prefilled syringes
... the reward side of the risk and reward equation. The claims made by prefilled syringe companies about how prefilled syringes can improve and add value to pharmaceutical products are not ...
... the reward side of the risk and reward equation. The claims made by prefilled syringe companies about how prefilled syringes can improve and add value to pharmaceutical products are not ...
BIOMED_presentation
... projects is one of the major challenge of the next years. Integrating up-to-date databanks and relevant algorithms is a clear requirement of such an analysis. Grid computing, such as the infrastructure provided by the EGEE European project, would be a viable solution to distribute data, algorithms, ...
... projects is one of the major challenge of the next years. Integrating up-to-date databanks and relevant algorithms is a clear requirement of such an analysis. Grid computing, such as the infrastructure provided by the EGEE European project, would be a viable solution to distribute data, algorithms, ...
TEMPERATURE SENSITIVE OPHTHALMIC HYDROGELS OF LEVOFLOXACIN HEMIHYDRATE
... Objective- The prolonged retention of drug formulation in the eye is of utmost importance for topical ophthalmic drug delivery. The objective of the present investigation is to develop mucoadhesive Temperature Sensitive Ophthalmic Gels of Levofloxacin hemihydrate, a Fluoroquinolone antibiotic drug w ...
... Objective- The prolonged retention of drug formulation in the eye is of utmost importance for topical ophthalmic drug delivery. The objective of the present investigation is to develop mucoadhesive Temperature Sensitive Ophthalmic Gels of Levofloxacin hemihydrate, a Fluoroquinolone antibiotic drug w ...
Cyclodextrins in peptide and protein delivery
... *Corresponding author. Tel.: 1 81 96 3714160; fax: 1 81 96 3727023; e-mail: [email protected] ...
... *Corresponding author. Tel.: 1 81 96 3714160; fax: 1 81 96 3727023; e-mail: [email protected] ...
Skin Barrier and Transdermal Drug Delivery
... • Microheterogeneity within extracellular spaces: “ There’s more to the mortar than lipid” • Persistent metabolic activity: dynamic changes in cytosol, cornified envelope, and interstices from inner to outer stratum corneum • Homeostatic links to the nucleated cell layers: barrier function regulates ...
... • Microheterogeneity within extracellular spaces: “ There’s more to the mortar than lipid” • Persistent metabolic activity: dynamic changes in cytosol, cornified envelope, and interstices from inner to outer stratum corneum • Homeostatic links to the nucleated cell layers: barrier function regulates ...
THEORETICAL STUDY ON PHYSICOCHEMICAL AND GEOMETRICAL PROPERTIES OF THE
... and their surfaces can be easily functionalized with different kinds of molecules7-10. Properly functionalized Au NPs not only can act as a drug reservoir, but also supply a long circulation time and cytotoxicity, so, they have appeared as attractive candidates for distributing different payloads in ...
... and their surfaces can be easily functionalized with different kinds of molecules7-10. Properly functionalized Au NPs not only can act as a drug reservoir, but also supply a long circulation time and cytotoxicity, so, they have appeared as attractive candidates for distributing different payloads in ...
Chapter-3 Drug and Excipients profile
... : Retinoic acid, 13-cis-.3,7-Dimethyl-9-(2,6,6-trimethyl1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-transnonatetraenoic acid. ...
... : Retinoic acid, 13-cis-.3,7-Dimethyl-9-(2,6,6-trimethyl1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-transnonatetraenoic acid. ...
Marine Origin Polysaccharides in Drug Delivery Systems
... agent from the device, thereby limiting drug release when the pH is low [39–41]. However, gelling sodium alginate with Ca2+ ions can solve pH dependent limitations related to the hydration, dilation and erosion of the carrier. Alginate has the ability of cross-linking with Ca2+ ions through an ionot ...
... agent from the device, thereby limiting drug release when the pH is low [39–41]. However, gelling sodium alginate with Ca2+ ions can solve pH dependent limitations related to the hydration, dilation and erosion of the carrier. Alginate has the ability of cross-linking with Ca2+ ions through an ionot ...
Factors that affect mass transport from drug eluting stents into the
... rejection or as immunosuppressive drugs [21,46]. In April 2003 the first DES to gain ...
... rejection or as immunosuppressive drugs [21,46]. In April 2003 the first DES to gain ...
6. Shanthakumar GS, Narayanacharyulu R, Divakar Goli
... Compared to other absorptive mucosa, buccal mucosa is considered as potential site for drug administration, rich blood supply, lower enzymatic activity of saliva, better patient acceptance are some other prominent meritorious visage of buccoadhesive systems 4. Buccal drug delivery provides an altern ...
... Compared to other absorptive mucosa, buccal mucosa is considered as potential site for drug administration, rich blood supply, lower enzymatic activity of saliva, better patient acceptance are some other prominent meritorious visage of buccoadhesive systems 4. Buccal drug delivery provides an altern ...
Formulation, Development and Evaluation of delayed release
... based on influence of physiological conditions like ...
... based on influence of physiological conditions like ...
National Conference on Nanoscience and Nanotechnology (NCNN
... Nanotechnology is a group of emerging technologies in which the structure of matter is controlled at the nanometre scale, to produce new, interesting materials and devices with unique properties. Nanotubes belong to the promising group of nanostructured materials. Though there are many other tubes b ...
... Nanotechnology is a group of emerging technologies in which the structure of matter is controlled at the nanometre scale, to produce new, interesting materials and devices with unique properties. Nanotubes belong to the promising group of nanostructured materials. Though there are many other tubes b ...
DESIGN AND DEVELOPMENT OF MUCOADHESIVE BUCCAL DELIVERY FOR PANTOPRAZOLE
... Objective: Pantoprazole undergoes hepatic first pass metabolism, hence it shows poor bioavailability. Stability of Pantoprazole in human saliva was improved using magnesium oxide due to its strong waterproofing effect. In present study attempt has been done to improve the bioavailability by formulat ...
... Objective: Pantoprazole undergoes hepatic first pass metabolism, hence it shows poor bioavailability. Stability of Pantoprazole in human saliva was improved using magnesium oxide due to its strong waterproofing effect. In present study attempt has been done to improve the bioavailability by formulat ...
literature review ii
... methocel K4 M. The matrix tablets gave slow, controlled and complete release over a period of 12 hrs. Drug release from these tablets followed first order kinetics and the release was diffusion controlled. The (n) values obtained from Peppas plots were within the range of 0.45 to 0.9, indicates the ...
... methocel K4 M. The matrix tablets gave slow, controlled and complete release over a period of 12 hrs. Drug release from these tablets followed first order kinetics and the release was diffusion controlled. The (n) values obtained from Peppas plots were within the range of 0.45 to 0.9, indicates the ...
Intranasal midazolam delivery procedure
... Intranasal sedation protocol: General points: Midazolam, ketamine, dexmedetomidine and sufentanil are the most commonly used sedative medications for IN delivery. o Midazolam results in mild somnolence with resultant reduction in anxiety and probably amnesia. It will not make the patient unconscio ...
... Intranasal sedation protocol: General points: Midazolam, ketamine, dexmedetomidine and sufentanil are the most commonly used sedative medications for IN delivery. o Midazolam results in mild somnolence with resultant reduction in anxiety and probably amnesia. It will not make the patient unconscio ...
12146005
... therapy. This approach of repetitive dosing, however, exhibits some drawbacks such as frequent administration especially for drugs with short biological half-life, patient noncompliance with multiple dosage regimens and sometimes, under medication or over medication at certain disease states (Gennar ...
... therapy. This approach of repetitive dosing, however, exhibits some drawbacks such as frequent administration especially for drugs with short biological half-life, patient noncompliance with multiple dosage regimens and sometimes, under medication or over medication at certain disease states (Gennar ...
, English, Pages 205
... Owing to its extreme hydrophobicity and low density, Gelucire® 39/01 may be considered an appropriate carrier for designing sustained release floating drug delivery systems of risedronate sodium. SEM, HSM, DSC showed that ageing of Gelucire® 39/01 is responsible for an increase in drug release. Furt ...
... Owing to its extreme hydrophobicity and low density, Gelucire® 39/01 may be considered an appropriate carrier for designing sustained release floating drug delivery systems of risedronate sodium. SEM, HSM, DSC showed that ageing of Gelucire® 39/01 is responsible for an increase in drug release. Furt ...
Sonophoresis - International Journal of Pharmacy and Technology
... impermeable membrane that consists of flat, dead cells that are filled with keratin fibers (corneocytes) surrounded by lipid bilayers. The highly ordered structure of lipid bilayers confers upon the SC an impermeable character2-7. Different techniques, such as chemical enhancers, iontophoresis, elec ...
... impermeable membrane that consists of flat, dead cells that are filled with keratin fibers (corneocytes) surrounded by lipid bilayers. The highly ordered structure of lipid bilayers confers upon the SC an impermeable character2-7. Different techniques, such as chemical enhancers, iontophoresis, elec ...
Development of Discriminative Dissolution Media for Marketed
... artifacts such as coning rather than true formulation changes. In most cases, a dissolution apparatus tends to become less discriminating when operated at higher stirring speeds (75 or 100 rpm) that result in flatter drug release profiles. In some cases, increased stirring speeds result in a method ...
... artifacts such as coning rather than true formulation changes. In most cases, a dissolution apparatus tends to become less discriminating when operated at higher stirring speeds (75 or 100 rpm) that result in flatter drug release profiles. In some cases, increased stirring speeds result in a method ...
Fig. 1 - BioImpacts
... Using suitable animal models and drug analyses techniques, drug liberation and distribution can be assessed. PK parameters such as AUC, Tmax and Cmax are normally the ones that are used for the relative bioavailability (the so-called “relative amount of absorption”) comparison among formulations, wh ...
... Using suitable animal models and drug analyses techniques, drug liberation and distribution can be assessed. PK parameters such as AUC, Tmax and Cmax are normally the ones that are used for the relative bioavailability (the so-called “relative amount of absorption”) comparison among formulations, wh ...
Mucoadhesive Buccal Films Embedded with Antiviral Drug Loaded
... INTRODUCTION Buccal route of drug delivery offers most promising alternative to oral route because of its potential to overcome first-pass hepatic metabolism as well as gastrointestinal-tract limitations (1, 2). Moreover, the buccal mucosa is relatively permeable with a rich blood supply and is read ...
... INTRODUCTION Buccal route of drug delivery offers most promising alternative to oral route because of its potential to overcome first-pass hepatic metabolism as well as gastrointestinal-tract limitations (1, 2). Moreover, the buccal mucosa is relatively permeable with a rich blood supply and is read ...
Biodegradable PLGA-b-PEG polymeric nanoparticles: synthesis
... polymers have been studied for nanomedicine applications and in particular as drug delivery systems. For this purpose, polymers must be non-toxic, biodegradable, and biocompatible. Polylactic-co-glycolic acid (PLGA) is one of the most studied polymers due to its complete biodegradability and ability ...
... polymers have been studied for nanomedicine applications and in particular as drug delivery systems. For this purpose, polymers must be non-toxic, biodegradable, and biocompatible. Polylactic-co-glycolic acid (PLGA) is one of the most studied polymers due to its complete biodegradability and ability ...
Preparation and Characterisation of Mucoadhesive Nasal Gel of
... in overcoming nausea and other gastrointestinal disturbances associated with venlafaxine [3]. After oral administration, venlafaxine undergoes extensive presystemic metabolism in the liver. Based on the mass balance studies, it was found that about 92% of the single dose of venlafaxine is absorbed b ...
... in overcoming nausea and other gastrointestinal disturbances associated with venlafaxine [3]. After oral administration, venlafaxine undergoes extensive presystemic metabolism in the liver. Based on the mass balance studies, it was found that about 92% of the single dose of venlafaxine is absorbed b ...
ELECTRICALLY ASSISTED TRANSDERMAL DELIVERY OF ESCIN
... 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt, 2Department of Pharmaceutics and Medicinal Chemistry, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California, USA. Email: [email protected] ...
... 1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, Egypt, 2Department of Pharmaceutics and Medicinal Chemistry, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California, USA. Email: [email protected] ...
Nicholas A. Peppas
Nicholas (Nikolaos) A. Peppas (Greek: Νικόλαος Α. Πέππας; born in Athens, Greece on August 25, 1948) is a chemical and biomedical engineer whose leadership in biomaterials science and engineering, drug delivery, bionanotechnology, pharmaceutical sciences, chemical and polymer engineering has led to numerous biomedical products or devices.