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Transcript
FBE FILM INTERPRETATION Term Anisocytosis Meaning variation in cell size Poikilocytosis variation in cell shape Macrocytosis raised red cell volume Microcytosis reduced red cell volume Rouleaux 'chains' of red cells Agglutination Spherocytes Elliptocytes Target cells 'clumped' red cells small round red cells rod shaped red cells dark centre to red cells Polychromasia large basophilic red cells nuclear remnants in red Howell Jolly cells bodies denatured haemoglobin Heinz bodies Burr cells Acanthocytes Schistocytes Left shift Right shift Toxic granulation irregularly crenated red cells spiky red cells red cell fragments myelocytes and metamyelocytes in film hypersegmented polymorphs increased granulation in neutrophils Possible Significance corresponds to raised RDW (see Full Blood Count) may be diagnostic (e.g. spherocytes) B12/folate deficiency, ethanol, hypothyroidism iron deficiency, thalassaemia trait raised protein in plasma e.g. infection, inflammation, myeloproliferative diseases eg myeloma cold autoagglutination hereditary, autoimmune hereditary, elliptocytosis thalassaemia, liver disease, iron deficiency, Hb C (Afro-Caribbeans) immature red cells (bleeding, haemolysis) post-splenectomy, hyposplenism oxidative haemolysis (e.g. G6PD deficiency) renal failure, hypothyroidism liver disease MAHA’s: Aortic stenosis/prosthetic valves, DIC, TTP, HUS, HELLP, HITS, glomerulonephritis infection, marrow infiltration megaloblastic anaemia implies bacterial infection MAHA: Microangiopathic haemolytic anaemia
