Download Example of the Course Test 4 2nd April, 8:00, registration from 7:30

Example of the Course Test 4
2nd April, 8:00, registration from 7:30
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for the test you must be registered in SIS
you must have your personal ID (no ISIC number) and credit book!
the test will contain:
22 questions multiplechoice
4 short answers
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examples of the questions are :
1) Select correct statements
a) Accumulated CpG dinucleotides are present in the promoter region of gene
b) Epigenetic modifications of genes can be a cause of tumor growth
c) Metastable epialleles have identical gene expression
d) Short noncoding RNAs are long 20-30 nucleotides
2) Which of the following is correct?
a) Morgan’s number equals 1 in complete linkage
b) Two allelic pairs located on one pair of homologs are in linkage
c) An example of recessive epistasis is Bombay allele
d) The principle of cumulative multiplicity with or without dominance resembles a principle of
multifactorial inheritance
3) Select correct statements
a) purine is formed during nucleotide degradation
b) ammonia is formed during the degradation of pyrimidine nucleotides
c) uric acid is formed in a reaction catalysed by xanthine oxidase
d) purine nucleotides require folic acid for their de novo synthesis
4) Select correct statements
a) Each oocyte is at the end of the 1st meiotic prophase (a stage called dictyotene) at the time of
birth of female baby
b) Chromosomes of daughter cells formed in the 1st meiotic division have only one chromatid
c) Haploid daughter cells are formed in the 1st meiotic division
d) Dispermy is the fertilization of a haploid ovum by an abnormal diploid sperm
5) Out of the following choose correct statements
a) Abnormality in embryonic development can be due to monogenic disorder
b) The presence of precursor H (coded by dominant allele H) is important for manifestation of alleles
A and B of AB0 blood group system
c) Mutation of one gene always affects a single trait
d) Influence of environmental factors on manifestation of monogenic disorder is minimal or none
6) Which of the following statements are true?
a) Recurrence risk of multifactorial disorder increases for more remote relatives of the proband
b) In one family the child with an unilateral cleft was born, in another family the child with a bilateral
cleft was born. The risk for the next child is higher in the family with the unilateral cleft
c) Intelligence is determined in polygenic manner
d) Preconceptional care is able to prevent monogenic inborn defects
7) Choose true statements
a) Insertion of one nucleotide is responsible for the frame shift mutation
b) Chronic infection with Toxoplasma gondi has teratogenic effect
c) Synonymous (same sense) mutation causes replacement of one amino acid by another
d) Gene polymorphisms are rare in the population
8) Choose true statements
a) Reccurent pregnancy losses are not indication to genetic counselling
b) Syndrome represents numerous independent anomalies, presumed to be causally related
c) Risks for relatives of persons affected by monogenic disorders are determined according to empiric
risks
d) Primary prevention is the prevention of the origin of an inborn error