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Kin 310 – Ex Met 2 Fuel Utilization and Neural – Endocrine Control 1. Describe the activation and translocation of free fatty acids into skeletal muscle that is required prior to metabolism as fuel. (do not include the regulation of translocation in your answer). 2. Describe the mobilization, circulation and uptake of free fatty acids during exercise. Why do researchers measure FFA levels in the blood during exercise? 3. Discuss the control of Free Fatty Acid translocation. Include a brief discussion on the current understanding of the role of AMP. 4. Describe the intercellular lactate shuttle. Describe the physiological benefits that are associated with lactate shuttles and how an increase in mitochondrial LDH in type I fibers with training is important? 5. Describe the intracellular lactate shuttle. Describe the physiological benefits that are associated with lactate shuttles and how an increase in mitochondrial LDH in type I fibers with training is important? 6. What are the sources of blood glucose? 7. Differentiate between fed state and fasted state metabolism of glucose in the liver. Including details of the changes in glucose movement. 8. Describe the control of Hepatic Glucose Production. What changes do we observe with the transition from 55% to 82% VO2 max? Explain the significance and control mechanisms with this transition from moderate to high intensity exercise. 9. Summarize the overall process of gluconeogenesis in the liver. 10. Describe the influences over gluconeogenesis in the liver by summarizing the control over changes cAMP between the fed and fasted (or exercise) state. 11. Describe the detailed influence of a rise in cAMP on gluconeogenesis in the liver.