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1
Table 1 A selection of most recent studies that used different endogenous miRNAs
and snRNAs for the data normalization
Disease
No. of
miRNAs of interest
source reference
patients
Acute stroke
136
Ref.
RNAs
miR-106b-5P, miR-4306,
plasma RNU-6B
(1)
(2)
miR-320e
Aortic stenosis
112
miR-1, miR-133, miR-378
plasma RNU-6
Atrial fibrillation
112
miR-21, miR-150
tissue, SNORD61, (3)
plasma SNORD95,
RNU6-2
Biliary cirrhosis
207
miR-505-3p, miR-197-3p
serum
miR-24
(4)
Bladder cancer
188
miR-210, miR-10b, miR-29c
urine
RNU-6
(5)
miR-221, miR-23a
Bladder cancer
126
miR-26a
tissue
RNU-6
(6)
Bladder cancer
114
miR-141
tissue
miR-148b,
(7)
miR-181b,
miR-874
Bladder cancer
250
miR‑148b‑3p
serum
miR‑193a‑5p (8)
miR‑16‑5p
Bowel Disease
119
miR-1246, miR-142-5p,
serum
miR-484
(9)
tissue
RNU-6,
(10)
miR-143, miR-595
Breast cancer
230
miR-10b
SNORD-68
Breast cancer
110
miR-127
tissue
RNU6
(11)
Breast cancer
168
miR-101, miR-372, miR-373
serum
miR-16,
(12)
miR-484
Breast cancer
172
miR-200c
tissue
RNU48
(13)
Breast cancer
232
miR-1280, miR-1260,
blood
miR-16
(14)
serum
miR-16,
(15)
miR-720
Breast cancer
127
miR-21, miR-210, miR-373
miR-484
Cervical cancer
133
miR-126
tissue
RNU-6B
(16)
Chronic hepatitis B
131
miR-122, MiR-124
serum
5S rRNA
(17)
2
Colorectal cancer
146
miR-155
serum
miR-16
(18)
Colorectal cancer
126
miR-196a, miR-196b
tissue
RNU-6
(19)
Colorectal cancer
158
miR-92a
tissue
RNU-6B
(20)
Colorectal cancer
245
miR-29
tissue
RNU-6B
(21)
Colorectal cancer
126
miR-15a, miR-16
tissue
RNU-6
(22)
Colorectal cancer
268
miR-34a-5p
tissue
RNU-6B
(23)
Colorectal cancer
190
miR-19a-3p, miR-223-3p,
serum
miR-191-5p (24)
miR-92a-3p
Colorectal cancer
560
miR-126
RNU-6
tissue
miR-103
(25)
miR-16
Colorectal cancer
169
miR-133a
tissue
RNU-6
(26)
Diabetic retinopathy
180
miR-21, miR-181c, miR-1179 serum
RNU-6
(27)
Epithelial ovarian cancer
211
let-7a
tissue
RNU48
(28)
Epithelial ovarian cancer
109
miR-22
tissue
RNU-6
(29)
miR-100
tissue
RNU-6B
(30)
Esophageal squamous cell 120
cancer
Glioma
162
miR-134
tissue
RNU-6B
(31)
Heart transplant rejection
113
miR-10a, miR-21, miR-31
serum
RNU48
(32)
Hepatocellular cancer
122
miR-122
serum
miR-16
(33)
Hepatocellular cancer
120
miR-34a
tissue
RNU-6
(34)
Hepatocellular cancer
104
miR-106
tissue
RNU-6
(35)
Hepatocellular cancer
180
miR-138
tissue
RNU-6B
(36)
Hepatocellular cancer
494
miR-206, miR-141-3p,
serum
miR-24
(37)
miR-433-3p
Hepatocellular cancer
50
In-stent restenosis
181
miR-21, miR-143, miR-145
plasma RNU-6
(38)
Lung cancer
155
miR-21, miR-31, miR-210
sputum miR-16,
(39)
RNU-6
Melanoma
283
miR-150, miR-15b, miR-425
serum
miR-30c-5p, (40)
miR-181a-5p
Multiple myeloma
103
miR-19a, miR-92a,
serum
miR-423-5
(41)
serum
miR-451-5p (42)
serum
RNU-6
miR-214-3p
Neovascular age-related
129
miR-301-3p, miR-361-5p,
Macular Degeneration
miR-424-5p
Non-small cell lung cancer 300
miR-152, miR-148a,
miR-148b
(43)
3
Non-small cell lung cancer 168
miR-20a, miR-145, miR-21
plasma miR-16
(44)
Non-small cell lung cancer 115
miR-224
tissue
RNU-6
(45)
Non-small cell lung cancer 137
miR-107
tissue
RNU-6
(46)
Osteosarcoma
166
miR-195
serum
RNU6
(47)
Papillary thyroid cancer
248
miR-146a, miR-146b
tissue
RNU-6
(48)
Premature ovarian failure
140
let-7b-5p, let-7c, miR-22-3p
plasma miR-16
(49)
Pre-eclampsia
115
miR-126
tissue
RNU-6
(50)
Renal cell cancer
107
miR-193a-3p, miR-362,
tissue
let-7d, let-7g (51)
miR-572
let-7i
This table represents different reference microRNAs that have been used for microRNA data
normalization. This table only contains most recent studies with more than 100 patients. If
several microRNAs were quantified in a study, only three microRNAs were specified.
Accordingly, this table is not meant to be comprehensive and is based on our own view.
4
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