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PATHOLOGY WRITTEN EXAM III 1. A 20 year old is found to have buccal and lip melanosis and hamartornatous polyps of the colon. Which of the following is the MOST LIKELY diagnosis based on these clinical findings? A. Lynch syndrome B. Gardner syndrome C. Peutz-Jegners syndrome D. juvenile polyposis E. Familial polyposis 2. Which of the following is NOT associated with increased risk for developing ovarian carcinoma: A. Mutation in BRCA2 gene B. Nulliparity C. Family history D. History of oral contraceptive use. E. Mutation in BRCA1 gene 3. The primary lesion of Lyme disease is: A. Erythema annulare B. Erythema migrans C. Erythema multiforme D. Erythema dyschromicum perstans E. Erythema auricularis 4. A child presents to their physician with a rash on the face, trunk and extremities. Ulcerated oral lesions are also noted. A biopsy of an enlarged lymph node reveals reticuloendothelial giant cells "Warthin-Finkeldey cells." Your diagnosis would be with an infection: A. Rubella virus B. Rubeola (measles) C. Secondary Syphilis D. Parvovirus Big E. Varicella Zoster 5. Dizygotic twin pregnancy may occur with which configuration of the placental dividing membrane? A. Monoamnionic - monochorionic B. Diamnionic - dichorionic C. Diamnionic - monochorionic D. Monoamnionic - dichorionic E. None of the above -1- 6. Which of the following regarding cervical (PAP) smears is/are true A. The slide containing the specimen should be allowed to air-dry B. Endometrial cells are normally found in smears from post-menopausal females C. The best time to perform the smear is during menstruation D. Is an effective screening test for cervical cancer and its precursor lesions E. All of the above 7. Which of the following is NOT considered a predisposing condition to development of colon adenocarcinorna? A. Familial polyposis B. Inflammatory bowel disease C. Adenomatous polyps D. Booerhaave's syndrome E. High fat diet 8. A 60-year-old woman notices scaling and crusting of the skin of her right nipple and areola. There is no nipple discharge or nipple retraction. A palpable mass is not detected on physical examination. A biopsy of the nipple shows very large cells surrounded by a clear zone within the epidermis. The cytoplasm of the Dells stains positively with a mucin stain. Which of the following statements is correct? A. The patient most likely has a fibroadenoma. B. The patient most likely has fat necrosis of the breast and nipple: C. The patient most likely has ductal carcinoma of the breast. D. The patient most likely has colon cancer which has metastasized to the breast. E. The patient most likely has malignant melanoma involving the breast. 9. Which statement regarding fine needle aspiration is true? This technique: A. Can be used to diagnose tumors B. Cannot be performed by pathologists C. Cannot be used to diagnose infections D. Is usually associated with significant risk to the patient E. Requires overnight hospital stay -2- 10. A 7 year old uncircumcised male presents with a chief complaint of recurrent episodes of reddening and irritation of the penile foreskin. His father indicates that similar episodes started two years ago, but now seem to be more frequent. Your physical examination shows a phimotic foreskin with obvious circumferential scarring and narrowing of the preputial orifice; even with moderate effort the patient cannot retract the foreskin. The foreskin and glans are hyperemic, and debris and retained urine are visible in the balanopreputial sulcus (cul-de-sac). Which ONE of the following should you do? A. Assure the father that there are no long term sequelae to phimosis. B. Dimiss the fathers concerns, tell him his son will "grow out of it" and recommend no treatment. C. Recommend circumcision. D. Prescribe anti-virals taken by mouth; no follow-up visit is needed. E. Inform the father that in spite of intense ongoing research, there is still no known treatment for his son's condition. 11. A 35-year-old woman notices a small amount of bloody nipple discharge from her right nipple. On physical examination, she has a 1 cm subareolar mass. The excised mass shows delicate papillary fronds covered by a single layer of cuboidal epithelium overlying a connective tissue stalk. Which of the following is the MOST LIKELY diagnosis? A. lntraductial papilloma B. Invasive ductal carcinoma C. Lobular hyperplasia D. Fibrocystic change E. Fibroadenoma 12. A patient presents to the E.R. with a genital draining ulcer and painful swollen inguinal lymph nodes. A darkfield exam is negative, however Gram stain of the lesion reveals Gram negative bacilli. What Is the MOST LIKELY diagnosis? A. Lymphogranulom venerum B. Herpes C. Chancroid C. Syphilis D. Papillomavirus 13. A 40 year old woman presents with a mass of the right parotid. A biopsy of the freely mobile mass confirms the diagnosis of pleomorphic adenoma (benign mixed tumor). Which form of therapy is MOST LIKELY to be recommended? A. enucleation of the mass B. local neck irradiation C. complete excision including a thin rim of normal parotid D. chemotheraphy E. radical neck dissection and lymph node dissection -3- 14. Which of the following IS NOT a cause of adrenal insufficiency? A. polyglandular autoimmune endocrinopathy B. Conn's syndrome C. rapid withdrawal of exogenous corticosteroids D. autoimmune adrenalitis E. tuberculous adrenalitis 15. An 18 year old girl presents with right sided abdominal pain. Ultrasonography reveals a 5 cm cystic ovarian mass which is subsequently removed. During perioperative inspection sebaceous material, hair and teeth are found within the cyst. The MOST LIKELY diagnosis in this case is A. Dysgerminoma B. Lymphoma C: Benign teratoma D. Metastatic carcinoma E. Malignant teratoma 16. A 25 year old male presents with complaints of pain on urination. You forget to ask him how long he has had this problem (shame on you). Before you examine hire you collect a urine specimen. During the digital prostate exam he remarks that the procedure is slightly uncomfortable but not painful. You procede with prostate massage and then milk the prostatic secretions from the urethra into a specimen cup. Finally, you ask the patient to provide a postmassage urine specimen. All 3 specimens are sent to the lab for routine bacterial culture and white blood cell (WBC) count. The results are as follows: Pre-massage urine = 1 WBC per high power field; bacterial culture no growth. Prostatic secretions = 100 WBC per high power field; bacterial culture no growth. Post-massage urine = 40 WBC per high power field; bacterial culture no growth. The MOST LIKELY diagnosis is; A. Chronic bacterial prostatitis. B. Sepsis of uncertain origin. C. Acute bacterial prostatitis. D. Chronic non-bacterial prostatitis. E. Urinary tract infection. 17. A 38 year old woman with bitemporal hemianopsia is evaluated with an MRI. A large sellar mass is identified. SerunVplasma hormone levels are obtained and prolactln is determined to be moderately elevated, but the remainder of the hormone levels are normal. The tumor is resected and does not stain for any of the pituitary hormones with immunohistochemical stains. Given this history, pathologic and clinical findings, which of the following is the MOST LIKELY diagnosis? A. somatotroptmic adenoma B. syndrome of inappropriate ADH secretion (SIADH) C. prolactinoma D. gonadotrophic adenoma E. null cell adenoma with stalk effect -4- 18. An umbilical cord configuration associated with an increased incidence of fetal malformations? A. Single umbilical artery B. Single umbilical vein C. Single veramentous insertion D. Single true knot 19. A highly communicable respiratory disease which initially presents with an incubation period or catarrhal phase foil owed by a period of severe coughing with an inspiratory gasp is MOST LIKELY due to A. Rubella B. Bordetella pertussis C. Corynebacterium diphtheriae D. Respiratory Syncytial virus E. Human Herpes Virus 6 20. A 66 year old male smoker with a chronic clinical history of reflux esophagilis is seen by you for an annual physical. He relates a history of continuing reflux symptoms, particularly after large meals. Endoscopy is performed and confirms intestinal metaplasis of the squamous mucosa from biopsies obtained from the distal esophagus. Which is the MOST LIKELY diagnosis? A. Normal esophagus B. Diffuse esophageal spasm C. Primary esophageal adenocarcinoma D. scleroderma E. Barren's esophagus 21. An elderly gentleman presents with a white plaque on his tongue. He has a long history of smoking. The biopsy is MOST LIKELY to show: A. Squamous dysplasia B. Mucocele C. Oral hairy leukoplalda D. Peripheral giant cell granuloma E. Herpes infection 22. Which of the following is the MOST LIKELY karyotype to be present in complete molar pregnancies: A. 46, XX B. 46, YY C. 69, XXY D. 69, XXX E. 46, XY -5- 23. Which of these malformations accompanies systemic hypertension and left ventricular hypertrophy? A. Anomalous pulmonary venous drainage to the right atrium B. Aortic valve atresia C. Coarclation of the aorta D. Truncus arteriosus E. intramuscular ventricular septal defect 24. A 63 year old Caucasian male presents to your office complaining of mild stomach discomfort and dyspepsia. He occasionally takes antacids and Pepcid AC for relief. Endoscopy is performed and shows no discernible alterations. Biopsies of the stomach antrum, body and fundus are obtained and submitted to surgical pathology for examination. A report from Dr. Farhood confirms chronic active gastritis in the antrum, but normal fundus and body biopsies. Helicobacter organisms are identified along the mucosal surface with special stains. No intestinal metaplasia or atrophy is present. Which of the following diagnoses is MOST CONSISTENT with the clinical findings and pathologic diagnoses? A. acute erosive gastropathy B. acute peptic ulcer C. diffuse antral gastritis (type B) D. multifocal atrophic gastitis (type C) E. diffuse corporal atrophic gastritis (type A) 25. A Tzanck smear from a rash noted to be in a dermatomal pattern is positive showing multinucleated giant cells. What would be the MOST LIKELY etiology? A. Varicella Zoster Virus B. Rubeola (measles) virus C. Mumps virus D. Cylomrgalovirus E. Rubella virus 26. Which of the following is a maternal gestational infection with a potential for teratogenicity? A. Pneumococcus B. Rubella C. Herpes simplex O. Group B beta hemolytic streptococcus E. Hemophilus influenza -6- 27. A 26 year old male presents with chief complaints of recent burning/tingling pains of his penis. He admits to having new sexual partners in the past months. On physical exam you note a group of small vesicles with erythematous bases on his glans. Some of the vesicles have ruptured and ulcerated or have crusts. There is moderate inguinal lymphadenopathy. What are you suspicious of and which ONE of the following should you do to confirm your clinical suspicions? A. Check for bubos to confirm the diagnosis of syphilis. B. Aspirate the fluid from one vesicle with a syringe and send for the anti-chiamydia antibody assay to confirm the diagnosis of syphilis. C. Use a scalpel to open an intact vesicle and scrape it's base and perform a Tzanck smear to look under the microscope for multinucleated giant cells and viral inclusions to confirm the diagnosis of herpes simplex. D. Scrape one of the crusted lesions and do a Tzanck smear to look for Donovan bodies. E. Obtain vesicle fluid and send it for Treponema pallidum cultures to rule out granuloma inguinale. 28. A 58 year old man Is evaluated for dysphagia and reflux in the evenings. He explains that on one occasion he found some of his evening meal undigested on his pillow at midnight, after retiring at 10 PM. He has been hospitalized previously for suspected aspiration pneumonia. Motility and Manometric studies confirm relative aperistalsis of the body of the esophagus, markedly increased baseline tone of the lower esophageal sphincter and incomplete relaxation of the lower esophageal sphincter. Barium swallow also confirms a dilated body of the esophagus. Endoscopy with biopsy of the lower esophagus confirms squamous mucosa with mild chronic inflammation. Based on the available clinical findings, what is the MOST LIKELY diagnosis? A. Barrett's esophagus B. achalasia C. scleroderma D. Diffuse esophageal spasm E. polymyositis 29. Gas gangrene is caused by which of the following bacteria? A. Escherichia coli B. Clostridium perfringens C. Pseudomonas aeruginosa D. Aerobacter aerogenes E. All of the above 30. Which of the following is a maternal infection with little potential for transplacental infection of the fetus? A. Cytomegalovirus B. Toxoplasmosis C. Group B beta hemolytic streptococcus D. Rubella E. Syphilis -7- 31. A 70 year woman with chronic constipation, requiring disimpaction in the emergency room on several recent occasions, presents again to the ER with complaints of moderate hematochezia. She exhibits out orthostatic hypotension on physical exam, pulse is 100, and reclining blood pressure is 90/60. She has a temperature of 100.8 degrees F. Abdominal exam confirms moderate tenderness of the left lower quadrant. Gynecologic exam is normal and the left adnexa are normal. Rectal exam confirms bright red blood intermixed with firm stool, but no palpable masses. Which ONE of the following is the MOST LIKELY diagnosis based on these findings? A. Mallory-Weiss injury B. Acute appendicitis C. Villous adenoma of the rectum D. Anorectal Crohn's disease E. Colonic diverticular disease 32. A 2 year old child presents with an abdominal mass and hematuria. CT of abdomen shows a 5cm mass arising from the right kidney. Plasma renin levels were elevated. The mass is resected and histology reveals areas with sheets of small blue cells, structures resembling primitive glomeruli and tubules, and areas wish spindle cells. The MOST LIKELY diagnosis in this case is: A. Renal cell carcinoma B. Wilms tumor C. Metastatic carcinoma D. Neuroblasloma E. Ganglioneuroma 33. A 30-year-old woman has surgery for resection of thyroid cancer. Post-operatively, she develops paresthesias In her hands, numbness around her mouth, and mental status changes. Which is likely? A. She may develop cardiac valvular insufficiency B. Suddenly low T3 and T4 levels are responsible for her symptoms C. Massive amounts of parathyroid hormone-related protein were released from the tumor in surgery D. She will have a positive Chvostek sign E. She Is at risk for developing osteitis fibrosa cystica 34. A 53 year old man presents with cutaneous flushing, episodic diarrhea, bronchospasm, and tricuspid Insufficiency with right heart failure. 24-hour urine is obtained for 5-HIAA levels (5hydroxy indole acetic acid) and determined to be severely elevated. Which of the following is MOST LIKELY? A. Autoimmune adrenalitis B. Carcinoid syndrome C. pheochromocytoma arising in the adrenal medulla D. Cushing's syndrome E. Addisonian crisis -8- 35. Which factors have a rate in the pathogenesis of congenital atresia of the ileum? A. Intrauterine damage to the gut wall. B. Chromosomal abnormality C. Defective canalization of the embryonal gut lumen. D. Absent ganglion cells in the Auerbach plexus 36. Several days after neurosugery for removal of a prolactinoma, a 28 year old male develops polyuria, polydipsia, and excessive thirst. Which of the following is the MOST LIKELY diagnosis? A. pituitary apoplexy B. persistent prolaciinoma with stalk effect C. psychogenic polydipsla D. syndrome of inappropriate AD H release E. diabetes insipidus 37. Which of the following treponernatoses affects the skin only? A. Bejel B. Syphilis C. Lyme disease D. Pinta E. Yaws 38. A congenital abnormality indicates presence at birth. Which of the following qualify for that designation? A. Cystic adanomatoid malformation B. Hyaline membrane disease C. Necrotizing enteropathy D. Kernicterus For each numbered item (Column 1) choose the letter of the MOST CLOSELY related item in Column 2. 39. 40-year-old woman with an enlarged and nodular uterus. 40. 61-year-old woman with an enlarged uterus and postmenopausal bleeding. 41. 25-year-old woman with an ovarian mass and virilization. A. Endometrioid adenocarcinorna B. Sertoli-Leydig cell tumor. C. Leiomyomas. 42. Which one of the following is TRUE for condyloma acuminatum. A. it can only be treated by intravenous anti-viral drugs, usually given for 6 months. B. It is associated with HPV (human papilloma virus) C. it is found exclusively on the penis in males. D. It is typically a deeply invasive neoplasm. E. It is not transmitted through sexual contact. -9- 43. A 55 year old woman has linilis plastica and bilateral, solid masses of the ovaries. She is also found to have an enlarged left supraclavicular node. What is the MOST LIKELY cause of the ovarian masses? A. mucinous cysladenomas B. Brenner's tumors C. Malignant lymphoma D. serous papillary carcinomas E. Krukenberg tumors 44. The MOST important finding to confirm the diagnosis of cystic renal dysplasia in a child with bilateral cystic renal disease is: A. Liver biopsy showing portal fibrosis and bite duct proliferation B. Microscopic examination of the kidney showing immature mesenchyme, primitive tubules, and cartilage C. Positive family history of cystic renal disease D. Presence of cysts in the renal medulla E. Microscopic examination of the kidney with confirmation of the collecting duct origin of the cysts 45. Which of the following rickettsioses is transmitted by aerosols? A. Typhus B. Rickettsialpox C. Erlichiosis D. Q fever E. Rocky Mountain spotted fever 46. What are the pathologic effects of a cardiac ventricular septa) detect with an unobstructed pulmonary valve? A. Pulmonary hypertension B. Splanchnic hypoperfusion C. Systemic arterial oxygen unsaturation and cyanosis D. Diminished pulse pressures in the lower extremities E. Diminished pulmonary blood flow 47. Potters syndrome (with oligohydramnios and pulmonary hypoplasia) can occur in association with: A. Acquired cystic renal disease B. Posterior urethral valve C. Simple cysts D. Non-uremic medullary cystic disease E. All of the above - 10 - 48. Oligohydrarnnios, a diminution in volume of amniotic fluid, has a high association with what fetal anomaly? A. Tetralogy of Fallot B. Urinary tract obstruction C. Germinal matrix hemorrhage D. Congenital cystic adenomatoid malformation E. None of the above 49. A 30 year old woman presents with bloody diarrhea, arthritis, and weight loss, with occasional unexplained fever and fatigue. CBC confirms a microcytic anemia and irondeficiency. Ova and parasite stool examination is negative, and routine bacteriologic cultures of the stool are also negative. Endoscopic exam shows cobblestoning of the terminal ileum, intervening, uninvolved “skip" regions, and fissuring and cobblestoning of the descending colon. Which of the o owing is the MOST LIKELY diagnosis? A. Colonic adenocarcinoma B. Amoebic colitis C. Ulcerative colitis D. Crohn's disease E. Diverticulosis 50. A 45-year-old woman undergoes a left breast biopsy for what is thought to MOST LIKELY be fibrocystic disease. Lobular carcinoma-in-situ is discovered along with the fibrocystic change. Which of the following is true of these findings? A. She has an increased risk of developing invasive carcinoma. B. if she develops invasive carcinoma, the cancer may be ductal or lobular. C. If she develops invasive carcinoma, the tumor is as likely to involve her right breast as it is her left. D. Lobular carcinoma-in-situ is less common than ductal carcinoma-in-situ. E. All of the above 51. Circumstance that makes an infant particularly vulnerable to respiratory distress syndrome with hyaline membrane disease? A. Transplacental rubella B. Aspiration of amniotic sac content C. Deficient surfactant D. Single umbilical artery E. Inspissated meconium - 11 - 52. A 15 year old presents with hematochezia and colonoscopy confirms multiple adenomatous polyps throughout the colon. Further physical examination of the patient reveals mandibular osteomas and numerous keratinous cysts (epidermal inclusion cysts) of the skin. Which is the MOST LIKELY DIAGNOSIS? A. Familial polyposis B. Lynch syndrome C. Gardner syndrome D. juvenile polyposis E. Peutz-Jeghers syndrome 53. Which of the following ovarian tumors is MOST LIKELY to be associated with endometriosis: A. Dermold cyst. B. Clear cell carolnoma. C. Dysgerminoma. D. Serous carcinoma. E. Brenner tumor. 54. A 45-year-old woman has hypercalcemia discovered on routine bloodwork. She has no symptoms of hypercalcemia and no other known medical conditions. Which of the following is the MOST LIKELY etiology? A. Secondary hyperparathyroidism B. Vitamin D intoxication C. Parathyroid adenoma D. Squamous cell carcinoma of the lung E. Parathyroid carcinoma 55. Which of the following clinical findings may be seen in cases of bacterial sepsis? A. Diffuse alveolar damage B. Fever C. Leukopenla D. Disseminated intravascular coagulopathy E. All of the above For each numbered item (Column 1) choose the letter of the MOST CLOSELY related item in Column 2 (GSD = glycogen storage disease). 56. Pompe's disease ((-glucosidase A. hepatic-hypoglycemic GSD deficiency) Infantile form presents with B. muscle-energy GSD enlarged heart, liver, tongue. C. lysosomal storage disease involving 57. von Glerke disease (GSD Type la; glycogen glucose-6-phosphatase deficiency) Enlarged liver, lactic acidosis, poor growth. 58. McArdle disease (GSD Type V: muscle phosphorylase deficiency) Muscle pain and cramps, myoglobinuria. - 12 - 59. A time during gestation when the embryo or fetus has maximum susceptibility to malformation or disruption by exogenous stimuli. A. First trimester B. 30th week gestational age C. Third trimester D. Second trimester For each numbered item (Column 1) choose the letter of the MOST CLOSELY related item in Column 2. Answers may be used more than once. 60. Brenner tumor A. Sex cord stromal tumor 61. Ovarian fibroma B. Germ cell tumor 62. Clear cell carcinoma C. Epithelial tumor 63. Endometriosis D. Congenital anomaly 64. Struma ovari E. None of the above 65. A 52 year old alcoholic male presents vomiting large amounts of bright red blood. You place an IV and stabilize his blood pressure. Emergency endoscopy is performed and shows linear, longitudinal mucosal tears of the lower esophagus. What is the MOST LIKELY diagnosis? A. Barrett's esophagus B. Traction diverticuli C. Severe erosive gastroesophageal reflux D. Mallory-Weiss Injury E. Herpes esophagitis 66. A 25-year-old woman has a tender right breast mass. She is 3 months post-parturn and has been breast feeding her infant. On physical examination, she has a 1 cm subareolar mass and fissuring of the right nipple. Which of the following is the MOST LIKELY diagnosis? A. Inflammatory carcinoma B. Fibroadenoma C. Fat necrosis D. Abscess caused by Staphylococcus E. Granulomatous inflammation caused by Mycobacterium 67. Which of the following anatomic structures would be, expected in a normal infant born at 40 weeks gestation? A. Germinal centers in the lymph nodes B. Germinal centers in the thymic medulla C. Valve competent foremen ovate D. Nephrogenic zone in the kidney - 13 - 68. A 58-year-old woman presented with postmenopausal bleeding. An endometrlal biopsy showed increase in endometrial glands relative to stroma with cystically dilated glands and no nuclear alypia. What is the diagnosis? A. Complex endometrial hyperplasia. B. Serous carcinoma. C. Endometrioid adenocarcinoma. D. Simple endometrial hyperplasia. E. Atypical endometrial hyperplasia. 69. A 30 year old woman is found to have multiple, shallow and fresh erosions scattered throughout the stomach. Which of the following entities should NOT be included in the differential diagnosis of etiologic agents In this patient's acute erosive gastritis? A. ethanol B. burns C. carbonated beverages D. shock E. nonsteroidal anti-inflammatory drugs 70. Which of the following is INCORRECT with reference to acute bacterial prostatitis (ABP)? A. The bacteria responsible for ABP are often the same as those found in urinary tract infections, such as E. coli. B. ABP usually presents with back or perineal pain, but is more often asymptomatic, C. ABP can be caused by the introduction of bacteria into the prostate during a surgical procedure. D. If ABP is clinically suspected, start empiric anti-bacterials without prostate massage. E. ABP can result in abscess formation in the prostate parenchyma. 71. Erysipeloid is caused by which of the following bacteria? A. Erysipelothrix rhusiopathiae B. Streptococcus pyogenes C. Streptococcus agalactiae D. Staphylococcus aureus E. None of the above 72. Which of the following is the MOST COMMON malignancy of the thyroid? A. anaplastic carcinoma S. lymphoma C. medullary carcinoma D. follicular carcinoma E. papillary carcinoma - 14 - 73. A patient presents to the ER with a painful genital vesicular lesion. A scraping of the lesion is collected and multinucleated syncylia are observed microscopically. What is the MOST LIKELY etiology? A. Syphilis B. Chancroid C. Herpes D. Papillomavirus E. Lymphogranuloma venerum 74. An 18 year old girl presents to the emergency room with right lower quadrant pain. Which of the following SHOULD NOT be included in your differential diagnosis as the etiology for her abdominal pain? A. mesenteric lymphadenitis B. acute pelvic inflammatory disease C. "milteishmerz'" D. acute appendicitis E. diverticulosis 75. In which of the following conditions does the aorta receive blood from the right ventricle? A. Coarctation of the aorta with a ligamemurn arteriosum B. Infracristal ventricular septal defect C. Pulmonic valve stenosis D. Foramen secundurn atrial septal defect E. Tetralogy of Fallot 76. Which one of the following is INCORRECT concerning infection/inflammation in the testes: A. Bilateral orchitis (inflammation of the testis) is seen in nearly all 8-12 year old boys with mumps. B. Gonorrhea can spread from the urethra to the prostate and eventually to the epididymis. C. Syphilitic orchitis is characterized by a lymphoplasmacytic infiltrate and obliterative endarteritis. D. Granulomatous inflammation is present in tuberculosis of the testis. E. Non-specific infections often result from spread of a microbe from a urinary tract infection. - 15 - Match the clinical situation with the MOST LIKELY organism. 77. A 20-year-old renal transplant A. Histoplasma patient develops a lymphoproliferative B. Eptein-Barr Virus disorder 2 months after transplant, C. Parvovinis B19 78. A 10-year-old girl with sickle cell D. Coccidiomyces disease develops a more severe , E. Sporothrix anemia than usual, and her bone marrow does not respond with the production of raticulocytes.(early red cells). 79. 3. A 30-year-old previously healthy man develops fever, cough, and pulmonary lesions on chest x-ray after a vacation in Santa Fe and the surrounding area. 80. 4. A 45-year-old man who works for a landscape company develops several ulcerated nodular lesions along the inner aspect of his right arm. 81. What are the TYPICAL anatomic features of Hirschsprung disease? A. Absent myenteric ganglion cells in the distal colon. B. Absent myenteric ganglion cells in the proximal colon. C. Constriction of the proximal colon D. Dilatation of the distal colon 82. A 43-year-old woman presents with vulvar itching. Examination showed multiple vulvar and perineal papule and macules. Some of the lesions were gray: some were white, while others were erythematous. A punch biopsy of one of the lesion was performed. Which of the following is the biopsy is MOST LIKELY to show: A. Chlamydia trachomatis infection. B. Vulvar intraepithelial neoplasia. C. Lymphogranuloma venereum. D. Granuloma inguinale. E. Primary syphilis. 83. Causes of Cushing's disease or syndrome include all of the following, EXCEPT: A. Pituitary adenoma B. Adrenal cortical adenoma C. Autoimmune adrenalitis D. exogenous corticosteroids E. Small cell carcinoma - 16 - 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 ANSWERS: C D B B B D E C A C A C C B C D E A B E A A C C A B C B B C E B D B A E D A C A B 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 - 17 - B E B D A B B D E C C B C E C A B A C A C E B D D C D C B A E C E E A B C D E A B C - 18 -