalent complex with a receptor:
A. esmolol
B. nadolol
C. both A and B are correct
D. neither A nor B is correct
X21. Can increase the level of cAMP in the heart:
A. isoproterenol
B. phenylephrine
C. both A and B are correct
D. neither A nor B is correct
Hu Bio 543
Quiz 2
October 17, 203
Page 4
X22. Contraindicated in a patient with asthma:
A. bethanechol
B. timolol
C. both A and B are correct
D. neither A nor B is correct
III. GREATER THAN – LESS THAN (1 point each)
For items X23 through X27 select:
A)
if A is GREATER THAN B
B)
if B is GREATER THAN A
C)
if BOTH A and B are EQUAL or NEARLY EQUAL
X23. Duration of action of:
A. acetylcholine
B. bethanechol
X24. Cardioselectivity of:
A. nadolol
B. timolol
X25. Duration of action of:
A. guanadrel
B. guanethidine
X26. Affinity of butoxamine for:
A. beta1-adrenergic receptors
B. beta2-adrenergic receptors
X27. Ability to act on the central nervous system after systemic administration:
A. acetylcholine
B. pilocarpine
Hu Bio 543
Quiz 2
October 17, 203
Page 5
IV. AUTONOMIC CHECKERBOARD (4 POINTS EACH)
DIRECTIONS: (Items X28 - X32) Please refer to the chart on the next page (you may
wish to remove the next page for ease of comparison). Assume that each VERTICAL
COLUMN represents a different animal which was pretreated with one or more drugs
before the test drug sequence. Assume the pretreatment drugs are used in doses at least
adequate to elicit their most characteristic pharmacological effects and that all
pretreatment drugs act throughout the experiment. Assume further that test drugs are
short-acting. The chart indicates the acute qualitative change (increase ⇑, decrease ⇓, no
change ⇒, respectively) in TOTAL PERIPHERAL RESISTANCE after intravenous
injection of each test drug. With careful attention to the key, you should choose the
MINIMUM number of pretreatment drugs which would be required to account for and
still be compatible with the observed results. SELECT:
A
B
C
D
E
F
G
H
I
J
K
L
M
N
Bretylium
Ipratropium
Prazosin
Propranolol
Reserpine
Atropine and guanethidine
Mecamylamine and nadolol
Phenoxybenzamine and timolol
Reserpine and timolol
Cocaine, mecamylamine, and scopolamine
Prazosin, propranolol, and scopolamine
Atropine, butoxamine, mecamylamine, and reserpine
Bretylium, mecamylamine, scopolamine, and timolol
Ipratropium, nadolol, prazosin, and reserpine
FOR EACH ITEM, FILL IN ONLY ONE CIRCLE ON YOUR ANSWER SHEETS.
X28.
Animal I was pretreated with:
X29.
Animal II was pretreated with:
X30.
Animal III was pretreated with:
X31.
Animal IV was pretreated with:
X32.
Animal V was pretreated with:
Hu Bio 543
Quiz 2
October 17, 203
Page 6
CONTROL
NO
PRETREAT-
ANIMAL
I
ANIMAL
II
ANIMAL
III
ANIMAL
IV
ANIMAL
V
MENT
ALB
AMP
CARB
DMPP
EPI
McN
⇓
⇑
⇓
⇑
⇑
⇑
⇓
⇒
⇓
⇒
⇑
⇓
⇓
⇒
⇓
⇓
⇓
⇓
⇓
⇒
⇑
⇑
⇑
⇒
⇒
⇒
⇒
⇒
⇒
⇒
⇒
⇑
⇓
⇒
⇑
⇑
NE
PHENYL
⇑
⇑
⇑
⇑
⇒
⇒
⇑
⇑
⇒
⇒
⇑
⇑
Where:
ALB =
AMP =
CARB =
DMPP =
EPI =
McN =
NE
=
PHENYL =
albuterol
amphetamine
carbachol
dimethylphenylpiperazinium
epinephrine
McN-A343
norepinephrine
phenylephrine
Suggestion: remove this page for easy comparison.
This is the end of the multiple choice questions.
Please be sure your name, student number, and answers
are correctly filled in on your answer sheet before going
on to the short answer/essay question.
GOOD LUCK
Hu Bio 543
Quiz 2
October 17, 203
Page 7
Name:________________________________
Student Number:________________________________
X33. Short Answer/Essay Question (20 points):
Please clearly write your answer in the space below. You may use the back of this page in the
unlikely event that you need more space. (Note : answers that are not sufficiently legible to be
deciphered will be assumed to be incorrect!)
A. Briefly explain the basis for the use of pilocarpine for the treatment of glaucoma.
Your answer should include the identity and location of the receptor at which pilocarpine
acts and how this results in the desired therapeutic effect (7 points) :
:
B. Briefly explain the basis for the use of timolol for the treatment of glaucoma. Your
answer should include identity and location of receptor at which timolol acts and how this
results in the desired therapeutic effect (7points):
C. Name a drug which acts at a target different from that of pilocarpine and timolol
which is indicated in the treatment of glaucoma, and briefly describe the basis for its use
(6 points):
REMEMBER TO TURN IN BOTH MULTIPLE CHOICE AND ESSAY ANSWERS!
Hu Bio 543
Quiz 2
October 17, 203
Page 8