Partial seizures
... similar to that of phenytoin blocks sodium channels inhibits high-frequency repetitive firing in neurons in culture It also acts presynaptically to decrease synaptic transmission ...
... similar to that of phenytoin blocks sodium channels inhibits high-frequency repetitive firing in neurons in culture It also acts presynaptically to decrease synaptic transmission ...
Antiseizure Drugs
... similar to that of phenytoin blocks sodium channels inhibits high-frequency repetitive firing in neurons in culture It also acts presynaptically to decrease synaptic transmission ...
... similar to that of phenytoin blocks sodium channels inhibits high-frequency repetitive firing in neurons in culture It also acts presynaptically to decrease synaptic transmission ...
Antiepilepsy Drugs: pharmacodynamics and
... CPS that occur either in isolation or in association with other types of seizures; also indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures in adults and children aged ≥10 years, and adjunctively in adults and children aged ≥10 years with multiple ...
... CPS that occur either in isolation or in association with other types of seizures; also indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures in adults and children aged ≥10 years, and adjunctively in adults and children aged ≥10 years with multiple ...
Pharmacological management of epilepsy
... zonisamide for treatment of epilepsy and it has International League Against Epilepsy (ILAE) level A evidence for efficacy/effectiveness as initial monotherapy for adults with partial-onset seizures. It is not known to be associated with clinically significant drug–drug interactions.22 Zonisamide di ...
... zonisamide for treatment of epilepsy and it has International League Against Epilepsy (ILAE) level A evidence for efficacy/effectiveness as initial monotherapy for adults with partial-onset seizures. It is not known to be associated with clinically significant drug–drug interactions.22 Zonisamide di ...
Antiepileptic Drugs
... iii. Precautions- caution in renal, hepatic, and cardiac disease; life threatening skin rashes have occurred iv. ADRs- CNS effects, sedation, dizziness, ataxia, diplopia, blurred vision, folate deficiency, weight gain, if rash develops D/C v. DDI- not significant vi. Monitor- drug level (2-20 mcg/ml ...
... iii. Precautions- caution in renal, hepatic, and cardiac disease; life threatening skin rashes have occurred iv. ADRs- CNS effects, sedation, dizziness, ataxia, diplopia, blurred vision, folate deficiency, weight gain, if rash develops D/C v. DDI- not significant vi. Monitor- drug level (2-20 mcg/ml ...
Antiepileptic drugsx
... First line drug for partial seizures Inhibits Na+ channels—use dependent Half-life: 6-12 hours Adverse effects: CNS sedation. Agranulocytosis and aplastic anemia in elderly patients, rare but very serious adverse. A mild, transient leukopenia (decrease in white cell count) occurs in about 10% of pat ...
... First line drug for partial seizures Inhibits Na+ channels—use dependent Half-life: 6-12 hours Adverse effects: CNS sedation. Agranulocytosis and aplastic anemia in elderly patients, rare but very serious adverse. A mild, transient leukopenia (decrease in white cell count) occurs in about 10% of pat ...
(AP)of Root Bark Ethanolic Extract of Carissa edulis (Vahl)
... Epilepsy is an episodic neurological disorder that affects up to 1% of the population, 2nd to stroke Prevalence of active epilepsy is ~2.5 million in the United States. 181,000 new cases of epilepsy are diagnosed/ year. Incidence is highest under the age of 2 and over 65. In 70 percent of new cases, ...
... Epilepsy is an episodic neurological disorder that affects up to 1% of the population, 2nd to stroke Prevalence of active epilepsy is ~2.5 million in the United States. 181,000 new cases of epilepsy are diagnosed/ year. Incidence is highest under the age of 2 and over 65. In 70 percent of new cases, ...
Pharmacology of Antiepileptic Drugs
... First line drug for partial seizures Inhibits Na+ channels—use dependent Half-life: 6-12 hours Adverse effects: CNS sedation. Agranulocytosis and aplastic anemia in elderly patients, rare but very serious adverse. A mild, transient leukopenia (decrease in white cell count) occurs in about 10% of pat ...
... First line drug for partial seizures Inhibits Na+ channels—use dependent Half-life: 6-12 hours Adverse effects: CNS sedation. Agranulocytosis and aplastic anemia in elderly patients, rare but very serious adverse. A mild, transient leukopenia (decrease in white cell count) occurs in about 10% of pat ...
(1)Simple partial seizures 单纯局限性发作
... grad mal, partial seizures with complex symptomatology first choice 2. Central algesia: trigeminal neuralgia more effective than phenytoin 3. mania(躁狂症)and depression 4. 尿崩症 ...
... grad mal, partial seizures with complex symptomatology first choice 2. Central algesia: trigeminal neuralgia more effective than phenytoin 3. mania(躁狂症)and depression 4. 尿崩症 ...
Anticonvulsants as mood stabilisers
... prophylactic effect in bipolar affective disorder (see Post et al, 1996 for review). It appears to be equally effective in reducing the frequency of manic and depressive episodes. However, a recent randomised multi-centre study (Greil et al, 1997) in 144 patients over 2.5 years, found that lithium w ...
... prophylactic effect in bipolar affective disorder (see Post et al, 1996 for review). It appears to be equally effective in reducing the frequency of manic and depressive episodes. However, a recent randomised multi-centre study (Greil et al, 1997) in 144 patients over 2.5 years, found that lithium w ...
Can drug resistance in epilepsy be minimized?
... with severe epilepsy, and are not necessarily applicable to an unselected population. This concept is well illustrated by the landmark study that, in the early 70s, led to the general acceptance of a therapeutic range for phenytoin (Lund 1974). This was a 3-year, prospective assessment of 32 patient ...
... with severe epilepsy, and are not necessarily applicable to an unselected population. This concept is well illustrated by the landmark study that, in the early 70s, led to the general acceptance of a therapeutic range for phenytoin (Lund 1974). This was a 3-year, prospective assessment of 32 patient ...
The pharmacologic treatment of Dravet syndrome
... further long-lasting seizures, the parents should be encouraged to administer oral/nasal/rectal benzodiazepine–diazepam or midazolam for any seizure lasting more than a few minutes. However, repetition of the seizures permits the diagnosis to be considered, and to no longer consider complicated febr ...
... further long-lasting seizures, the parents should be encouraged to administer oral/nasal/rectal benzodiazepine–diazepam or midazolam for any seizure lasting more than a few minutes. However, repetition of the seizures permits the diagnosis to be considered, and to no longer consider complicated febr ...
Drug treatment of paediatric epilepsy RICHARD E. APPLETON and J. HELEN CROSS
... age of 12 years. Of these new AEDs, lamotrigine, topiramate and levetiracetam would appear to have the broadest spectrum of action, being effective against many generalised and focal seizure types, and relatively free of serious side effects, other than lamotrigine producing an allergic or idiosyncr ...
... age of 12 years. Of these new AEDs, lamotrigine, topiramate and levetiracetam would appear to have the broadest spectrum of action, being effective against many generalised and focal seizure types, and relatively free of serious side effects, other than lamotrigine producing an allergic or idiosyncr ...
Bipolar Disorder - Steven Bander
... • First trimester - neural tube defects, craniofacial abnormalities ...
... • First trimester - neural tube defects, craniofacial abnormalities ...
Drug Monitoring: Simultaneous Analysis of Lamotrigine
... Lamotrigine (Lamictal, GlaxoSmithKline) is a broad-spectrum anti-epileptic drug of the phenyltriazine class chemically unrelated to other anti-convulsants that was approved by the Food and Drug Administration (FDA) for treatment of epilepsy in 1994 (1,2). In 2003, lamotrigine received an additional ...
... Lamotrigine (Lamictal, GlaxoSmithKline) is a broad-spectrum anti-epileptic drug of the phenyltriazine class chemically unrelated to other anti-convulsants that was approved by the Food and Drug Administration (FDA) for treatment of epilepsy in 1994 (1,2). In 2003, lamotrigine received an additional ...
Use of Antipsychotics in Treating Schizophrenia and other
... antimanic drug with another or with placebo, the authors found that overall antipsychotics were significantly more effective than mood stabilizers, with Risperdal, Olanzapine and Haloperidol showing the best efficacy profile in the treatment of acute ...
... antimanic drug with another or with placebo, the authors found that overall antipsychotics were significantly more effective than mood stabilizers, with Risperdal, Olanzapine and Haloperidol showing the best efficacy profile in the treatment of acute ...
Pharmacotherapy of Bipolar Disorders in Late Life
... findings from randomized, placebo controlled trials of continuation-maintenance treatment in bipolar patients aged 55 years and older found evidence of efficacy for which of the following: ...
... findings from randomized, placebo controlled trials of continuation-maintenance treatment in bipolar patients aged 55 years and older found evidence of efficacy for which of the following: ...
Harvard-MIT Division of Health Sciences and Technology
... not yet completely defined, and none are currently used as the first treatment for epilepsy. Felbamate was approved by the FDA in early 1994 and was the first new drug for epilepsy to be approved in 15 years. Although there was great initial enthusiasm for this agent, in less than a year post-mark ...
... not yet completely defined, and none are currently used as the first treatment for epilepsy. Felbamate was approved by the FDA in early 1994 and was the first new drug for epilepsy to be approved in 15 years. Although there was great initial enthusiasm for this agent, in less than a year post-mark ...
Drugs for primary generalized epilepsy
... none are currently used as the first treatment for epilepsy. Felbamate was approved by the FDA in early 1994 and was the first new drug for epilepsy to be approved in 15 years. Although there was great initial enthusiasm for this agent, in less than a year post-marketing surveillance revealed an una ...
... none are currently used as the first treatment for epilepsy. Felbamate was approved by the FDA in early 1994 and was the first new drug for epilepsy to be approved in 15 years. Although there was great initial enthusiasm for this agent, in less than a year post-marketing surveillance revealed an una ...
Bipolar Disorder
... While there is no cure for bipolar disorder, it is a treatable and manageable illness. After an accurate diagnosis, most people can be successfully treated. Medication is an essential part of successful treatment for people with bipolar disorder. Maintenance treatment with a mood stabilizer substant ...
... While there is no cure for bipolar disorder, it is a treatable and manageable illness. After an accurate diagnosis, most people can be successfully treated. Medication is an essential part of successful treatment for people with bipolar disorder. Maintenance treatment with a mood stabilizer substant ...
lec.8-426
... occurs often in children at the at the age of 4 to 8 years. • Psychomotor seizures – characterized by attacks without convulsions lasting from 2 to 3 min. ...
... occurs often in children at the at the age of 4 to 8 years. • Psychomotor seizures – characterized by attacks without convulsions lasting from 2 to 3 min. ...
Epilepsy For Internists 2003
... • Once pregnancy achieved: balance risk of AED exposure with risk of in utero seizures • Most AEDs have increased clearance in pregnancy and women should be followed closely by neuro/high risk OB • Vitamin K supplementation in last 4 weeks ...
... • Once pregnancy achieved: balance risk of AED exposure with risk of in utero seizures • Most AEDs have increased clearance in pregnancy and women should be followed closely by neuro/high risk OB • Vitamin K supplementation in last 4 weeks ...
partial
... Figure 1. A 17-year-old boy had generalized tonic–clonic seizures for four years. When the seizures began, a computed tomographic scan of his brain and an electroencephalogram were normal. Treatment with 300 mg of phenytoin per day was subsequently begun and continued unsupervised for a period of t ...
... Figure 1. A 17-year-old boy had generalized tonic–clonic seizures for four years. When the seizures began, a computed tomographic scan of his brain and an electroencephalogram were normal. Treatment with 300 mg of phenytoin per day was subsequently begun and continued unsupervised for a period of t ...
Psychotropics in Psychiatric Patient – Bipolar disorders
... Evidence base for combinations of antipsychotics with lithium or anticonvulsants. Evidence base: +, positive in at least one placebo-controlled trial; ?, no evidence available from clinical trials; -, negative results in clinical trials so far ...
... Evidence base for combinations of antipsychotics with lithium or anticonvulsants. Evidence base: +, positive in at least one placebo-controlled trial; ?, no evidence available from clinical trials; -, negative results in clinical trials so far ...
EPILEPSY
... Simple Partial • These produce symptoms associated with the area of abnormal neural activity in the brain confined to single locus: ...
... Simple Partial • These produce symptoms associated with the area of abnormal neural activity in the brain confined to single locus: ...
Lamotrigine
Lamotrigine /ləˈmoʊtrɨˌdʒiːn/, marketed in most of the world as Lamictal /ləˈmɪktəl/ by GlaxoSmithKline, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating clinical depression. For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, lamotrigine also seems to act as an effective mood stabilizer, and has been the first US Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type I.Chemically unrelated to other anticonvulsants (due to lamotrigine being a phenyltriazine), lamotrigine has many possible side-effects. Lamotrigine is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs, but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties. Lamotrigine is inactivated by glucuronidation in the liver.