Decreased Expression of Claudin 1, 3, 4, 5 and 7: A New Prognostic
... proteins. This family of proteins consists of 27 known claudin members with a size ranging from 20-27 kDa [4,5]. They are essential for the formation of tight junctions between epithelial cells together with other adherent proteins called occludins [6]. Several studies have reported altered expressi ...
... proteins. This family of proteins consists of 27 known claudin members with a size ranging from 20-27 kDa [4,5]. They are essential for the formation of tight junctions between epithelial cells together with other adherent proteins called occludins [6]. Several studies have reported altered expressi ...
PDF - Genome Medicine
... show that these key properties of INSPIRE lead to biologically more relevant and statistically more robust features than alternative methods. When we apply INSPIRE to nine gene expression datasets from ovarian cancer studies (Fig. 2c), we identify a novel tumor-associated stromal marker, HOPX, which ...
... show that these key properties of INSPIRE lead to biologically more relevant and statistically more robust features than alternative methods. When we apply INSPIRE to nine gene expression datasets from ovarian cancer studies (Fig. 2c), we identify a novel tumor-associated stromal marker, HOPX, which ...
EUS in the detection of early gastric cancer
... Early gastric carcinoma is mainly detected and diagnosed by endoscopic examination with or without biopsy. In general, the diagnosis of early gastric carcinoma is easily accomplished by endoscopic observation and pathologic evaluation of endoscopic biopsy. Endoscopic detection of gastric carcinoma d ...
... Early gastric carcinoma is mainly detected and diagnosed by endoscopic examination with or without biopsy. In general, the diagnosis of early gastric carcinoma is easily accomplished by endoscopic observation and pathologic evaluation of endoscopic biopsy. Endoscopic detection of gastric carcinoma d ...
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
... Matsuno et al [8] noted that the mean duration between initial diagnosis and metastasis to the skull base was 4 years. This cannot be applied to our patient because the exact duration of malignancy prior to metastasis is not known as the patient sought medical help only after the onset of epistaxis, ...
... Matsuno et al [8] noted that the mean duration between initial diagnosis and metastasis to the skull base was 4 years. This cannot be applied to our patient because the exact duration of malignancy prior to metastasis is not known as the patient sought medical help only after the onset of epistaxis, ...
MSH6 Mutations Arise in Glioblastomas during
... Purpose: Over the past few years, the alkylating agent temozolomide has become the standardof-care therapy for patients with glioblastoma, the most common brain tumor. Recently, largescale cancer genome sequencing efforts have identified a hypermutation phenotype and inactivating MSH6 mismatch repai ...
... Purpose: Over the past few years, the alkylating agent temozolomide has become the standardof-care therapy for patients with glioblastoma, the most common brain tumor. Recently, largescale cancer genome sequencing efforts have identified a hypermutation phenotype and inactivating MSH6 mismatch repai ...
Sputum MicroRNA Profiling: A Novel Approach for the Early
... in surgically resected lung tumor tissues is reliably correlated with the diagnosis and prognosis of the lung cancer patients [14-16, 21-22]. It is becoming evident that miRNA-based detection techniques could improve upon cytology (with its low sensitivity) and of computed tomography (with its high ...
... in surgically resected lung tumor tissues is reliably correlated with the diagnosis and prognosis of the lung cancer patients [14-16, 21-22]. It is becoming evident that miRNA-based detection techniques could improve upon cytology (with its low sensitivity) and of computed tomography (with its high ...
Comparison of elastic scattering spectroscopy with histology
... routine histopathologic assessment, which is considered to be the gold standard. Each ESS spectrum consists of ∼900 elements over the 330–760-nm wavelength range. Before analysis, the spectra are subjected to preprocessing in order to reduce noise and normalization to account for variations in inten ...
... routine histopathologic assessment, which is considered to be the gold standard. Each ESS spectrum consists of ∼900 elements over the 330–760-nm wavelength range. Before analysis, the spectra are subjected to preprocessing in order to reduce noise and normalization to account for variations in inten ...
Final Program - The North American Association of Central Cancer
... are otherwise new to the organization, your experience here will also benefit from meeting and talking with others who are involved in this important work. Don’t hesitate to introduce yourself to NAACCR members and ask lots of questions. If you’re a seasoned member of NAACCR, take time to talk with ...
... are otherwise new to the organization, your experience here will also benefit from meeting and talking with others who are involved in this important work. Don’t hesitate to introduce yourself to NAACCR members and ask lots of questions. If you’re a seasoned member of NAACCR, take time to talk with ...
Papillary Renal Cell Carcinoma: Radiologic
... Most RCCs are incidentally diagnosed at imaging; the number of cases diagnosed by using the classic triad of hematuria, flank pain, and a mass in the abdomen continues to decline. The incidence of RCC is gradually increasing, partly due to increased use of imaging and partly due to the increasing in ...
... Most RCCs are incidentally diagnosed at imaging; the number of cases diagnosed by using the classic triad of hematuria, flank pain, and a mass in the abdomen continues to decline. The incidence of RCC is gradually increasing, partly due to increased use of imaging and partly due to the increasing in ...
TNM STAGING OF HEAD AND NECK CANCER AND NECK
... subglottic larynx. Subglottic tumors tend to metastasize to paratracheal (Level VI) as well as middle or lower jugular lymph (Levels III and IV) node groups. Treatment of laryngeal cancers varies widely from center to center, and for early-stage lesions radiotherapy or transoral endoscopic excision ...
... subglottic larynx. Subglottic tumors tend to metastasize to paratracheal (Level VI) as well as middle or lower jugular lymph (Levels III and IV) node groups. Treatment of laryngeal cancers varies widely from center to center, and for early-stage lesions radiotherapy or transoral endoscopic excision ...
WEILL CORNELL MEDICAL COLLEGE CURRICULUM VITAE
... We have developed novel methods to characterize cancer genomes. We worked out the mutational landscapes of several cancer and played a key role in a number of TCGA cancer genomics consortium studies. We mapped 4 new cancer genes that are among the most widely altered in human cancers. We helpe ...
... We have developed novel methods to characterize cancer genomes. We worked out the mutational landscapes of several cancer and played a key role in a number of TCGA cancer genomics consortium studies. We mapped 4 new cancer genes that are among the most widely altered in human cancers. We helpe ...
Mismatch repair deficiency endows tumors with a unique mutation
... better prognosis, but do not seem to benefit from 5-fluorouracil-based adjuvant chemotherapy, which is the first-choice chemotherapy for CRC. In particular, in MMR-deficient tumors, mismatches induced by 5-fluorouracil are tolerated, leading to failure to induce cell death (Fischer et al., 2007). MM ...
... better prognosis, but do not seem to benefit from 5-fluorouracil-based adjuvant chemotherapy, which is the first-choice chemotherapy for CRC. In particular, in MMR-deficient tumors, mismatches induced by 5-fluorouracil are tolerated, leading to failure to induce cell death (Fischer et al., 2007). MM ...
S-1 in the Management of Squamous Cell Carcinoma of Head and
... The first high-frequency (13%) therapeutic target of smoking-associated SqCC FGFR1 amplification induced a strong FGFR1 dependency in FGFR1 amplified SqCC FGFR1 amplification is a negative prognostic factor in resected lung SqCC FGFR1-amplification is associated with cigarettesmoking in a dose-depen ...
... The first high-frequency (13%) therapeutic target of smoking-associated SqCC FGFR1 amplification induced a strong FGFR1 dependency in FGFR1 amplified SqCC FGFR1 amplification is a negative prognostic factor in resected lung SqCC FGFR1-amplification is associated with cigarettesmoking in a dose-depen ...
Genetic alterations in head and neck squamous cell carcinoma: The
... knowledge on the genetics basis of head and neck squamous cell carcinoma. New insights and new perspectives on the mutational landscape implicated in head and neck squamous cell carcinoma provide improved tools for prognostication. More importantly, depend on the patient’s tumor subtypes and progno ...
... knowledge on the genetics basis of head and neck squamous cell carcinoma. New insights and new perspectives on the mutational landscape implicated in head and neck squamous cell carcinoma provide improved tools for prognostication. More importantly, depend on the patient’s tumor subtypes and progno ...
Glassy Cell
... 7.4% of endometrial ADSQs.44 If carcinomas with more than 85% of tumor histology showing GCF are considered to be glassy cell carcinomas, then 11% of cervical and 3% of endometrial adenocarcinomas/ADSQs in our series were glassy cell carcinomas, which is similar to other reports. 27 ' 4446 We electe ...
... 7.4% of endometrial ADSQs.44 If carcinomas with more than 85% of tumor histology showing GCF are considered to be glassy cell carcinomas, then 11% of cervical and 3% of endometrial adenocarcinomas/ADSQs in our series were glassy cell carcinomas, which is similar to other reports. 27 ' 4446 We electe ...
Document
... containing 10% dimethyl sulfoxide (DMSO; an antifreeze compound) is necessary in order to sustain sufficient cell viability after thawing for successful stocking of VX2 cells under liquid nitrogen (at -196°C) [66] . In 1978, Shah and Dickson further reported on the in vitro preservation of the VX2 ...
... containing 10% dimethyl sulfoxide (DMSO; an antifreeze compound) is necessary in order to sustain sufficient cell viability after thawing for successful stocking of VX2 cells under liquid nitrogen (at -196°C) [66] . In 1978, Shah and Dickson further reported on the in vitro preservation of the VX2 ...
Verrucous Carcinoma of the Lower Lip: A Case Report
... some cases, small or superficial biopsy specimens will show ...
... some cases, small or superficial biopsy specimens will show ...
Guideline for the Management of Patients with Squamous Cell
... inflammatory disease, and those with lymphoma or leukaemia, are at increased risk of this tumour. The risk of SCC with the new wave of ‘biologic’ therapies (for inflammatory and haematological disease) has yet to be quantified, although reports identify cases of rapid-onset or reactivation of SCC in ...
... inflammatory disease, and those with lymphoma or leukaemia, are at increased risk of this tumour. The risk of SCC with the new wave of ‘biologic’ therapies (for inflammatory and haematological disease) has yet to be quantified, although reports identify cases of rapid-onset or reactivation of SCC in ...
Combined Use of Diffusion-Weighted MRI and H MR Spectroscopy
... prostate cancer were studied using endorectal T2-weighted imaging, 2D chemical shift imaging (CSI), and isotropic apparent diffusion coefficient (ADC) maps. Regions of interest (ROIs) were drawn around the entire gland, central gland, and peripheral zone tumor, diagnostically defined as low signal i ...
... prostate cancer were studied using endorectal T2-weighted imaging, 2D chemical shift imaging (CSI), and isotropic apparent diffusion coefficient (ADC) maps. Regions of interest (ROIs) were drawn around the entire gland, central gland, and peripheral zone tumor, diagnostically defined as low signal i ...
Benchmarking the Multiplex Circulating and Cellular miRNA Assays
... • Use of hydrogel particles, which provides 75x increase in hybridization sensitivity and two extra logs of dynamic range when compared with the ...
... • Use of hydrogel particles, which provides 75x increase in hybridization sensitivity and two extra logs of dynamic range when compared with the ...
Decreased BECN1 mRNA Expression in Human
... Both BRCA1 and Beclin 1 (BECN1) are tumor suppressor genes, which are in close proximity on the human chromosome 17q21 breast cancer tumor susceptibility locus and are often concurrently deleted. However, their importance in sporadic human breast cancer is not known. To interrogate the effects of BE ...
... Both BRCA1 and Beclin 1 (BECN1) are tumor suppressor genes, which are in close proximity on the human chromosome 17q21 breast cancer tumor susceptibility locus and are often concurrently deleted. However, their importance in sporadic human breast cancer is not known. To interrogate the effects of BE ...
Evaluation of BRAF (V600E) Mutation by Immunohistochemical
... by immunohistochemistry with anti-BRAF V600E (VE1) mouse monoclonal antibody and by sequencing (220 colon cancer cases, 55 papillary thyroid carcinoma cases). Our data demonstrated concordance between IHC and DNA sequencing in 266 out of total 275 cases (96.7%). The 98.2% of cases (162/165) that wer ...
... by immunohistochemistry with anti-BRAF V600E (VE1) mouse monoclonal antibody and by sequencing (220 colon cancer cases, 55 papillary thyroid carcinoma cases). Our data demonstrated concordance between IHC and DNA sequencing in 266 out of total 275 cases (96.7%). The 98.2% of cases (162/165) that wer ...
Adenoma development in familial adenomatous polyposis
... and tumours that develop within the bowel [8]. Despite major initiatives to analyse sporadic colorectal cancers [9], little is known about the somatic landscape of tumours from patients with hereditary forms of the disease. Here we set out to profile somatic mutations in pre-malignant adenomas in tw ...
... and tumours that develop within the bowel [8]. Despite major initiatives to analyse sporadic colorectal cancers [9], little is known about the somatic landscape of tumours from patients with hereditary forms of the disease. Here we set out to profile somatic mutations in pre-malignant adenomas in tw ...
IFAC 2003 keynote - UCLA Computer Science
... Challenge III: Terms used in the query are too general Expanding the general terms in the query to specific terms that are used in the document Query: lung cancer, diagnosis chest x-rayoptions , bronchography, … ...
... Challenge III: Terms used in the query are too general Expanding the general terms in the query to specific terms that are used in the document Query: lung cancer, diagnosis chest x-rayoptions , bronchography, … ...
Multiple mechanisms generate HLA class I altered phenotypes in
... also possible to identify samples with both LOH in one HLA haplotype and lack of expression of HLA specificities in the other, giving rise to tumor samples with no HLA expression (phenotype I) or a combination of LOH and downregulation of HLA-A or B locus products (phenotype IIIa or IIIb). The freque ...
... also possible to identify samples with both LOH in one HLA haplotype and lack of expression of HLA specificities in the other, giving rise to tumor samples with no HLA expression (phenotype I) or a combination of LOH and downregulation of HLA-A or B locus products (phenotype IIIa or IIIb). The freque ...