Download Chapter 19(10E).

chapter 19
Student: ___________________________________________________________________________
1.
Choose the following that best characterizes the formation of uncontrolled division of cells or cancer.
A.mutations in DNA for the protein which activates repair enzymes
B.mutation in genes for inhibiting the cell cycle
C.mutations in proto-oncogenes/tumor suppressor genes
D.active telomerase
E.All of the choices are correct.
2.
Normal cells typically divide 60-70 times while cancer cells:
A.divide an unlimited number of times
B.divide twice that amount
C.may divide 60-70 times
D.are unable to divide
3.
Cancer cells have abnormal nuclei because:
A.the nuclear membrane is malformed
B.there are too many nucleoli
C.the chromosomes are abnormal, often showing gene amplification
D.of the disappearance of chromosomes, making the nucleus smaller
4.
What is the function of telomerase?
A.rebuild telomere sequences
B.destroy telomere sequences
C.connect different telomere sequences
D.separate different telomere sequences
5.
Choose the following that is NOT a characteristic of cancer cells.
A.They do not differentiate.
B.They invade nearby tissues if malignant.
C.They secrete angiogenic growth factors.
D.They display contact inhibition.
1
6.
When cancer cells metastasize:
A.tumors release growth factors
B.tumors spread throughout the body
C.tumors have nondifferentiated cells
D.tumors get larger and larger
7.
Cancer cells are able to move about the body when:
A.T cells attach and carry the cancer cells to different tissues
B.they produce proteinase which degrades the basement membrane allowing invasion of other tissues
C.telomeres attach to the basement membrane and pull cancer cells through to other tissues
D.None of the choices are correct.
8.
A mutation in the Bax gene results in:
A.less likelihood of apoptosis
B.less Bax protein present
C.possible tumor formation
D.All of the choices are correct.
9.
Ras oncogenes
A.produce cyclin.
B.activate repair enzymes.
C.promote apoptosis.
D.activate cyclin.
10. Which of the following mutated genes ultimately results in increased cyclin activity?
A.p16
B.Ras
C.p53
D.both p16 and Ras
11. Stimulatory pathways are:
A.proto-oncogenes
B.tumor suppressor genes
2
12. Inhibitory pathways are:
A.proto-oncogenes
B.tumor suppressor genes
13. Cancer causing genes are
A.apoptosis
B.leukemia
C.oncogenes
14. Programmed cell death is:
A.apoptosis
B.leukemia
C.oncogenes
15. Cancer of blood forming cells is
A.apoptosis
B.leukemia
C.oncogenes
16. What are telomeres?
A.specific proteins
B.repair enzymes
C.special repetitive DNA end sequences
D.signalling chemicals
17. What is the role of telomeres?
A.protect chromosome ends
B.act as molecular handles
C.repair enzymes
D.unfold chromosomes
3
18. An oncogene:
A.is the gene that causes p53 to be readily available
B.is a gene that causes a cell to become differentiated
C.is a gene that codes for the lipid component of the plasma membrane
D.can make cyclin available at all times
19. The regulatory network in cells that controls cell growth includes:
A.growth factor receptors in the plasma membrane
B.signaling proteins in the cytoplasm
C.genes in the nucleus
D.All of the choices are correct.
20. Which is NOT associated with the development of cancer?
A.plasma membrane receptors
B.the Golgi apparatus
C.cytoplasmic enzymes
D.genes in the nucleus
21. Which is NOT associated with the development of cancer?
A.plasma membrane receptors
B.the Golgi apparatus
C.cytoplasmic enzymes
D.genes in the nucleus
22. A tumor-suppressor gene:
A.is a cancer-causing gene
B.is a gene that codes for inhibitory proteins that prevent cell division and promote apoptosis
C.is a gene that causes myeloma in muscle cells
D.is a gene that stops a tumor once it has developed
23. During the formation of cancer, which of the following occurs?
A.initiation
B.promotion
C.progression
D.All of the choices are correct.
4
24. The uncontrolled division of cells is called:
A.cancer
B.mitosis
C.mutation
D.metastasis
25. An accumulation of cancer cells is called a:
A.bolus
B.diverticulum
C.tumor
D.metastasis
26. The development of cancer is called:
A.oogenesis
B.carcinogenesis
C.apoptosis
D.metastasis
27. Forming blood vessels is:
A.metastasis
B.apoptosis
C.angiogenesis
28. Cell death is:
A.metastasis
B.apoptosis
C.angiogenesis
29. Which type of tumor is usually encapsulated and noninvasive?
A.benign tumor
B.malignant tumor
5
30. Cancers in blood-forming cells are called:
A.lymphomas
B.melanomas
C.carcinomas
D.leukemias
31. A tumor developing in lymphatic tissues is a:
A.lymphoma
B.carcinoma
C.sarcoma
D.leukemia
32. A tumor arising in epithelial tissues is a:
A.lymphoma
B.carcinoma
C.sarcoma
D.leukemia
33. Which of the following changes in DNA?
A.mutagen
B.carcinogen
C.Both choices are correct.
34. Which behaviors are NOT associated with cancer development?
A.smoking cigars and drinking alcohol
B.poor sleeping habits
C.exposure to radon
D.a high-fat diet
35. Which of these seems to play a role in the development of cancer?
A.heredity
B.carcinogens
C.mutations
D.All of the choices are correct.
6
36. Which of these is considered a carcinogen or carcinogenic?
A.radiation
B.toxic chemicals
C.viruses
D.All of the choices are correct.
37. Regular Pap smears are credited with preventing what percentage of cervical cancer deaths?
A.10%
B.30%
C.65%
D.90%
38. Magnetic resonance imaging is particularly useful for determining the location of tumors:
A.in the blood
B.of the cervix
C.of the brain and spinal cord
D.lymphatic tumors
39. Use of taxol to treat ovarian cancer is an example of what type of treatment?
A.gene therapy
B.antimetastatic drugs
C.chemotherapy
D.antihormone therapy
40. Chemotherapy may not be an effective treatment for some cancers because:
A.effective therapies have not been discovered
B.some cancer cells may be resistant
C.cancers caused by viruses are nonsusceptible
D.chemotherapy is a new therapy and not yet proven its effectiveness
41. Which of these diagnostic procedures is used for breast cancer?
A.mammography
B.pap smear
C.sigmoidoscopy
D.stool blood test
7
42. Which of these diagnostic procedures is used for colon cancer?
A.colonoscopy
B.CEA blood test
C.white cell count
D.both a colonoscopy and CEA blood test
43. Which of these is NOT associated with the presence of a cancer?
A.a sore that does not heal
B.a lump in the breast
C.changes in sleeping habits
D.indigestion/change in bowel habits
44. The American Cancer Society recommends breast self-exams and testicular self-exams every:
A.day
B.month
C.6 months
D.year
45. Which of the following has been proposed as future therapy?
A.cancer vaccines
B.monoclonal antibodies
C.p53 gene therapy/induced tumor apoptosis
D.angiogenesis inhibition
E.All of the choices are correct.
46. Which vegetables are associated with cancer prevention?
A.peas and string beans
B.potatoes and rice
C.cabbage and broccoli
D.mushrooms and peppers
8
chapter 19 Key
1.
Choose the following that best characterizes the formation of uncontrolled division of cells or cancer.
a.
b.
c.
d.
E
mutations in DNA for the protein which activates repair enzymes
mutation in genes for inhibiting the cell cycle
mutations in proto-oncogenes/tumor suppressor genes
active telomerase
All of the choices are correct.
Mader - 019 Chapter... #1
2.
Normal cells typically divide 60-70 times while cancer cells:
A
b.
c.
d.
divide an unlimited number of times
divide twice that amount
may divide 60-70 times
are unable to divide
Mader - 019 Chapter... #2
3.
Cancer cells have abnormal nuclei because:
a.
b.
C
d.
the nuclear membrane is malformed
there are too many nucleoli
the chromosomes are abnormal, often showing gene amplification
of the disappearance of chromosomes, making the nucleus smaller
Mader - 019 Chapter... #3
4.
What is the function of telomerase?
A
b.
c.
d.
rebuild telomere sequences
destroy telomere sequences
connect different telomere sequences
separate different telomere sequences
Mader - 019 Chapter... #4
1
5.
Choose the following that is NOT a characteristic of cancer cells.
a.
b.
c.
D
They do not differentiate.
They invade nearby tissues if malignant.
They secrete angiogenic growth factors.
They display contact inhibition.
Mader - 019 Chapter... #5
6.
When cancer cells metastasize:
a.
B
c.
d.
tumors release growth factors
tumors spread throughout the body
tumors have nondifferentiated cells
tumors get larger and larger
Mader - 019 Chapter... #6
7.
Cancer cells are able to move about the body when:
a. T cells attach and carry the cancer cells to different tissues
B they produce proteinase which degrades the basement membrane allowing invasion of other
tissues
c. telomeres attach to the basement membrane and pull cancer cells through to other tissues
d. None of the choices are correct.
Mader - 019 Chapter... #7
8.
A mutation in the Bax gene results in:
a.
b.
c.
D
less likelihood of apoptosis
less Bax protein present
possible tumor formation
All of the choices are correct.
Mader - 019 Chapter... #8
2
9.
Ras oncogenes
a.
b.
c.
D
produce cyclin.
activate repair enzymes.
promote apoptosis.
activate cyclin.
Mader - 019 Chapter... #9
10.
Which of the following mutated genes ultimately results in increased cyclin activity?
a.
b.
c.
D
p16
Ras
p53
both p16 and Ras
Mader - 019 Chapter... #10
11.
Stimulatory pathways are:
A proto-oncogenes
b. tumor suppressor genes
Mader - 019 Chapter... #11
12.
Inhibitory pathways are:
a. proto-oncogenes
B tumor suppressor genes
Mader - 019 Chapter... #12
13.
Cancer causing genes are
a. apoptosis
b. leukemia
C oncogenes
Mader - 019 Chapter... #14
3
14.
Programmed cell death is:
A apoptosis
b. leukemia
c. oncogenes
Mader - 019 Chapter... #15
15.
Cancer of blood forming cells is
a. apoptosis
B leukemia
c. oncogenes
Mader - 019 Chapter... #16
16.
What are telomeres?
a.
b.
C
d.
specific proteins
repair enzymes
special repetitive DNA end sequences
signalling chemicals
Mader - 019 Chapter... #17
17.
What is the role of telomeres?
A
b.
c.
d.
protect chromosome ends
act as molecular handles
repair enzymes
unfold chromosomes
Mader - 019 Chapter... #18
18.
An oncogene:
a.
b.
c.
D
is the gene that causes p53 to be readily available
is a gene that causes a cell to become differentiated
is a gene that codes for the lipid component of the plasma membrane
can make cyclin available at all times
Mader - 019 Chapter... #19
4
19.
The regulatory network in cells that controls cell growth includes:
a.
b.
c.
D
growth factor receptors in the plasma membrane
signaling proteins in the cytoplasm
genes in the nucleus
All of the choices are correct.
Mader - 019 Chapter... #20
20.
Which is NOT associated with the development of cancer?
a.
B
c.
d.
plasma membrane receptors
the Golgi apparatus
cytoplasmic enzymes
genes in the nucleus
Mader - 019 Chapter... #22
21.
Which is NOT associated with the development of cancer?
a.
B
c.
d.
plasma membrane receptors
the Golgi apparatus
cytoplasmic enzymes
genes in the nucleus
Mader - 019 Chapter... #22
22.
A tumor-suppressor gene:
a.
B
c.
d.
is a cancer-causing gene
is a gene that codes for inhibitory proteins that prevent cell division and promote apoptosis
is a gene that causes myeloma in muscle cells
is a gene that stops a tumor once it has developed
Mader - 019 Chapter... #23
23.
During the formation of cancer, which of the following occurs?
a.
b.
c.
D
initiation
promotion
progression
All of the choices are correct.
Mader - 019 Chapter... #24
5
24.
The uncontrolled division of cells is called:
A
b.
c.
d.
cancer
mitosis
mutation
metastasis
Mader - 019 Chapter... #25
25.
An accumulation of cancer cells is called a:
a.
b.
C
d.
bolus
diverticulum
tumor
metastasis
Mader - 019 Chapter... #26
26.
The development of cancer is called:
a.
B
c.
d.
oogenesis
carcinogenesis
apoptosis
metastasis
Mader - 019 Chapter... #27
27.
Forming blood vessels is:
a. metastasis
b. apoptosis
C angiogenesis
Mader - 019 Chapter... #28
28.
Cell death is:
a. metastasis
B apoptosis
c. angiogenesis
Mader - 019 Chapter... #29
6
29.
Which type of tumor is usually encapsulated and noninvasive?
A benign tumor
b. malignant tumor
Mader - 019 Chapter... #31
30.
Cancers in blood-forming cells are called:
a.
b.
c.
D
lymphomas
melanomas
carcinomas
leukemias
Mader - 019 Chapter... #33
31.
A tumor developing in lymphatic tissues is a:
A
b.
c.
d.
lymphoma
carcinoma
sarcoma
leukemia
Mader - 019 Chapter... #34
32.
A tumor arising in epithelial tissues is a:
a.
B
c.
d.
lymphoma
carcinoma
sarcoma
leukemia
Mader - 019 Chapter... #35
33.
Which of the following changes in DNA?
a. mutagen
b. carcinogen
C Both choices are correct.
Mader - 019 Chapter... #40
7
34.
Which behaviors are NOT associated with cancer development?
a.
B
c.
d.
smoking cigars and drinking alcohol
poor sleeping habits
exposure to radon
a high-fat diet
Mader - 019 Chapter... #45
35.
Which of these seems to play a role in the development of cancer?
a.
b.
c.
D
heredity
carcinogens
mutations
All of the choices are correct.
Mader - 019 Chapter... #46
36.
Which of these is considered a carcinogen or carcinogenic?
a.
b.
c.
D
radiation
toxic chemicals
viruses
All of the choices are correct.
Mader - 019 Chapter... #47
37.
Regular Pap smears are credited with preventing what percentage of cervical cancer deaths?
a.
b.
c.
D
10%
30%
65%
90%
Mader - 019 Chapter... #53
38.
Magnetic resonance imaging is particularly useful for determining the location of tumors:
a.
b.
C
d.
in the blood
of the cervix
of the brain and spinal cord
lymphatic tumors
Mader - 019 Chapter... #55
8
39.
Use of taxol to treat ovarian cancer is an example of what type of treatment?
a.
b.
C
d.
gene therapy
antimetastatic drugs
chemotherapy
antihormone therapy
Mader - 019 Chapter... #56
40.
Chemotherapy may not be an effective treatment for some cancers because:
a.
B
c.
d.
effective therapies have not been discovered
some cancer cells may be resistant
cancers caused by viruses are nonsusceptible
chemotherapy is a new therapy and not yet proven its effectiveness
Mader - 019 Chapter... #58
41.
Which of these diagnostic procedures is used for breast cancer?
A
b.
c.
d.
mammography
pap smear
sigmoidoscopy
stool blood test
Mader - 019 Chapter... #60
42.
Which of these diagnostic procedures is used for colon cancer?
a.
b.
c.
D
colonoscopy
CEA blood test
white cell count
both a colonoscopy and CEA blood test
Mader - 019 Chapter... #61
43.
Which of these is NOT associated with the presence of a cancer?
a.
b.
C
d.
a sore that does not heal
a lump in the breast
changes in sleeping habits
indigestion/change in bowel habits
Mader - 019 Chapter... #62
9
44.
The American Cancer Society recommends breast self-exams and testicular self-exams every:
a.
B
c.
d.
day
month
6 months
year
Mader - 019 Chapter... #63
45.
Which of the following has been proposed as future therapy?
a.
b.
c.
d.
E
cancer vaccines
monoclonal antibodies
p53 gene therapy/induced tumor apoptosis
angiogenesis inhibition
All of the choices are correct.
Mader - 019 Chapter... #70
46.
Which vegetables are associated with cancer prevention?
a.
b.
C
d.
peas and string beans
potatoes and rice
cabbage and broccoli
mushrooms and peppers
Mader - 019 Chapter... #73
10
chapter 19 Summary
Category
Mader - 019 Chapter...
1
# of
Questions
46