Metabolic downregulation during diapause in embryos of Artemia
... exposure to environmental stresses that limit energy availability is largely related to the degree of metabolic depression achieved. In order to withstand such environmental challenges, it is crucial to depress both energy consuming and energy producing pathways. Otherwise it is possible that cellul ...
... exposure to environmental stresses that limit energy availability is largely related to the degree of metabolic depression achieved. In order to withstand such environmental challenges, it is crucial to depress both energy consuming and energy producing pathways. Otherwise it is possible that cellul ...
Reprint
... challenged on the basis that significant generation of carbonyl compounds was detected only in the case when chloramine was in the α-position from the carboxyl group, as in the case of α-amino acid chloramines [48]. There was no evidence that aldehydes are formed from εamino-Lys chloramines [49]. Mo ...
... challenged on the basis that significant generation of carbonyl compounds was detected only in the case when chloramine was in the α-position from the carboxyl group, as in the case of α-amino acid chloramines [48]. There was no evidence that aldehydes are formed from εamino-Lys chloramines [49]. Mo ...
Investigating the Role of ADP-forming Acetyl-CoA
... revealed that this enzyme may function in the direction of acetate production for generation of ATP and CoA during growth in the high glucose environment of the small intestine, and in acetate assimilation to acetyl-CoA in the high acetate environment of the lower intestine during colonization. EhAC ...
... revealed that this enzyme may function in the direction of acetate production for generation of ATP and CoA during growth in the high glucose environment of the small intestine, and in acetate assimilation to acetyl-CoA in the high acetate environment of the lower intestine during colonization. EhAC ...
Characterization of the Two-Component, FAD-Dependent Monooxygenase SgcC That Requires Carrier Protein-Tethered
... similarities.17–19 The first class, or one-component monooxygenases, are single polypeptides that utilize FAD or FMN as a cofactor and require NADH or NADPH to initiate oxidation of substrates; thus, these monooxygenases have both flavin reductase and monooxygnease activity. The second class, or two ...
... similarities.17–19 The first class, or one-component monooxygenases, are single polypeptides that utilize FAD or FMN as a cofactor and require NADH or NADPH to initiate oxidation of substrates; thus, these monooxygenases have both flavin reductase and monooxygnease activity. The second class, or two ...
Analysis and engineering of acetyl
... the mitochondrial pyrfffiate-dehydrogenase (PDH) compleffi yields acetyl-CoA in the mitochondrial matriffi. A second soffrce of mitochondrial acetyl-CoA depends on actifiity of the mitochondrial Ach1 protein, flhich can transfer the CoA groffp from sffccinyl-CoA to acetate, forming acetyl-CoA and sffccinate. Al ...
... the mitochondrial pyrfffiate-dehydrogenase (PDH) compleffi yields acetyl-CoA in the mitochondrial matriffi. A second soffrce of mitochondrial acetyl-CoA depends on actifiity of the mitochondrial Ach1 protein, flhich can transfer the CoA groffp from sffccinyl-CoA to acetate, forming acetyl-CoA and sffccinate. Al ...
Biochemistry of coenzyme B12‐dependent glycerol and diol
... The coenzyme B12 -dependent glycerol and diol dehydratases are involved in the anaerobic utilization of small molecules, they catalyze molecular rearrangements that generate an aldehyde which can be reduced (i.e. glycerol fermentation) or dismutated to more oxidized and more reduced compounds (i.e. ...
... The coenzyme B12 -dependent glycerol and diol dehydratases are involved in the anaerobic utilization of small molecules, they catalyze molecular rearrangements that generate an aldehyde which can be reduced (i.e. glycerol fermentation) or dismutated to more oxidized and more reduced compounds (i.e. ...
Biochemical Characterization of 2-Nitropropane Dioxygenase from
... 2-Nitropropane dioxygenase from Hansenula mrakii is a flavin-dependent enzyme that catalyzes the oxidation of anionic nitroalkanes into the corresponding carbonyl compounds and nitrite, with oxygen as the electron acceptor. Although nitroalkanes are anticipated to be toxic and carcinogenic, they are ...
... 2-Nitropropane dioxygenase from Hansenula mrakii is a flavin-dependent enzyme that catalyzes the oxidation of anionic nitroalkanes into the corresponding carbonyl compounds and nitrite, with oxygen as the electron acceptor. Although nitroalkanes are anticipated to be toxic and carcinogenic, they are ...
Burger_JR - NWU-IR Home - North
... A total 7 050 patients (39.5%, n = 17 866) or approximately every third patient from the metabolic syndrome category had at least one other Chronic Disease List (CDL) condition during 2008. An average chronic disease count of 1.4 ± 0.63 (median 1) (range: 1-5) per patient was calculated. Diseases th ...
... A total 7 050 patients (39.5%, n = 17 866) or approximately every third patient from the metabolic syndrome category had at least one other Chronic Disease List (CDL) condition during 2008. An average chronic disease count of 1.4 ± 0.63 (median 1) (range: 1-5) per patient was calculated. Diseases th ...
Novel control of lactate dehydrogenase from the freeze
... strong effects on enzymes including altering activity, kinetic parameters, protein stability, protein–protein or subunit–subunit interactions, and subcellular localization (Cohen, 2002). Reversible phosphorylation has long been known to have major regulatory effects on many enzymes of intermediary m ...
... strong effects on enzymes including altering activity, kinetic parameters, protein stability, protein–protein or subunit–subunit interactions, and subcellular localization (Cohen, 2002). Reversible phosphorylation has long been known to have major regulatory effects on many enzymes of intermediary m ...
1 Chapter 1 Chemistry On The Pyrimidine Ring
... ring closure or opening. The enzymes that catalyze these reactions are called amidohydrolases, and they are part of a superfamily comprising a diverse set of enzymes that catalyze mainly hydrolysis reactions, and some isomerization reactions. They function on a variety of substrates such as sugars, ...
... ring closure or opening. The enzymes that catalyze these reactions are called amidohydrolases, and they are part of a superfamily comprising a diverse set of enzymes that catalyze mainly hydrolysis reactions, and some isomerization reactions. They function on a variety of substrates such as sugars, ...
Glutamine and the bowel
... the systemic flux of glutamine. → intestinal glutamine metabolism: 1. Contribute a nutritionally important portion of intestinal energy generation. 2. As precursor:synthesis of ornithine, cotrulline, proline and arginine. ...
... the systemic flux of glutamine. → intestinal glutamine metabolism: 1. Contribute a nutritionally important portion of intestinal energy generation. 2. As precursor:synthesis of ornithine, cotrulline, proline and arginine. ...
Drug Metabolism Current Concepts CORINA IONESCU MINO R. CAIRA
... metabolism (drug biotransformation), to illustrate the wide-ranging medical implications of such biological processes and to provide the reader with a perspective on current research in this area. The general intention is to demonstrate that the metabolism of a drug is a primary concern throughout i ...
... metabolism (drug biotransformation), to illustrate the wide-ranging medical implications of such biological processes and to provide the reader with a perspective on current research in this area. The general intention is to demonstrate that the metabolism of a drug is a primary concern throughout i ...
Z ^ _ b ^
... • Describe in details the development of le; atrium.(79) • give an account on fetal circulation & changes. which occur after birth.(81,84, 92) • give an account on : o Development of interatrial. o Development of arch of aorta. • Enumerate the anomalies of the heart. • Describe the development of th ...
... • Describe in details the development of le; atrium.(79) • give an account on fetal circulation & changes. which occur after birth.(81,84, 92) • give an account on : o Development of interatrial. o Development of arch of aorta. • Enumerate the anomalies of the heart. • Describe the development of th ...
Breast Reconstruction Following Prophylactic Or Therapeutic
... and implant malposition, and the possibility of a single-stage “direct to implant” procedure for carefully selected patients. • These benefits should be weighed against the potentially higher risks of mastectomy skin necrosis, postoperative seroma, and infection, and mastectomy skin necrosis in HADM ...
... and implant malposition, and the possibility of a single-stage “direct to implant” procedure for carefully selected patients. • These benefits should be weighed against the potentially higher risks of mastectomy skin necrosis, postoperative seroma, and infection, and mastectomy skin necrosis in HADM ...
3 Citrate metabolism and aroma compound production in lactic acid
... citrate utilization by LAB has promoted research into the proteins and effectors controlling its metabolic pathway. In this chapter we summarize the current knowledge of citrate utilization by LAB. The transport of citrate and its metabolism to pyruvate, as well as further conversion to aroma compou ...
... citrate utilization by LAB has promoted research into the proteins and effectors controlling its metabolic pathway. In this chapter we summarize the current knowledge of citrate utilization by LAB. The transport of citrate and its metabolism to pyruvate, as well as further conversion to aroma compou ...
Propionate stimulates pyruvate oxidation in the - AJP
... purification. The various 13C isotopomers of sodium acetate, glucose, and propionate were purchased and used as supplied from Cambridge Isotopes (Andover, MA). Trityl-OXO63 free radical was purchased from Oxford Instruments Molecular Biotools (Oxford, UK). Protocol. The protocol was approved by the ...
... purification. The various 13C isotopomers of sodium acetate, glucose, and propionate were purchased and used as supplied from Cambridge Isotopes (Andover, MA). Trityl-OXO63 free radical was purchased from Oxford Instruments Molecular Biotools (Oxford, UK). Protocol. The protocol was approved by the ...
Development, validation and biological application of
... magnetic resonance (NMR) analytical technique for the simultaneous determination of de novo lipogenesis, elongation, unsaturation, glycerol and cholesterol synthesis fluxes. The first chapter of this dissertation will provide the mathematical formulas necessary for the determination of these fluxes. ...
... magnetic resonance (NMR) analytical technique for the simultaneous determination of de novo lipogenesis, elongation, unsaturation, glycerol and cholesterol synthesis fluxes. The first chapter of this dissertation will provide the mathematical formulas necessary for the determination of these fluxes. ...
The metabolic basis of Candida albicans
... Recent studies have elucidated the signal transduction pathways and quorum sensing molecules that affect the morphological transition of C. albicans. The metabolic mechanisms that recognize, and respond to, such signaling molecules and promote the morphological changes at a system level, however, re ...
... Recent studies have elucidated the signal transduction pathways and quorum sensing molecules that affect the morphological transition of C. albicans. The metabolic mechanisms that recognize, and respond to, such signaling molecules and promote the morphological changes at a system level, however, re ...
Metabolic network modelling
Metabolic network reconstruction and simulation allows for an in-depth insight into the molecular mechanisms of a particular organism. In particular, these models correlate the genome with molecular physiology. A reconstruction breaks down metabolic pathways (such as glycolysis and the Citric acid cycle) into their respective reactions and enzymes, and analyzes them within the perspective of the entire network. In simplified terms, a reconstruction collects all of the relevant metabolic information of an organism and compiles it in a mathematical model. Validation and analysis of reconstructions can allow identification of key features of metabolism such as growth yield, resource distribution, network robustness, and gene essentiality. This knowledge can then be applied to create novel biotechnology.In general, the process to build a reconstruction is as follows: Draft a reconstruction Refine the model Convert model into a mathematical/computational representation Evaluate and debug model through experimentation↑