Physiological studies on the sex-linked dwarfism of the fowl: a
... injection of ovine prolactin or growth hormone, but such a stimulation could not be observed in dwarf embryos (Kuhn et al., 1986). This lack of T3 response in dwarfs was explained by a malfunction at the level of the peripheral monodeiodination. Similarly, a lower in vitro activity of the liver 5’-D ...
... injection of ovine prolactin or growth hormone, but such a stimulation could not be observed in dwarf embryos (Kuhn et al., 1986). This lack of T3 response in dwarfs was explained by a malfunction at the level of the peripheral monodeiodination. Similarly, a lower in vitro activity of the liver 5’-D ...
Serum sample containing endogenous antibodies interfering with
... result, which has not been confirmed by other diagnostic methods and which does not fit the overall clinical picture for the patient under consideration. This is probably because many clinicians are unaware of the pitfalls that can befall immunoassays and have blind (and misplaced) faith in the inte ...
... result, which has not been confirmed by other diagnostic methods and which does not fit the overall clinical picture for the patient under consideration. This is probably because many clinicians are unaware of the pitfalls that can befall immunoassays and have blind (and misplaced) faith in the inte ...
Neuroendocrinology of Amphibian Metamorphosis
... release of glucocorticoids which are transported in the blood bound to corticosteroidbinding globulin. Cellular uptake of T3 and T4 is achieved by organic anion, monocarboxylate, and amino acid transporters; there is also evidence that thyroid hormones may enter cells bound to transthyretin via a re ...
... release of glucocorticoids which are transported in the blood bound to corticosteroidbinding globulin. Cellular uptake of T3 and T4 is achieved by organic anion, monocarboxylate, and amino acid transporters; there is also evidence that thyroid hormones may enter cells bound to transthyretin via a re ...
primary effect - Semantic Scholar
... injection of ovine prolactin or growth hormone, but such a stimulation could not be observed in dwarf embryos (Kuhn et al., 1986). This lack of T3 response in dwarfs was explained by a malfunction at the level of the peripheral monodeiodination. Similarly, a lower in vitro activity of the liver 5’-D ...
... injection of ovine prolactin or growth hormone, but such a stimulation could not be observed in dwarf embryos (Kuhn et al., 1986). This lack of T3 response in dwarfs was explained by a malfunction at the level of the peripheral monodeiodination. Similarly, a lower in vitro activity of the liver 5’-D ...
Hypothyroidism due to enzyme defects
... changes in iodine metabolism (Wayne, Kontras & Alexander, 1964) with a low value for plasma inorganic iodine (PII), and increased thyroid avidity for tracer doses of radioiodine. The pattern of hormonogenesis is altered with an increased amount of MIT relative to DIT and of iodotyrosines relative to ...
... changes in iodine metabolism (Wayne, Kontras & Alexander, 1964) with a low value for plasma inorganic iodine (PII), and increased thyroid avidity for tracer doses of radioiodine. The pattern of hormonogenesis is altered with an increased amount of MIT relative to DIT and of iodotyrosines relative to ...
Phylogenetic Distribution and Function of the Hypophysiotropic
... 1974; Winokur and Utiger, 1974). In an attempt to determine the source of extrahypothalamic TRH, we have studied the effects of classical thyrotrophic area lesions which bring about a reduction in hypothalamic TRH by two-thirds (Table 2). The extrahypothalamic brain TRH content was unaffected in rat ...
... 1974; Winokur and Utiger, 1974). In an attempt to determine the source of extrahypothalamic TRH, we have studied the effects of classical thyrotrophic area lesions which bring about a reduction in hypothalamic TRH by two-thirds (Table 2). The extrahypothalamic brain TRH content was unaffected in rat ...
Injecting human growth hormone as a performance
... modulates secretion through the hormones ghrelin and growth hormone-releasing hormone which promote release, and somatostatin, which inhibits release (Veldhuis, 2003). Changes in the amount (and rate of secretion) of growth hormone also occur throughout life, with the highest being during puberty1 w ...
... modulates secretion through the hormones ghrelin and growth hormone-releasing hormone which promote release, and somatostatin, which inhibits release (Veldhuis, 2003). Changes in the amount (and rate of secretion) of growth hormone also occur throughout life, with the highest being during puberty1 w ...
Thyroid - Milestone Centers, Inc.
... are diagnosed with hyperthyroidism. A radioactive thyroid scan and a radioactive iodine uptake test may be done to find the cause of the hyperthyroidism. ...
... are diagnosed with hyperthyroidism. A radioactive thyroid scan and a radioactive iodine uptake test may be done to find the cause of the hyperthyroidism. ...
Thyroid Hormone Regulation of Peptidylglycine a
... EC 1.14.17.3) is a copper-, molecular oxygen-, and ascorbate-dependent enzyme which catalyzes the COOH-terminal amidation of bioactive peptides. Expression of PAM in the adult male rat anterior pituitary was evaluated after experimental manipulation of thyroid status. Levels of PAM mRNA increased 4- ...
... EC 1.14.17.3) is a copper-, molecular oxygen-, and ascorbate-dependent enzyme which catalyzes the COOH-terminal amidation of bioactive peptides. Expression of PAM in the adult male rat anterior pituitary was evaluated after experimental manipulation of thyroid status. Levels of PAM mRNA increased 4- ...
The Selective Loss of the Type 2 Iodothyronine Deiodinase in
... To elucidate the effect of inactivating the pituitary Dio2 gene on the other elements of the hypothalamic-pituitarythyroid axis, we measured the pre-proTRH mRNA expression in the PVN (Supplemental Figure 5A) and pyroglutamyl peptidase II mRNA, a TRH-inactivating enzyme expressed in tanycytes, in the ...
... To elucidate the effect of inactivating the pituitary Dio2 gene on the other elements of the hypothalamic-pituitarythyroid axis, we measured the pre-proTRH mRNA expression in the PVN (Supplemental Figure 5A) and pyroglutamyl peptidase II mRNA, a TRH-inactivating enzyme expressed in tanycytes, in the ...
Lesson 6. FEEDBACK REGULATION IN THYROID
... 2. A patient suspected of chronic hypothyroidism has blood samples taken every few days and the averaged measured levels of [TH] = 36.7 µg/L and [TSH] = 4.6 confirm the original suspicion. [TH] level is low, but because [TSH] is too high, the thyroid deficiency may be due to a reduced affinity of th ...
... 2. A patient suspected of chronic hypothyroidism has blood samples taken every few days and the averaged measured levels of [TH] = 36.7 µg/L and [TSH] = 4.6 confirm the original suspicion. [TH] level is low, but because [TSH] is too high, the thyroid deficiency may be due to a reduced affinity of th ...
Hypothyroidism, Functional Hypothyroidism, And Functional
... • A number of situations can contribute – Inadequate production of T4 – Poor conversion from T4 to T3 – Problems with the cell’s ability to take up T3 – Problems with receptor function – Problems with intracellular transport ...
... • A number of situations can contribute – Inadequate production of T4 – Poor conversion from T4 to T3 – Problems with the cell’s ability to take up T3 – Problems with receptor function – Problems with intracellular transport ...
Environmental Stress as a Developmental Cue: Corticotropin
... homology with the mammalian and frog CRHs (Montecucchi and Henschen, 1981). Corticotropin-releasing hormone is the central and primary neuroendocrine regulator of the vertebrate stress response, and activation of CRH neurons leads to an elevation in plasma corticosteroid levels (see Vale, 1992). Thu ...
... homology with the mammalian and frog CRHs (Montecucchi and Henschen, 1981). Corticotropin-releasing hormone is the central and primary neuroendocrine regulator of the vertebrate stress response, and activation of CRH neurons leads to an elevation in plasma corticosteroid levels (see Vale, 1992). Thu ...
Endocrine Effects on Migration1 This paper is
... Grant and Cooper (1965) and Crim (1975) facilitating movement onto land. As noted have shown that migration to water and above, prolactin can also increase locoassociated skin and tail changes can be ini- motor behavior. Whether this is via an tiated in the intact or hypophysectomized effect on circ ...
... Grant and Cooper (1965) and Crim (1975) facilitating movement onto land. As noted have shown that migration to water and above, prolactin can also increase locoassociated skin and tail changes can be ini- motor behavior. Whether this is via an tiated in the intact or hypophysectomized effect on circ ...
Congenital Hypothyroidism Presenting with Postpartum Bradycardia
... congenital factors.6 Severity of the symptoms and physical manifestations are correlated with the degree of hypothyroidism.6 CH is the most common preventable cause of mental retardation. Right after delivery, TSH levels increase due to hypothermia and stress, and then decrease gradually over the ne ...
... congenital factors.6 Severity of the symptoms and physical manifestations are correlated with the degree of hypothyroidism.6 CH is the most common preventable cause of mental retardation. Right after delivery, TSH levels increase due to hypothermia and stress, and then decrease gradually over the ne ...
Plasma thyrotropin concentration in the male pig: profile from
... wk. A second experiment involved 2 groups of young adult boars housed either in a socially nonrestrictive environment (adjacent to estrual females) or a socially restrictive environment (not in direct physical contact with females). TRH stimulated secretion of TSH and the magnitude of this response ...
... wk. A second experiment involved 2 groups of young adult boars housed either in a socially nonrestrictive environment (adjacent to estrual females) or a socially restrictive environment (not in direct physical contact with females). TRH stimulated secretion of TSH and the magnitude of this response ...
Hormones - University of Delhi
... Cyclic AMP (cAMP) is known as the second messenger as it brings about the response to the hormone which is the first messenger. Cyclic AMP lasts for a limited period of time after which it is destroyed by an intracellular enzyme, phosphodiesterase. For the action of the hormone to continue, new mole ...
... Cyclic AMP (cAMP) is known as the second messenger as it brings about the response to the hormone which is the first messenger. Cyclic AMP lasts for a limited period of time after which it is destroyed by an intracellular enzyme, phosphodiesterase. For the action of the hormone to continue, new mole ...
Low Testosterone Handout
... Prostate cancer. Prostate cancer is very common in men as they age. It is currently felt that testosterone therapy does not cause prostate cancer, but may stimulate any prostate cancer which is already present to grow and potentially cause problems. If you are older than 45-50 years old, you will ...
... Prostate cancer. Prostate cancer is very common in men as they age. It is currently felt that testosterone therapy does not cause prostate cancer, but may stimulate any prostate cancer which is already present to grow and potentially cause problems. If you are older than 45-50 years old, you will ...
Amenorrhea 5-16-11 - UNC School of Medicine
... A thorough history and physical examination as well as laboratory testing can help narrow the diagnosis of amenorrhea. In patients with primary amenorrhea, the presence or absence of sexual development should direct evaluation. Constitutional delay of puberty is a diagnosis of exclusion. ...
... A thorough history and physical examination as well as laboratory testing can help narrow the diagnosis of amenorrhea. In patients with primary amenorrhea, the presence or absence of sexual development should direct evaluation. Constitutional delay of puberty is a diagnosis of exclusion. ...
Stimulants and growth in children with attention-deficit/hyperactivity disorder Bianca Lee Negrao ⇑
... decreases in serum IGF-1 and IGF binding protein 3 (IGFBP-3) levels, while Toren et al. [45] found that boys with ADHD treated with methylphenidate do not differ from untreated boys, or from control subjects, with regards to fasting serum GH, GH binding protein (GHBP) or IGF-1 levels. More than the ...
... decreases in serum IGF-1 and IGF binding protein 3 (IGFBP-3) levels, while Toren et al. [45] found that boys with ADHD treated with methylphenidate do not differ from untreated boys, or from control subjects, with regards to fasting serum GH, GH binding protein (GHBP) or IGF-1 levels. More than the ...
A Baby Boy with Hypothyroidism and
... and infantile HHE was first described in 2000 (5 ). The majority of consumptive hypothyroidism cases have been described in children with hemangioendotheliomas, but cases have also been reported in adults with massive vascular and fibrous tumors (6 – 8 ). The tumor expression of D3 enzyme activity i ...
... and infantile HHE was first described in 2000 (5 ). The majority of consumptive hypothyroidism cases have been described in children with hemangioendotheliomas, but cases have also been reported in adults with massive vascular and fibrous tumors (6 – 8 ). The tumor expression of D3 enzyme activity i ...
Calculating Thyroid Replacement Hormones (Synthroid, Cytomel
... plus triiodothyronine. Similarly, among 15 visual-analogue scales used to indicate mood and physical status, the results for 10 were significantly better after treatment with thyroxine plus triiodothyronine. The pulse rate and serum sex hormone–binding globulin concentrations were slightly higher af ...
... plus triiodothyronine. Similarly, among 15 visual-analogue scales used to indicate mood and physical status, the results for 10 were significantly better after treatment with thyroxine plus triiodothyronine. The pulse rate and serum sex hormone–binding globulin concentrations were slightly higher af ...
Enzyme Immunoassay for the Quantitative Determination of Thyroid
... hormone (TRH) produced by the hypothalamus. The levels of TSH and TRH are inversely related to the level of thyroid hormone. When there is a high level of thyroid hormone in the blood, less TRH is released by the hypothalamus, so less TSH is secreted by the pituitary. The opposite action will occur ...
... hormone (TRH) produced by the hypothalamus. The levels of TSH and TRH are inversely related to the level of thyroid hormone. When there is a high level of thyroid hormone in the blood, less TRH is released by the hypothalamus, so less TSH is secreted by the pituitary. The opposite action will occur ...
Hypopituitarism
Hypopituitarism is the decreased (hypo) secretion of one or more of the eight hormones normally produced by the pituitary gland at the base of the brain. If there is decreased secretion of most pituitary hormones, the term panhypopituitarism (pan meaning ""all"") is used.The signs and symptoms of hypopituitarism vary, depending on which hormones are undersecreted and on the underlying cause of the abnormality. The diagnosis of hypopituitarism is made by blood tests, but often specific scans and other investigations are needed to find the underlying cause, such as tumors of the pituitary, and the ideal treatment. Most hormones controlled by the secretions of the pituitary can be replaced by tablets or injections. Hypopituitarism is a rare disease, but may be significantly underdiagnosed in people with previous traumatic brain injury. The first description of the condition was made in 1914 by the German physician Dr Morris Simmonds.