... fraction being approximately 30%. Protein binding of cefixime is only concentration dependent in human serum at very high concentrations, which are not seen following clinical dosing. From in vitro studies, serum or urine concentrations of 1 mg/L or greater were considered to be adequate for most co ...
Synthesis and Evaluation of Antifungal Activity of Benzothiazole
... dolastatin. Due to their important pharmaceutical utilities, the synthesis of these compounds is of considerable interests. Being a heterocyclic compound, benzothiazole finds its use in research as a starting material for the synthesis of bioactive molecules. Its aromaticity makes it relatively stab ...
... dolastatin. Due to their important pharmaceutical utilities, the synthesis of these compounds is of considerable interests. Being a heterocyclic compound, benzothiazole finds its use in research as a starting material for the synthesis of bioactive molecules. Its aromaticity makes it relatively stab ...
Advances in Pharmacological Research of Eugenol
... Numerous studies on the antimycotic,18 antiviral,19 desinsection,20 and antiparasitic21 activities of eugenol and other volatile oils were implemented. Katayama et al.22 studied the structure of antibiotic substance in flavoring agents. Their results showed that the benzene ring compound containing ...
... Numerous studies on the antimycotic,18 antiviral,19 desinsection,20 and antiparasitic21 activities of eugenol and other volatile oils were implemented. Katayama et al.22 studied the structure of antibiotic substance in flavoring agents. Their results showed that the benzene ring compound containing ...
Olive - Hindawi Publishing Corporation
... Ethnopharmacology: O. europaea (Oleaceae) has been extensively used in traditional medicine for a wide range of ailments including stomach problems, diabetes, hypertension, diarrhea, respiratory and urinary tract infections, skin diseases, bacterial and fungal infections, hemorrhoids, rheumatism, as ...
... Ethnopharmacology: O. europaea (Oleaceae) has been extensively used in traditional medicine for a wide range of ailments including stomach problems, diabetes, hypertension, diarrhea, respiratory and urinary tract infections, skin diseases, bacterial and fungal infections, hemorrhoids, rheumatism, as ...
Nowhere to hide: interrogating different metabolic parameters of Plasmodium
... require a drug to be at pharmacologically relevant concentrations for as long as mature gametocytes circulate (up to 30 days), the most appropriate point of intervention is to target the host gametocytes and eliminate the parasite population thus interrupting transmission. Currently, only artesunate ...
... require a drug to be at pharmacologically relevant concentrations for as long as mature gametocytes circulate (up to 30 days), the most appropriate point of intervention is to target the host gametocytes and eliminate the parasite population thus interrupting transmission. Currently, only artesunate ...
phytochemical and pharmacological
... eczema, cutaneous tubercles, glandular tumors, blood pressure, dyspepsia, constipation, amenorrhoea, general debility, expel worms and stimulate reproductive organs and many, as a result Carica papaya can be regarded as a Neutraceutical. Studies conducted in some countries have shown that there is a ...
... eczema, cutaneous tubercles, glandular tumors, blood pressure, dyspepsia, constipation, amenorrhoea, general debility, expel worms and stimulate reproductive organs and many, as a result Carica papaya can be regarded as a Neutraceutical. Studies conducted in some countries have shown that there is a ...
BAX 855, a PEGylated rFVIII product with prolonged half-life
... Preclinical studies showed improved pharmacokinetic behaviour and clinically relevant prolonged efficacy compared to ADVATETM without any signs of toxicity or elevated immunogenicity. The comprehensive preclinical data package formed the basis for approval of the phase 1 clinical study by European a ...
... Preclinical studies showed improved pharmacokinetic behaviour and clinically relevant prolonged efficacy compared to ADVATETM without any signs of toxicity or elevated immunogenicity. The comprehensive preclinical data package formed the basis for approval of the phase 1 clinical study by European a ...
annexure – ii
... K. Maiti et al. has stated that a novel formulation of curcumin in combination with the phospholipids was developed to overcome the limitation of absorption and to investigate the protective effect of curcumin–phospholipid complex on carbon tetrachloride induced acute liver damage in rats. The antio ...
... K. Maiti et al. has stated that a novel formulation of curcumin in combination with the phospholipids was developed to overcome the limitation of absorption and to investigate the protective effect of curcumin–phospholipid complex on carbon tetrachloride induced acute liver damage in rats. The antio ...
Martindale: The Complete Drug Reference
... Uses and Administration (Latest modification: 05-Sep-2009) Cefuroxime is a second-generation cephalosporin antibacterial used in the treatment of infections caused by susceptible Gram-positive and Gram-negative bacteria, including infections of the bones and joints, CNS, skin and skin structures, re ...
... Uses and Administration (Latest modification: 05-Sep-2009) Cefuroxime is a second-generation cephalosporin antibacterial used in the treatment of infections caused by susceptible Gram-positive and Gram-negative bacteria, including infections of the bones and joints, CNS, skin and skin structures, re ...
Fortaz - GlaxoSmithKline
... antibacterial agents not directed against Clostridium difficile. In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation, and treatment with an antibacterial agent clinically effective against Clostridium difficile. Surgical eval ...
... antibacterial agents not directed against Clostridium difficile. In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation, and treatment with an antibacterial agent clinically effective against Clostridium difficile. Surgical eval ...
Review Articles` Abstracts - source url
... Psoriasis is a chronic disease that can have substantial psychological and social impact on patient's life. Psoriasis has been shown to affect health-related Quality of Life to an extent similar to the effects of other chronic diseases such as depression, myocardial infarction, hypertension, etc. Th ...
... Psoriasis is a chronic disease that can have substantial psychological and social impact on patient's life. Psoriasis has been shown to affect health-related Quality of Life to an extent similar to the effects of other chronic diseases such as depression, myocardial infarction, hypertension, etc. Th ...
ABSTRACT Title of Dissertation: ENERGETICS OF DRUG INTERACTIONS
... Figure 3-3. ITC scan of FLP binding to β-cyclodextrin at T = 298.15 K, pH 6.1 and no added salt and fit of a 1:1 binding model to the binding isotherm data.. …………..45 Figure 3-4. ITC scan of NAB binding to β-cyclodextrin at T = 293.15 K, pH 7.1 and no added salt and fit of a 1:1 binding model to the ...
... Figure 3-3. ITC scan of FLP binding to β-cyclodextrin at T = 298.15 K, pH 6.1 and no added salt and fit of a 1:1 binding model to the binding isotherm data.. …………..45 Figure 3-4. ITC scan of NAB binding to β-cyclodextrin at T = 293.15 K, pH 7.1 and no added salt and fit of a 1:1 binding model to the ...
PRODUCT MONOGRAPH PRIMAXIN® (imipenem and cilastatin
... Clostridium difficile-associated disease (CDAD) has been reported with the use of many antibacterial agents, including PRIMAXIN®. CDAD may range in severity from mild diarrhea to fatal colitis. It is important to consider this diagnosis in patients who present with diarrhea, or symptoms of colitis, ...
... Clostridium difficile-associated disease (CDAD) has been reported with the use of many antibacterial agents, including PRIMAXIN®. CDAD may range in severity from mild diarrhea to fatal colitis. It is important to consider this diagnosis in patients who present with diarrhea, or symptoms of colitis, ...
A Multifaceted GABAA Receptor Modulator
... the test compounds were normalized to the maximal response elicited by GABA on each oocyte. Data analysis and statistical analysis were performed using Prism GraphPad, version 6.0a (GraphPad Software, Inc. La Jolla, CA). Concentration-response and concentrationinhibition curves were fitted by nonlin ...
... the test compounds were normalized to the maximal response elicited by GABA on each oocyte. Data analysis and statistical analysis were performed using Prism GraphPad, version 6.0a (GraphPad Software, Inc. La Jolla, CA). Concentration-response and concentrationinhibition curves were fitted by nonlin ...
Advances in and applications of proteasome inhibitors
... which only differ from the salinosporamides in the C2 alkyl side chain, have comparable potency in vitro with IC50 values in the low nanomolar range. It remains, however, to be shown if the cinnabaramides have the same anticancer properties as salinosporamide A. Further proteasome inhibitors of the ...
... which only differ from the salinosporamides in the C2 alkyl side chain, have comparable potency in vitro with IC50 values in the low nanomolar range. It remains, however, to be shown if the cinnabaramides have the same anticancer properties as salinosporamide A. Further proteasome inhibitors of the ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... Invitro Study of Thrombolytic Activity by Using Aqueous Preparation of Different Parts of Carica lobes. Unusually for such large plants, the trees are dioecious. The tree is usually unbranched, unless lopped. The flowers are similar in shape to the flowers of the plumeria, but are much smaller and ...
... Invitro Study of Thrombolytic Activity by Using Aqueous Preparation of Different Parts of Carica lobes. Unusually for such large plants, the trees are dioecious. The tree is usually unbranched, unless lopped. The flowers are similar in shape to the flowers of the plumeria, but are much smaller and ...
Pharmacologically Active Drug Metabolites: Impact on Drug
... ABBREVIATIONS: CNS, central nervous system; COPD, chronic obstructive pulmonary disease; CSF, cerebrospinal fluid; EM, extensive metabolizer; fu, fraction unbound in plasma; HMGCoA, 3-hydroxy-3-methylglutaryl-coenzyme A; HPLC-MS, high pressure liquid chromatography-mass spectrometry; 5-HT, serotonin ...
... ABBREVIATIONS: CNS, central nervous system; COPD, chronic obstructive pulmonary disease; CSF, cerebrospinal fluid; EM, extensive metabolizer; fu, fraction unbound in plasma; HMGCoA, 3-hydroxy-3-methylglutaryl-coenzyme A; HPLC-MS, high pressure liquid chromatography-mass spectrometry; 5-HT, serotonin ...
Synopsis of Some Recent Tactical Application of Bioisosteres in
... Inhibitors. The high electronegativity of F reduces the basicity of proximal amines while increasing the acidity of acids (data summarized quantitatively in Table 4).43 The strategic deployment of a fluorine atom to modulate basicity was probed in the context of inhibitors of kinesin spindle protein ...
... Inhibitors. The high electronegativity of F reduces the basicity of proximal amines while increasing the acidity of acids (data summarized quantitatively in Table 4).43 The strategic deployment of a fluorine atom to modulate basicity was probed in the context of inhibitors of kinesin spindle protein ...
6-keto, 7,8
... Fentanyl is a μ agonist with about 80 times the poyency of morphine. The advantages of fentanyl over morphine for anesthetic procedures are its short duration of action (1to 2 hours). A fentenyl patch has been released for the treatment of severe chronic pain. Fentanyl’s short duration of acti ...
... Fentanyl is a μ agonist with about 80 times the poyency of morphine. The advantages of fentanyl over morphine for anesthetic procedures are its short duration of action (1to 2 hours). A fentenyl patch has been released for the treatment of severe chronic pain. Fentanyl’s short duration of acti ...
Ministerstvo zdravotnictva SR k d. k. s04544-oKCLP-2012
... K intake, hypersensitivity to vitamin K, and rapid drug deactivation. Patient education is necessary to improve compliance and to mitigate adverse effects of warfarin therapy, regardless of the dose. In time, it may be possible to individualize anticoagulant dosing on the basis of genetic testing fo ...
... K intake, hypersensitivity to vitamin K, and rapid drug deactivation. Patient education is necessary to improve compliance and to mitigate adverse effects of warfarin therapy, regardless of the dose. In time, it may be possible to individualize anticoagulant dosing on the basis of genetic testing fo ...
Amphotericin B as a mycolic acid specific targeting agent in tuberculosis
... use of a sterol binding drug, Amphotericin B (haptophore). Isoniazid was covalently linked to Amphotericin B via a Schiff base to a linker molecule, terephthalaldehyde. Although this molecule showed a loss of biological activity, a discovery was made by serendipity that could have great impact in un ...
... use of a sterol binding drug, Amphotericin B (haptophore). Isoniazid was covalently linked to Amphotericin B via a Schiff base to a linker molecule, terephthalaldehyde. Although this molecule showed a loss of biological activity, a discovery was made by serendipity that could have great impact in un ...
Chlorhexidine: The Gold Standard Antiplaque Agent
... Chlorhexidine is an antimicrobial agent. It acts on the inner cytoplasmic membrane hence it is a membrane active type of substance. It is dicationic at pH levels above 3.5. It prevents plaque accumulation, hence it is a antiplaque and antigingivitis agent[6] and reduces the adherence of Porphyromona ...
... Chlorhexidine is an antimicrobial agent. It acts on the inner cytoplasmic membrane hence it is a membrane active type of substance. It is dicationic at pH levels above 3.5. It prevents plaque accumulation, hence it is a antiplaque and antigingivitis agent[6] and reduces the adherence of Porphyromona ...
Research Paper Synthesis and Evaluation of Clozapine
... dopamine system has been strongly linked to Schizophrenia and related psychosis, with abnormally high dopamine action apparently leading to these conditions. Numbers of drugs having the activity for blocking the neurotransmission of dopaminergic receptor in the central nervous system (Ross JB et al. ...
... dopamine system has been strongly linked to Schizophrenia and related psychosis, with abnormally high dopamine action apparently leading to these conditions. Numbers of drugs having the activity for blocking the neurotransmission of dopaminergic receptor in the central nervous system (Ross JB et al. ...
introduction - international journal of advances in pharmaceutical
... For the sustained release matrix tablets, Hibiscus rosa sinensis leaves mucilage is used due to its good swelling, good flow rate, and suitability for matrix formulation. [6] This mucilage is used as a binder in various pharmaceutical tablets. It has a glossy dark green leaves with medium texture. I ...
... For the sustained release matrix tablets, Hibiscus rosa sinensis leaves mucilage is used due to its good swelling, good flow rate, and suitability for matrix formulation. [6] This mucilage is used as a binder in various pharmaceutical tablets. It has a glossy dark green leaves with medium texture. I ...
Full-Text PDF
... thrombin in the coagulation cascade. Selective inhibition of FXa was unable to affect the pre-existing thrombin level, and activation and aggregation of the platelets reduced the risk of bleeding when compared with traditional anti-coagulants [2]. In addition, FXa plays a vital role in amplifying th ...
... thrombin in the coagulation cascade. Selective inhibition of FXa was unable to affect the pre-existing thrombin level, and activation and aggregation of the platelets reduced the risk of bleeding when compared with traditional anti-coagulants [2]. In addition, FXa plays a vital role in amplifying th ...
Discovery and development of cephalosporins
Cephalosporins are a broad class of bactericidal antibiotics that include the β-lactam ring and share a structural similarity and mechanism of action with other β-lactam antibiotics (e.g. penicillins, carbapenems and monobactams). The cephalosporins (and other β-lactams) have the ability to kill bacteria by inhibiting essential steps in the bacterial cell wall synthesis which in the end results in osmotic lysis and death of the bacterial cell. Cephalosporins are widely used antibiotics because of their clinical efficiency and desirable safety profile.The cephalosporins are diverse in their antibacterial spectrum, water solubility, acid tolerability, oral bioavailability, biological half-life and other properties. Therefore the cephalosporins can be further classified into generations depending on antibacterial activity, time of invention and structural basis.