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Supplementary Table 1. Genes of Mycobacterium sp. 012931 involved in virulence, disease and defense
category.
Categories/Genes
Number
Resistance to antibiotics and toxic compounds
42
Copper homeostasis
9
Multicopper oxidase
3
Lead, cadmium, zinc and mercury transporting ATPase
3
Copper chaperone
2
Copper resistance protein D
1
Bile hydrolysis
4
Bile acid 7-alpha dehydratase BaiE (EC 4.2.1.106)
2
Choloylglycine hydrolase
1
Alpha-ketoglutarate-dependent taurine dioxygenase
1
Cobalt-zinc-cadmium resistance
5
Transcriptional regulator, MerR family
3
Cobalt-zinc-cadmium resistance protein CzcD
2
Resistance to fluoroquinolones
2
DNA gyrase subunit A
1
DNA gyrase subunit B
1
Arsenic resistance
8
Arsenical pump-driving ATPase
3
Arsenate reductase
3
Arsenical resistance operon repressor
1
Arsenic efflux pump protein
1
Beta-lactamase
11
Beta-lactamase class A
6
Beta-lactamase class C and other penicillin binding proteins
2
Beta-lactamase class A
2
Metal-dependent hydrolases of the beta-lactamase superfamily III
1
Mercuric reductase
3
FAD-dependent NAD(P)-disulphide oxidoreductase
Invasion and intracellular resistance
Mycobacterium virulence operon involved in an unknown function with a Jag Protein and YidC and
YidD
3
129
2
RNA-binding protein Jag
1
Inner membrane protein translocase component YidC, long form
1
Mycobacterium virulence operon involved in an Esx-1 secretion system
4
ESX-1 secretion system protein (Rv3616c)
2
Highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for
Mycobacterium tuberculosis infection
1
ESX-1 secreted protein regulator EspR
1
Mycobacterium virulence operon possibly involved in quinolinate biosynthesis
3
L-aspartate oxidase
1
Quinolinate synthetase
1
Quinolinate phosphoribosyltransferase [decarboxylating]
1
PPE gene cluster in Mycobacteria
38
PE-PGRS family protein
28
NADH dehydrogenase
4
Type VII secretion AAA-ATPase EccA
1
Type VII secretion protein EccE
1
Type VII secretion-associated serine protease mycosin
1
Type VII secretion integral membrane protein EccD
1
PE family protein
1
Mg(2+) transport ATPase protein C
1
Mycobacterium virulence operon involved in DNA transcription
2
DNA-directed RNA polymerase beta subunit
Mycobacterium virulence operon involved in protein synthesis (SSU ribosomal proteins)
2
5
Translation elongation factor Tu
1
Translation elongation factor G
1
SSU ribosomal protein S7p
1
SSU ribosomal protein S12p
1
Membrane protein
1
Mycobacterium virulence operon involved in fatty acids biosynthesis
6
Propionyl-CoA carboxylase beta chain
3
3-oxoacyl-[acyl-carrier-protein] synthase, KASII
3
Mycobacterium virulence operon involved in lipid metabolism
4
Fatty acid desaturase occurring in virulence cluster
3
tRNA dihydrouridine synthase B
1
Mycobacterium virulence operon involved in protein synthesis (LSU ribosomal proteins)
3
Translation initiation factor 3
1
LSU ribosomal protein L20p
1
LSU ribosomal protein L35p
1
Mycobacterium virulence operon MCE involved in cell invasion
59
MCE-family protein Mce1F
8
MCE-family lipoprotein LprK (MCE-family lipoprotein Mce1e)
7
MCE-family protein Mce1A
7
MCE-family protein Mce1B
7
MCE-family protein Mce1C
7
Conserved hypothetical integral membrane protein YrbE1B
7
Conserved hypothetical integral membrane protein YrbE1A
6
Mycobacterium virulence operon involved in an unknown function with Superoxide dismutase
3
Conserved MCE associated membrane protein
2
Conserved MCE associated protein
1
Conserved MCE associated transmembrane protein
1
Superoxide dismutase [Mn/Fe]
1
Conserved transmembrane protein
1
FIG017534: hypothetical protein
1
Mycobacterium virulence operon involved in an unknown function with Superoxide dismutase
3
Superoxide dismutase [Mn/Fe] (EC 1.15.1.1)
1
Conserved transmembrane protein
1
FIG017534: hypothetical protein
1
Total
171