Molecular mechanics of the interactions of spermine with DNA: DNA
... the three central torsion angles are 180°, which forces the central diaminobutane moiety into a fully extended conformation and produces a single distance (approximately 6.3 A) between the secondary amino groups (data not shown). The aminopropyl groups attached to the secondary amino groups assume a ...
... the three central torsion angles are 180°, which forces the central diaminobutane moiety into a fully extended conformation and produces a single distance (approximately 6.3 A) between the secondary amino groups (data not shown). The aminopropyl groups attached to the secondary amino groups assume a ...
to view
... is very small. Why such type of adjustment is there in higher organisms? Ans.Female gamete is large and non motile, is an adaptation for storing more food which will be required for the future development. The male gamete has to move to reach the counterpart, so it has the machinery for its reaching ...
... is very small. Why such type of adjustment is there in higher organisms? Ans.Female gamete is large and non motile, is an adaptation for storing more food which will be required for the future development. The male gamete has to move to reach the counterpart, so it has the machinery for its reaching ...
Functional Analysis of Maize RAD51 in Meiosis and
... and develop well under normal conditions, but are male sterile and have substantially reduced seed set. Light microscopic analyses of male meiosis in these plants reveal reduced homologous pairing, synapsis of nonhomologous chromosomes, reduced bivalents at diakinesis, numerous chromosome breaks at ...
... and develop well under normal conditions, but are male sterile and have substantially reduced seed set. Light microscopic analyses of male meiosis in these plants reveal reduced homologous pairing, synapsis of nonhomologous chromosomes, reduced bivalents at diakinesis, numerous chromosome breaks at ...
Gene Section MLL (myeloid/lymphoid or mixed lineage leukemia) Atlas of Genetics and Cytogenetics
... 3969 amino acids; 431 KDa; contains two DNA binding motifs: a AT hook homologous to high mobility group proteins HMGI-(Y) and HMGI(C) that binds to the minor groove of DNA, and zinc fingers, a DNA methyl transferase motif, a bromodomain, and segments of homology with trithorax, in particular in the ...
... 3969 amino acids; 431 KDa; contains two DNA binding motifs: a AT hook homologous to high mobility group proteins HMGI-(Y) and HMGI(C) that binds to the minor groove of DNA, and zinc fingers, a DNA methyl transferase motif, a bromodomain, and segments of homology with trithorax, in particular in the ...
arXiv:0708.2724v1 [cond-mat.other] 20 Aug 2007
... have one trait in common: they employ nanoscale probes to examine the structural or electronic signatures of individual DNA bases. That is, they rely on physical differences between the bases. This is a major departure from existing sequencing paradigms which rely on chemical techniques and physical ...
... have one trait in common: they employ nanoscale probes to examine the structural or electronic signatures of individual DNA bases. That is, they rely on physical differences between the bases. This is a major departure from existing sequencing paradigms which rely on chemical techniques and physical ...
of Lactobacillus pentosus
... Davis et al., 1984, Davis and Henderson, 1987). This xylE gene was not found within the cluster of xyl genes but is present on a separate locus on theE. coli chromosome. The xylR gene codes for a regulatory protein involved in the activation of expression of the xylose genes in the presence of D-xyl ...
... Davis et al., 1984, Davis and Henderson, 1987). This xylE gene was not found within the cluster of xyl genes but is present on a separate locus on theE. coli chromosome. The xylR gene codes for a regulatory protein involved in the activation of expression of the xylose genes in the presence of D-xyl ...
Fitness landscapes of gene regulation in variable - UvA-DARE
... ll living organisms are equipped with mechanisms that enable them to sense their environment and respond to it. In many cases the response consists of regulating gene expression. For bacteria the link between sensing and response is often formed by a small network of interacting proteins and regulat ...
... ll living organisms are equipped with mechanisms that enable them to sense their environment and respond to it. In many cases the response consists of regulating gene expression. For bacteria the link between sensing and response is often formed by a small network of interacting proteins and regulat ...
Resolving Individuals Contributing Trace Amounts of DNA to Highly
... components of the mixture [8]. Nevertheless, these methods based on STRs expectedly suffer from limited power when using severely degraded DNA [8,9]. Mitochondrial DNA (mtDNA) based on hypervariable region sequencing is useful when analyzing degraded DNA due to its high copy number and improved stab ...
... components of the mixture [8]. Nevertheless, these methods based on STRs expectedly suffer from limited power when using severely degraded DNA [8,9]. Mitochondrial DNA (mtDNA) based on hypervariable region sequencing is useful when analyzing degraded DNA due to its high copy number and improved stab ...
PDF
... and polarized light sensors (Hardie, 1985). According to their differentiated function, R1-6 innervate the first OL neuropil, which is the lamina, whereas R7 and R8 axons run across the lamina to innervate the neuropil beneath, which is the medulla. Next, the lobula and lobula plate (together called ...
... and polarized light sensors (Hardie, 1985). According to their differentiated function, R1-6 innervate the first OL neuropil, which is the lamina, whereas R7 and R8 axons run across the lamina to innervate the neuropil beneath, which is the medulla. Next, the lobula and lobula plate (together called ...
Two Classes of sir3 Mutants Enhance the sir1
... DNA replication, however, so the mechanistic significance of the Sir1p-Orc1p interaction is not yet understood. Sir3p is a key component of silent chromatin (reviewed in Stone and Pillus 1998). It is an integral subunit of the multiprotein complex that functions at the silent mating-type loci and at ...
... DNA replication, however, so the mechanistic significance of the Sir1p-Orc1p interaction is not yet understood. Sir3p is a key component of silent chromatin (reviewed in Stone and Pillus 1998). It is an integral subunit of the multiprotein complex that functions at the silent mating-type loci and at ...
Hox patterning of the vertebrate axial skeleton
... Many studies over the past 2 decades have characterized the details of Hox expression in vertebrate embryos, the response of Hox gene expression to embryologic and genetic manipulation, as well as the effects of targeted loss of Hox function on axial patterning. In this review, Hox expression from i ...
... Many studies over the past 2 decades have characterized the details of Hox expression in vertebrate embryos, the response of Hox gene expression to embryologic and genetic manipulation, as well as the effects of targeted loss of Hox function on axial patterning. In this review, Hox expression from i ...
PDF
... mothers and therefore contain maternally deposited wild-type UTX1 protein are viable and show no morphological abnormalities. However, the mutant progeny from utx-1 homozygotes (i.e. lacking both zygotic and maternal UTX-1 protein) arrest development at the late embryonic stage (Vandamme et al., 201 ...
... mothers and therefore contain maternally deposited wild-type UTX1 protein are viable and show no morphological abnormalities. However, the mutant progeny from utx-1 homozygotes (i.e. lacking both zygotic and maternal UTX-1 protein) arrest development at the late embryonic stage (Vandamme et al., 201 ...
Inhibition of RNA Synthesis by Anthracycline Analogs
... and inactivate its template function essential for nucleic acid synthesis. Recently, several structural analogs of these antineoplastic agents have been synthesized and some of them were shown to be considerably more effective against experimental tumors than the parent compounds. The majority of re ...
... and inactivate its template function essential for nucleic acid synthesis. Recently, several structural analogs of these antineoplastic agents have been synthesized and some of them were shown to be considerably more effective against experimental tumors than the parent compounds. The majority of re ...
Tomé, S., Manley, K., Simard, J.P., Clark, G.W., Slean, M.M., Swami
... arise between individuals with expanded repeats, suggesting the existence of modifiers of repeat instability. Mice with expanded CAG/CTG repeats show variable levels of instability depending upon mouse strain. However, to date the genetic modifiers underlying these differences have not been identifi ...
... arise between individuals with expanded repeats, suggesting the existence of modifiers of repeat instability. Mice with expanded CAG/CTG repeats show variable levels of instability depending upon mouse strain. However, to date the genetic modifiers underlying these differences have not been identifi ...
Chance and Necessity in Arthur Peacocke`s Scientific Work
... that time, one can not but be impressed with Peacocke’s courage and vision at undertaking this research direction. Results of these studies were published in journals that are to this day considered to be among the most prestigious. From that time until the end of his research carrier, Peacocke’s ma ...
... that time, one can not but be impressed with Peacocke’s courage and vision at undertaking this research direction. Results of these studies were published in journals that are to this day considered to be among the most prestigious. From that time until the end of his research carrier, Peacocke’s ma ...
History of Discoveries in Molecular Biology
... like a Honey-comb, but that the pores of it were not regular. . . . these pores, or cells, . . . were indeed the first microscopical pores I ever saw, and perhaps, that were ever seen, for I had not met with any Writer or Person, that had made any mention of them before this. . . BTC 563 ...
... like a Honey-comb, but that the pores of it were not regular. . . . these pores, or cells, . . . were indeed the first microscopical pores I ever saw, and perhaps, that were ever seen, for I had not met with any Writer or Person, that had made any mention of them before this. . . BTC 563 ...
p53 in Hematologic Malignancies
... Cases of AML and MDS have been reported that have cell lines have about a 50% frequency of p53 mutations,"" high levels of p53 protein, as determined by either immunoprecipitation or immunochemistry, buthaveno detectable p53 mutations are rarely found in patients with newly diagp53 m~tations.~"."' O ...
... Cases of AML and MDS have been reported that have cell lines have about a 50% frequency of p53 mutations,"" high levels of p53 protein, as determined by either immunoprecipitation or immunochemistry, buthaveno detectable p53 mutations are rarely found in patients with newly diagp53 m~tations.~"."' O ...
Human RIF1 and protein phosphatase 1 stimulate DNA replication
... interactions are required for origin stabilization as much of the data provided relies on broadspectrum PP1 inhibitors. These data would significantly strengthen the novel findings in this paper. This is a very good suggestion. We have added a panel (‘Extended View’ Fig. EV3A in the revised version) ...
... interactions are required for origin stabilization as much of the data provided relies on broadspectrum PP1 inhibitors. These data would significantly strengthen the novel findings in this paper. This is a very good suggestion. We have added a panel (‘Extended View’ Fig. EV3A in the revised version) ...
WOTD - Brookwood High School
... V:multiple alleles refer to a trait (one gene) which is coded for by more than two alleles. ...
... V:multiple alleles refer to a trait (one gene) which is coded for by more than two alleles. ...
Prof. Kamakaka`s Lecture 12 Notes
... and its mutant phenotype we need to study the gene at multiple levels: Genetics- mutant gene- mutant phenotype Now what? Genetics will relate specific mutation to specific phenotype It usually provides No Information about how the protein generates the phenotype For p53 We would like to know The nuc ...
... and its mutant phenotype we need to study the gene at multiple levels: Genetics- mutant gene- mutant phenotype Now what? Genetics will relate specific mutation to specific phenotype It usually provides No Information about how the protein generates the phenotype For p53 We would like to know The nuc ...
Review of the p53 Tumor Suppressor Gene and its Role in Gliomas
... In the same way, cells begin to differentiate at a ...
... In the same way, cells begin to differentiate at a ...
Cancer epigenetics
Cancer epigenetics is the study of epigenetic modifications to the genome of cancer cells that do not involve a change in the nucleotide sequence. Epigenetic alterations are as important as genetic mutations in a cell’s transformation to cancer, and their manipulation holds great promise for cancer prevention, detection, and therapy. In different types of cancer, a variety of epigenetic mechanisms can be perturbed, such as silencing of tumor suppressor genes and activation of oncogenes by altered CpG island methylation patterns, histone modifications, and dysregulation of DNA binding proteins. Several medications which have epigenetic impact are now used in several of these diseases.