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Crohn’s and Ulcerative Colitis By Fred Hui, M.D. The Traditional Etiology of the Disease Like many other unsolvable chronic diseases traditionally viewed as autoimmune disease, conventional medicine views the mechanism of Crohn’s disease is as an overactive immune system hitting innocent tissues and organs. The mode of the quieting the riot is to suppress the hyperactive policemen. Immunosuppressive medicine such as Prednisone, is used as the trump card in most severe flare up. While the medicine usually achieves dramatic results, as soon as doctors observe that everything is under control, they like to lower the dose. As doctors are well aware of the extensive side effects of Predinisone, some of which include diabetes, weight gain , osteoporosis, ,high blood pressure, and cataracts, they often have wishful thinking that when things are quiet, somehow everything will be all right when the immunosuppressive drugs are cut down. However, most of the time, as soon as the bound hands of the “policemen” are loosened, they do their due diligence to hit again, and often do so with bigger vengeance. Physicians will usually conclude that we need to use even stronger drugs, such as Remicade, Immurane, Methotrexate, Cyclosporins (transplant anti-rejection medications), given that the goal of the intervention is to knock down the policemen so to prevent them from ever managing to get up again.Eventually, when the bowel becomes out of control, ulcerates and bleeds, the only option is to cut the rotten segment out. An Alternative Approach to Understanding the Disease Being an integrative physician, I always try to think out of the box. This is one stellar example where accepting a different view point and approach will bring tremendous success where conventional wisdom fails. Over the years of treating numerous Crohn’s and Ulcerative Colitis patients, I came to put together a protocol that has yielded very successful results. To deal with this condition, instead of frowning my forehead when I come across such patients, I now look forward to treating these types of patients. The gratification of seeing them dramatically and quietly turn around is exciting. In my opinion, the underlying mechanism of the disease is as follows: There is actually an underlying genetic food allergy in most of these patients. It could be any food, but most commonly milk products, wheat or others. Normally, when any food is ingested, it is eventually broken down into the most basic single “alphabets” (Proteins into amino acids, carbohydrates into simple glucose, and fat into fatty acids). For one who does not have enough digestive enzymes, either geneticallyor by virtue of an episode of bowel infection, the food is presented to the body as an unfamiliar combination of “alphabets”. When the body sees this alien molecule trying to enter the bowel wall, the emergency response team will start to bombard these “insurgents” (foreigners). The inner lining of the bowel wall where these aliens are trying to cross, are bombed and attacked by the body’s white blood cells and chemicals. If the bowel lining is still perfectly intact, the main action of the deportation team is to wash the undigested food out by pouring in copious amounts of liquid (watery diarrhea) and squeezing them out through the rear door (cramps). Symptomatic treatment with Imodium, Codeine or narcotics paralyzes the squeezing action of the pulsatile intestines to cut down cramps and diarrhea. If the bowel lining is damaged by the friendly fire bombing, however, we now have a phenomenon of a broken fence (leaky gut). More undigested food will be able to cross the border un-scrutinized. Vicious cycles are set in. More leaky gut will ensure more ulcerative wall, will bleed or secrete more mucous in the intestine, there are always some anaerobic bacteria living there. If they ever enter the body through these broken fences, they will infect the thickness of the bowel wall itself, causing pockets of abscesses and rotted through walls (perforation and fistulas). When these bacteria flow into the blood stream, the body will get into a mode of national alert in the form of chills and episodes of low-grade fever. Those floating in the blood usually get killed by the immune system or doctors’ prescribed antibiotics. But for the insurgents that have ventured into the joints, or ‘hidden caves’, they have found safe havens and are protected against the immune system. Since there is no blood flow into joints spaces beyond the cartilages, the army can only bomb outside the caves, which results in collateral damage to the surrounding tissues. Will they ever get rid of these ‘insurgents’? With enough chronic inflammatory bowel diseases, associated joint involvements may occur. Another common etiology of chronic inflammatory bowel disease is parasites or tough bacteria such as C. Difficile. Their infestation constantly damage and inflame the bowel lining. This is particularly likely if the initial onset was started by a “Traveler’s Diarrhea”. My Protocol 1) Identify the food allergy There is a finger prick blood test that we can send to the US, called IgG delayed food antibody tests. It will identify among a list of 100 food groups which are the patients is allergic to. Avoidance of the offending food is paramount. 2) Do a detailed stool and saliva antibodies analysis for parasites and bacteria infection. 3) Use Digestive Enzymes A comprehensive digestive enzyme is taken with each meal. Megazyme is my favourite brand. 4) Patch up the leaky guy I prescribe a pre-digested protein from white fish (A brand called Sea Cure) to patch up the leaky gut. It seems like the body likes this material to patch up the leaky filters and broken lining. Two capsules are taken, three times a day before meals. 5) Reinstall a colony of good bacteria to drive out the bad bacteria from the intestinal lumen. They also seem to reinstall the right environment (eg. pH balance) for the body’s digestive enzyme to function optimally. 6) Clean up the aerobic bacteria in the pockets of the bowel wall, the blood and the joints. Antibiotics such as Cipro, Metronidazole, and sulphur drugs are prescribed by physicians. These antibiotics have some success, but they have limited penetrating power, often cause antibiotic resistance, and some have side effects causing an upset gut, nausea and diarrhea, in addition to what the patient already has. As an alternative, an intravenous of Hydrogen Peroxide, together with penetrating agent (hylauronic acid) seems to be able to diffuse into any place the blood reaches and fumigates into abscesses pockets and joints (Hydrogen peroxide is metabolized into water and oxygen.). The anaerobic bacteria strives in pockets of abscesses, joints that are low in concentration of oxygen and get killed in areas of higher oxygen concentration. After a few sessions of low dose IV Hydrogen Peroxide, patients will notice that the occasional episode of chills and low grade flu-like achiness will no longer return. Most patients notice a distinct difference within ten sessions of twice a week treatments. If successful, they will go on to more sessions until all the symptoms of inflammatory bowel disease have subsided. Average patients “graduate” after 20-30 treatments. The above proposed mechanism of the disease and the treatment is (vs. may be) my way of explaining my observed success. With eradication of the underlying real cause, most patients get off their immune suppressive drugs and symptomatic drugs. No more chills and “flu”, no more aches and pain, no more cramps, gas and diarrhea…and no more blood!