Download 2-years postdoctoral fellowship in the CIIL

2-years postdoctoral fellowship in the CIILTeam Lung infection and innate immunity
Starting in December 2014 at Pasteur Institute (Lille)
Description of the Topic:
Lung inflammatory disorders such as chronic obstructive pulmonary disease (COPD)
are associated with an increased susceptibility to respiratory infections which trigger
episodes of exacerbation, a phenomenon that is clinically of increasing importance.
Our aim is to better define the molecular mechanisms involved in the altered
immunity present during COPD. Indeed, it is essential to adapt the immunotherapeutic approach (including vaccination) to this particular context. To reach this
aim, we have developed murine models of acute exacerbation in COPD and in vitro
approaches which have been designed to mimic as closely as possible the human
pathology. A precise survey of pulmonary immune response (cell phenotype and
functions, cytokine network) has been performed to better understand the
mechanisms leading to the altered innate response. We have identified new
mechanisms of susceptibility in this context and we would like to corroborate these
data in the relevant clinical situation.
In this context, the overall goal of this proposal is to evaluate the efficacy and the
safety of new therapeutic approaches in our mouse model of COPD exacerbation,
based on inhalation to cigarette smoke, intercalated with S. pneumoniae infection and
to establish a proof of concept in human cell models. The capacity of these therapies
to trigger efficient and safe host defense mechanisms, to control the infection and to
limit the progression of the disease will be measured. This project will also precise
the signature of the response to the different treatments during COPD.
The candidate should have a PhD and the desire to undertake a first or second postdoctoral fellowship. You should already have a validated experience in experimental
models (animal experimentation accreditation is required) and in immunology. Some
knowledge about the mechanisms involved in lung inflammation and diseases will
be appreciated.
We seek autonomous, enthusiastic and energetic people with strong teamwork skills.
Contacts:
Pichavant Muriel ([email protected])
Gosset Philippe ([email protected])