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History of the Otsuka Group Otsuka-people creating new products for better health worldwide Strategic evolution of Otsuka Group 1964 Establishment of Otsuka Pharmaceutical 1963 Establishment of Taiho Pharmaceutical 2008 Establishment of Otsuka Holdings NutraClinical ceuticals nutrition 1965 OTC 1961 Establishment of Otsuka Warehouse Chemicals Maximizing the corporate value of the Otsuka Group Chemicals 1921 Establishment of Otsuka Pharmaceutical Factory Clinical nutrition Clinical nutrition Chemicals Pharmaceuticals Consumer products OTC Clinical nutrition 1946 1950 Establishment of Otsuka Chemical OTC Clinical nutrition 1971 Establishment of first research laboratory Nutraceuticals Diagnostics Cosmedics Pharmaceuticals Nutraceuticals Diagnostics Chemicals Pharmaceuticals 1980 Chemicals 2005 OTC Consumer products OTC Consumer products Nutraceuticals (nutrition + pharmaceuticals): Products with timeless value based on scientifically proven concepts Cosmedics (cosmetic + medicine): Products based on the unique concept of 'health for skin' The history of the Otsuka Group began in 1921, when Busaburo products and nutraceuticals to support the daily health of people, Otsuka established a factory manufacturing chemical compounds Otsuka Pharmaceutical established its first research laboratory in in Naruto, Tokushima Prefecture (now Otsuka Pharmaceutical Tokushima in 1971, marking the start of research into the Factory Inc.). After this beginning as small-scale manufacturer of development of proprietary drugs, based on the concept of chemical raw materials, in 1946 the company began producing creating innovative pharmaceutical products. and selling intravenous solutions, marking its entry into the pharmaceutical products market. In 1950, the organic chemicals division split off from Otsuka In the Nutraceuticals business, Otsuka Pharmaceutical has leveraged its pharmaceuticals research expertise to develop proprietary products and business models, creating various Pharmaceutical Factory to form Otsuka Chemical and Medical innovative products that anticipated consumer needs and Products, Inc. (now Otsuka Chemical Co., Ltd.), which continues to established entirely new market of their own. contribute to human health with pharmaceutical intermediates and other chemical products. In 1961, the Otsuka Pharmaceutical Factory transport and warehousing division split off from the company to become Otsuka In 2005, Otsuka Pharmaceutical entered the skin care market with products based on the concept of "healthy skin." Otsuka Holdings was established in July 2008 as a holding company of the Group, with the aim of maximizing the Warehouse Co., Ltd., now involved mainly in pharmaceuticals corporate value of the Otsuka Group, a comprehensive and food products distribution. corporate group dedicated to integrated healthcare. Taiho Pharmaceutical Co., Ltd was established in 1963, with 08 Chemicals 1953 Chemicals Nutraceuticals Clinical nutrition The Otsuka Group will function as a unified group under this operations specializing in oncology. Otsuka Pharmaceutical Co., holdings structure as we strive to contribute to the health and Ltd. was established in 1964. Initially pursuing growth in OTC prosperity of people worldwide.