4-Antimanic (edited)..
... these drugs work in the same way that they act to control seizure activity • The only difference is that they work on different parts of the brain ...
... these drugs work in the same way that they act to control seizure activity • The only difference is that they work on different parts of the brain ...
choosing the right medical treatment and recent advances
... Initial and periodic eye exams are recommended. ...
... Initial and periodic eye exams are recommended. ...
118768 thigpen handouts
... changes (but the family will be) ▪ Behavioral effects (irritability and hostility) are the main concerns with levetiracetam, often seen at the start of therapy (occurring in up to 40% or more) ▪ “placebo effect” seen more often in children Cramer JA, et al. Expert Rev Neurother. 2010;10(6):885‐891 ...
... changes (but the family will be) ▪ Behavioral effects (irritability and hostility) are the main concerns with levetiracetam, often seen at the start of therapy (occurring in up to 40% or more) ▪ “placebo effect” seen more often in children Cramer JA, et al. Expert Rev Neurother. 2010;10(6):885‐891 ...
epilepsy - ichapps.com
... Oxcarbazepine is a less potent inducer of CYP3A4 and UGT than carbamazepine. The adverse effects profile is similar to that of other antiepileptic drugs with respect to nausea, vomiting, headache, and visual disturbance. Phenobarbital: Phenobarbital was synthesized in 1902 and brought to the market ...
... Oxcarbazepine is a less potent inducer of CYP3A4 and UGT than carbamazepine. The adverse effects profile is similar to that of other antiepileptic drugs with respect to nausea, vomiting, headache, and visual disturbance. Phenobarbital: Phenobarbital was synthesized in 1902 and brought to the market ...
DEVELOPMENT AND CHARACTERIZATION OF LAMOTRIGINE ORODISPERSIBLE TABLETS: INCLUSION COMPLEX WITH HYDROXYPROPYL Β CYCLODEXTRIN
... provide significant benefits to the pediatric and geriatric populations, as well as other patients who prefer the convenience of easily swallow able dosage forms. This tablet disintegrates instantaneously when placed on tongue, releasing the drug that dissolves or disperses ...
... provide significant benefits to the pediatric and geriatric populations, as well as other patients who prefer the convenience of easily swallow able dosage forms. This tablet disintegrates instantaneously when placed on tongue, releasing the drug that dissolves or disperses ...
Medications That Interact With What Does the Evidence Say?
... norethindrone, and ethinyl estradiol, ovarian activity, and breakthrough bleeding. Contraception 2005; 71:402 • Helms SE, et al, Oral contraceptive failure rates and oral antibiotics. J Am Acad Dermatol 1997: 36:705 • Weaver K, Glasier A, Interaction between broad broad-spectrum antibiotics and the ...
... norethindrone, and ethinyl estradiol, ovarian activity, and breakthrough bleeding. Contraception 2005; 71:402 • Helms SE, et al, Oral contraceptive failure rates and oral antibiotics. J Am Acad Dermatol 1997: 36:705 • Weaver K, Glasier A, Interaction between broad broad-spectrum antibiotics and the ...
click here
... • Methodological difficulties between studies make comparison complicated • The era in which the drug was approved • Phenobarbital vs carbamazepine vs vigabatrin ...
... • Methodological difficulties between studies make comparison complicated • The era in which the drug was approved • Phenobarbital vs carbamazepine vs vigabatrin ...
PowerPoint 簡報
... (slow titration upwards); minimal s/e profile (esp body wt & cognitive function), thus better compliance • Acute Rx of bipolar depression I, as maintenance Rx & for rapid-cycling BP II (no antimanic properties), & perhaps BP I recently manic or depressed • Less effective for mixed episode, rapid cyc ...
... (slow titration upwards); minimal s/e profile (esp body wt & cognitive function), thus better compliance • Acute Rx of bipolar depression I, as maintenance Rx & for rapid-cycling BP II (no antimanic properties), & perhaps BP I recently manic or depressed • Less effective for mixed episode, rapid cyc ...
4.8 Anti-epileptics - Doncaster and Bassetlaw Hospitals NHS
... skin disorders, and advised to seek immediate medical attention if symptoms such as fever, sore throat, rash, mouth ulcers, bruising or bleeding develop. Leucopenia which is severe, progressive or associated with clinical symptoms requires withdrawal. Lamotrigine The authors of a recent large multic ...
... skin disorders, and advised to seek immediate medical attention if symptoms such as fever, sore throat, rash, mouth ulcers, bruising or bleeding develop. Leucopenia which is severe, progressive or associated with clinical symptoms requires withdrawal. Lamotrigine The authors of a recent large multic ...
Antiepileptic Drugs
... • However, significantly improve the quality of life (destigmatization, ability to work etc) and prevent development of further CNS deteriorations • Monotherapy is the preferable approach – The combination treatments can be complicated by PK and PD interactions – Before the combination of antiepilep ...
... • However, significantly improve the quality of life (destigmatization, ability to work etc) and prevent development of further CNS deteriorations • Monotherapy is the preferable approach – The combination treatments can be complicated by PK and PD interactions – Before the combination of antiepilep ...
ANTIEPILEPTIC DRUGS
... 5) Absence . Loss of consciousness without involving motor area. Most common in children ( 4-12 yrs ). 6) Status epilepticus ( re-occuring seizure ). Continuous seizure without intervening return of consciousness. ...
... 5) Absence . Loss of consciousness without involving motor area. Most common in children ( 4-12 yrs ). 6) Status epilepticus ( re-occuring seizure ). Continuous seizure without intervening return of consciousness. ...
NEWER ANTIEPLEPTICS CENTRALLY ACTING MUSCLE
... saturability, which means that increasing the dose does not proportionately increase the amount absorbed. This makes gabapentin relatively safe and free of side effects associated with overdosing. ...
... saturability, which means that increasing the dose does not proportionately increase the amount absorbed. This makes gabapentin relatively safe and free of side effects associated with overdosing. ...
Effect of Lamotrigine on Mood and Cognition in Patients Receiving
... corticosteroid therapy. Thus, these cases are of interest; we suggest that this agent may be useful in treating corticosteroid-induced depression as well as bipolar depression.25 At baseline the participants showed low-average performance on the declarative memory task of the Rey Auditory Verbal Lea ...
... corticosteroid therapy. Thus, these cases are of interest; we suggest that this agent may be useful in treating corticosteroid-induced depression as well as bipolar depression.25 At baseline the participants showed low-average performance on the declarative memory task of the Rey Auditory Verbal Lea ...
ANTIEPILEPTIC DRUGS
... Pharmacological effects Resembles phenytoin in its pharmacological effects Well absorbed from GIT Metabolised primarily by glucuronidation Does not induce or inhibit C. P-450 isozymes ( its metabolism is inhibitted by valproate ) Plasma t 1/2 approx. 24 hrs. • Mechanism of Action: Inhibits excitator ...
... Pharmacological effects Resembles phenytoin in its pharmacological effects Well absorbed from GIT Metabolised primarily by glucuronidation Does not induce or inhibit C. P-450 isozymes ( its metabolism is inhibitted by valproate ) Plasma t 1/2 approx. 24 hrs. • Mechanism of Action: Inhibits excitator ...
Drugs used to treat Bipolar Disorder
... of Bipolar and many other anxiety, behavioral and substance abuse problems, possibly pain disorders GABA analogue not bound to plasma proteins, not metabolized, few drug interactions Half-Life is 5-7 hours Side Effects include sleepiness,dizziness,ataxia and double vision ...
... of Bipolar and many other anxiety, behavioral and substance abuse problems, possibly pain disorders GABA analogue not bound to plasma proteins, not metabolized, few drug interactions Half-Life is 5-7 hours Side Effects include sleepiness,dizziness,ataxia and double vision ...
CONTRACEPTIVE CHOICES FOR WOMEN WITH EPILEPSY
... used as early as possible and followed by a pregnancy test three weeks later. ...
... used as early as possible and followed by a pregnancy test three weeks later. ...
Epilepsy
... Epilepsy is usually controlled but not cured with medication. Up to 80% of patients can expect partial or complete control of seizures with appropriate treatment. 20% no response to treatment non pharmacological ...
... Epilepsy is usually controlled but not cured with medication. Up to 80% of patients can expect partial or complete control of seizures with appropriate treatment. 20% no response to treatment non pharmacological ...
View Dr. Liu`s presentation file.
... from the FDA for Suvorexant in June 2013. The company is evaluating the requests in the CRL and plans to submit definitive data in response to the FDA in early 2014. Mechanism of Action: Orexin receptor antagonist designed to inhibit the binding of the neuropeptide orexin to its receptor ...
... from the FDA for Suvorexant in June 2013. The company is evaluating the requests in the CRL and plans to submit definitive data in response to the FDA in early 2014. Mechanism of Action: Orexin receptor antagonist designed to inhibit the binding of the neuropeptide orexin to its receptor ...
Mood Stabilisers
... half life 33 hours Higher if used concurrently with other anticonvulsant medication Metabolised through the liver ...
... half life 33 hours Higher if used concurrently with other anticonvulsant medication Metabolised through the liver ...
Anti Epileptic Drugs
... Time to steady state 3 – 15 days Protein binding 55 % 85 % metabolised by conjugation in liver and excreted as glucuronide Active metabiolite – none 10 % excreted by kidneys unchanged Eliminated more rapidly in patients on hepatic enzyme inducing drugs like phenytoin, phenobarbitone and carbamazepin ...
... Time to steady state 3 – 15 days Protein binding 55 % 85 % metabolised by conjugation in liver and excreted as glucuronide Active metabiolite – none 10 % excreted by kidneys unchanged Eliminated more rapidly in patients on hepatic enzyme inducing drugs like phenytoin, phenobarbitone and carbamazepin ...
Which should be the first-line drug for newly diagnosed epilepsy
... This year saw the publication of the SANAD study, published as 2 papers in the Lancet by Marson et al. [1,2]. The SANAD study consisted of 2 arms. In arm A1, the effectiveness of carbamazepine, taken as the standard treatment for partial onset seizures, was compared to that of 4 other anti-epileptic ...
... This year saw the publication of the SANAD study, published as 2 papers in the Lancet by Marson et al. [1,2]. The SANAD study consisted of 2 arms. In arm A1, the effectiveness of carbamazepine, taken as the standard treatment for partial onset seizures, was compared to that of 4 other anti-epileptic ...
Carbamazepine
... Not Dose Related Headache Dermatologic 10% benign rash 3/1,000 adults—severe rash Do not rapidly escalate dose Warn patients about rash ...
... Not Dose Related Headache Dermatologic 10% benign rash 3/1,000 adults—severe rash Do not rapidly escalate dose Warn patients about rash ...
Bipolar I Disorder
... Table 15.1-37 US Food and Drug Administration (FDA)Approved Medications for the Treatment of Bipolar ...
... Table 15.1-37 US Food and Drug Administration (FDA)Approved Medications for the Treatment of Bipolar ...
antiepileptic drug selection for people with hiv/aids
... A retrospective cohort study and numerous pharmacokinetic studies indicate that EI-AEDs interact with ARVs. The optimal choice of epilepsy treatment in patients with HIV should reflect an accounting for the metabolic and inhibitory/inducing profiles of coadministered drugs. Clinicians who prescribe ...
... A retrospective cohort study and numerous pharmacokinetic studies indicate that EI-AEDs interact with ARVs. The optimal choice of epilepsy treatment in patients with HIV should reflect an accounting for the metabolic and inhibitory/inducing profiles of coadministered drugs. Clinicians who prescribe ...
Lamotrigine
Lamotrigine /ləˈmoʊtrɨˌdʒiːn/, marketed in most of the world as Lamictal /ləˈmɪktəl/ by GlaxoSmithKline, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating clinical depression. For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, lamotrigine also seems to act as an effective mood stabilizer, and has been the first US Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type I.Chemically unrelated to other anticonvulsants (due to lamotrigine being a phenyltriazine), lamotrigine has many possible side-effects. Lamotrigine is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs, but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties. Lamotrigine is inactivated by glucuronidation in the liver.