Neuropathic pain The pharmacological management
... sequencing of therapeutic classes. This may lead to inadequate pain control, with considerable morbidity. In the context of this guideline, non-specialist settings are defined as primary and secondary care services that do not provide specialist pain services. These include general practice, general ...
... sequencing of therapeutic classes. This may lead to inadequate pain control, with considerable morbidity. In the context of this guideline, non-specialist settings are defined as primary and secondary care services that do not provide specialist pain services. These include general practice, general ...
catechol-o-methyltransferase activity: assay, distribution
... Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of compounds which have a catechol structure. A high-sensitivity and reliable high-performance liquid chromatography (HPLC) with coulometric detection was developed to analyze the COMT reaction products, vanillic acid and i ...
... Catechol-O-methyltransferase (COMT) is an important enzyme in the metabolism of compounds which have a catechol structure. A high-sensitivity and reliable high-performance liquid chromatography (HPLC) with coulometric detection was developed to analyze the COMT reaction products, vanillic acid and i ...
WHO monographs on medicinal plants commonly used in the Newly
... should be set in accordance with national requirements by the appropriate authorities of Member States. Each medicinal plant and the specific plant part used as crude drug material contain active or major chemical constituents with a characteristic profile that can be used for chemical quality contr ...
... should be set in accordance with national requirements by the appropriate authorities of Member States. Each medicinal plant and the specific plant part used as crude drug material contain active or major chemical constituents with a characteristic profile that can be used for chemical quality contr ...
Erythromycin delayed release capsules USP
... The safety of ERYC for use during breast feeding has not been established. Erythromycin is excreted in breast milk. Neonates The safety of ERYC for use in neonates has not been established. Geriatrics: Clinical studies with ERYC did not include sufficient numbers of subjects aged 65 and over to dete ...
... The safety of ERYC for use during breast feeding has not been established. Erythromycin is excreted in breast milk. Neonates The safety of ERYC for use in neonates has not been established. Geriatrics: Clinical studies with ERYC did not include sufficient numbers of subjects aged 65 and over to dete ...
Special Contribution Acetaminophen-Induced Hepatotoxicity: Still an
... Acetaminophen (APAP), the most commonly sold over-the-counter antipyretic analgesic, is generally considered harmless at therapeutic doses. However, APAP overdose causes severe and sometimes fatal hepatic damage in humans and experimental animals. In the United States and Europe, the incidence of li ...
... Acetaminophen (APAP), the most commonly sold over-the-counter antipyretic analgesic, is generally considered harmless at therapeutic doses. However, APAP overdose causes severe and sometimes fatal hepatic damage in humans and experimental animals. In the United States and Europe, the incidence of li ...
HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights
... Use of KADIAN as the First Opioid Analgesic There has been no evaluation of KADIAN as an initial opioid analgesic in the management of pain. Because it may be more difficult to titrate a patient to adequate analgesia using an extended-release morphine, begin treatment using an immediate-release morp ...
... Use of KADIAN as the First Opioid Analgesic There has been no evaluation of KADIAN as an initial opioid analgesic in the management of pain. Because it may be more difficult to titrate a patient to adequate analgesia using an extended-release morphine, begin treatment using an immediate-release morp ...
Paracetamol - IARC Monographs on the Evaluation of Carcinogenic
... = 0.045, Fisher's exact test) (Flaks et al., 1985). (The Working Group noted that there were increased incidences of calculi, hyperplasia and tumours of the bladder in treated animaIs but there was no relationship between the presence of calculI and the presence of either hyperplasia or tumours.) ...
... = 0.045, Fisher's exact test) (Flaks et al., 1985). (The Working Group noted that there were increased incidences of calculi, hyperplasia and tumours of the bladder in treated animaIs but there was no relationship between the presence of calculI and the presence of either hyperplasia or tumours.) ...
Pharmacokinetics and pharmacodynamics of oral oxycodone in
... of noroxycodone to ␣- and -noroxycodol and reduction of oxymorphone to ␣- and -oxymorphol are feasible. There is no available information on the opioid receptor binding characteristics of these reduced metabolites. Some or all of these primary and secondary metabolites of oxycodone may contribute ...
... of noroxycodone to ␣- and -noroxycodol and reduction of oxymorphone to ␣- and -oxymorphol are feasible. There is no available information on the opioid receptor binding characteristics of these reduced metabolites. Some or all of these primary and secondary metabolites of oxycodone may contribute ...
KHAT (CATHA EDULIS) A CONTROVERSIAL PLANT: BLESSING
... Retardation of growth rate was considered to be due to decreased absorption of food and not to decreased food consumption. In pregnant rats, khat reduced food consumption and maternal weight gain (Maitai, 1977; Islam et al. 1994). Many reports have confirmed enhanced locomotor activity with enhanced ...
... Retardation of growth rate was considered to be due to decreased absorption of food and not to decreased food consumption. In pregnant rats, khat reduced food consumption and maternal weight gain (Maitai, 1977; Islam et al. 1994). Many reports have confirmed enhanced locomotor activity with enhanced ...
THE AMERICAN UNIVERSITY IN CAIRO School of Sciences and Engineering
... Abstract Curcumin (Cur.) is a well known traditional medicine due to its anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been extensively studied to investigate its use in clinical and therapeutic applications. However, its low water solubility ...
... Abstract Curcumin (Cur.) is a well known traditional medicine due to its anti-inflammatory and antioxidant properties. Its pharmacological mechanism of action and safety have been extensively studied to investigate its use in clinical and therapeutic applications. However, its low water solubility ...
SLEEP
... non-REM sleep. It has long been known that drugs such as amphetamine and cocaine, which enhance the release or synaptic concentrations of DA and NE, dramatically enhance and prolong wakefulness. Acetylcholine is released from nerve terminals in the thalamus and cortex in highest concentrations in as ...
... non-REM sleep. It has long been known that drugs such as amphetamine and cocaine, which enhance the release or synaptic concentrations of DA and NE, dramatically enhance and prolong wakefulness. Acetylcholine is released from nerve terminals in the thalamus and cortex in highest concentrations in as ...
R A EVIEW RTICLE
... Nicotine increases heart rate and myocardial contractility, constricts some blood vessels, and transiently increases blood pressure. For additional details and references, the reader is referred to another recent review.[3] With prolonged or repeated exposures to nicotine, many nicotine receptors be ...
... Nicotine increases heart rate and myocardial contractility, constricts some blood vessels, and transiently increases blood pressure. For additional details and references, the reader is referred to another recent review.[3] With prolonged or repeated exposures to nicotine, many nicotine receptors be ...
Ann N Y Acad Sci
... pain, successful long-term treatment is more difficult than for acute pain. Most often acute pain is nociceptive, whereas chronic pain can be nociceptive (i.e., in response to noxious stimuli), neuropathic (i.e., initiated by a primary lesion or dysfunction in the nervous system) or mixed in origin. ...
... pain, successful long-term treatment is more difficult than for acute pain. Most often acute pain is nociceptive, whereas chronic pain can be nociceptive (i.e., in response to noxious stimuli), neuropathic (i.e., initiated by a primary lesion or dysfunction in the nervous system) or mixed in origin. ...
Print - Circulation
... at the transcriptional and protein levels.7 Biochemical evidence and physiological evidence for a myocardial H⫹/K⫹ATPase have also been found.8 Furthermore, Beisvag and coworkers7 showed a contribution from the H⫹/K⫹-ATPase of ⬇25% of total 86Rb⫹ uptake in rat hearts and suggested that the enzyme co ...
... at the transcriptional and protein levels.7 Biochemical evidence and physiological evidence for a myocardial H⫹/K⫹ATPase have also been found.8 Furthermore, Beisvag and coworkers7 showed a contribution from the H⫹/K⫹-ATPase of ⬇25% of total 86Rb⫹ uptake in rat hearts and suggested that the enzyme co ...
- International Journal of Pharmaceutical Sciences and
... drugs or excipient in the final product. Opacifiers such as titanium dioxide and magnesium oxide are also included to provide whiteness to the final product. Glidants: Improve the flow property of material from hopper to the die cavity by reducing interparticulate friction. Colloidal silica, that is ...
... drugs or excipient in the final product. Opacifiers such as titanium dioxide and magnesium oxide are also included to provide whiteness to the final product. Glidants: Improve the flow property of material from hopper to the die cavity by reducing interparticulate friction. Colloidal silica, that is ...
The Science of Megestrol Acetate Delivery | SpringerLink
... decrease food intake in animal models, progestational agents such as megestrol acetate antagonize this effect.[40] ...
... decrease food intake in animal models, progestational agents such as megestrol acetate antagonize this effect.[40] ...
Artemisia annua(Sweet Annie), Other Artemisia Species, Artemisinin
... creating a powerful free radical form of the artemisinin, which then attacks parasite proteins without harming the host.9 It appears to be a very targeted oxidative agent, and one that is not cyclically oxidized and reduced. Artemisinins actually appear to work against multiple forms of the parasite ...
... creating a powerful free radical form of the artemisinin, which then attacks parasite proteins without harming the host.9 It appears to be a very targeted oxidative agent, and one that is not cyclically oxidized and reduced. Artemisinins actually appear to work against multiple forms of the parasite ...
Aminoglycosides
... - Conc. of Amgl.s in CSF with parenteral administ. usually are subtherapeutic ( Concentration in CSF is< 10% of plasma & ↑ to 25% in meningitis and intrathecal & intraventricular administration of Amgl.s and can achieve therapeutic levels) . ...
... - Conc. of Amgl.s in CSF with parenteral administ. usually are subtherapeutic ( Concentration in CSF is< 10% of plasma & ↑ to 25% in meningitis and intrathecal & intraventricular administration of Amgl.s and can achieve therapeutic levels) . ...
Oxycodone - Thblack.com
... were given diclofenac sodium 1 mg/kg intramuscularly and dexamethasone 8 mg twice a day. The oxycodone bolus was set at 0.03 mg/kg and that of tramadol was ten-fold higher, the lockout-time was 5 min. Pain was assessed at rest and during activity (mouth opening) before and after loading, at 2 h afte ...
... were given diclofenac sodium 1 mg/kg intramuscularly and dexamethasone 8 mg twice a day. The oxycodone bolus was set at 0.03 mg/kg and that of tramadol was ten-fold higher, the lockout-time was 5 min. Pain was assessed at rest and during activity (mouth opening) before and after loading, at 2 h afte ...
Nasal Drug Delivery
... because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate impl ...
... because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate impl ...
PRODUCT MONOGRAPH UNIPHYL Theophylline Sustained
... serum theophylline levels measured which would enable doses and dosing regimens to be tailored for each patient in order to maintain therapeutic levels, ensure optimal clinical response and avoid toxicity. The incidence of adverse reactions increases at theophylline levels greater than 15 mcg/mL (82 ...
... serum theophylline levels measured which would enable doses and dosing regimens to be tailored for each patient in order to maintain therapeutic levels, ensure optimal clinical response and avoid toxicity. The incidence of adverse reactions increases at theophylline levels greater than 15 mcg/mL (82 ...
P M harmacist’s anual
... This pharmacist’s manual is intended to summarize and explain the basic requirements for prescribing, administering, and dispensing controlled substances under the Controlled Substances Act (CSA), Title 21 United States Code (21 U.S.C.) 801-971 and the DEA regulations, Title 21, Code of Federal Regu ...
... This pharmacist’s manual is intended to summarize and explain the basic requirements for prescribing, administering, and dispensing controlled substances under the Controlled Substances Act (CSA), Title 21 United States Code (21 U.S.C.) 801-971 and the DEA regulations, Title 21, Code of Federal Regu ...
Effects of grapefruit juice on the pharmacokinetics of selected
... juice to interact with the CYP3A4 substrates buspirone, cisapride, simvastatin, atorvastatin, and pravastatin was studied in healthy human volunteers in randomized cross-over studies. In addition, the effect of grapefruit juice dose in pharmacokinetic interaction and the duration of grapefruit juice ...
... juice to interact with the CYP3A4 substrates buspirone, cisapride, simvastatin, atorvastatin, and pravastatin was studied in healthy human volunteers in randomized cross-over studies. In addition, the effect of grapefruit juice dose in pharmacokinetic interaction and the duration of grapefruit juice ...
Psychopharmacology
Psychopharmacology (from Greek ψῡχή, psȳkhē, ""breath, life, soul""; φάρμακον, pharmakon, ""drug""; and -λογία, -logia) is the scientific study of the effects drugs have on mood, sensation, thinking, and behavior. It is distinguished from neuropsychopharmacology, which emphasizes the correlation between drug-induced changes in the functioning of cells in the nervous system and changes in consciousness and behavior.The field of psychopharmacology studies a wide range of substances with various types of psychoactive properties, focusing primarily on the chemical interactions with the brain.Psychoactive drugs interact with particular target sites or receptors found in the nervous system to induce widespread changes in physiological or psychological functions. The specific interaction between drugs and their receptors is referred to as ""drug action"", and the widespread changes in physiological or psychological function is referred to as ""drug effect"". These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical synthesis in the laboratory.