Download Supplementary Table 1

Supplementary Table 1: Overview and references of previously reported disease
associations for the markers selected in the present study.
Marker (alternative name)
HLA-A
HLA-B
rs2239528 (BAT1 -348)
rs9281523 (BAT1 NcoI RFLP)
rs1129640 (BAT1 +348/+885)
rs2071592 (IKBL -63/-62)
rs3130062 (IKBL +738)
rs909253 (LTA or TNFβ NcoI RFLP/+252/+249)
rs1800629 (TNF -308)
rs361525 (TNF -238)
rs3093662 (TNF +851)
rs2076523
Gene
HLA-A
HLA-B
BAT1
BAT1
BAT1
NFKBIL1
NFKBIL1
LTA
TNF
TNF
TNF
BTNL2
Disease association
JIA, MS, T1D
AS, SLE, T1D
RA
T1D
RA
RA
SLE, pSS, UC
CD, GD
AS, CD, UC
GD
JOA
Sarcoidosis
References
1-8
1; 9-14
15
16
17
18
19; 20
21; 22
22-25
26
27
28
Only markers with direct evidence for disease association are shown. Alternative name:
previously used (common) marker names. AS: ankylosing spondylitis; CD: celiac
disease; GD: Graves’ disease; JIA: juvenile idiopathic arthritis; JOA: juvenile
oligoarthritis; MS: multiple sclerosis; RA: rheumatoid arthritis; SLE: systemic lupus
erythematosus; pSS: primary Sjögren’s syndrome; T1D: type 1 diabetes; UC: ulcerative
colitis.
References:
1.
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2.
Noble JA, Martin A, Valdes AM, Lane JA, Galgani A, Petrone A et al. Type 1
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Noble JA, Valdes AM, Bugawan TL, Apple RJ, Thomson G & Erlich HA. The
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4.
Brynedal B, Duvefelt K, Jonasdottir G, Roos IM, Akesson E, Palmgren J et al.
HLA-A confers an HLA-DRB1 independent influence on the risk of multiple
sclerosis. PLoS ONE 2007; 2(7): e664.
5.
Fogdell-Hahn A, Ligers A, Gronning M, Hillert J & Olerup O. Multiple sclerosis:
a modifying influence of HLA class I genes in an HLA class II associated
autoimmune disease. Tissue Antigens 2000; 55(2): 140-148.
6.
Harbo HF, Lie BA, Sawcer S, Celius EG, Dai KZ, Oturai A et al. Genes in the
HLA class I region may contribute to the HLA class II-associated genetic
susceptibility to multiple sclerosis. Tissue Antigens 2004; 63(3): 237-247.
7.
Zeggini E, Donn RP, Ollier WE & Thomson W. Evidence for linkage of HLA loci
in juvenile idiopathic oligoarthritis: independent effects of HLA-A and HLADRB1. Arthritis Rheum 2002; 46(10): 2716-2720.
8.
Hall PJ, Burman SJ, Laurent MR, Briggs DC, Venning HE, Leak AM et al.
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