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Development of face and oral Cavity Development of the face Formation of the face Both the frontonasal process and the branchial arches play a large part in the formation of the face and the oral cavity. Frontonasal prominence Nasal placode Maxillary process 1. Pharyngeal arch (mandibular) 2. Pharyngeal arch (hyoid arch) 3. Pharyngeal arch 4. And 6. Pharyngeal arch Developing heart Formation of the face The face derives from five prominences that surround the stomodeum. The prominences are: • the single median frontonasal prominence and • the paired maxillary prominences • and mandibular prominences; (derivatives of the first pharyngeal arch) Formation of the face Tissues from the mandibular arches form all the lower face and most of the midface while the other pairs of arches, including branchial grooves and pharyngeal pouches, are involved mainly in the formation of the neck region. Formation of the face The frontonasal prominence is the largest and is composed of an upper frontal and a lower nasal portion. In the fourth week, within 3 to 4 days, two oval ectodermal thickenings, the nasal placodes, appear bilaterally, located on the nasal process. Formation of the face The mesenchyme beneath the ectodermal thickenings rapidly proliferate, causing a tissue elevation around the placodes. Each nasal placode possesses an outer lateral nasal and an inner medial nasal swelling. Formation of the face In the fifth week, the lateral and medial nasal swellings enlarge rapidly, with the medials advancing toward one another and eventually fusing. Formation of the face The maxillary prominence is dimensionally not impressive early in development. With medial growth of its terminals and broadening of its other borders, the maxillary prominence presses onto the nasal swellings forcing their medial and lateral arms closer together. Formation of the face During the following week, the medial and lateral nasal swellings unite and merge with the maxillary process. The line of fusion of the maxillary process with the lateral nasal swelling is marked by a trough, the nasolacrimal groove. Formation of the face The union of the medial nasal swellings forms the intermaxillary process of the maxillary arch. The intermaxillary process produces: • the philtrum of the lip, • the segment of the maxilla bearing the incisor teeth, and • the primary palate. Fused palatal process Formation of the face The lateral nasal prominences give rise to the wings or alae of the nose. The medial nasal processes produce the inferior segment of the nasal septum. Formation of the face By the end of the fourth week, the two mandibular prominences have grown towards one another and merged. The mandible, the lower lip, the lower portion of the cheek, the chin, and the gingiva take their origins from the mandibular prominences. The maxillary process gives rise to the lateral portions of the upper lip and cheeks, the maxilla, and the secondary palate with its associated gingiva. Formation of the face A = Maxillary process B = Mandibular process C = Medial nasal process D = Lateral nasal process Development of face and oral Cavity Development of the palate Formation of the palate The formation of primary palate is a contribution of the fusion of medial nasal processes. The secondary palate originates from lateral palatine processes, a ledge like outgrowths of the maxillary process Formation of the palate These lateral palatine processes make their appearance in the sixth week of development. Early in their formation, they are located along the sides of the developing tongue. Indication of initiation of tooth development is also visible (dental lamina). Formation of the palate Another view of the same situation. The lateral palatine processes are situated besides developing tongue. Formation of the palate Later as the tongue takes a deeper position in the primitive oral cavity, the palatine processes rise and grow toward each other. Formation of the palate By the eighth week, the lateral palatine processes fuse with each other as well as with the primary palate and nasal septum. These fusions complete the formation of the ceiling of the oral cavity and the floor of the nasal cavity. The nasal septum separates the right and left passages of the nose. Formation of the palate Fused palatine processes. Development of face and oral Cavity Development of the tongue Formation of the tongue The tongue is a muscular organ composed of: an anterior movable part, termed the body, and the posterior firmly attached base/root or branchial part. Formation of the tongue The tongue originates from the first, second, and third pharyngeal arches and from a migration of muscles from the occipital somites. The anterior part arising from the first arch is formed from three masses, the two lateral lingual swellings and the tuberculum impar. Formation of the tongue These lateral lingual swellings rapidly enlarge, merge with each other, and overgrow the tuberculum impar to form the oral part of the tongue. An U-shaped sulcus develops in front of and on both sides of this oral part, which allows it to be free and highly mobile, except at the region of the lingual frenulum where it remains attached to the floor of the mouth. Formation of the tongue The root of the tongue develops mainly from the third pharyngeal arch. Initially it is indicated by a midline elevation that appears behind the tuberculum imper, which is a large branchial eminence of the third and fourth arches (hypobranchial eminence). Later this eminence overgrows the second pharyngeal arch, to become continuous with the body of the tongue. Formation of the tongue The site of union between the base and the body of the tongue is delineated by a V-shaped groove called the sulcus terminalis. Development of face and oral Cavity Development of the mandible Development of the mandible The basic growth pattern of the mandibular body and condyle appeared in week 7 of fertilization. Histologically, the embryonic mandible originated in the lower part of the first branchial arch from primary intramembranous ossification in the fibrous mesenchymal tissue around the Meckel's cartilage. Development of the mandible Development of the mandible Before the begin of ossification the mandibular nerve and its branches are developed and they ensure the formation of canals around them. From this initial ossification, the ramifying trabecular bones developed forward, backward and upward, to form the symphysis, mandibular body, and coronoid process, respectively. (following the path way of the incisive and the inferior alveolar nerve) Development of the mandible Development of the mandible The accessory cartilages are: • the condylar cartilage • the coronoid cartilage • the symphysial cartilage Development of the mandible The condylar cartilage is the largest and most important one. It appears in the 12th week i. u. and is quickly replaced by enchondral ossification. A thin layer of cartilage remains in the condylar head and persists until the 20 years of life providing a mechanism of mandibular growth. Growth of the mandible The shape and size of the mandible undergo considerable transformation from embryonic to adult mandible. Growth of the mandible The mandible grows in all directions: • Anterio-posterior by bone deposition along the posterior border of the ramus. • Vertical by growth of the condyle, along the upper border of the ramus and the formation of the alveolar process. صورة • Transverse by bone deposition on the external surface and bone resorption at the inner surface. Development of the mandible The alveolar bone formation begins as the teeth reach the early bell stage. The bone begins to grow around the tooth germs and upward in occlusal direction. Later this area is called alveolar bone and is divided into alveoli by septa.