LIPOSOMES FOR THE DELIVERY OF NUCLEIC ACID DRUGS A
... the use of the cationic and fusogenic lipids described earlier. PEGylated systems typically exhibit relatively low-transfection efficiencies. This is mainly due to the ability of the PEG coating to inhibit cell association and uptake. Ideally, PEG–lipid conjugates would have the ability to dissociat ...
... the use of the cationic and fusogenic lipids described earlier. PEGylated systems typically exhibit relatively low-transfection efficiencies. This is mainly due to the ability of the PEG coating to inhibit cell association and uptake. Ideally, PEG–lipid conjugates would have the ability to dissociat ...
Newer Delivery Systems for Local Anesthesia in Dentistry
... and most effective drugs in all of medicine for the prevention and management of pain. Nonetheless, the administration of these drugs is the most frightening and uncomfortable part of the dental appointment for most patients. The needle is the most fear inducing part of the armamentarium for the del ...
... and most effective drugs in all of medicine for the prevention and management of pain. Nonetheless, the administration of these drugs is the most frightening and uncomfortable part of the dental appointment for most patients. The needle is the most fear inducing part of the armamentarium for the del ...
MS_349Formated - University of Alberta
... maintain a constant plasma drug concentration within the therapeutically effective concentration range. The use of high viscosity hydromiscible vehicles such as hydrophilic gels, is one of various approaches for controlled drug delivery, and represents an important area of pharmaceutical research an ...
... maintain a constant plasma drug concentration within the therapeutically effective concentration range. The use of high viscosity hydromiscible vehicles such as hydrophilic gels, is one of various approaches for controlled drug delivery, and represents an important area of pharmaceutical research an ...
Ophthalmic Preparations - triphasepharmasolutions.com
... Oral delivery alone or in combination with topical delivery has been investigated for different reasons. Topical delivery alone failed to produce therapeutic concentrations in the posterior segment. Also, oral delivery was studied as a possible noninvasive and patient-preferred route to treat chroni ...
... Oral delivery alone or in combination with topical delivery has been investigated for different reasons. Topical delivery alone failed to produce therapeutic concentrations in the posterior segment. Also, oral delivery was studied as a possible noninvasive and patient-preferred route to treat chroni ...
A Systematic Review on Advanced Drug Delivery Technologies to
... Lymphatic systems maintains the body water balance, helps in the absorption of lipids, fatty acids, triglycerides, fat soluble vitamins and also play an important role in body’s immune system. Lymphoedema, Lymphoma and several other diseases are associated with lymphatic system. In addition to these ...
... Lymphatic systems maintains the body water balance, helps in the absorption of lipids, fatty acids, triglycerides, fat soluble vitamins and also play an important role in body’s immune system. Lymphoedema, Lymphoma and several other diseases are associated with lymphatic system. In addition to these ...
DEVELOPMENT AND CHARACTERIZATION OF FLUTAMIDE CONTAINING SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM (SMEDDS)
... leads to limited oral bioavailability, high intra and inter subject variability and lack of dose proportionality. To overcome the above discussed drawbacks, various other formulation strategies have been adopted including the use of cyclodextrins, nanoparticles, solid dispersions and permeation enha ...
... leads to limited oral bioavailability, high intra and inter subject variability and lack of dose proportionality. To overcome the above discussed drawbacks, various other formulation strategies have been adopted including the use of cyclodextrins, nanoparticles, solid dispersions and permeation enha ...
Guar gum/borax hydrogel - eXPRESS Polymer Letters
... T. Coviello1, P. Matricardi1, F. Alhaique1, R. Farra2, G. Tesei2, S. Fiorentino2, F. Asaro3, G. Milcovich3, M. Grassi2* ...
... T. Coviello1, P. Matricardi1, F. Alhaique1, R. Farra2, G. Tesei2, S. Fiorentino2, F. Asaro3, G. Milcovich3, M. Grassi2* ...
Lower critical solution temperature versus volume phase transition
... used for the determination of the LCST value by calorimetric and absorbance studies is low (0.5– 1%, w/v) [10, 11]. The LCST value determined at low concentration is then taken as the VPTT of the hydrogel, although the physical and chemical crosslinked hydrogels used in biomedical applications are p ...
... used for the determination of the LCST value by calorimetric and absorbance studies is low (0.5– 1%, w/v) [10, 11]. The LCST value determined at low concentration is then taken as the VPTT of the hydrogel, although the physical and chemical crosslinked hydrogels used in biomedical applications are p ...
Long-term in vitro study of paclitaxel
... inhibition of coronary stenosis by paclitaxel [26–28]. Drugeluting polymer-coated stents have thus moved into the limelight as vehicles for local drug administration [29,30]. In addition to usage in bioresorbable drug-eluting stents, our novel coating technique can be used for stable stents, where o ...
... inhibition of coronary stenosis by paclitaxel [26–28]. Drugeluting polymer-coated stents have thus moved into the limelight as vehicles for local drug administration [29,30]. In addition to usage in bioresorbable drug-eluting stents, our novel coating technique can be used for stable stents, where o ...
Supramolecular Chemistry: An Alternative Approach to Improve
... crystalline complexes of two or more neutral molecular constituents bound through noncovalent interactions in the crystal lattice in specific stoichiometry. Co-crystals, not only widen the alternatives to modify the physicochemical properties of ionizable drugs, but also offer an attractive approach ...
... crystalline complexes of two or more neutral molecular constituents bound through noncovalent interactions in the crystal lattice in specific stoichiometry. Co-crystals, not only widen the alternatives to modify the physicochemical properties of ionizable drugs, but also offer an attractive approach ...
In Vitro Inhaled Aerosol Comparison of a Conserver Nebulizer
... increases drug delivery and allows treatment times with the Circulaire® II to be deliberately shortened to about 2–4 minutes while accomplishing the same or greater inhaled drug mass typically achieved with the BAN. The Circulaire® II can be used in this manner with a multitude of different drugs, b ...
... increases drug delivery and allows treatment times with the Circulaire® II to be deliberately shortened to about 2–4 minutes while accomplishing the same or greater inhaled drug mass typically achieved with the BAN. The Circulaire® II can be used in this manner with a multitude of different drugs, b ...
srija
... leads to radical physical changes as change in particle size that alters drug release. During cooling, this system crosses the point of zero spontaneous curvature and minimal surface tension, prompting the formation of finely dispersed oil droplets. Microemulsions can be prepared by controlled addit ...
... leads to radical physical changes as change in particle size that alters drug release. During cooling, this system crosses the point of zero spontaneous curvature and minimal surface tension, prompting the formation of finely dispersed oil droplets. Microemulsions can be prepared by controlled addit ...
NATURAL AND SYNTHETIC HYDROPHILIC MATRICES FOR DEVELOPMENT OF PREGABALIN Review Article
... method with 40, 50 and 60 percent of Carbopol 71G using spray dried lactose as filler. All the batches showed good extended release profile with 28.09%, 16.82% and 13.33% release in first two hours; 64.72%, 65.3% and 50.07% percent release in six hours; 95.31%, 80.88% and 79.85% release in twelve ho ...
... method with 40, 50 and 60 percent of Carbopol 71G using spray dried lactose as filler. All the batches showed good extended release profile with 28.09%, 16.82% and 13.33% release in first two hours; 64.72%, 65.3% and 50.07% percent release in six hours; 95.31%, 80.88% and 79.85% release in twelve ho ...
Design and Optimization of Sustained
... In general, increasing the moisture content of a powder decreases its ability to flow smoothly (19,20). One of the main causes of this phenomenon may be the increased thickness of the adsorbed liquid layer, which increases the strength of liquid bridges formed between particles (21). Divalproex is a ...
... In general, increasing the moisture content of a powder decreases its ability to flow smoothly (19,20). One of the main causes of this phenomenon may be the increased thickness of the adsorbed liquid layer, which increases the strength of liquid bridges formed between particles (21). Divalproex is a ...
Full-Text
... linked to the main chain through highly stable conjugated imine groups. The novel copolymer has interesting properties that justify its potential applications in biomedical fields such as tissue engineering, drug delivery, and nerve probes where electroactivity is required. Thus, the copolymer is wa ...
... linked to the main chain through highly stable conjugated imine groups. The novel copolymer has interesting properties that justify its potential applications in biomedical fields such as tissue engineering, drug delivery, and nerve probes where electroactivity is required. Thus, the copolymer is wa ...
Medical applications of membranes: Drug delivery, artificial organs
... 8.4.3. Scaffold design . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Conclusions and outlook . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
... 8.4.3. Scaffold design . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Conclusions and outlook . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ...
formulation and in vitro evaluation of bilayered buccal patches of a
... buccal mucosa and attachment of the patch with buccal mucosa without collapse are the two prime considerations in the design of a conventional buccal adhesive patch .However, an additional consideration in the case of PPI’s is the stability of PPI’s in human saliva, since it is very unstable in acid ...
... buccal mucosa and attachment of the patch with buccal mucosa without collapse are the two prime considerations in the design of a conventional buccal adhesive patch .However, an additional consideration in the case of PPI’s is the stability of PPI’s in human saliva, since it is very unstable in acid ...
Course Description Word File
... Course Code: GC1022 To increase the design ability of polymer materials by studying the fundamentals of polymer materials and characterization, by selecting polymer materials, which can be found in our living environment and industries, and performing team projects with them in order to learn materi ...
... Course Code: GC1022 To increase the design ability of polymer materials by studying the fundamentals of polymer materials and characterization, by selecting polymer materials, which can be found in our living environment and industries, and performing team projects with them in order to learn materi ...
Liquid Equipoise Anabolic Androgenic Steroids CAS 13103-34
... It is a derivative, which exhibits strong anabolic and moderately androgenic properties. The undecylenate ester greatly extends the activity of the drug (the undecylenate ester is only one carbon atom longer than decanoate), so that clinically injections would need to be repeated every three or four ...
... It is a derivative, which exhibits strong anabolic and moderately androgenic properties. The undecylenate ester greatly extends the activity of the drug (the undecylenate ester is only one carbon atom longer than decanoate), so that clinically injections would need to be repeated every three or four ...
Formulation and Evaluation of Bioadhesive Gels Containing Miconazole Nitrate
... hydroxypropylmethyl cellulose (HPMC), carbopol 934 and sodium alginate. Determination of drug content, pH, viscosity, % adhesion and in vitro release through both artificial and natural diffusion barrier were investigated for all the prepared bioadhesive gels alone and incorporated with enhancers na ...
... hydroxypropylmethyl cellulose (HPMC), carbopol 934 and sodium alginate. Determination of drug content, pH, viscosity, % adhesion and in vitro release through both artificial and natural diffusion barrier were investigated for all the prepared bioadhesive gels alone and incorporated with enhancers na ...
Various techniques for solubility enhancement: An overview
... 20%) increase in dissolution in at 30 minutes biorelevant media [8, 9]. (b) Nanonization [10] Recently, various nanonization strategies have emerged to increase the dissolution rates and bioavailability of numerous drugs that are poorly soluble in water. Nanonization broadly refers to the study and ...
... 20%) increase in dissolution in at 30 minutes biorelevant media [8, 9]. (b) Nanonization [10] Recently, various nanonization strategies have emerged to increase the dissolution rates and bioavailability of numerous drugs that are poorly soluble in water. Nanonization broadly refers to the study and ...
Case Studies - Richman Chemical Inc.
... distributor notify FDA if it intends to market a dietary supplement in the U.S. that contains a "new dietary ingredient." • New requirements for complete disclosure of the manufacturer, packer, or distributor; a complete list of ingredients; and the net contents on the label. Richman Chemical Inc. w ...
... distributor notify FDA if it intends to market a dietary supplement in the U.S. that contains a "new dietary ingredient." • New requirements for complete disclosure of the manufacturer, packer, or distributor; a complete list of ingredients; and the net contents on the label. Richman Chemical Inc. w ...
formulation and evalution of medicated chewing gum of
... During the chewing gum process, most of the drug products are released into the saliva and either absorbed through buccal mucosa or swallowed through GIT2. Chewing Gum has been used for centuries to clean the mouth and freshen breath. Medicated Chewing Gums are solid, single dose preparations with a ...
... During the chewing gum process, most of the drug products are released into the saliva and either absorbed through buccal mucosa or swallowed through GIT2. Chewing Gum has been used for centuries to clean the mouth and freshen breath. Medicated Chewing Gums are solid, single dose preparations with a ...
Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery
... general information about SLN structures and properties, production procedures, characterization. In addition, recent progress on development of drug and gene delivery systems using SLNs was reviewed. ...
... general information about SLN structures and properties, production procedures, characterization. In addition, recent progress on development of drug and gene delivery systems using SLNs was reviewed. ...
Nicholas A. Peppas
Nicholas (Nikolaos) A. Peppas (Greek: Νικόλαος Α. Πέππας; born in Athens, Greece on August 25, 1948) is a chemical and biomedical engineer whose leadership in biomaterials science and engineering, drug delivery, bionanotechnology, pharmaceutical sciences, chemical and polymer engineering has led to numerous biomedical products or devices.