serum-free media for cell culture
... animal welfare, but our primary concern is the extraction of blood from living foetuses. Products derived from adult animals, or at slaughter may cause less suffering, but media containing no animal‐derived ingredients are preferable. ...
... animal welfare, but our primary concern is the extraction of blood from living foetuses. Products derived from adult animals, or at slaughter may cause less suffering, but media containing no animal‐derived ingredients are preferable. ...
Characterization of thymic hyperplasia associated with autoimmune
... was mediated by an autoimmune response indicated by (1) frequent association with other autoimmune diseases, (2) presence of transient MG symptoms in 10-15% of newborns from myasthenic mothers (neonatal MG), (3) inflammatory infiltrates in muscle and pathological changes in thymus, (4) beneficial ef ...
... was mediated by an autoimmune response indicated by (1) frequent association with other autoimmune diseases, (2) presence of transient MG symptoms in 10-15% of newborns from myasthenic mothers (neonatal MG), (3) inflammatory infiltrates in muscle and pathological changes in thymus, (4) beneficial ef ...
the effects of thymus and other lymphoid organs enclosed in
... per cent suspension in normal saline. Each mouse was given 0.2 ml intraperitoneally at 6 to 8 weeks of age. Ten days after injection each mouse was bled from the retroorbital plexus and serum antibody titrations performed at room temperature. Doubling dilutions of serum were added to 6 mm by 50 mm t ...
... per cent suspension in normal saline. Each mouse was given 0.2 ml intraperitoneally at 6 to 8 weeks of age. Ten days after injection each mouse was bled from the retroorbital plexus and serum antibody titrations performed at room temperature. Doubling dilutions of serum were added to 6 mm by 50 mm t ...
Amino acid concentrations in fluids from the bovine oviduct and
... cleavage-stage embryos to the uterus for implantation and further development. Some of the difficulties encountered in producing embryos of various species in vitro, such as the block stage, occur during the oviductal phase of development reflecting an important role of the oviduct during that phase ...
... cleavage-stage embryos to the uterus for implantation and further development. Some of the difficulties encountered in producing embryos of various species in vitro, such as the block stage, occur during the oviductal phase of development reflecting an important role of the oviduct during that phase ...
Boundless Study Slides
... • monoclonal antibody Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope • mucous membrane ...
... • monoclonal antibody Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are the same because they are made by identical immune cells that are all clones of a unique parent cell. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope • mucous membrane ...
the avian thrombocyte is a specialized immune cell
... Thrombocytes are the most abundant circulating cells next to red blood cells in avian blood. Avian thrombocytes are homologous in function to mammalian platelets. Avian thrombocytes and the mammalian platelet are widely recognized contributors to inflammatory responses upon stimulation with various ...
... Thrombocytes are the most abundant circulating cells next to red blood cells in avian blood. Avian thrombocytes are homologous in function to mammalian platelets. Avian thrombocytes and the mammalian platelet are widely recognized contributors to inflammatory responses upon stimulation with various ...
Psoriasis - New England Journal of Medicine
... understanding of molecular immune mechanisms can be translated into innovative therapies. Although many factors that contribute to the generation of psoriatic lesions remain obscure, compelling circumstantial and experimental evidence suggests a primary T-lymphocyte–based immunopathogenesis (Fig. 3) ...
... understanding of molecular immune mechanisms can be translated into innovative therapies. Although many factors that contribute to the generation of psoriatic lesions remain obscure, compelling circumstantial and experimental evidence suggests a primary T-lymphocyte–based immunopathogenesis (Fig. 3) ...
Commins, et al, JACI, 2014
... ii. IgE plasma cells can be derived by direct switch from IgM or via IgG B cells which have undergone maturation in germinal centers . iii. They suggest that only IgE antibodies made via the germinal center route are relevant to allergic disease and even that low affinity antibodies are protective. ...
... ii. IgE plasma cells can be derived by direct switch from IgM or via IgG B cells which have undergone maturation in germinal centers . iii. They suggest that only IgE antibodies made via the germinal center route are relevant to allergic disease and even that low affinity antibodies are protective. ...
PhD Rika 140511 - Laboratory of Parasitology
... regulating the permeability of the tight junctional complex. Moreover, Giardia may alter other tight junctional proteins, including the claudins (Troeger et al., 2007). Besides, activated T lymphocytes cause the brush border to retract. Several cytokines are possibly involved in this effect on the m ...
... regulating the permeability of the tight junctional complex. Moreover, Giardia may alter other tight junctional proteins, including the claudins (Troeger et al., 2007). Besides, activated T lymphocytes cause the brush border to retract. Several cytokines are possibly involved in this effect on the m ...
Inflammation Macrophage Activation and Acute TLR-2 and IL
... Chitin regulation of macrophage IL-17A and IL-17A receptor To begin to determine whether chitin regulated macrophage function, macrophages were incubated with big chitin (70 –100 m) and chitin fragments (40 –70 m) or their vehicle controls. The production of IL-17 and the expression of the IL-17A ...
... Chitin regulation of macrophage IL-17A and IL-17A receptor To begin to determine whether chitin regulated macrophage function, macrophages were incubated with big chitin (70 –100 m) and chitin fragments (40 –70 m) or their vehicle controls. The production of IL-17 and the expression of the IL-17A ...
prolongation of allograft survival in ccr7
... Ph.D., Visceral and Transplantation Surgery, Hannover Medical dawar (9). Recipients were anesthetized, shaved, and grafted with School, 30625 Hannover, Germany. Email: hoffmann.matthias@ tail skin on the back or flank. Bandages were removed after 8 days, ...
... Ph.D., Visceral and Transplantation Surgery, Hannover Medical dawar (9). Recipients were anesthetized, shaved, and grafted with School, 30625 Hannover, Germany. Email: hoffmann.matthias@ tail skin on the back or flank. Bandages were removed after 8 days, ...
1 High resolution metabolomics with acyl
... cultured cells and tissue samples (Fig. 1A). The detailed sample preparation procedure from cultured cells was discussed in a previous study (21) but the method was extended to consider tissue extraction. Cell or tissue extracts were separated by three chromatography methods comprising one normal an ...
... cultured cells and tissue samples (Fig. 1A). The detailed sample preparation procedure from cultured cells was discussed in a previous study (21) but the method was extended to consider tissue extraction. Cell or tissue extracts were separated by three chromatography methods comprising one normal an ...
prolactin and autoimmune diseases prolakt
... Production of the Th1 cytokine, IL-2, is defective in lymphoid cells from NZB/NZW mice but is nevertheless detrimental in these autoimmune animals (45ô. In the past, it was not understood how this cytokine with low grade secretion could direct autoimmune processes. It is now recognized that the func ...
... Production of the Th1 cytokine, IL-2, is defective in lymphoid cells from NZB/NZW mice but is nevertheless detrimental in these autoimmune animals (45ô. In the past, it was not understood how this cytokine with low grade secretion could direct autoimmune processes. It is now recognized that the func ...
Distinct and Separable Roles of the Complement System in Factor H
... specificity, a phenomenon that can lead to protection from complement activation on normal cells, as well as malignant cells and adapted microorganisms (8,9). The inability of Cfh to bind to host tissue sites, particularly because of mutations that affect the final SCR, also may underlie the pathoge ...
... specificity, a phenomenon that can lead to protection from complement activation on normal cells, as well as malignant cells and adapted microorganisms (8,9). The inability of Cfh to bind to host tissue sites, particularly because of mutations that affect the final SCR, also may underlie the pathoge ...
Allergic disease: the diagnosis of peanut allergy and the role of heat
... The 16 peanut allergens so far known are outlined in table 1. Ara h 4 is not mentioned, as this is now recognized as being similar to Ara h 3. Knowledge of the protein family helps in understanding possible cross-reactivities and functions of the protein. Ara h: peanut allergen (Arachis hypogaea); G ...
... The 16 peanut allergens so far known are outlined in table 1. Ara h 4 is not mentioned, as this is now recognized as being similar to Ara h 3. Knowledge of the protein family helps in understanding possible cross-reactivities and functions of the protein. Ara h: peanut allergen (Arachis hypogaea); G ...
Morphology of autoimmune hepatitis - pathologie
... Classification of autoimmune hepatitis Autoimmune hepatitis is a chronic progressive inflammation of the liver, which if left untreated will ultimately result in progressive destruction of the organ. The exact aetiology has not been sufficiently clarified. There are two different types of autoimmune ...
... Classification of autoimmune hepatitis Autoimmune hepatitis is a chronic progressive inflammation of the liver, which if left untreated will ultimately result in progressive destruction of the organ. The exact aetiology has not been sufficiently clarified. There are two different types of autoimmune ...
Document
... lethal to foals fail to produce pulmonary abscesses, unless immunosuppressive therapy is instituted.9 –11 Therefore, incompletely understood host-specific natural conditions exclusive to the foal are necessary for R. equi to establish disease. The unique susceptibility of young foals to R. equi dise ...
... lethal to foals fail to produce pulmonary abscesses, unless immunosuppressive therapy is instituted.9 –11 Therefore, incompletely understood host-specific natural conditions exclusive to the foal are necessary for R. equi to establish disease. The unique susceptibility of young foals to R. equi dise ...
Role of Endoplasmic Reticulum Aminopeptidases in Health and
... risk of preeclampsia, a heritable pregnancy specific disorder characterized by new-onset hypertension and proteinuria [46,47]. Of note, ERAP2 expression was previously found altered in first trimester placentas of women prone to develop preeclampsia [48]. 4.2. Bacterial and Viral Infections The firs ...
... risk of preeclampsia, a heritable pregnancy specific disorder characterized by new-onset hypertension and proteinuria [46,47]. Of note, ERAP2 expression was previously found altered in first trimester placentas of women prone to develop preeclampsia [48]. 4.2. Bacterial and Viral Infections The firs ...
View PDF - Cardiovascular Research
... The interleukin-17 (IL-17) family of cytokines and their ubiquitous receptors play a major role in host defense against pathogens. Six known IL-17 family members (IL17A-F), including the prototypical IL-17A (also known as IL-17), exert potent proinflammatory effects and are produced by a myriad of i ...
... The interleukin-17 (IL-17) family of cytokines and their ubiquitous receptors play a major role in host defense against pathogens. Six known IL-17 family members (IL17A-F), including the prototypical IL-17A (also known as IL-17), exert potent proinflammatory effects and are produced by a myriad of i ...
Curriculum Vitae
... 5. Chung JL, Sun J, Sidney J, Sette A, Peters B. IMMUNOCAT-a data management system for epitope mapping studies. J Biomed Biotechnol. 2010;2010:856842. PMCID: PMC2871663 6. Solomon C, Southwood S, Hoof I, Rudersdorf R, Peters B, Sidney J, Pinilla C, Marcondes MC, Ling B, Marx P, Sette A, Mothé BR. T ...
... 5. Chung JL, Sun J, Sidney J, Sette A, Peters B. IMMUNOCAT-a data management system for epitope mapping studies. J Biomed Biotechnol. 2010;2010:856842. PMCID: PMC2871663 6. Solomon C, Southwood S, Hoof I, Rudersdorf R, Peters B, Sidney J, Pinilla C, Marcondes MC, Ling B, Marx P, Sette A, Mothé BR. T ...
The demonstration of nickel in the urease of Helicobacter pylori by
... present only in the 61 kDa polypeptide and in the ratio of between five and six atoms to one molecule of urease, suggesting a hexameric structure. These results are discussed in relation to other bacterial ureases and urease activity at low pH. ...
... present only in the 61 kDa polypeptide and in the ratio of between five and six atoms to one molecule of urease, suggesting a hexameric structure. These results are discussed in relation to other bacterial ureases and urease activity at low pH. ...
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... cardiovascular system. It is clear that thrombin aids in the formation of blood clots by catalyzing the conversion of ?brinogen to ?brin. which is an integral part of most clots. In addition. thrombin is known to act directly on cells in the blood and in the interior blood vessel wall. and speci?cal ...
... cardiovascular system. It is clear that thrombin aids in the formation of blood clots by catalyzing the conversion of ?brinogen to ?brin. which is an integral part of most clots. In addition. thrombin is known to act directly on cells in the blood and in the interior blood vessel wall. and speci?cal ...
Novel tests for diagnosing tuberculous pleural effusion: what works and what REVIEW
... Recently, in vitro, T-cell-based IFN-c release assays (IGRAs) have been developed and licensed for diagnosis of latent TB infection. Normally, these tests use peripheral blood mononuclear cells (PBMCs), but they can be used with pleural fluid mononuclear cells. These assays detect IFN-c secreted by ...
... Recently, in vitro, T-cell-based IFN-c release assays (IGRAs) have been developed and licensed for diagnosis of latent TB infection. Normally, these tests use peripheral blood mononuclear cells (PBMCs), but they can be used with pleural fluid mononuclear cells. These assays detect IFN-c secreted by ...
Maggini S et al. Selected vitamins and trace elements support
... affecting innate, T cell mediated and adaptive antibody responses, leading to dysregulation of the balanced host response. This situation increases susceptibility to infections, with increased morbidity and mortality. In turn, infections aggravate micronutrient deficiencies by reducing nutrient inta ...
... affecting innate, T cell mediated and adaptive antibody responses, leading to dysregulation of the balanced host response. This situation increases susceptibility to infections, with increased morbidity and mortality. In turn, infections aggravate micronutrient deficiencies by reducing nutrient inta ...
C YTOKINES AND IMMUNE BALANCE IN PREECLAMPSIA
... with insufficient penetration of the trophoblasts, leading to impaired maternal blood flow through narrow spiral arteries. However, the cause of this defective trophoblast behavior is not known. The maternal immune system has been proposed to have an influence on both the placentation and the subseq ...
... with insufficient penetration of the trophoblasts, leading to impaired maternal blood flow through narrow spiral arteries. However, the cause of this defective trophoblast behavior is not known. The maternal immune system has been proposed to have an influence on both the placentation and the subseq ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.