The Making of a CYP3A Biomarker Panel for Guiding
... CYP3A4 *4, *5 and *6 occur only in Asian populations with MAF of 1.5%–3%, <1%, and <1%, respectively. Subjects heterozygous for *4, *5, and *6 displayed decreased urinary ratios of 6β-hydroxycortisol over cortisol as a measure of CYP3A4 activity, but the number of subjects was small and all were tak ...
... CYP3A4 *4, *5 and *6 occur only in Asian populations with MAF of 1.5%–3%, <1%, and <1%, respectively. Subjects heterozygous for *4, *5, and *6 displayed decreased urinary ratios of 6β-hydroxycortisol over cortisol as a measure of CYP3A4 activity, but the number of subjects was small and all were tak ...
Activity and Enzyme Kinetics of Human UDP
... quantitatively changes the enzyme kinetic parameters, presumably by removing ―internal‖ inhibitors that bind to binary (enzyme • UDPGA) or ternary (enzyme • UDPGA • aglycone) complexes, but the underlying compulsory-order ternary-complex mechanism remains unaffected. In addition, based on enzyme kin ...
... quantitatively changes the enzyme kinetic parameters, presumably by removing ―internal‖ inhibitors that bind to binary (enzyme • UDPGA) or ternary (enzyme • UDPGA • aglycone) complexes, but the underlying compulsory-order ternary-complex mechanism remains unaffected. In addition, based on enzyme kin ...
Therapeutic and pharmacological potential of Foeniculum vulgare Mill
... Fennel has been used in traditional medicine to treat various diseases for thousands of years in the East Asian countries, India and China (16). People have long been familiar with fennel plant. In the middle ages people believed that chewing the seeds is important to eliminate abdomen noise (24). I ...
... Fennel has been used in traditional medicine to treat various diseases for thousands of years in the East Asian countries, India and China (16). People have long been familiar with fennel plant. In the middle ages people believed that chewing the seeds is important to eliminate abdomen noise (24). I ...
Wrightia tinctoria R. Br. - Journal of Coastal Life Medicine
... tinctoria[2]. In Karnataka and Tamilnadu (states of India), the tree named as “jaundice curative tree”, since the juice of its tender leaves is used as an effective drug for treatment of jaundice[11]. Fresh leaves are pungent and when crushed fresh leaf filled in the cavity of decayed tooth or chewe ...
... tinctoria[2]. In Karnataka and Tamilnadu (states of India), the tree named as “jaundice curative tree”, since the juice of its tender leaves is used as an effective drug for treatment of jaundice[11]. Fresh leaves are pungent and when crushed fresh leaf filled in the cavity of decayed tooth or chewe ...
Tetracyclines in malaria | Malaria Journal | Full Text
... Tetracyclines are synthetic antibiotics derived from a cycline that is naturally produced by bacteria from the genus Streptomyces [1]. Tetracycline consists of three groups, based on pharmacological differences: the longacting group, which includes doxycycline and minocycline, are the most active ag ...
... Tetracyclines are synthetic antibiotics derived from a cycline that is naturally produced by bacteria from the genus Streptomyces [1]. Tetracycline consists of three groups, based on pharmacological differences: the longacting group, which includes doxycycline and minocycline, are the most active ag ...
C 3 R
... Cytochrome P450 (P450s) are involved in the metabolism of approximately 80% of the drugs currently on the market (1, 2). In some cases drugs can be oxidized by P450s to electrophilic reactive intermediates, which subsequently can react with nucleophilic functional groups in biomolecules such as prot ...
... Cytochrome P450 (P450s) are involved in the metabolism of approximately 80% of the drugs currently on the market (1, 2). In some cases drugs can be oxidized by P450s to electrophilic reactive intermediates, which subsequently can react with nucleophilic functional groups in biomolecules such as prot ...
Cox-2-Selective Inhibitors: The New Super Aspirins
... NSAID therapy and, conversely, that the indiscriminate inhibition of Cox-1 likely resulted in the side effects commonly associated with NSAIDs stimulated an intense and highly competitive race to identify compounds that would selectively inhibit only Cox-2. Development of Cox-2-Selective Inhibitors ...
... NSAID therapy and, conversely, that the indiscriminate inhibition of Cox-1 likely resulted in the side effects commonly associated with NSAIDs stimulated an intense and highly competitive race to identify compounds that would selectively inhibit only Cox-2. Development of Cox-2-Selective Inhibitors ...
International Journal of Ayurveda and Pharma Research
... T. chebula extract on the age dependent shortening of the telomere length as shown by the Southern Blots of the terminal restriction fragments of DNA extracted from sub-culture passages[32]. It exhibited the development of duodenal ulcers and appeared to exert a cytoprotective effect on the gast ...
... T. chebula extract on the age dependent shortening of the telomere length as shown by the Southern Blots of the terminal restriction fragments of DNA extracted from sub-culture passages[32]. It exhibited the development of duodenal ulcers and appeared to exert a cytoprotective effect on the gast ...
Journal home page: http://www.iajpr.com/index.php/en/ INDO
... Tremendous approved pharmacological activity of Aegle marmelos Antidiabetic activity Diabetes mellitus is metabolic disorder which independent risk factor for coronary artery disease, hypertension, myocardial infaraction & hyperlipidemia. Diabetes & its related complication are closely related with ...
... Tremendous approved pharmacological activity of Aegle marmelos Antidiabetic activity Diabetes mellitus is metabolic disorder which independent risk factor for coronary artery disease, hypertension, myocardial infaraction & hyperlipidemia. Diabetes & its related complication are closely related with ...
Effect of Khat chewing on the bioavailability of ampicillin and
... 40% for ampicillin. 6 Moreover, concurrent administration of ampicillin with food reduces its absorption significantly, whereas amoxycillin absorption is unaffected.7 The observed pronounced reduction of ampicillin absorption and the limited effect in the case of amoxycillin are consistent with thes ...
... 40% for ampicillin. 6 Moreover, concurrent administration of ampicillin with food reduces its absorption significantly, whereas amoxycillin absorption is unaffected.7 The observed pronounced reduction of ampicillin absorption and the limited effect in the case of amoxycillin are consistent with thes ...
Peridex and PerioMed Oral Rinse Brochure
... gluconate was equal to that at baseline. PHARMACOKINETICS: Pharmacokinetic studies with Peridex oral rinse indicate approximately 30% of the active ingredient, chlorhexidine gluconate, is retained in the oral cavity following rinsing. This retained drug is slowly released into the oral fluids. Studi ...
... gluconate was equal to that at baseline. PHARMACOKINETICS: Pharmacokinetic studies with Peridex oral rinse indicate approximately 30% of the active ingredient, chlorhexidine gluconate, is retained in the oral cavity following rinsing. This retained drug is slowly released into the oral fluids. Studi ...
A SURVEY OF ANTIMICROBIAL USAGE ... SPECIFIC REFERENCE TO FOOD ANIMALS
... to therapeutic antimicrobials used for the treatment of disease in human medicine. The other three classes mentioned above, the penicillins, tetracyclines and sulphonamides are also relevant because of well-documented evidence of the ability to select for resistance or because of their structural r ...
... to therapeutic antimicrobials used for the treatment of disease in human medicine. The other three classes mentioned above, the penicillins, tetracyclines and sulphonamides are also relevant because of well-documented evidence of the ability to select for resistance or because of their structural r ...
Targeting the Bacterial Division Protein FtsZ
... developmental behaviors and emphasize the importance of coordinating the correct timing of cell division and chromosome segregation. Many studies have indicated that unknown regulators of bacterial FtsZ may be awaiting discovery. 2.5. FtsZ Biophysics and Mechanics. An average E. coli cell during log ...
... developmental behaviors and emphasize the importance of coordinating the correct timing of cell division and chromosome segregation. Many studies have indicated that unknown regulators of bacterial FtsZ may be awaiting discovery. 2.5. FtsZ Biophysics and Mechanics. An average E. coli cell during log ...
The Essential Medicinal Chemistry of Curcumin
... “curcuminoids” unless a more explicit description (e.g., of a single chemical structure) is deemed necessary. On the basis of our literature review, many in vitro studies use pure, synthetic 1, while most in vivo studies and clinical trials use a curcuminoid mixture. The dynamic nature of solubilize ...
... “curcuminoids” unless a more explicit description (e.g., of a single chemical structure) is deemed necessary. On the basis of our literature review, many in vitro studies use pure, synthetic 1, while most in vivo studies and clinical trials use a curcuminoid mixture. The dynamic nature of solubilize ...
Synthesis, Characterisation, and Evaluation of a Cross
... of disulphide cross-linked poly(amidoamine) dendrimers [7] and nanocapsules [8] have been reported as carrier in effective drug delivery. In general, cross-linked disulphide polymers are more insoluble than linear chain disulphide polymers [9–11]. Wilkes (1981) [12] stated that chemical cross-linkin ...
... of disulphide cross-linked poly(amidoamine) dendrimers [7] and nanocapsules [8] have been reported as carrier in effective drug delivery. In general, cross-linked disulphide polymers are more insoluble than linear chain disulphide polymers [9–11]. Wilkes (1981) [12] stated that chemical cross-linkin ...
Actions of bufalin and cinobufotalin, two bufadienolides respectively
... legend of which contains the three equations. The goodness of fit in each case is highly significant and the slopes of the lines are not significantly different. The lCsovalues are shown in Table 1. From these it is seen that bufalin is almost seven times as potent as ouabain and cinobufotalin is le ...
... legend of which contains the three equations. The goodness of fit in each case is highly significant and the slopes of the lines are not significantly different. The lCsovalues are shown in Table 1. From these it is seen that bufalin is almost seven times as potent as ouabain and cinobufotalin is le ...
PHYTOCHEMICAL, BIOLOGICAL AND TOXICOLOGICAL STUDIES
... immediate past Dean, College of Science and Technology, Covenant University, Prof. J. Katende and the present Dean, Prof. F.K. Hymore, for their encouragement and support throughout the duration of the research. My deep appreciation also goes to the Dean and Sub-Dean, School of Postgraduate Studies, ...
... immediate past Dean, College of Science and Technology, Covenant University, Prof. J. Katende and the present Dean, Prof. F.K. Hymore, for their encouragement and support throughout the duration of the research. My deep appreciation also goes to the Dean and Sub-Dean, School of Postgraduate Studies, ...
Symposium Report Correlating Structure and Function of Drug
... From a structural perspective, we probably know most about specific small-molecule ligand interactions with P450 enzymes garnered largely from structures determined by X-ray crystallography. Building on approaches used to determine the first structure of a membrane cytochrome P450 in 2000 (Williams ...
... From a structural perspective, we probably know most about specific small-molecule ligand interactions with P450 enzymes garnered largely from structures determined by X-ray crystallography. Building on approaches used to determine the first structure of a membrane cytochrome P450 in 2000 (Williams ...
A review on pharmacological property of Mimusops elengi Linn.
... elengi was evaluated for their In-vitro and In-vivo antiinflammatory activity. In-vitro anti-inflammatory activity was evaluated by using membrane stabilization assay, proteinase inhibitory activity and immunomodulatory activity using macrophages. Methanolic and Aqueous extracts of Mimusops elengi l ...
... elengi was evaluated for their In-vitro and In-vivo antiinflammatory activity. In-vitro anti-inflammatory activity was evaluated by using membrane stabilization assay, proteinase inhibitory activity and immunomodulatory activity using macrophages. Methanolic and Aqueous extracts of Mimusops elengi l ...
SCLEROTIUM ROLFSII AND ANTIFUNGAL ACTIVITY Research Article
... nausea, electrolyte imbalance and nephrotoxicity are of great concern. It is thought that the aggregated form of AmB, which is largely responsible for membrane damage, brings about these side‐ effects18. In order to mitigate these side effects several drug delivery systems such ...
... nausea, electrolyte imbalance and nephrotoxicity are of great concern. It is thought that the aggregated form of AmB, which is largely responsible for membrane damage, brings about these side‐ effects18. In order to mitigate these side effects several drug delivery systems such ...
amoxicillin: a broad spectrum antibiotic
... penicillin that was also effective against these strains, resulting in the combination of amoxicillin and clavulanic acid (amoxicillin/clavulanate)18, 20. In 1981, SmithKline Beecham patented amoxicillin or amoxicillin/clavulanate potassium tablets, and first sold the ...
... penicillin that was also effective against these strains, resulting in the combination of amoxicillin and clavulanic acid (amoxicillin/clavulanate)18, 20. In 1981, SmithKline Beecham patented amoxicillin or amoxicillin/clavulanate potassium tablets, and first sold the ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... Natural products are the direct or indirect sources of most of the drugs introduced in the past 30 years. Natural products from plants are a rich source of lead compounds for the development of new drugs against protozoan parasitic diseases such as malaria 4. Nitidine was first isolated in 1959 fr ...
... Natural products are the direct or indirect sources of most of the drugs introduced in the past 30 years. Natural products from plants are a rich source of lead compounds for the development of new drugs against protozoan parasitic diseases such as malaria 4. Nitidine was first isolated in 1959 fr ...
Chapter 7
... In 1928, Fleming observed that a mold, Penicillium notatum, produced a substance that inhibited the growth of certain bacteria ...
... In 1928, Fleming observed that a mold, Penicillium notatum, produced a substance that inhibited the growth of certain bacteria ...
Discovery and development of cephalosporins
Cephalosporins are a broad class of bactericidal antibiotics that include the β-lactam ring and share a structural similarity and mechanism of action with other β-lactam antibiotics (e.g. penicillins, carbapenems and monobactams). The cephalosporins (and other β-lactams) have the ability to kill bacteria by inhibiting essential steps in the bacterial cell wall synthesis which in the end results in osmotic lysis and death of the bacterial cell. Cephalosporins are widely used antibiotics because of their clinical efficiency and desirable safety profile.The cephalosporins are diverse in their antibacterial spectrum, water solubility, acid tolerability, oral bioavailability, biological half-life and other properties. Therefore the cephalosporins can be further classified into generations depending on antibacterial activity, time of invention and structural basis.