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when a bone breaks it takes a lot of strength from the organism to fix it facts questions bones are designed to What kind of chemical break when put under a signals do the brain send great amount of pressure out? when a bone is broken, its cartilage breaks and It sends out endorphins to cause 100s of blood kill the pain for a few vessels to break minutes the cartilage sends nervous messages to the brain, and the brain sends back natural pain killers called endorphins endorphins are amino acids after 10 minutes the endorphins were off and the body feels incredible pain blood cells called platelets lock together to try and heal the wound tissues around the fracture send out chemical signals stem cells are responsible for replacing dead and damaged tissue.