Download Abdul Majeed Seayad Project Synopsis (96 - ACE

MEDIA STORY BANK: PROPOSALS TO RECEIVE FUNDING FROM THE GSK-SINGAPORE GREEN AND SUSTAINABLE MANUFACTURING PARTNERSHIP
Projects
Novel approach
Story opportunity
Activation of alcohols
Alcohol activation by hydrogen
The activation of alcohols, a readily available and nonhazardous Developing sustainable technologies to convert
borrowing strategy: Alcohols as
feedstock, for useful transformations without functional group readily available nontoxic feedstock would
electrophiles in C-N and C-C bond
interconversions is a challenge in organic and process chemistry. In a greatly impact the way in which APIs are
forming reactions
classic synthesis, the less active alcohols are converted to the active manufactured in the future.
forms which are generally genotoxic and the process would generate
hazardous waste raising environmental concerns. We approach this
problem by using the novel catalytic “hydrogen borrowing strategy”
that converts the alcohols in situ to an active intermediate that react
with another suitable molecule to form the desired product. In this
project, we target to design cost-effective catalysts and greener
technologies for batch and continuous process for the alkylation of
amines using non-hazardous and readily available alcohols.
Principal investigator:
Dr. Abdul Majeed Seayad
Scientist
Institution: Institute of Chemical &
Engineering Sciences, A*STAR
Email: [email protected]
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