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Gaustad Neuroscience Network (GNN) CMBN and GNN minisymposium February 4-5, 2008: Biology of Aging and Neurodegeneration – Focus on Genome Dynamics Venue: February 4 - Seminar room B1.1017 and February 5 - Auditorium 1 Green, Rikshospitalet, Oslo, Norway Sign up before January 31 to Helene Wold Ranum at [email protected] All talks are 15 min + 5 min discussion. The program might be subject to small adjustments. Monday February 4 9:00 Welcome – Tone Tønjum, CMBN and University of Oslo 9:05 Vilhelm A. Bohr, Laboratory of Molecular gerontology, National Inst. on Aging (NIA), National Institutes of Health (NIH), US DNA Repair, premature aging and neurodegeneration 9:30 Tinna Stevnsner, University of Århus, Denmark Aging aspects of mitochondrial repair 9:50 Coffee 10:15 Arne Klungland/Line Nordstrand, CMBN: Distinct roles of the ALkB family of dioxygenases for demethylating DNA, RNA and protein 10:35 Magnar Bjørås, CMBN Base excision repair of oxidative DNA damage 10:55 Ingrun Alseth, CMBN: Functional characterisation of genetic alterations in DNA glycosylase genes in patients with primary sclerosing cholangitis and cholangiocarsinoma 11:15 Tone Tønjum / Tonje Davidsen, CMBN Genome dynamics in CNS pathogenesis 12:00-13:00 Lunch 13:00 Ole Petter Ottersen, CMBN Maintaining brain water homeostasis 13:20 Mahmood Amiry-Moghaddam, CMBN Mechanisms governing expression of AQP4 13:40 Elise Rundèn-Pran, CMBN: DNA repair in relation to ischemic brain damage 14:00 Farrukh A. Chaudhry, Biotechnology Center of Oslo and CMBN Functional roles of amino acid transporters in neuronal signaling 14:20 Coffee 14:40 Thomas Espeseth/Ivar Reinvang, Department of Psychology, University of Oslo: Neurogenetics of brain structure and function in aging 15:00 Trygve Leergaard / Jan Bjaalie, CMBN: Localization of function: multimodality imaging and atlasing in rat brain under health and disease 15:30 Meet the speaker – graduate students and postdocs 16:30 Pizza and beverages at Rikshospitalet Tuesday February 5 9:00 Introduction – Vilhelm A. Bohr, NIA/NIH 9:05 David Wilson III, NIA, NIH Roles of core and auxiliary base excision DNA repair proteins 9:25 Yie Liu, NIA, NIH The role of BER in telomere maintenance in vivo 9:45 Alexander D. Rowe /Torbjørn Rognes, CMBN: The role of FEN1 in CAG-repeat expansion in transgenic Huntington mice 10:05 Coffee break 10:30 Herman Ambur, CMBN: DNA signatures in evolution: News on DUS 10:50 Stephan A. Frye, CMBN: Compensation for genetic isolation in Mycobacterium tuberculosis 11:20 Vidar Gundersen, CMBN and Rikshospitalet: Drugs affecting glutamate signalling in clinical neurology 12:00–13:00 Lunch 13:00 Panel discussion – Forefront visions in science & technology - Burning scientific topics. Open questions? What are the new technologies, and how do we exploit them? 13:45 Concluding remarks – Vilhelm A. Bohr, Ole Petter Ottersen and Tone Tønjum 14:00 Meeting ends, but the discussions go on…