Ketone body metabolism and cardiovascular disease - AJP
... Beyond. Other articles appearing in this collection, as well as a full archive of all collections, can be found online at http:// ajpheart.physiology.org/. ...
... Beyond. Other articles appearing in this collection, as well as a full archive of all collections, can be found online at http:// ajpheart.physiology.org/. ...
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... including inflammation, innate immunity, and cell fate transitions [9]. Abnormalities in any of these metabolic or signaling functions can be directly or indirectly linked to a growing number of diseases, ranging from rare genetic disorders (e.g., Zellweger syndrome, X-linked adrenoleukodystrophy, a ...
... including inflammation, innate immunity, and cell fate transitions [9]. Abnormalities in any of these metabolic or signaling functions can be directly or indirectly linked to a growing number of diseases, ranging from rare genetic disorders (e.g., Zellweger syndrome, X-linked adrenoleukodystrophy, a ...
Title of Document: HIGH-THROUGHPUT TIME-SERIES
... university rules and schedule conflict Prof. Quackenbush could not be part of the final official committee I am really thankful to him for all his suggestions during the course of the PhD and allowing us to work in his lab for doing the extractions. I would also specially like to thank Prof. Wang, P ...
... university rules and schedule conflict Prof. Quackenbush could not be part of the final official committee I am really thankful to him for all his suggestions during the course of the PhD and allowing us to work in his lab for doing the extractions. I would also specially like to thank Prof. Wang, P ...
CYP 2D6 Polymorphism
... As a specific, endogen activator of RXR, 5β-pregnane3,20-dione has been identified. In contrast, PXR is much less specific and is activated by glucocorticoids as well as by anti-glucocorticoids. Conversely, the unspecific constitutive androgen receptor (CAR) is found in the cytoplasm and dimerizes w ...
... As a specific, endogen activator of RXR, 5β-pregnane3,20-dione has been identified. In contrast, PXR is much less specific and is activated by glucocorticoids as well as by anti-glucocorticoids. Conversely, the unspecific constitutive androgen receptor (CAR) is found in the cytoplasm and dimerizes w ...
Cytochrome P450 and Polymorphism - uni
... CYP 2D6 poor metabolizers in 5-8 % of the european, 10 % of the caucasian, and <1% of the japanese population. Over expression (gene duplication) among parts of the african and oriental population. CYP 3A4 only few mutations ...
... CYP 2D6 poor metabolizers in 5-8 % of the european, 10 % of the caucasian, and <1% of the japanese population. Over expression (gene duplication) among parts of the african and oriental population. CYP 3A4 only few mutations ...
Electron Transport Chains of Lactic Acid Bacteria
... extracellular electron acceptors, via an electron transport chain (ETC) that can generate a proton motive force (PMF). This is in contrast to fermentation, defined as the oxidation of organic compounds using endogenous electron acceptors that are usually catabolic intermediates of the same organic c ...
... extracellular electron acceptors, via an electron transport chain (ETC) that can generate a proton motive force (PMF). This is in contrast to fermentation, defined as the oxidation of organic compounds using endogenous electron acceptors that are usually catabolic intermediates of the same organic c ...
Elucidation and Modulation of CEB Metabolism in Fischer 344 Rats
... activity towards some xenobiotic. The liver receives blood from the splanchnic area which contains not only nutrients but various foreign substances, or xenobiotics, as well. These compounds are metabolized by the liver prior to release into the systemic circulation. Other tissues involved in biotra ...
... activity towards some xenobiotic. The liver receives blood from the splanchnic area which contains not only nutrients but various foreign substances, or xenobiotics, as well. These compounds are metabolized by the liver prior to release into the systemic circulation. Other tissues involved in biotra ...
Journal of Applied Microbiology
... phenotypic and genetic characteristics (De Boer et al. 1987; Fessehaie et al. 2002). Erwinia c. betavasculorum and E. c. wasabiae also define groups of similar strains and cause soft rot of sugar beet and Japanese horseradish, respectively (Thomson et al. 1981; Goto and Matsumoto 1987). Some strains ...
... phenotypic and genetic characteristics (De Boer et al. 1987; Fessehaie et al. 2002). Erwinia c. betavasculorum and E. c. wasabiae also define groups of similar strains and cause soft rot of sugar beet and Japanese horseradish, respectively (Thomson et al. 1981; Goto and Matsumoto 1987). Some strains ...
619Kb
... of 2,3-oxidosqualene. During this process, internal bonds are introduced into the oxidosqualene backbone, resulting in the formation of predominantly polycyclic molecules containing varying numbers of 5- and 6-membered rings. The high number of possibilities for establishing different internal linka ...
... of 2,3-oxidosqualene. During this process, internal bonds are introduced into the oxidosqualene backbone, resulting in the formation of predominantly polycyclic molecules containing varying numbers of 5- and 6-membered rings. The high number of possibilities for establishing different internal linka ...
Ch23-Oxidation of Fatty Acids and Ketone Bodies
... Carnitine serves as the carrier that transports activated long chain fatty acyl groups across the inner mitochondrial membrane (Fig. 23.4). Carnitine acyl transferases are able to reversibly transfer an activated fatty acyl group from CoA to the hydroxyl group of carnitine to form an acylcarnitine e ...
... Carnitine serves as the carrier that transports activated long chain fatty acyl groups across the inner mitochondrial membrane (Fig. 23.4). Carnitine acyl transferases are able to reversibly transfer an activated fatty acyl group from CoA to the hydroxyl group of carnitine to form an acylcarnitine e ...
Production of L-(+) Lactic Acid From Blackstrap Molasses by
... prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order. ...
... prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order. ...
carboxylesterase 1 plays an essential role in non
... factors including dietary fat, genetic predisposition, gut microbiome and metabolic disorders such as type 2 diabetes, obesity and cardiovascular diseases can often contribute to the development of NAFLD. Hepatic steatosis is a hallmark in NAFLD and is often associated with disrupted glucose and lip ...
... factors including dietary fat, genetic predisposition, gut microbiome and metabolic disorders such as type 2 diabetes, obesity and cardiovascular diseases can often contribute to the development of NAFLD. Hepatic steatosis is a hallmark in NAFLD and is often associated with disrupted glucose and lip ...
Suberin biosynthesis in O. sativa: characterisation of a cytochrome
... An organism is defined to be alive when it features certain characteristics: It has to have the ability to reproduce itself, a metabolism to absorb and convert energy from the environment and to build its own components, it has to be discrete from its surrounding media, and maintain its homoeostasis ...
... An organism is defined to be alive when it features certain characteristics: It has to have the ability to reproduce itself, a metabolism to absorb and convert energy from the environment and to build its own components, it has to be discrete from its surrounding media, and maintain its homoeostasis ...
Mechanism of citric acid accumulation by Aspergillus niger in solid
... and, possibly, NAD-and NADP-specific isocitrate dehydrogenases in the parents. Although most other enzymes decreased their activities during the later phase of cultivation, there was no definite difference between each parent and its mutant. However, oxaloacetate hydrolase, for oxalate formation, wa ...
... and, possibly, NAD-and NADP-specific isocitrate dehydrogenases in the parents. Although most other enzymes decreased their activities during the later phase of cultivation, there was no definite difference between each parent and its mutant. However, oxaloacetate hydrolase, for oxalate formation, wa ...
Enzymes responsible for chlorate reduction by Pseudomonas sp
... Thauera selenatis and to other reductases, dehydrogenases, and heme proteins based on sequencing data. However, these enzymes differ in their physical and biochemical properties, suggesting that a wide variety of enzymes may catalyze chlorate and perchlorate reduction. Pseudomonas sp. PDA is a relati ...
... Thauera selenatis and to other reductases, dehydrogenases, and heme proteins based on sequencing data. However, these enzymes differ in their physical and biochemical properties, suggesting that a wide variety of enzymes may catalyze chlorate and perchlorate reduction. Pseudomonas sp. PDA is a relati ...
Evolution of Conifer Diterpene Synthases
... bicyclization of GGPP followed by rearrangement of a (+)-copalyl diphosphate intermediate at two discrete class II and class I active sites. In contrast, similar diterpenes of gibberellin primary (i.e. general) metabolism are produced by the consecutive activity of two monofunctional class II and cl ...
... bicyclization of GGPP followed by rearrangement of a (+)-copalyl diphosphate intermediate at two discrete class II and class I active sites. In contrast, similar diterpenes of gibberellin primary (i.e. general) metabolism are produced by the consecutive activity of two monofunctional class II and cl ...
Effect of micellar p-sitosterol on cholesterol
... psitosterol was appreciated and the transport of the plant sterol to the basolateral medium was negligible. Cholesterol synthesis and HMGCoA reductase activities were decreased in cells incubated with p-sitosterol. This was associated with a decrease in reductase mass and mRNA levels. Cholesteryl es ...
... psitosterol was appreciated and the transport of the plant sterol to the basolateral medium was negligible. Cholesterol synthesis and HMGCoA reductase activities were decreased in cells incubated with p-sitosterol. This was associated with a decrease in reductase mass and mRNA levels. Cholesteryl es ...
Molecular Mechanisms of Inhibition of Streptococcus Species by
... been reported to be hydrophobic while their avirulent counterpart strains lacked this feature [57–60]. Studies have shown that S. pneumoniae adheres to abiotic surfaces, e.g., polystyrene or glass, and forms three-dimensional biofilm structures that are about 25 micrometers deep [34]. This three-dim ...
... been reported to be hydrophobic while their avirulent counterpart strains lacked this feature [57–60]. Studies have shown that S. pneumoniae adheres to abiotic surfaces, e.g., polystyrene or glass, and forms three-dimensional biofilm structures that are about 25 micrometers deep [34]. This three-dim ...
Molecular and biochemical characterization of cytosolic
... interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P), with glucose 1,6-bisphosphate (G16BP) being a cofactor in this reaction (Ray et al., 1983). In plant tissues, PGM is present in the cytosol and the plastid (MuÈhlbach and Schnarrenberger, 1978; Sangwan and Singh, 1987; Popov ...
... interconversion of glucose 1-phosphate (G1P) and glucose 6-phosphate (G6P), with glucose 1,6-bisphosphate (G16BP) being a cofactor in this reaction (Ray et al., 1983). In plant tissues, PGM is present in the cytosol and the plastid (MuÈhlbach and Schnarrenberger, 1978; Sangwan and Singh, 1987; Popov ...
Fructose, Glucocorticoids and Adipose Tissue: Implications for the
... and locally produced glucocorticoids have a crucial role in modulating adipocyte function as well as proliferation/differentiation [26,27]. The intracellular active glucocorticoids (cortisol and corticosterone are the major glucocorticoids in humans and rodents, respectively) are generated from thei ...
... and locally produced glucocorticoids have a crucial role in modulating adipocyte function as well as proliferation/differentiation [26,27]. The intracellular active glucocorticoids (cortisol and corticosterone are the major glucocorticoids in humans and rodents, respectively) are generated from thei ...
Bile acids activate ryanodine receptors in pancreatic acinar cells via
... Article history: Received 22 December 2014 Received in revised form 10 March 2015 Accepted 30 March 2015 Available online xxx Keywords: Ryanodine receptor SERCA Calcium release Pancreas Pancreatitis Bile acid ...
... Article history: Received 22 December 2014 Received in revised form 10 March 2015 Accepted 30 March 2015 Available online xxx Keywords: Ryanodine receptor SERCA Calcium release Pancreas Pancreatitis Bile acid ...
Roles of the Methylcitrate and Methylmalonyl
... uses a bifunctional isocitrate lyase/methylisocitrate lyase (ICL/MCL), is one of the two routes for metabolism of propionyl-CoA. A mutant strain of M. tuberculosis lacking the ICL/MCL was rapidly cleared from the lungs of infected mice. However, the upstream enzymes of this pathway have been demonst ...
... uses a bifunctional isocitrate lyase/methylisocitrate lyase (ICL/MCL), is one of the two routes for metabolism of propionyl-CoA. A mutant strain of M. tuberculosis lacking the ICL/MCL was rapidly cleared from the lungs of infected mice. However, the upstream enzymes of this pathway have been demonst ...
Gene Section GAST (gastrin) Atlas of Genetics and Cytogenetics
... sites. PC1/3 is active early in the secretory pathway in granules with a neutral pH (i.e., pH ≈ 7) and cleaves the prohormone after the arginine 36-arginine 37 and arginine 73-arginine 74 sequences, releasing the Cterminal flanking peptide, and generating G34. The post-cleavage residual basic residu ...
... sites. PC1/3 is active early in the secretory pathway in granules with a neutral pH (i.e., pH ≈ 7) and cleaves the prohormone after the arginine 36-arginine 37 and arginine 73-arginine 74 sequences, releasing the Cterminal flanking peptide, and generating G34. The post-cleavage residual basic residu ...
Characterization of NAD Salvage Pathways and their Role in
... primarily responsible for nicotinamide riboside import. Furthermore, a pnuC mutant is ...
... primarily responsible for nicotinamide riboside import. Furthermore, a pnuC mutant is ...
Fructose Intake from Sugar-Sweetened Beverages
... of high fructose corn syrup (HFCS). In New Zealand, sucrose from cane sugar is the main source of added sugar in processed foods. Along with free fructose in ripe fruit, sucrose is the main source of fructose in the New Zealand diet (1). HFCS is not widely used in New Zealand and is most commonly fo ...
... of high fructose corn syrup (HFCS). In New Zealand, sucrose from cane sugar is the main source of added sugar in processed foods. Along with free fructose in ripe fruit, sucrose is the main source of fructose in the New Zealand diet (1). HFCS is not widely used in New Zealand and is most commonly fo ...