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Name: _______________________________________ Period:_____________________
Cellular Respiration Review Worksheet
1. What are the 2 types of respiration that a cell can use to make ATP and what determines which pathway is
used?
______________________________________________________________________________________________
______________________________________________________________________________________________
2. Write the overall equation for cellular respiration.
Aerobic: _____________________________________________________________________________________
Anaerobic (type 1): ____________________________________________________________________________
Anaerobic (type 2): ____________________________________________________________________________
3. What are the 3 phases of the cellular respiration process?
Aerobic: ______________________________________________________________________________________
Anaerobic: ____________________________________________________________________________________
4. Where in the cell does the glycolysis part of cellular respiration occur? _________________________________
5. Where in the cell does the Krebs (Citric Acid) cycle part of cellular respiration occur?
_____________________
6. Where in the cell does the electron transport part of cellular respiration occur?
___________________________
7. How many ATP are made in the glycolysis part of cellular respiration?__________
8. How many ATP are made in the Kreb’s cycle part of cellular respiration? ___________
9. How many ATP are made in the electron transport part of cellular respiration? ____________
10. In which phase of cellular respiration is carbon dioxide made? _______________________________
11. What are NAD+ and FAD? What do they do and what do they become?
______________________________________________________________________________________________
______________________________________________________________________________________________
12. In which phase of cellular respiration is water made?______________________________________________
13. What would happen to the cellular respiration process if the enzyme (aka catalyst) for one step of the process
was missing or defective?
______________________________________________________________________________________________
______________________________________________________________________________________________
14. Where does the process of fermentation take place?________________________________
15. What are the products of lactate fermentation? ________________________________
16. What are the products of ethanol fermentation? ________________________________
17. Draw and label a mitochondrion and include all of the parts that are used during cellular respiration.
MULTIPLE CHOICE. Circle ALL that are TRUE. There may be MORE THAN one correct answer.
18. _______________________ is the first step in cellular respiration that begins releasing energy stored in glucose.
A. Alcoholic fermentation
B. Lactic acid fermentation
C. Glycolysis
D. Electron transport chain
19. The carriers for energy and high energy electrons during GLYCOLYSIS are ________.
A. ATP
B. NADH
C. FADH2
D. NADPH
20. If oxygen is NOT present, glycolysis is followed by _____________________
A. Krebs cycle
B. electron transport chain
C. fermentation
21. Name the 3 carbon molecule produced when glucose is broken in half during glycolysis.
A. pyruvic acid
B. lactic acid
C. Acetyl-CoA
D. citric acid
22. Since fermentation does not require oxygen it is said to be __________________.
A. aerobic
B. anaerobic
23. Which high energy electron carrier is regenerated during fermentation that allows cells to continue to make
ATP using glycolysis?
A. NAD+
B. NADPH
C. ATP
D. ADP
24. How many ATP molecules are added to get glycolysis started? _________
25. Since glycolysis produces 4 ATP molecules, this results in a NET GAIN of _____ ATP’s
26. MATCH THE LETTER IN THE DIAGRAM WITH THE LABEL: (You can use them MORE THAN ONCE)
Hint E is located outside the mitochondria. It is representing the “jelly” of the cell.
______ MATRIX
______ INTERMEMBRANE SPACE
______ CYTOPLASM
______ OUTER MEMBRANE
______ INNER MEMBRANE (CRISTAE)
______ Place GLYCOLYSIS happens
27. Write the complete overall chemical equation for cellular respiration using chemical symbols instead of words:
____________ + _______________ → ________________+_________________+________________
28. Compare this reaction to the one you learned about last chapter for PHOTOSYNTHSIS
(6 H2O + 6 CO2 + light energy → C6H12O6 + 6 O2) How are these equations related?
______________________________________________________________________________________________________
Tell the kind of fermentation used in each example:
29. Yeast use this to make bread dough rise ________________________
30. Your muscle cells use this during rapid exercise when oxygen is low ________________
31. Bacteria and yeast use this to make beer and wine _____________________
32. Bacteria use this to make cheese, yogurt, and sour cream ___________________
33. If alcoholic fermentation is used to make bread dough rise, how come you don’t become intoxicated when you
eat the bread?
_____________________________________________________________________
The Krebs Cycle and Electron Transport Chain
MULTIPLE CHOICE: Circle the answer or answers that best complete the statement or answer the question. (THERE MAY BE
MORE THAN ONE RIGHT ANSWER.)
34. Which of the following shows the correct sequence during cellular respiration?
A. Electron transport chain → glycolysis → Krebs cycle
B. Glycolysis → Electron transport chain → Krebs cycle
C. Krebs cycle → Electron transport chain → glycolysis
D. Glycolysis → Krebs cycle → Electron transport chain
35. Where do the carbon atoms in pyruvic acid end up following the Krebs cycle?
A. They enter the electron transport chain and make ATP
B. They become part of a carbon dioxide molecule and end up in the atmosphere
C. They join with citric acid to make Acetyl-CoA
D. They build up in the intermembrane space
36. Because cellular respiration requires oxygen it is said to be _________________
A. aerobic
B. anaerobic
37. How many total ATP molecules are produced by 1 molecule of glucose completing cellular respiration?
2
6
24
36
38. WHICH OF THE FOLLOWING ARE PRODUCED DURING THE KREBS CYCLE?
A. ATP
B. NADH
C. FADH2
D. CO2
39. What molecule is the final electron acceptor at the end of the Electron transport chain?
A. oxygen
B. carbon dioxide
C. glucose
D. NADH
40. The movement of which ion across the membrane from the intermembrane space to the matrix causes ATP synthase to
spin and make ATP
A. Na+ ions
B. oxygen
C. H+ ions
D. water
41. Which stage of cellular respiration produces the most ATP?
A. glycolysis
B. Krebs cycle
C. Electron transport
D. Acetyl-CoA charging
42. Which of the following happens as electrons pass down the Electron Transport chain?
A. Energy from the moving electrons transports H+ ions into the intermembrane space
B. Carbon dioxide is released
C. Energy from H+ ions crossing back into the matrix causes ATP synthase to make ATP.
D. Water is produced
43. Use the diagram to the right to name the molecule that joins in this reaction
to make Acetyl-CoA.
A. ATP
B. NADP+
C. Coenzyme A
D. citric acid
44. Looking at the diagram on the right… If oxygen is present, what will happen
to the NADH produced in this reaction?
A. Its electrons will enter the Electron transport chain
B. It will donate its H+ ions to make glucose
C. It will join with ATP to make citric acid
D. It will join with oxygen to make CO2
45. Name the 6 carbon molecule that forms when Acetyl-CoA joins its 2 carbons to a 4 carbon molecule during the Krebs
cycle.
A. ATP
B. pyruvic acid
C. glucose
D. citric acid
46. MATCH THE LETTER IN THE DIAGRAM WITH THE LABEL: (You can use them MORE THAN ONCE or NOT AT ALL)
Hint E is located outside the mitochondria. It is representing the “jelly” of the cell.
______ Place where glycolysis happens
______ Place where enzymes for the Electron
Transport Chain are located
_____ Place that fills with H+ ions as electrons move down the Electron transport chain
______ Place where ADP and P join to make ATP
______ Place where oxygen acts as the final electron acceptor to make water
CELLULAR RESPIRATION VOCABULARY REVIEW
47. __ __ __ __ __ __ __ __ __ __ is a 6 carbon molecule that is produced first when acetyl-CoA joins with a 4
carbon molecule to enter the Krebs cycle.
48. __ __ __ __ __ __ __ __ __ __ is the process of splitting a glucose molecule into 2 pyruvic acid molecules.
49. The molecule used by cells to store and transfer energy is __ __ __.
50. Glycolysis happens outside the mitochondria in the __ __ __ __ __ __ __ __ __ of the cell.
51. __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ happens when oxygen is present and includes
glycolysis, Krebs cycle, and Electron transport.
52. This describes a process that requires oxygen = __ __ __ __ __ __ __
53. This high energy electron carrier produces fewer ATP’s than NADH as its electrons pass
Transport Chain because it enters farther down the chain =__ __ __ __ __
through the Electron
54. This atmospheric gas is required for aerobic respiration = __ __ __ __ __ __.
55. This describes a process that does NOT require oxygen; it means “without air” = __ __ __ __ __ __ __ __ __
56. Type of fermentation used by human muscles in low oxygen conditions and microorganisms to make yogurt,
cheese, pickles, sauerkraut and kimchi. = __ __ __ __ __ __ __ __ __ __
57. As electrons pass down the electron transport chain, H+ ions build up in the
__ __ __ __ __ __ __ __ __ __ __ __ __ space.
58. The __ __ __ __ __ cycle breaks down pyruvic acid into carbon dioxide and produces NADH, FADH 2, and ATP.
59. The NADH and FADH2 produced during the Krebs cycle pass their electrons down the
__ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ __ chain to produce ATP.
60. The passage of H+ ions through __ __ __ __ __ __ __ __ __ __ __ causes it to spin and produce ATP.
61. This 3 carbon molecule is produced during glycolysis when glucose splits in half
= __ __ __ __ __ __ __ __ __ __ __
62. Cell organelle which acts as the cell’s power plant to burn glucose and store energy as ATP
= __ __ __ __ __ __ __ __ __ __ __ __
63. If oxygen is NOT present, glycolysis is followed by __ __ __ __ __ __ __ __ __ __ __ __.
64. Type of fermentation used to make bread dough rise and produce beer and wine.
= __ __ __ __ __ __ __ __ __
65. This molecule has the formula C6H12O6 and is split in half during glycolysis = __ __ __ __ __ __ __
66. The carbon atoms in pyruvic acid end up as __ __ __ in the atmosphere following the Krebs cycle.
67. The folded inner membranes inside a mitochondrion are called __ __ __ __ __ __ __.
68. __ __ __ __ __ __ __ __ __ forms when Coenzyme A attaches to two carbons from pyruvic acid.
69. __ __ __ __ __ __ __ __ is the storage form of glucose used by animal cells which can be broken down for
energy when glucose is used up.
70. The area inside the cristae where the Krebs cycle happens is the __ __ __ __ __ __.
71. Label numbers 1,2,3
Cellular Respiration Review Worksheet
1. What are the 2 types of respiration that a cell can use to make ATP and what determines which pathway is
used?
Aerobic respiration & anaerobic respiration; they depend on the presence or absence of oxygen
2. Write the overall equation for cellular respiration.
Aerobic: Glucose + oxygen yields carbon dioxide + water
Anaerobic (alcohol fermentation): Glucose→ ethanol alcohol + carbon dioxide
Anaerobic (lactate formation): Glucose → lactic acid
3. What are the 3 phases of the cellular respiration process?
Aerobic: Glycolysis & Kreb’s cycle/electron transport chain
Anaerobic: Glycolysis & Lactate Formation or Alcohol Feremntation
4. Where in the cell does the glycolysis part of cellular respiration occur? Why?
Cytoplasm; the necessary enzymes are located there
5. Where in the cell does the Krebs (Citric Acid) cycle part of cellular respiration occur? Why?
Mitochondrial matrix; the necessary enzymes are located there
6. Where in the cell does the electron transport part of cellular respiration occur? Why?
Mitochondrial membrane/cristae; increased surface area for more ATP production
7. How many ATP are made in the glycolysis part of cellular respiration?
2
8. How many ATP are made in the Kreb’s cycle part of cellular respiration?
2
9. How many ATP are made in the electron transport part of cellular respiration?
32
10. In which phase of cellular respiration is carbon dioxide made?
Kreb’s cycle
11. What are NAD+ and FAD? What do they do and what do they become?
They are electron carriers in the ETC; they become NADH and FADH2
12. In which phase of cellular respiration is water made?
Electron Transport Chain or ETC
13. What would happen to the cellular respiration process if the enzyme (aka catalyst) for one step of the process
was missing or defective?
The process would stop and no more products would be made
14. Where does the process of fermentation take place?
cytoplasm
15. What are the products of lactate fermentation?
Crista (plural cristae)
Lactic acid
16. What are the products of ethanol fermentation?
Ethanol and carbon dioxide
17. Draw and label a mitochondrion and include all of the parts that are used during cellular respiration.
Answer given and labeled picture given above
CELLULAR RESPIRATION
MULTIPLE CHOICE. Circle ALL that are TRUE. There may be MORE THAN one correct answer.
18. _______________________ is the first step in cellular respiration that begins releasing energy stored in glucose.
A. Alcoholic fermentation
B. Lactic acid fermentation
C. Glycolysis
D. Electron transport chain
19. The carriers for energy and high energy electrons during GLYCOLYSIS are ________.
A. ATP
B. NADH
C. FADH2
D. NADPH
20. If oxygen is NOT present, glycolysis is followed by _____________________
A. Krebs cycle
B. electron transport chain
C. fermentation
21. Name the 3 carbon molecule produced when glucose is broken in half during glycolysis.
A. pyruvic acid
B. lactic acid
C. Acetyl-CoA
D. citric acid
22. Since fermentation does not require oxygen it is said to be __________________.
A. aerobic
B. anaerobic
23. Which high energy electron carrier is regenerated during fermentation that allows cells to continue to make ATP using
glycolysis?
A. NAD+
B. NADPH
C. ATP
D. ADP
24. How many ATP molecules are added to get glycolysis started? _2________
25. Since glycolysis produces 4 ATP molecules, this results in a NET GAIN of __2___ ATP’s
26. MATCH THE LETTER IN THE DIAGRAM WITH THE LABEL:
(You can use them MORE THAN ONCE)
__D____ MATRIX
___B___ INTERMEMBRANE SPACE
___E__ CYTOPLASM
___A___ OUTER MEMBRANE
__C____ INNER MEMBRANE (CRISTAE)
___E___ Place GLYCOLYSIS happens
27. Write the complete overall chemical equation for cellular respiration using chemical symbols instead of words:
C6H12O6 + ______O2_________ → ______CO2__________+________H2O_________+_______ATP_________
28. Compare this reaction to the one you learned about last chapter for PHOTOSYNTHSIS
(6 H2O + 6 CO2 + light energy → C6H12O6 + 6 O2) How are these equations related?
They are complimentary or opposite reactions.
Tell the kind of fermentation used in each example:
29. Yeast use this to make bread dough rise ____ALCOHOL____________________
30. Your muscle cells use this during rapid exercise when oxygen is low _______LACTIC_________
31. Bacteria and yeast use this to make beer and wine _________ALCOHOL____________
32. Bacteria use this to make cheese, yogurt, and sour cream ______LACTIC_____________
33. If alcoholic fermentation is used to make bread dough rise, how come you don’t become intoxicated when you
eat the bread? IT BREAKS DOWN OR DENATURES AS IT COOKS. This is why you can have red wine sauce
under the age of 21…
The Krebs Cycle and Electron Transport
MULTIPLE CHOICE:
Circle the answer or answers that best complete the statement or answer the question.
(THERE MAY BE MORE THAN ONE RIGHT ANSWER.)
34. Which of the following shows the correct sequence during cellular respiration?
A. Electron transport chain → glycolysis → Krebs cycle
B. Glycolysis → Electron transport chain → Krebs cycle
C. Krebs cycle → Electron transport chain → glycolysis
D. Glycolysis → Krebs cycle → Electron transport chain
35. Where do the carbon atoms in pyruvic acid end up following the Krebs cycle?
A. They enter the electron transport chain and make ATP
B. They become part of a carbon dioxide molecule and end up in the atmosphere
C. They join with citric acid to make Acetyl-CoA
D. They build up in the intermembrane space
36. Because cellular respiration requires oxygen it is said to be _________________
A. aerobic
B. anaerobic
37. How many total ATP molecules are produced by 1 molecule of glucose completing cellular respiration ?
2
6
24
36
38. WHICH OF THE FOLLOWING ARE PRODUCED DURING THE KREBS CYCLE?
A. ATP
B. NADH
C. FADH2
D. CO2
39. What molecule is the final electron acceptor at the end of the Electron transport chain?
A. oxygen
B. carbon dioxide
C. glucose
D. NADH
40. The movement of which ion across the membrane from the intermembrane space to the matrix causes ATP synthase to spin
and make ATP
A. Na+ ions
B. oxygen
C. H+ ions
D. water
41. Which stage of cellular respiration produces the most ATP?
A. glycolysis
B. Krebs cycle
C. Electron transport
D. Acetyl-CoA charging
42. Which of the following happens as electrons pass down the Electron Transport chain?
A. Energy from the moving electrons transports H + ions into the intermembrane space
B. Carbon dioxide is released
C. Energy from H+ ions crossing back into the matrix causes ATP synthase to make ATP.
D. Water is produced
43. Use the diagram to the right to name the molecule that joins in this reaction to
make Acetyl-CoA.
A. ATP
B. NADP+
C. Coenzyme A
D. citric acid
44. Looking at the diagram on the right… If oxygen is present, what will happen to
the NADH produced in this reaction?
A. Its electrons will enter the Electron transport chain
B. It will donate its H+ ions to make glucose
C. It will join with ATP to make citric acid
D. It will join with oxygen to make CO2
45. Name the 6 carbon molecule that forms when Acetyl-CoA joins its 2 carbons to a 4 carbon molecule during the Krebs
cycle.
A. ATP
B. pyruvic acid
C. glucose
D. citric acid
46. MATCH THE LETTER IN THE DIAGRAM WITH THE LABEL:
(You can use them MORE THAN ONCE or NOT AT ALL)
___E__ Place where glycolysis happens
___C__ Place where enzymes for the Electron
Transport Chain are located
___B__ Place that fills with H+ ions as electrons move
down the Electron transport chain
___C__ Place where ADP and P join to make ATP
____D__ Place where oxygen acts as the final electron
acceptor to make water
CELLULAR RESPIRATION VOCABULARY REVIEW
47. _CITRIC ACID _ is a 6 carbon molecule that is produced first when acetyl-CoA joins with a 4 carbon molecule to
enter the Krebs cycle.
48. _G L Y C O L Y S I S _is the process of splitting a glucose molecule into 2 pyruvic acid molecules.
49. The molecule used by cells to store and transfer energy is A T P.
50. Glycolysis happens outside the mitochondria in the _C_ _Y_ _T_ _O_ _P_ _L_ _A_ _S_ _M_ of the cell.
51. _A _E_ R__O _B_ I__C
R _E_ S__P _I_ R A__T _I_ O__N _ happens when oxygen is present and includes glycolysis, Krebs
cycle, and Electron transport.
52. This describes a process that requires oxygen = A E R O B I C.
53. This high energy electron carrier produces fewer ATP’s than NADH as its electrons pass through the Electron Transport Chain
because it enters farther down the chain =_FADH2_
54. This atmospheric gas is required for aerobic respiration = O X Y G E N.
55. This describes a process that does NOT require oxygen; it means “without air”
=A N A E R O B I C
56. Type of fermentation used by human muscles in low oxygen conditions and microorganisms to make yogurt, cheese, pickles,
sauerkraut and kimchi. = L A C T I C A C I D .
57. As electrons pass down the electron transport chain, H + ions build up in the
I N T E R M E M B R A N E space.
58. The K R E B S cycle breaks down pyruvic acid into carbon dioxide and produces NADH, FADH 2, and ATP.
59. The NADH and FADH2 produced during the Krebs cycle pass their electrons down the
E L E C T R O N T R A N S P O R T chain to produce ATP.
60. The passage of H+ ions through A T P
S Y N T H A S E causes it to spin and produce ATP.
61. This 3 carbon molecule is produced during glycolysis when glucose splits in half
= P Y R U V I C A C I D or Pyruvate
62. Cell organelle which acts as the cell’s power plant to burn glucose and store energy as ATP
=M I T O C H O N D R I A
63. If oxygen is NOT present, glycolysis is followed by F E R M E N T A T I O N .
64. Type of fermentation used to make bread dough rise and produce beer and wine.
=A L C O H O L I C
65. This molecule has the formula C6H12O6 and is split in half during glycolysis = G L U C O S E
66. The carbon atoms in pyruvic acid end up as C O 2 in the atmosphere following the Krebs cycle.
67. The folded inner membranes inside a mitochondrion are called C R I S T A E
68 A C E T Y L
C O A or Coenzyme A forms when Coenzyme A attaches to two carbons from pyruvic acid.
69. G L Y C O G E N is the storage form of glucose used by animal cells which can be broken down for energy when glucose is
used up.
70. The area inside the cristae where the Krebs cycle happens is the M A T R I X
71. LABEL &/OR EXPLAIN EACH OF THE FOLLOWING DIAGRAMS: On your sheet there is only 1 diagram here are 2 more to
practice with…
INTERMEMBRANE SPACE
 INNER MITOCHONDRIAL MEMBRANE
CYTOPLASM
 MATRIX
OUTER
MITOCHONDRIAL
MEMBRANE
1. GLYCOLYSIS
2. KREBS
3. ELECTRON TRANSPORT CHAIN
ADP+P
GLYCOLYSIS
 TO ELECTRON
TRAINSPORT CHAIN
TO
ATMOSPHERE
INTERMEDIATE STEP
 TO ELECTRON
TRAINSPOTY CHAIN
TO KREBS CYCLE