Intracellular fibroblast growth factor 14: emerging risk factor for brain
... genome wide association studies (GWAS) to be a putative risk factor for other neuropsychiatric diseases including depression, addiction and schizophrenia, as well as neurodegenerative diseases, such as Alzheimer’s Disease (Detera-Wadleigh et al., 1999; Park et al., 2004; Mulle et al., 2005; Need et ...
... genome wide association studies (GWAS) to be a putative risk factor for other neuropsychiatric diseases including depression, addiction and schizophrenia, as well as neurodegenerative diseases, such as Alzheimer’s Disease (Detera-Wadleigh et al., 1999; Park et al., 2004; Mulle et al., 2005; Need et ...
Presentation - Neuropathology
... Types of Leukodystrophy of Adulthood: Adult cerebral X-linked and female heterozygote Adrenoleukodystrophy, Adrenomyeloneuropathy, Alexander disease, Leukodystrophy with neuroaxonal spheroids, Vanishing white matter disease, Metachromatic ...
... Types of Leukodystrophy of Adulthood: Adult cerebral X-linked and female heterozygote Adrenoleukodystrophy, Adrenomyeloneuropathy, Alexander disease, Leukodystrophy with neuroaxonal spheroids, Vanishing white matter disease, Metachromatic ...
The Blood-Brain Barrier in Neuroinflammatory Diseases
... BLOOD-BRAIN BARRIER IN NEUROINFLAMMATORY DISEASES ...
... BLOOD-BRAIN BARRIER IN NEUROINFLAMMATORY DISEASES ...
M1 muscarinic acetylcholine receptor in Alzheimer`s disease
... activation also alters β-secretase (BACE1) levels via uncertain mechanisms. In addition, M1 mAChR stimulation counteracts Aβ-induced neurotoxicity through the Wnt signaling pathway, as Aβ impairs this pathway by destabilizing β-catenin, and M1 mAChR stimulation inactivates GSK-3β via PKC activation, ...
... activation also alters β-secretase (BACE1) levels via uncertain mechanisms. In addition, M1 mAChR stimulation counteracts Aβ-induced neurotoxicity through the Wnt signaling pathway, as Aβ impairs this pathway by destabilizing β-catenin, and M1 mAChR stimulation inactivates GSK-3β via PKC activation, ...
Basal ganglia
... Motor Control by the Basal Ganglia The BG are the five interactive structures on each side of the brain: ...
... Motor Control by the Basal Ganglia The BG are the five interactive structures on each side of the brain: ...
Neuronal migration
... mutations in ®lamin, an actin-associated protein (see Fox et al., 1998; Fox and Walsh, 1999). This observation shows that, like axonal growth cones, leading tip elongation requires the contractility of actin micro®laments. Nonmuscle ®lamin is a large protein (265±280 kDa) with two actin-binding doma ...
... mutations in ®lamin, an actin-associated protein (see Fox et al., 1998; Fox and Walsh, 1999). This observation shows that, like axonal growth cones, leading tip elongation requires the contractility of actin micro®laments. Nonmuscle ®lamin is a large protein (265±280 kDa) with two actin-binding doma ...
neurobiological aspects of depressive disorder and
... bidirectional communication between neurons and glial cells at the synapses, a concept of ”gliotransmission” and “tripartite synapse“ was postulated where astrocytes are seen as active partners of neurons (Araque et al., 1999). Astrocytes participate in the neurotransmitter uptake from synaptic clef ...
... bidirectional communication between neurons and glial cells at the synapses, a concept of ”gliotransmission” and “tripartite synapse“ was postulated where astrocytes are seen as active partners of neurons (Araque et al., 1999). Astrocytes participate in the neurotransmitter uptake from synaptic clef ...
The glucocorticoids (GCs) secreted from the adrenal cortex (corti
... those concentrations GCs preserve the physiological metabolism of the neurons and regulate the normal activity of the HPA axis. However, recent pharmacological evidence indicates that chronic administration of the GR agonist dexamethasone - as part of the anti-inflammatory therapy for rheumatoid art ...
... those concentrations GCs preserve the physiological metabolism of the neurons and regulate the normal activity of the HPA axis. However, recent pharmacological evidence indicates that chronic administration of the GR agonist dexamethasone - as part of the anti-inflammatory therapy for rheumatoid art ...
Mesenchymal stem cell-derived extracellular vesicles: a glimmer of
... EVs were described in the 1980s by Pan and Johnstone (71). These vesicles can be categorized into different subtypes, mainly based on their origin of biogenesis. Presently, exosomes are the most well characterized and widely studied EVs. In general, they are defined as nano-sized vesicles ranging fr ...
... EVs were described in the 1980s by Pan and Johnstone (71). These vesicles can be categorized into different subtypes, mainly based on their origin of biogenesis. Presently, exosomes are the most well characterized and widely studied EVs. In general, they are defined as nano-sized vesicles ranging fr ...
Temporal and spatial expression of Drosophila DLGS97 during
... 1.3. DLGS97 expression in the brain The main structures of the adult Drosophila brain include the mushroom bodies (MBs) (Strausfeld et al., 1998), the optic ganglia (Jefferis et al., 2002) and the antennal lobe (Stocker, 1994). At larvae stage the brain is formed by several structures that are eithe ...
... 1.3. DLGS97 expression in the brain The main structures of the adult Drosophila brain include the mushroom bodies (MBs) (Strausfeld et al., 1998), the optic ganglia (Jefferis et al., 2002) and the antennal lobe (Stocker, 1994). At larvae stage the brain is formed by several structures that are eithe ...
Overexpression of mutant PrP induce amyloidogenesis in otherwise
... clinical signs of disease are observed, but tissues are able to transmit disease to recipient ...
... clinical signs of disease are observed, but tissues are able to transmit disease to recipient ...
Human brain amyloidoses.
... been reported in which the presence of a significant number of diffuse plaques is asymptomatic. If the diffuse plaques precede the mature plaques, then in AD amyloid formation is preceded by a condition in which the amyloidogenic protein is aggregated but does not form ß-pleated sheets. Although the ...
... been reported in which the presence of a significant number of diffuse plaques is asymptomatic. If the diffuse plaques precede the mature plaques, then in AD amyloid formation is preceded by a condition in which the amyloidogenic protein is aggregated but does not form ß-pleated sheets. Although the ...
Focus on medicine
... Super-antibodies as therapy “After an HIV infection, a small number of patients exhibit a low concentration of the virus in their blood over a long time,” describes Reddy. The clinical symptoms are also correspondingly milder. These patients are known as super controllers. They possess antibodies th ...
... Super-antibodies as therapy “After an HIV infection, a small number of patients exhibit a low concentration of the virus in their blood over a long time,” describes Reddy. The clinical symptoms are also correspondingly milder. These patients are known as super controllers. They possess antibodies th ...
TFP5/TP5 peptide provides neuroprotection in the MPTP model of
... Cyclin-dependent kinase 5 (Cdk5) is a member of the serine-threonine kinase family of cyclin-dependent kinases. Cdk5 is critical to normal mammalian nervous system development and plays important regulatory roles in multiple cellular functions. Recent evidence indicates that Cdk5 is inappropriately ...
... Cyclin-dependent kinase 5 (Cdk5) is a member of the serine-threonine kinase family of cyclin-dependent kinases. Cdk5 is critical to normal mammalian nervous system development and plays important regulatory roles in multiple cellular functions. Recent evidence indicates that Cdk5 is inappropriately ...
Solving the binding problem
... described in the frames of the β-neurexin-neuroligin model developed by Georgiev (2002) and is proposed novel mechanism for control of the neurons that are temporarily entangled to produce every single conscious moment experienced as present. The model provides psychiatrists with ‘deeper’ understand ...
... described in the frames of the β-neurexin-neuroligin model developed by Georgiev (2002) and is proposed novel mechanism for control of the neurons that are temporarily entangled to produce every single conscious moment experienced as present. The model provides psychiatrists with ‘deeper’ understand ...
Neuron-astrocyte coupling and its possible role in epilepsy
... S. Nadkarni, P.J. and H. Levine, Astrocytes optimize synaptic transmission of information, submitted ...
... S. Nadkarni, P.J. and H. Levine, Astrocytes optimize synaptic transmission of information, submitted ...
Cohort Studies
... Introduction • All studies involve some descriptive or analytic type of comparison of exposure and disease status. • Analytical study design options include: observational or interventional (which one is based on the role of the investigator). • There are three basic types of observational analytic ...
... Introduction • All studies involve some descriptive or analytic type of comparison of exposure and disease status. • Analytical study design options include: observational or interventional (which one is based on the role of the investigator). • There are three basic types of observational analytic ...
Somatic and visceral nervous systems - an ancient
... EMBL, Developmental Biology Unit, Meyerhofstrasse 1, Heidelberg 69012, Germany ...
... EMBL, Developmental Biology Unit, Meyerhofstrasse 1, Heidelberg 69012, Germany ...
Fulminant Form of Mitochondrial Myopathy, Encephalopathy, Lactic
... a prodrome (such as headache, subtle neurologic symptoms, and systemic illness) or predisposing conditions. Seizures, a key feature in the present case, are observed in only 2% - 33% of ischemic strokes [8] but a common presenting feature of other cerebrovascular diseases. Subsequent investigation r ...
... a prodrome (such as headache, subtle neurologic symptoms, and systemic illness) or predisposing conditions. Seizures, a key feature in the present case, are observed in only 2% - 33% of ischemic strokes [8] but a common presenting feature of other cerebrovascular diseases. Subsequent investigation r ...
GCSE B1 3MB - The John Warner School
... The body needs cholesterol. Cells use cholesterol to make new cell membranes and some hormones. The liver makes cholesterol for the body. Some drugs can help people with high cholesterol levels. Statins block the enzyme in the liver that is used to produce cholesterol. People will normally have to t ...
... The body needs cholesterol. Cells use cholesterol to make new cell membranes and some hormones. The liver makes cholesterol for the body. Some drugs can help people with high cholesterol levels. Statins block the enzyme in the liver that is used to produce cholesterol. People will normally have to t ...
Most of the Abundant Protein Fractions of
... by the neuroectoderm, and thus they may be transported from their production or storage sites to the cephalic cavities, most probably via E-serum. The extraneural origin of most of these protein fractions, together with the crucial roles exerted by the analysed gene products of this fluid and the di ...
... by the neuroectoderm, and thus they may be transported from their production or storage sites to the cephalic cavities, most probably via E-serum. The extraneural origin of most of these protein fractions, together with the crucial roles exerted by the analysed gene products of this fluid and the di ...
NeuroDoWo Göttingen - Georg-August
... respectively, promote survival and growth of several developing neurons in the CNS and PNS and additionally impact maturation and differentiation processes. The pool of β-actin proteins depends on the presence of β-actin mRNAs at the growth cone tips. Neurotrophins like NGF, BDNF or NT-3, respective ...
... respectively, promote survival and growth of several developing neurons in the CNS and PNS and additionally impact maturation and differentiation processes. The pool of β-actin proteins depends on the presence of β-actin mRNAs at the growth cone tips. Neurotrophins like NGF, BDNF or NT-3, respective ...
RAJIV GANDHI UNIVERSITY OF HEALTH SCIENCES
... diseases. MRI is considered far superior to CT and the imaging modality of choice in white matter diseases. However, with the advent of multiecho sequences of MR, even subtle lesions of demyelination can be detected. A correct diagnosis could be made in majority of the patients based on MR findings ...
... diseases. MRI is considered far superior to CT and the imaging modality of choice in white matter diseases. However, with the advent of multiecho sequences of MR, even subtle lesions of demyelination can be detected. A correct diagnosis could be made in majority of the patients based on MR findings ...
Differential expression of galanin in the cholinergic basal forebrain
... Introduction: Depletion of cholinergic neurons within the nucleus basalis of Meynert (nbM) is thought to contribute to the development of cognitive impairments in both Alzheimer’s disease (AD) and Lewy body disorders (LBD). It has been reported that, in late stage AD, a network of fibres that contai ...
... Introduction: Depletion of cholinergic neurons within the nucleus basalis of Meynert (nbM) is thought to contribute to the development of cognitive impairments in both Alzheimer’s disease (AD) and Lewy body disorders (LBD). It has been reported that, in late stage AD, a network of fibres that contai ...
Cerebrovascular lesions induce transient b
... areas from APPswe/PS1dE9 mice after middle cerebral artery occlusion. Stroke areas were delimited by haematoxylin–eosin staining and the selected area in the ipsilateral hemisphere was used as a phantom area in the contralateral hemisphere for comparison. One in every 10 sections from stroke areas w ...
... areas from APPswe/PS1dE9 mice after middle cerebral artery occlusion. Stroke areas were delimited by haematoxylin–eosin staining and the selected area in the ipsilateral hemisphere was used as a phantom area in the contralateral hemisphere for comparison. One in every 10 sections from stroke areas w ...
Neurodegeneration
Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases including amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's occur as a result of neurodegenerative processes. Such diseases are incurable, resulting in progressive degeneration and/or death of neuron cells. As research progresses, many similarities appear that relate these diseases to one another on a sub-cellular level. Discovering these similarities offers hope for therapeutic advances that could ameliorate many diseases simultaneously. There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death. Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic.