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AnS SI Session 16 Sunday, 2/7, 7pm CQoD: “Before you criticize someone, you should walk a mile in their shoes. That way, when you criticize them, you're a mile way and you have their shoes.” - Author Unknown A. T3 and T4 (EMC) 1) Note the effects of T3 and T4 on the following: Oxygen consumption: Metabolic rate: Heat production: Heart rate: Respiration rate: Cardiac contractility: Apetite: CHO, lipid, protein storage: 2) T3 and T4 are made from ___________________________ and ___________________________, by cleavage of the amino acid from ___________________________. 3) Are T3 and T4 water soluble? How are they transported in the bloodstream? How does this affect the hormones' choice of cell targets and how does this allow them to regulate metabolism? 4) What is the hypothalamic-pituitary hormone axis that controls release of TH? What kind of feedback does TH have on the brain? 5) Where are T3 and T4 synthesized? What substrates are required for their synthesis? 6) How are T3 and T4 transported in the blood? How does this influence how they exert their effects on the cell? 7) List the effects of T3 and T4 on Mitochondria: Ribosomes: Nuclear DNA: 8) Name the 3 conditions triggered by low TH secretions. Include symptoms of each. ________________________: ________________________: ________________________: 9) What is the cause of toxic goiter? B. Parathyroid hormone (MC) 1) What is the effect of PTH on blood calcium levels? 2) What is the effect of PTH on calcitriol levels? 3) The result of hypoparathyrodism is.... Hyperparathyroidism? C. Adrenal Medulla (EMC) 1) Innervation to the medulla consists of a ________________________________________, which in turn receives signals from sympathetic ________________________________ fibers. The first structure consists of a special neuron type called ________________________________ cells. In general, neural stimulation results in the the release of ________________________________ and ________________________________. These serve to increase _________________, _________________ and _________________. Additionally, these hormones tend to _________________ metabolic rate. They inhibit the secretion of _________________ and stimulate the processes of ________________________________ and ________________________________, resulting in a net _________________ of blood glucose levels. Under stress, cells of the adrenal medulla stimulate the ________________________________. D. Adrenal Cortex (EMC) 1) Name the 3 classes of hormones produced by the adrenal cortex, give the hormone(s) produced by each, as well as their main effect on the body. Class Hormone(s) Effect(s)