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Transcript
Supplementary Table 2: Candidate desaturases and elongases, in map order Gene ID1 Gene name Function Right2 Left2 Desaturases on chromosome 2 CG9078 ifc Sphingolipid 4 desaturase3 Mst26Aa bib CG13279a Cyt-b5-r sal cad 6 desaturase4 a 4 CG17928 sal cad 5 desaturase Desaturases on chromosome 3 CG7923 desatF Fatty acyl-coA-desaturase5 Mapped 6 CG8630 Stearoyl-coA 9-desaturase gl desat1 CG5887 b desat 1 Myristoyl-coA 9-desaturase7 Mapped CG5925 b desat 2 Stearoyl-coA 9-desaturase7 desat1* pros 6 CG9747 Stearoyl-coA 9-desaturase jan (end) CG15531 Stearoyl-coA 9-desaturase6 jan (end) 6 CG9743 Stearoyl-coA 9-desaturase jan (end) Elongases on chromosome 2 CG30008 Elongase6 Pgi G-o c 6 CG18609 Elongase pm grh CG17821c Elongase6 pm grh Elongases on chromosome 3 CG11801d Fatty acid elongase activity8 desatF Sod* Elo68 d 8 CG32072 Fatty acid elongase activity desatF Sod* Elo68 9 CG3971 baldspot Elongase st Cat CG31522e Elongase6 Cat Gld CG31523e Elongase6 Cat Gld 6 CG2781 Fatty acid elongase activity dsx* e CG9458f Elongase6 pros MtnA* f 6 CG9459 Elongase pros MtnA* CG16904f Elongase6 pros MtnA* f 10 CG16905 eloF Elongase pros MtnA* CG8534f Elongase6 pros MtnA* g 6 CG5326 Elongase MtnA slo In QTL? no no no Adjacent to 7,11-PD 7,11-PD, T T T, adjacent to 7-T no no no no no no Adjacent to 7,11-HD, T, 7-T Adjacent to 7,11-HD, T, 7-T no no no T All CHC All CHC All CHC All CHC All CHC 7,11-HD, 7-P; adjacent to all others CG6921g CG5278g CG33110g CG6660 CG31141 Elongase6 Elongase6 Elongase6 Elongase6 Fatty acid elongase activity6 MtnA MtnA MtnA MtnA MtnA slo slo slo slo slo 7,11-HD, 7-P; adjacent to all others 7,11-HD, 7-P; adjacent to all others 7,11-HD, 7-P; adjacent to all others 7,11-HD, 7-P; adjacent to all others 7,11-HD, 7-P; adjacent to all others 1 The gene ID number is given for D. melanogaster. The superscripts a-g indicate sets of genes that are adjacent in D. simulans The marker to the right and left of the gene are indicated. An asterisk indicates that the gene is less than 20 kb from these markers in D. simulans. 3 Ternes et al, 2002 4 These genes have cytochrome domains similar to yeast, but no demonstrated activity (J.A. Napier, pers. comm.) 5 Legendre et al, 2008 6 Dallerac et al, 2000; Wicker-Thomas et al, 1997 7 Wicker-Thomas and Chertemps, 2010 8 Chertemps et al, 2005 9 Jung et al, 2007, Rice and Duffy, 2001 10 Chertemps et al, 2007 2 References Chertemps T, Duportets L, Labeur C, Ueda R, Takahashi K, Saigo K et al (2007). A female-biased expressed elongase involved in long-chain hydrocarbon biosynthesis and courtship behavior in Drosophila melanogaster. Proc Natl Acad Sci USA 104(11): 4273-4278. Chertemps T, Duportets L, Labeur C, Wicker-Thomas C (2005). A new elongase selectively expressed in Drosophila male reproductive system. Biochem Biophys Res Commun 333: 1066-1072. Dallerac R, Labeur C, Jallon J-M, Knipple DC, Roelofs WL, Wicker-Thomas C (2000). A ∆9 desaturase gene with a different substrate specificity is responsible for the cuticular diene hydrocarbon polymorphism in Drosophila melanogaster. Proc Natl Acad Sci USA 97(17): 94499454. Jung A, Hollman M, Schäfer MA (2007). The fatty acid elongase NOA is necessary for viability and has a somatic role in Drosophila sperm development. J Cell Sci 120(16): 2924-2934. Legendre A, Miao X-X, Da Lage J-L, Wicker-Thomas C (2008). Evolution of a desaturase involved in female pheromonal cuticular hydrocarbon biosynthesis and courtship behavior in Drosophila. Insect Biochem Mol Biol 38(2): 244-255. Rice AH, Duffy JB (2001). Characterization of baldspot, a putative gene involved in dorsal-ventral patterning during Drosophila oogenesis. Drosophila Research Conference 42: 667A Ternes P, Franke S, Zaehringer U, Sperling P, Heinz E (2002). Identification and characterization of a sphingolipid Delta4-desaturase family. The Journal of Biological Chemistry 28: 25512-25518. Wicker-Thomas C, Chertemps T (2010). Molecular biology and genetics of hydrocarbon production. In: Blomquist GJ and Bagnères AG (eds) Insect Hydrocarbons : Biology, Chemistry and Chemical Ecology, p In press. Wicker-Thomas C, Henriet C, Dallerac R (1997). Partial characterization of a fatty acid desaturase gene in Drosophila melanogaster. Insect Biochem Mol Biol 27: 963-972.
