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Download QUIZ #7 NUCLEOTIDE METABOLISM
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QUIZ #7 170. NUCLEOTIDE METABOLISM Which of the following is used during the conversion of uracil to thymine? a. SAM b. THF c. THB d. Biotin e. CO2 171. The nitrogens of a purine molecule are derived from all of the following amino acids EXCEPT: a. Aspartic Acid b. Asparagine c. Glutamine d. Glycine 172. What is the correct sequence of appearance of intermediates in the degradation of adenosine? a. Adenosine --> hypoxanthine -->xanthine --> inosine --> uric acid b. Adenosine --> inosine --> hypoxanthine --> xanthine --> uric acid c. Adenosine --> xanthine --> hypoxanthine --> inosine --> uric acid d. none of the above are correct 173. Which of the following is NOT utilized in the the conversion of ribose to deoxyribose? a. NADPH b. FADH2 c. UMP d. Thioredoxin e. Ribonucleotide reductase 174. GLN-PRPP amidotransferase is inhibited by: a. High [PRPP] b. High [NMP], [NDP] and [NTP] c. Insulin d. Glucose 175. Phosphoribosyl pyrophosphate is: a. Formed during a regulated step in purine synthesis b. Formed by the action of phosphoribosyl synthetase c. A substrate for both purine and pyrimidine biosynthesis d. Hydrolyzed by the action of inorganic pyrophosphate phosphatase e. 1), 2) and 3) are correct 176. During nucleotide biosynthesis, which of the following contribute to the structure of BOTH purines and pyrimidines? a. Aspartic acid b. Methylene-THF c. Glutamine d. Glycine e. 1), 2) and 3) are correct 177. Which of the following is NOT a nucleoside? a. Adenosine b. Cytidine c. Cytosine d. Guanosine e. Uridine 178. Which of the following bases is least likely to appear as a nucleotide? a. AMP b. d-ADP c. d-GTP d. d-UMP e. Thymidylic acid 179. GTP inhibits which of the following reactions in purine biosynthesis? a. PRPP --> PRNH2 b. IMP --> GMP c. IMP --> AMP d. 1) and 2) are correct e. 1), 2) and 3) are correct 180. Carbamoyl phosphate synthetase II (CPS-II) is: a. Activated by PRPP b. Inhibited by UMP c. Activated by ATP d. The key committed step in the formation of carbamoyl~phosphate e. All of the above are correct 181. Complete this analogy: NOR-EPINEPHRINE : EPINEPHRINE as URACIL : ? a. Cytosine b. Hypoxanthine c. Xanthine d. Thymine e. Orotic Acid 182. Methotrexate inhibits: a. ribonucleotide reductase b. thymidylate synthase c. dihydrofolate reductase d. PRPP-amidotransferase e. HX/G-phosphoribosyl transferase 183. G/HX phosphoribosyl transferase: a. is utilized in the synthesis of the purine ring b. is required for the salvage of purine bases c. converts hypoxanthine to guanine d. is inhibited by methotrexate e. is required to convert purines to uric acid