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NAVBO's Vascular Biology Publication Alert
April 2016 Issue (papers published in March 2016)
NAVBO Members are highlighted in dark red
The American Journal of Pathology
Yuhua Wang, Emmanuel Tadjuidje, Ram Naresh Pandey, James A. Stefater III, Lois E.H. Smith, Richard A. Lang,
Rashmi S. Hegde. The Eyes Absent Proteins in Developmental and Pathological Angiogenesis. Am J Pathol.,
186(3):568–578
Weixin Zhou, Yang Jo Chung, Edgardo R. Parrilla Castellar, Ying Zheng, Hye-Jung Chung, Russell Bandle, Juhong
Liu, Lino Tessarollo, Eric Batchelor, Peter D. Aplan, David Levens. Far Upstream Element Binding Protein Plays a
Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels. Am J
Pathol., 186(3):701–715
Biochemical Journal
No vascular biology related publications this month
Blood
A. A. Alhasan, O. G. Izuogu, H. H. Al-Balool, J. S. Steyn, A. Evans, M. Colzani, C. Ghevaert, J. C. Mountford, L.
Marenah, D. J. Elliott, M. Santibanez-Koref and M. S. Jackson. Circular RNA enrichment in platelets is a
signature of transcriptome degradation. Blood, 127:e1-e11
E. Bianchi, R. Norfo, V. Pennucci, R. Zini and R. Manfredini. Genomic landscape of megakaryopoiesis and
platelet function defects. Blood, 127:1249-1259
C. E. Evans, P. O. Bendahl, M. Belting, C. Branco and R. S. Johnson. Diverse roles of cell-specific hypoxiainducible factor 1 in cancer-associated hypercoagulation. Blood, 127:1355-1360
Y. Hou, Q. Feng, M. Xu, G. S. Li, X. N. Liu, Z. Sheng, H. Zhou, J. Ma, Y. Wei, Y. X. Sun, Y. Y. Yu, J. H. Qiu, L. L. Shao,
X. G. Liu, M. Hou and J. Peng. High-dose dexamethasone corrects impaired myeloid-derived suppressor cell
function via Ets1 in immune thrombocytopenia. Blood, 127:1587-1597
Y. Huang, S. Joshi, B. Xiang, Y. Kanaho, Z. Li, B. A. Bouchard, C. L. Moncman and S. W. Whiteheart. Arf6 controls
platelet spreading and clot retraction via integrin alphaIIbbeta3 trafficking. Blood, 127:1459-1467
P. Kaimakis, E. de Pater, C. Eich, P. Solaimani Kartalaei, M. L. Kauts, C. S. Vink, R. van der Linden, M. Jaegle, T.
Yokomizo, D. Meijer and E. Dzierzak. Functional and molecular characterization of mouse Gata2-independent
hematopoietic progenitors. Blood, 127:1426-1437
K. R. Machlus, S. K. Wu, D. J. Stumpo, T. S. Soussou, D. S. Paul, R. A. Campbell, H. Kalwa, T. Michel, W. Bergmeier,
A. S. Weyrich, P. J. Blackshear, J. H. Hartwig and J. E. Italiano, Jr. Synthesis and dephosphorylation of MARCKS
in the late stages of megakaryocyte maturation drive proplatelet formation. Blood, 127:1468-1480
V. Magarotto, S. Bringhen, M. Offidani, G. Benevolo, F. Patriarca, R. Mina, A. P. Falcone, L. De Paoli, G. Pietrantuono,
S. Gentili, C. Musolino, N. Giuliani, A. Bernardini, C. Conticello, S. Pulini, G. Ciccone, V. Maisnar, M. Ruggeri, R.
Zambello, T. Guglielmelli, A. Ledda, A. M. Liberati, V. Montefusco, R. Hajek, M. Boccadoro and A. Palumbo. Triplet
vs doublet lenalidomide-containing regimens for the treatment of elderly patients with newly diagnosed
multiple myeloma. Blood, 127:1102-1108
I. Martinelli, A. W. Lensing, S. Middeldorp, M. Levi, J. Beyer-Westendorf, B. van Bellen, H. Bounameaux, T. A.
Brighton, A. T. Cohen, M. Trajanovic, M. Gebel, P. Lam, P. S. Wells and M. H. Prins. Recurrent venous
thromboembolism and abnormal uterine bleeding with anticoagulant and hormone therapy use. Blood,
127:1417-1425
S. Matsuura, R. Mi, M. Koupenova, A. Eliades, S. Patterson, P. Toselli, J. Thon, J. E. Italiano, Jr., P. C. Trackman, N.
Papadantonakis and K. Ravid. Lysyl oxidase is associated with increased thrombosis and platelet reactivity.
Blood, 127:1493-1501
M. P. Motley, D. H. Madsen, H. J. Jurgensen, D. E. Spencer, R. Szabo, K. Holmbeck, M. J. Flick, D. A. Lawrence, F. J.
Castellino, R. Weigert and T. H. Bugge. A CCR2 macrophage endocytic pathway mediates extravascular fibrin
clearance in vivo. Blood, 127:1085-1096
N. O'Regan, K. Gegenbauer, J. M. O'Sullivan, S. Maleki, T. M. Brophy, N. Dalton, A. Chion, P. G. Fallon, G. E. Grau,
U. Budde, O. P. Smith, A. G. Craig, R. J. Preston and J. S. O'Donnell. A novel role for von Willebrand factor in the
pathogenesis of experimental cerebral malaria. Blood, 127:1192-1201
M. Palomo, E. Mir, M. Rovira, G. Escolar, E. Carreras and M. Diaz-Ricart. What is going on between defibrotide
and endothelial cells? Snapshots reveal the hot spots of their romance. Blood, 127:1719-1727
M. Y. Shen, F. Y. Chen, J. F. Hsu, R. H. Fu, C. M. Chang, C. T. Chang, C. H. Liu, J. R. Wu, A. S. Lee, H. C. Chan, J.
R. Sheu, S. Z. Lin, W. C. Shyu, T. Sawamura, K. C. Chang, C. Y. Hsu and C. H. Chen. Plasma L5 levels are
elevated in ischemic stroke patients and enhance platelet aggregation. Blood, 127:1336-1345
X. Sim, M. Poncz, P. Gadue and D. L. French. Understanding platelet generation from megakaryocytes:
implications for in vitro-derived platelets. Blood, 127:1227-1233
E. M. Sparkenbaugh, P. Chantrathammachart, K. Chandarajoti, N. Mackman, N. S. Key and R. Pawlinski. Thrombinindependent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of
sickle cell disease. Blood, 127:1371-1373
J. D. Welsh, R. W. Muthard, T. J. Stalker, J. P. Taliaferro, S. L. Diamond and L. F. Brass. A systems approach to
hemostasis: 4. How hemostatic thrombi limit the loss of plasma-borne molecules from the microvasculature.
Blood, 127:1598-1605
D. A. Wilcox. Megakaryocyte- and megakaryocyte precursor-related gene therapies. Blood, 127:1260-1268
Cancer Cell
No vascular biology related publications this month
Cancer Research
O. Argyros, T. Karampelas, X. Asvos, A. Varela, N. Sayyad, A. Papakyriakou, C. H. Davos, A. G. Tzakos, D. Fokas
and C. Tamvakopoulos. Peptide-Drug Conjugate GnRH-Sunitinib Targets Angiogenesis Selectively at the Site
of Action to Inhibit Tumor Growth. Cancer Res, 76:1181-1192
S. H. Choi, J. K. Nam, B. Y. Kim, J. Jang, Y. B. Jin, H. J. Lee, S. Park, Y. H. Ji, J. Cho and Y. J. Lee. HSPB1 Inhibits
the Endothelial-to-Mesenchymal Transition to Suppress Pulmonary Fibrosis and Lung Tumorigenesis. Cancer
Res, 76:1019-1030
D. M. Corey, Y. Rinkevich and I. L. Weissman. Dynamic Patterns of Clonal Evolution in Tumor Vasculature
Underlie Alterations in Lymphocyte-Endothelial Recognition to Foster Tumor Immune Escape. Cancer Res,
76:1348-1353
W. Wang, G. Zimmerman, X. Huang, S. Yu, J. Myers, Y. Wang, S. Moreton, J. Nthale, A. Awadallah, R. Beck, W. Xin,
D. Wald, A. Y. Huang and L. Zhou. Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute
Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function. Cancer Res,
76:1641-1652
Cell
Ingber DE. Reverse Engineering Human Pathophysiology with Organs-on-Chips. Cell, 164:1105-9
Clinical Science
Iris Schuster, Shokoufeh Mahmoodzadeh, Elke Dworatzek, Frédéric Jaisser, Smail Messaoudi, Ingo Morano, Vera
Regitz-Zagrosek. Cardiomyocyte-specific overexpression of oestrogen receptor β improves survival and
cardiac function after myocardial infarction in female and male mice. Clin Sci., 130(5):365-376
Rui Xue, Shaoqing Lei, Zhong-yuan Xia, Yang Wu, Qingtao Meng, Liying Zhan, Wating Su, Huimin Liu, Jinjin Xu,
Zhenzhen Liu, Bin Zhou, Zhengyuan Xia. Selective inhibition of PTEN preserves ischaemic post-conditioning
cardioprotection in STZ-induced Type 1 diabetic rats: role of the PI3K/Akt and JAK2/STAT3 pathways. Clin
Sci., 130(5):377-392
Ryan J. Stark, Hyehun Choi, Stephen R. Koch, Benjamin A. Fensterheim, Fred S. Lamb, Edward R. Sherwood.
Endothelial cell tolerance to lipopolysaccharide challenge is induced by monophosphoryl lipid A. Clin Sci.,
130(6):451-461
Development
S. Y. Ang, A. Uebersohn, C. I. Spencer, Y. Huang, J. E. Lee, K. Ge and B. G. Bruneau. KMT2D regulates specific
programs in heart development via histone H3 lysine 4 di-methylation. Development, 143:810-821
F. M. Bosada, V. Devasthali, K. A. Jones and K. Stankunas. Wnt/beta-catenin signaling enables developmental
transitions during valvulogenesis. Development, 143:1041-1054
M. J. Foglia and K. D. Poss. Building and re-building the heart by cardiomyocyte proliferation. Development,
143:729-740
J. Semo, J. Nicenboim and K. Yaniv. Development of the lymphatic system: new questions and paradigms.
Development, 143:924-935
P. Tandon, C. M. Wilczewski, C. E. Williams and F. L. Conlon. The Lhx9-integrin pathway is essential for
positioning of the proepicardial organ. Development, 143:831-840
W. Yu, X. Huang, X. Tian, H. Zhang, L. He, Y. Wang, Y. Nie, S. Hu, Z. Lin, B. Zhou, W. Pu, K. O. Lui and B. Zhou.
GATA4 regulates Fgf16 to promote heart repair after injury. Development, 143:936-949
Developmental Biology
A. L. Koenig, K. Baltrunaite, N. I. Bower, A. Rossi, D. Y. Stainier, B. M. Hogan and S. Sumanas. Vegfa signaling
promotes zebrafish intestinal vasculature development through endothelial cell migration from the posterior
cardinal vein. Dev Biol, 411:115-127
S. C. Kwiatkowski, A. F. Ojeda and P. Y. Lwigale. PlexinD1 is required for proper patterning of the periocular
vascular network and for the establishment of corneal avascularity during avian ocular development. Dev
Biol, 411:128-139
N. Nohata, Y. Uchida, A. N. Stratman, R. H. Adams, Y. Zheng, B. M. Weinstein, Y. S. Mukouyama and J. S. Gutkind.
Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis. Dev Biol, 411:183-194
Developmental Cell
M. H. Baron and J. Barminko. Chromatin Condensation and Enucleation in Red Blood Cells: An Open
Question. Dev Cell, 36:481-482
C-F. Pereira, B. Chang, A. Gomes, J. Bernitz, D. Papatsenko, X. Niu, G. Swiers, E. Azzoni, M. F. de Bruijn, C.
Schaniel, I. R. Lemischka and K. A. Moore. Hematopoietic Reprogramming In Vitro Informs In Vivo Identification
of Hemogenic Precursors to Definitive Hematopoietic Stem Cells. Dev Cell, 36:525-539
X. Tan, W. A. Liu, X. J. Zhang, W. Shi, S. Q. Ren, Z. Li, K. N. Brown and S. H. Shi. Vascular Influence on Ventral
Telencephalic Progenitors and Neocortical Interneuron Production. Dev Cell, 36:624-638
Developmental Dynamics
Kazenwadel J, Harvey NL. Morphogenesis of the lymphatic vasculature: A focus on new progenitors and
cellular mechanisms important for constructing lymphatic vessels. Dev Dyn., 245(3):209-19
N. El Robrini, H. C. Etchevers, L. Ryckebusch, E. Faure, N. Eudes, K. Niederreither, S. Zaffran and N. Bertrand.
Cardiac outflow morphogenesis depends on effects of retinoic acid signaling on multiple cell lineages. Dev
Dyn, 245:388-401
A. Ruiz-Villalba, S. Hoppler and M. J. van den Hoff. Wnt signaling in the heart fields: Variations on a common
theme. Dev Dyn, 245:294-306
EMBO
No vascular biology related publications this month
EMBO Reports
No vascular biology related publications this month
FASEB Journal
Aiken J, Roudier E, Ciccone J, Drouin G, Stromberg A, Vojnovic J, Olfert IM, Haas T, Gustafsson T, Grenier G, Birot
O. Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal
muscle and regulates primary endothelial cell migration and FoxO gene expression. FASEB J., 30(3):1120-34
Takyar S, Zhang Y, Haslip M, Jin L, Shan P, Zhang X, Lee PJ. An endothelial TLR4-VEGFR2 pathway mediates
lung protection against oxidant-induced injury. FASEB J., 30(3):1317-27
Martinez-Moreno JM, Herencia C, Montes de Oca A, Muñoz-Castañeda JR, Rodríguez-Ortiz ME, Díaz-Tocados JM,
Peralbo-Santaella E, Camargo A, Canalejo A, Rodriguez M, Velasco-Gimena F, Almaden Y. Vitamin D modulates
tissue factor and protease-activated receptor 2 expression in vascular smooth muscle cells. FASEB J.,
30(3):1367-76
Saddouk FZ, Sun LY, Liu YF, Jiang M, Singer DV, Backs J, Van Riper D, Ginnan R, Schwarz JJ, Singer HA.
Ca2+/calmodulin-dependent protein kinase II-γ (CaMKIIγ)negatively regulates vascular smooth muscle cell
proliferation and vascular remodeling. FASEB J., 30(3):1051-64
Zhao Y, Schwartz EA, Palmer GM, Zennadi R. MEK1/2 inhibitors reverse acute vascular occlusion in mouse
models of sickle cell disease. FASEB J., 30(3):1171-86
Kim C, Smith KE, Castillejos A, Diaz-Aguilar D, Saint-Geniez M, Connor KM. The alternative complement pathway
aids in vascular regression during the early stages of a murine model of proliferative retinopathy. FASEB J.,
30(3):1300-5
Genes & Development
No vascular biology related publications this month
Journal of Biological Chemistry
Loeven MA, Rops AL, Lehtinen MJ, van Kuppevelt TH, Daha MR, Smith RJ, Bakker M, Berden JH, Rabelink TJ,
Jokiranta TS, van der Vlag J. Mutations in Complement Factor H Impair Alternative Pathway Regulation on
Mouse Glomerular Endothelial Cells in Vitro. J Biol Chem., 291(10):4974-81
Farwell SL, Kanyi D, Hamel M, Slee JB, Miller EA, Cipolle MD, Lowe-Krentz LJ. Heparin Decreases in Tumor
Necrosis Factor α (TNFα)-induced Endothelial Stress Responses Require Transmembrane Protein 184A and
Induction of Dual Specificity Phosphatase 1. J Biol Chem., 291(10):5342-54
Mai J, Nanayakkara G, Lopez-Pastrana J, Li X, Li YF, Wang X, Song A, Virtue A, Shao Y, Shan H, Liu F, Autieri MV,
Kunapuli SP, Iwakura Y, Jiang X, Wang H, Yang XF. Interleukin-17A Promotes Aortic Endothelial Cell Activation
via Transcriptionally and Post-translationally Activating p38 Mitogen-activated Protein Kinase (MAPK)
Pathway. J Biol Chem., 291(10):4939-54
Pugh RJ, Slee JB, Farwell SL, Li Y, Barthol T, Patton WA, Lowe-Krentz LJ. Transmembrane Protein 184A Is a
Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin. J Biol Chem., 291(10):5326-41
Walker A, Chung CW, Neu M, Burman M, Batuwangala T, Jones G, Tang CM, Steward M, Mullin M, Tournier N,
Lewis A, Korczynska J, Chung V, Catchpole I. Novel Interaction Mechanism of a Domain Antibody-based
Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency than Ranibizumab and
Bevacizumab and Improved Capacity over Aflibercept. J Biol Chem., 291(11):5500-11
Huang LH, Melton EM, Li H, Sohn P, Rogers MA, Mulligan-Kehoe MJ, Fiering SN, Hickey WF, Chang CC, Chang
TY. Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and
Suppresses Atherosclerosis Progression. J Biol Chem., 291(12):6232-44
Chávez-Vargas L, Adame-García SR, Cervantes-Villagrana RD, Castillo-Kauil A, Bruystens JG, Fukuhara S, Taylor
SS, Mochizuki N, Reyes-Cruz G, Vázquez-Prado J. Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac
Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. J Biol
Chem., 291(12):6182-99
Journal of Cell Biology
No vascular biology related publications this month
Journal of Cell Science
Tsuji-Tamura K, Ogawa M. Inhibition of the PI3K/Akt and mTORC1 signaling pathways promotes the
elongation of vascular endothelial cells. J Cell Sci., 129:1165-1178
Hayashi H, Al Mamun A, Sakima M, Sato M. Activator of G-protein signaling 8 is involved in VEGF-mediated
signal processing in angiogenesis. J Cell Sci., 129:1210-1222
Kumar R, Janjanam J, Nikhlesh NK, Rao GN. A new role for cofilin in retinal neovascularization. J Cell Sci.,
129:1234-1249
Journal of Clinical Investigation
Noelia Escobedo, Steven T. Proulx, Sinem Karaman, Miriam E. Dillard, Nicole Johnson, Michael Detmar, and
Guillermo Oliver. Restoration of lymphatic function rescues obesity in Prox1-haploinsufficient mice. J Clin
Invest., 1(2)
Baeyens N, Bandyopadhyay C, Coon BG, Yun S, Schwartz MA. Endothelial fluid shear stress sensing in
vascular health and disease. J Clin Invest., 126(3):821-8
Kuang SQ, Medina-Martinez O, Guo DC, Gong L, Regalado ES, Reynolds CL, Boileau C, Jondeau G, Prakash SK,
Kwartler CS, Zhu LY, Peters AM, Duan XY, Bamshad MJ, Shendure J, Nickerson DA, Santos-Cortez RL, Dong X,
Leal SM, Majesky MW, Swindell EC, Jamrich M, Milewicz DM. FOXE3 mutations predispose to thoracic aortic
aneurysms and dissections. J Clin Invest., 126(3):948-61
Lerner TR, de Souza Carvalho-Wodarz C, Repnik U, Russell MR, Borel S, Diedrich CR, Rohde M, Wainwright H,
Collinson LM, Wilkinson RJ, Griffiths G, Gutierrez MG. Lymphatic endothelial cells are a replicative niche for
Mycobacterium tuberculosis. J Clin Invest., 126(3):1093-108
Journal of Experimental Medicine
Misra A, Sheikh AQ, Kumar A, Luo J, Zhang J, Hinton RB, Smoot L, Kaplan P, Urban Z, Qyang Y, Tellides G, Greif
DM. Integrin β3 inhibition is a therapeutic strategy for supravalvular aortic stenosis. J Exp Med., 213(3):451-63
Shirai T, Nazarewicz RR, Wallis BB, Yanes RE, Watanabe R, Hilhorst M, Tian L, Harrison DG, Giacomini JC,
Assimes TL, Goronzy JJ, Weyand CM. The glycolytic enzyme PKM2 bridges metabolic and inflammatory
dysfunction in coronary artery disease. J Exp Med., 213(3):337-54
Journal of Immunology
Asosingh K, Vasanji A, Tipton A, Queisser K, Wanner N, Janocha A, Grandon D, Anand-Apte B, Rothenberg ME,
Dweik R, Erzurum SC. Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in
the Atopic Asthmatic Response. J Immunol., 196(5):2377-87
Journal of Lipid Research
No vascular biology related publications this month
Molecular and Cellular Biology
Sabapathy K. p73: a Positive or Negative Regulator of Angiogenesis, or Both? Mol Cell Biol., 36(6):848-54
Molecular Biology of the Cell
Aude Guillabert-Gourgues, Beatrice Jaspard-Vinassa, Marie-Lise Bats, Raj N. Sewduth, Nathalie Franzl, Claire
Peghaire, Sylvie Jeanningros, Catherine Moreau, Etienne Roux, Frederic Larrieu-Lahargue, Pascale Dufourcq,
Thierry Couffinhal, and Cecile Duplàa. Kif26b controls endothelial cell polarity through the Dishevelled/Daam1dependent planar cell polarity–signaling pathway. Mol. Biol. Cell, 27(6):941-953
Nature
No vascular biology related publications this month
Nature Cell Biology
No vascular biology related publications this month
Nature Genetics
No vascular biology related publications this month
Nature Medicine
No vascular biology related publications this month
PNAS
Ghosh CC, David S, Zhang R, Berghelli A, Milam K, Higgins SJ, Hunter J, Mukherjee A, Wei Y, Tran M, Suber F,
Kobzik L, Kain KC, Lu S, Santel A, Yano K, Guha P, Dumont DJ, Christiani DC, Parikh SM. Gene control of
tyrosine kinase TIE2 and vascular manifestations of infections. Proc Natl Acad Sci U S A., 113(9):2472-7
Smith TL, Yuan Z, Cardó-Vila M, Sanchez Claros C, Adem A, Cui MH, Branch CA, Gelovani JG, Libutti SK, Sidman
RL, Pasqualini R, Arap W. AAVP displaying octreotide for ligand-directed therapeutic transgene delivery in
neuroendocrine tumors of the pancreas. Proc Natl Acad Sci U S A., 113(9):2466-71
Pattenden SG, Simon JM, Wali A, Jayakody CN, Troutman J, McFadden AW, Wooten J, Wood CC, Frye SV, Janzen
WP, Davis IJ. High-throughput small molecule screen identifies inhibitors of aberrant chromatin accessibility.
Proc Natl Acad Sci U S A., 113(11):3018-3023
Rosenfeld D, Landau S, Shandalov Y, Raindel N, Freiman A, Shor E, Blinder Y, Vandenburgh HH, Mooney DJ,
Levenberg S. Morphogenesis of 3D vascular networks is regulated by tensile forces. Proc Natl Acad Sci U S
A., 113(12):3215-20
Kolesky DB, Homan KA, Skylar-Scott MA, Lewis JA. Three-dimensional bioprinting of thick vascularized tissues.
Proc Natl Acad Sci U S A., 113(12):3179-84
Sun X, Fu Y, Gu M, Zhang L, Li D, Li H, Chien S, Shyy JY, Zhu Y. Activation of integrin α5 mediated by flow
requires its translocation to membrane lipid rafts in vascular endothelial cells. Proc Natl Acad Sci U S A.,
113(3):769-74
Science
Pattabiraman DR, Bierie B, Kober KI, Thiru P, Krall JA, Zill C, Reinhardt F, Tam WL, Weinberg RA. Activation of
PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability. Science,
351(6277):aad3680
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A,
Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder
Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, TybjærgHansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P,
Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS,
Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ; CHD Exome+ Consortium; CARDIoGRAM
Exome Consortium; Global Lipids Genetics Consortium. Rare variant in scavenger receptor BI raises HDL
cholesterol and increases risk of coronary heart disease. Science, 351(6278):1166-71
Member Submissions
Woo M, Patterson EK, Cepinskas G, Clarson C, Omatsu T, Fraser DD. Dynamic Regulation of Plasma Matrix
Metalloproteinases in Human Diabetic Ketoacidosis. Pediatr Res., 79(2):295-300
Sun X, Lin J, Zhang Y, Kang S, Belkin N, Wara AK, Icli B, Hamburg NM, Li D, Feinberg MW. MicroRNA-181b
Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose
Tissue. Circ Res., 118(5):810-21
Scheitlin CG, Julian JA, Shanmughapriya S, Madesh M, Tsoukias NM, Alevriadou BR. Endothelial mitochondria
regulate the intracellular Ca2+ response to fluid shear stress. Am J Physiol Cell Physiol. 310(6):C479-90
Andreas M. Beyer, Julie K. Freed, Matthew J. Durand, Michael Riedel, Karima Ait-Aissa, Paula Green, Joseph C.
Hockenberry, R. Garret Morgan, Anthony J. Donato, Refael Peleg, Mario Gasparri, Chris K. Rokkas, Janine H.
Santos, Esther Priel, David D. Gutterman. Critical Role for Telomerase in the Mechanism of Flow Mediated
Dilation in the Human Microcirculation. Circulation Research, 118(5):856-66
Hutcheson JD, Goettsch C, Bertazzo S, Maldonado N, Ruiz JL, Goh W, Yabusaki K, Faits T, Bouten C, Franck G,
Quillard T, Libby P, Aikawa M, Weinbaum S, Aikawa E. Genesis and growth of extracellular-vesicle-derived
microcalcification in atherosclerotic plaques. Nat Mater., 15(3):335-43
Park C, Lee TJ, Bhang SH, Liu F, Nakamura R, Oladipupo SS, Pitha-Rowe I, Capoccia B, Choi HS, Kim TM, Urao
N, Ushio-Fukai M, Lee D, Miyoshi H, Kim BS, Lim DS, Apte RS, Ornitz DM, Choi K. Injury-Mediated Vascular
Regeneration Requires Endothelial ER71/ETV2. Arterioscler Thromb Vasc Biol., 36(1):86-96
Rahman HN, Wu H, Dong Y, Pasula S, Wen A, Sun Y, Brophy ML, Tessneer KL, Cai X, McManus J, Chang B,
Kwak S, Rahman NS, Xu W, Fernandes C, Mcdaniel JM, Xia L, Smith L, Srinivasan S, Chen H. Selective
Targeting of a Novel Epsin-VEGFR2 Interaction Promotes VEGF-Mediated Angiogenesis. Circ Res.,
118(6):957-69
Kur E, Kim J, Tata A, Comin CH, Harrington KI, Costa LD, Bentley K, Gu C. Temporal modulation of collective
cell behavior controls vascular network topology. Elife, 24;5
Franco, C.A., M.L. Jones, M.O. Bernabeu, A.C. Vion, P. Barbacena, J. Fan, T. Mathivet, C.G. Fonseca, A. Ragab,
T.P. Yamaguchi, P.V. Coveney, R.A. Lang, and H. Gerhardt. Non-canonical Wnt signalling modulates the
endothelial shear stress flow sensor in vascular remodelling. Elife, 5
Sachiko Nishimoto, Daiju Fukuda, Yasutomi Higashikuni, Kimie Tanaka, Yoichiro Hirata, Chie Murata, Joo-ri KimKaneyama, Fukiko Sato, Masahiro Bando, Shusuke Yagi, Takeshi Soeki, Tetsuya Hayashi, Issei Imoto, Hiroshi
Sakaue, Michio Shimabukuro and Masataka Sata. Obesity-induced DNA released from adipocytes stimulates
chronic adipose tissue inflammation and insulin resistance. Science Advances, 2(3):e1501332
Mammoto T, Chen Z, Jiang A, Jiang E, Ingber DE, Mammoto A. Acceleration of Lung Regeneration by PlateletRich Plasma Extract tohrough the Low-Density Lipoprotein Receptor-Related Protein 5-Tie2 Pathway. Am J
Respir Cell Mol Biol., 54:103-113
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