Download Cori Cycle - COFFEE BREAK CORNER

Cori Cycle Definition Source Fate Functions It is the conversion of glucose into lactate in peripheral tissues, followed by conversion of lactate into glucose in liver From glycolysis especially in RBCs due to absence of mitochondria and muscle during exercises due to oxygen lack 1. Glucose formation a) Lactate formed in muscles and RBCS may diffuse to the blood then to the liver b) In the liver, lactate is converted to glucose by gluconeogenesis. Glucose may diffuse back to the blood, then to red cells or muscles to be used for production of energy. This cycle is called Lactic acid cycle or Cori cycle 2. Conversion into pyruvate a) If oxygen gets available, lactate is converted into pyruvate w’ proceeds into Krebs cycle 3. Lactate may be accumulated in muscles causing muscle fatigue 4. Lactate is excreted in urine and sweat ♣ Prevent loss of lactate as waste products in urine ♣ Oxidation of reduced NAD ♣ Supplies RBCs & contracting muscles with glucose for reutilization How liver helps during exercise? By Cori Cycle