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Diseases of the Circulatory system The condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased. Persons with anemia may feel tired and fatigue easily, appear pale, develop palpitations and become unusually short of breath. Children with chronic anemia are prone to infections and learning problems. Anemia has four basic causes. One or more of these causes must be operating to produce anemia: Hemorrhage -- bleeding Hemolysis -- excessive destruction of red blood cells Underproduction of red blood cells Not enough normal hemoglobin Women are more likely than men to have anemia because of the loss of blood each month through menstruation. Iron deficiency anemia is common and in adults is most often due to chronic blood loss. This can be from menstruation or from small amounts of repeated bleeding (which can be very subtle) and in children is due mainly to not enough iron in the diet. Anemia is also often due to gastrointestinal bleeding caused by medications including such very common drugs as aspirin and ibuprofen (Advil or Motrin). There are many forms of anemia, some of them common, others rare. They include, for example: Aplastic anemia Benzene poisoning Fanconi anemia Hemolytic disease of the newborn Hereditary spherocytosis Iron deficiency anemia Osteopetrosis Pernicious anemia Sickle cell disease Thalassemia Myelodysplastic syndrome and a host of other bone marrow diseases Aneurysm: A localized widening (dilatation) of an artery, vein, or the heart. At the area of an aneurysm, there is typically a bulge and the wall is weakened and may rupture. The word “aneurysm” comes from the Greek “aneurysma” meaning “a widening.” Angina: Angina is chest pain that is due to an inadequate supply of oxygen to the heart muscle. The chest pain of angina is typically severe and crushing. There is a feeling just behind the breastbone (the sternum) of pressure and suffocation. The word “angina” comes from the Latin verb “angere” meaning “to choke or throttle.” “Angina” is now the same as “angina pectoris” (the Latin “pectus” = “chest”). Angina was first described by the English physician William Heberden (1710- 1801). Hypertension: High blood pressure or hypertension means high pressure (tension) in the arteries. The arteries are the vessels that carry blood from the pumping heart to all of the tissues and organs of the body. Hypertension does not mean excessive emotional tension, although emotional tension and stress can temporarily increase the blood pressure. High blood pressure is generally defined as a level exceeding 140/90 mm Hg that has been confirmed on multiple occasions. The systolic blood pressure, which is the top number, represents the pressure in the arteries as the heart contracts and pumps blood into the circulation. The diastolic pressure, which is the bottom number, represents the pressure in the arteries as the heart relaxes after the contraction. The diastolic pressure, therefore, reflects the minimum pressure to which the arteries are exposed. Congenital heart disease: A malformation of the heart or the large blood vessels near the heart. The term “congenital” speaks only to time, not to causation; it means “born with” or “present at birth.” Congenital heart disease is the most frequent form of major birth defects in newborns affecting close to 1% of newborn babies (8 per 1,000). Atherosclerosis: A process of progressive thickening and hardening of the walls of mediumsized and large arteries as a result of fat deposits on their inner lining. Risk factors for atherosclerosis include high levels of "bad" cholesterol, high blood pressure (hypertension), smoking, diabetes and a genetic family history of atherosclerotic disease. Atherosclerosis is responsible for much coronary artery disease (angina and heart attacks) and many strokes Arteriosclerosis: Hardening and thickening of the walls of the arteries. Arteriosclerosis can occur because of fatty deposits on the inner lining of arteries (atherosclerosis), calcification of the wall of the arteries, or thickening of the muscular wall of the arteries from chronically elevated blood pressure (hypertension). Angioplasty: Procedure with a balloon-tipped catheter to enlarge a narrowing in a coronary artery. Coronory Bypass surgery- open heart surgery