a calcium/calmodulin-dependent protein kinase
... processes (Kretsinger, 1979). In some cases,such as muscle contraction (Cold Spring Harbor Laboratories, 1972), the mechanism by which calcium ion exerts its effects is fairly well understood. In others, such as the control of synaptic transmission (Kelly et al., 1979) or neuronal gene expression (W ...
... processes (Kretsinger, 1979). In some cases,such as muscle contraction (Cold Spring Harbor Laboratories, 1972), the mechanism by which calcium ion exerts its effects is fairly well understood. In others, such as the control of synaptic transmission (Kelly et al., 1979) or neuronal gene expression (W ...
Discovery Process for Antibody-Based Therapeutics
... viable target for an antibody-based therapeutic project. First, the target molecule should reside in a physiological location accessible to a systemically administered therapeutic antibody. As such, the targeted moiety should be present either on the cell surface (cell surface target), in the extrac ...
... viable target for an antibody-based therapeutic project. First, the target molecule should reside in a physiological location accessible to a systemically administered therapeutic antibody. As such, the targeted moiety should be present either on the cell surface (cell surface target), in the extrac ...
Circuit reactivation dynamically regulates synaptic
... connection strength between two monosynaptically connected neurons can be experimentally modified by varying the relative time that they fire action potentials8–12. These spike-timingdependent plasticity (STDP) protocols are in agreement with Hebb’s hypothesis and suggest a link between studies conduc ...
... connection strength between two monosynaptically connected neurons can be experimentally modified by varying the relative time that they fire action potentials8–12. These spike-timingdependent plasticity (STDP) protocols are in agreement with Hebb’s hypothesis and suggest a link between studies conduc ...
Case Report Vulval Elephantiasis: A Case Report
... The most widespread filarial infection is due to Wuchereria bancrofti (98%) and the remaining to Brugia malayi (2%) [6]. In India, the state of Bihar has highest endemicity (over 17%) followed by Kerala (15.7%) and Uttar Pradesh (14.6%). Mosquito vector for disease transmission in humans is Culex qu ...
... The most widespread filarial infection is due to Wuchereria bancrofti (98%) and the remaining to Brugia malayi (2%) [6]. In India, the state of Bihar has highest endemicity (over 17%) followed by Kerala (15.7%) and Uttar Pradesh (14.6%). Mosquito vector for disease transmission in humans is Culex qu ...
village chicken production
... Australian and developing-country researchers in areas where Australia has special research competence. It also administers Australia’s contribution to the International Agricultural Research Centres. Where trade names are used this constitutes neither endorsement of nor discrimination against any p ...
... Australian and developing-country researchers in areas where Australia has special research competence. It also administers Australia’s contribution to the International Agricultural Research Centres. Where trade names are used this constitutes neither endorsement of nor discrimination against any p ...
Poultry village management
... Australian and developing-country researchers in areas where Australia has special research competence. It also administers Australia’s contribution to the International Agricultural Research Centres. Where trade names are used this constitutes neither endorsement of nor discrimination against any p ...
... Australian and developing-country researchers in areas where Australia has special research competence. It also administers Australia’s contribution to the International Agricultural Research Centres. Where trade names are used this constitutes neither endorsement of nor discrimination against any p ...
2010 Carl Ludwig Distinguished Lectureship of the APS Neural
... in skeletal muscles that are normally used to produce movement and posture, thermogenesis in BAT is the specific metabolic function of this tissue, which is an important thermoregulatory effector not only in small mammals, but also in humans (21, 26, 94, 96). BAT thermogenesis arises from the heatge ...
... in skeletal muscles that are normally used to produce movement and posture, thermogenesis in BAT is the specific metabolic function of this tissue, which is an important thermoregulatory effector not only in small mammals, but also in humans (21, 26, 94, 96). BAT thermogenesis arises from the heatge ...
The Effects of A High Fat Diet On Mitochondrial Biogenesis
... infiltration (56). M1 macrophages activate pro-inflammatory cytokines and reactive oxygen species, which have been shown to cause mitochondrial collapse (25). A paucity of research has been done to elucidate the effects of HFD’s on skeletal muscle; however, there is a gap in understanding if similar ...
... infiltration (56). M1 macrophages activate pro-inflammatory cytokines and reactive oxygen species, which have been shown to cause mitochondrial collapse (25). A paucity of research has been done to elucidate the effects of HFD’s on skeletal muscle; however, there is a gap in understanding if similar ...
Morphometric Investigation of Neurons in the Hippocampal
... involvement of the brain in sepsis and underlying mechanisms of SAE is not completely understood. The mechanism proposed in the pathogenesis of SAE involves; microorganisms directly invading the CNS or affecting it with their toxins, metabolic alterations that could adversely affect CNS function, br ...
... involvement of the brain in sepsis and underlying mechanisms of SAE is not completely understood. The mechanism proposed in the pathogenesis of SAE involves; microorganisms directly invading the CNS or affecting it with their toxins, metabolic alterations that could adversely affect CNS function, br ...
Cystine/Glutamate Exchange Modulates Glutathione Supply for
... The cystine/glutamate exchanger (xCT) provides intracellular cyst(e)ine for production of glutathione, a major cellular antioxidant. Using xCT overexpression and underexpression, we present evidence that xCT-dependent glutathione production modulates both neuroprotection from oxidative stress and ce ...
... The cystine/glutamate exchanger (xCT) provides intracellular cyst(e)ine for production of glutathione, a major cellular antioxidant. Using xCT overexpression and underexpression, we present evidence that xCT-dependent glutathione production modulates both neuroprotection from oxidative stress and ce ...
Predominant Cerebellar Volume Loss as a Neuroradiologic Feature
... been modified from an adult classification system— ie, the modified adult criteria (6). We previously studied the clinical course and outcome of 113 patients with mitochondrial disease diagnosed by using these modified criteria (7), representing one of the largest published series concerning the ped ...
... been modified from an adult classification system— ie, the modified adult criteria (6). We previously studied the clinical course and outcome of 113 patients with mitochondrial disease diagnosed by using these modified criteria (7), representing one of the largest published series concerning the ped ...
Dementia pugilistica
... neocortical neurofibrillary tangle formation in the absence of amyloid betapeptide deposition. The distribution of the tau pathology suggested that the pathogenesis of cytoskeletal abnormalities may involve damage to blood vessels or perivascular elements. The rotational injury further damages other ...
... neocortical neurofibrillary tangle formation in the absence of amyloid betapeptide deposition. The distribution of the tau pathology suggested that the pathogenesis of cytoskeletal abnormalities may involve damage to blood vessels or perivascular elements. The rotational injury further damages other ...
monoclonal antibodies to choline acetyltransferase: production
... the nitrocellulose sheet by suction filtration. This technique was modified from electrophoretic procedures used for protein transfer (Burnette, 1981) and DNA blotting techniques. The physical assembly used for blotting consisted of the following. The nitrocellulose sheet was laid on two sheets of f ...
... the nitrocellulose sheet by suction filtration. This technique was modified from electrophoretic procedures used for protein transfer (Burnette, 1981) and DNA blotting techniques. The physical assembly used for blotting consisted of the following. The nitrocellulose sheet was laid on two sheets of f ...
PDF - Akassoglou Lab
... Primary demyelination is a hallmark of multiple sclerosis (MS)1 and a prominent pathological feature of several other inflammatory diseases of the central nervous system (CNS) that is considered to contribute significantly to functional neurological deficits. It is a complex immunemediated process t ...
... Primary demyelination is a hallmark of multiple sclerosis (MS)1 and a prominent pathological feature of several other inflammatory diseases of the central nervous system (CNS) that is considered to contribute significantly to functional neurological deficits. It is a complex immunemediated process t ...
A Reversible Cause of Skin Hyperpigmentation and Postural
... dairy products, meat, eggs, fish, and shellfish. Vitamin B12 deficiency becomes important in high-risk populations such as the elderly, patients with either malabsorption diseases as in gastric and ileal resection or gastric mucosal disease resulting from either an autoimmune process or from gastric ...
... dairy products, meat, eggs, fish, and shellfish. Vitamin B12 deficiency becomes important in high-risk populations such as the elderly, patients with either malabsorption diseases as in gastric and ileal resection or gastric mucosal disease resulting from either an autoimmune process or from gastric ...
Isoaspartic acid is present at specific sites in myelin basic protein
... Full list of author information is available at the end of the article ...
... Full list of author information is available at the end of the article ...
EFFECT OF RESVERATROL AND ENVIRONMENTAL
... Numerous studies have been carried out on both resveratrol and EE with much attention been focused on their beneficial role on aging and age related disorders to the neglect of their possible beneficial role especial in young healthy animals (Muhammad et al. 2014). The physiological effects of resv ...
... Numerous studies have been carried out on both resveratrol and EE with much attention been focused on their beneficial role on aging and age related disorders to the neglect of their possible beneficial role especial in young healthy animals (Muhammad et al. 2014). The physiological effects of resv ...
Susceptibility Weighted Imaging (SWI): Contributions to Multiple
... Multiple sclerosis is the most common neurological disease of young adult caucasian and the most common cause of neurological disability in young adults. It is an inflammatory and demyelinating disease characterized by inflammation, demyelination plaques, axonal loss and gliosis. MRI is nowadays a m ...
... Multiple sclerosis is the most common neurological disease of young adult caucasian and the most common cause of neurological disability in young adults. It is an inflammatory and demyelinating disease characterized by inflammation, demyelination plaques, axonal loss and gliosis. MRI is nowadays a m ...
Selective Cortical Layering Abnormalities and Behavioral Deficits in
... neurons ectopically located at the uppermost position in the mutant cortical plate (CP) (see Fig. 3 B, B#). Vglut1! cell aggregates were also detected within the subcortical white matter, which also contains fibers of the radiatio corporis callosi (see Fig. 3 B, B#, arrows), the hippocampal SVZ and ...
... neurons ectopically located at the uppermost position in the mutant cortical plate (CP) (see Fig. 3 B, B#). Vglut1! cell aggregates were also detected within the subcortical white matter, which also contains fibers of the radiatio corporis callosi (see Fig. 3 B, B#, arrows), the hippocampal SVZ and ...
Selective Cortical Layering Abnormalities and Behavioral Deficits in
... neurons ectopically located at the uppermost position in the mutant cortical plate (CP) (see Fig. 3 B, B⬘). Vglut1⫹ cell aggregates were also detected within the subcortical white matter, which also contains fibers of the radiatio corporis callosi (see Fig. 3 B, B⬘, arrows), the hippocampal SVZ and ...
... neurons ectopically located at the uppermost position in the mutant cortical plate (CP) (see Fig. 3 B, B⬘). Vglut1⫹ cell aggregates were also detected within the subcortical white matter, which also contains fibers of the radiatio corporis callosi (see Fig. 3 B, B⬘, arrows), the hippocampal SVZ and ...
SELECTIVE DAMAGE TO AND PROTECTION OF IN VITRO
... The dysregulation of motility typical in inflammatory bowel disease (IBD) indicates involvement of the enteric nervous system (ENS). Indeed, animal models of IBD have demonstrated that intestinal inflammation is typified by the early loss of enteric neurons. It has been proposed that ischemia may oc ...
... The dysregulation of motility typical in inflammatory bowel disease (IBD) indicates involvement of the enteric nervous system (ENS). Indeed, animal models of IBD have demonstrated that intestinal inflammation is typified by the early loss of enteric neurons. It has been proposed that ischemia may oc ...
MRS in the Diagnosis and Monitoring of Maple Syrup Urine Disease
... 1.33 ppm. As many of these compounds resonate at adjacent frequencies there is some overlapping of the peaks, making spectroscopic quantification of some of the compounds difficult, although leucine was clearly distinguishable on this spectrum at 0.96ppm. The brain concentration of the compounds in ...
... 1.33 ppm. As many of these compounds resonate at adjacent frequencies there is some overlapping of the peaks, making spectroscopic quantification of some of the compounds difficult, although leucine was clearly distinguishable on this spectrum at 0.96ppm. The brain concentration of the compounds in ...
Fulltext: english,
... between the ventricular surface (the proliferative zones) and the pial surface, acting as guides by which immature neurons migrate to reach their final destination. The organization of the radial “glia” explains how the immense population of neurons that constitute the human cerebral cortex is gene ...
... between the ventricular surface (the proliferative zones) and the pial surface, acting as guides by which immature neurons migrate to reach their final destination. The organization of the radial “glia” explains how the immense population of neurons that constitute the human cerebral cortex is gene ...
Neurodegeneration
Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons. Many neurodegenerative diseases including amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's occur as a result of neurodegenerative processes. Such diseases are incurable, resulting in progressive degeneration and/or death of neuron cells. As research progresses, many similarities appear that relate these diseases to one another on a sub-cellular level. Discovering these similarities offers hope for therapeutic advances that could ameliorate many diseases simultaneously. There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death. Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic.