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Automated Metered Dose Inhaler Presentation #5 (04/07/04) Presented By Group 11: The “MDI Auto-Maniacs” Maria del Carmen Carrillo Jennifer B. Struble Loyrirk Temiyakarn Problem Definition Automatic Metered Dose Inhalant (MDI) delivery device: Electromechanical, in-hospital inhalant drug delivery system Patients are mechanically ventilated and sedated Medication delivered automatically as prescribed electronically Medication must be well shaken (homogenized with propellant) Background What is a Metered Dose Inhaler? Who Uses Them? pocket-sized handheld inhaler delivers standardized dose of medication for bronchodilation Patients with asthma or chronic obstructive pulmonary disease (COPD) Setting? Critical patients in hospitals Prescriptions for outpatient or in-home use Current Issues Recent Statistics 1/25 patients are intubated and mechanically ventilated (1997) Methods in-use Manual administration Patent Search Automatic methods are NOT for mechanically ventilated patients Patent Number 6,095,141 QuickTime™ and a TIFF (LZW) decompressor are needed to see this picture. Design Factors Integration with existing endotracheal tubing Homogenization with propellant Delivery of medication into ventilation system Tubing length Synchronization of delivery with breathing Software/Automation User interface Prescription error checking Shaking = Homogenization Key obstacle homogenization Actuators homogenize and administer Albuterol Pneumatic Simple singular directional motion Set stroke length Controlled through relays/valves by computer Experiment on Homogenization 1. 2. 3. 4. Overall - Difficult to quantify and so based on subjective analysis Soft vs. Vigorous Shakes Soft more effective Various Vigorous Shakes One worked better than two Various Soft Shakes - Five better than three or ten With the Spacer - ineffective, has to be inhaled to leave the spacer Project Status Research completed Ventilators (Siemens Servo I) Ventilation circuits Albuterol canisters Homogenization Parts obtained Festo pneumatics Computer w/ DAQ card Parts still needed Cylinders Valves Tubing Relays Casing/Enclosure Prototype in construction Working Design: Using Prefabricated Canisters Integrated with existing ventilation circuit Homogenize In-line using AeroChamber Pneumatic Actuator Computer-controlled LabVIEW Prescribe dosage by timer/alarm Homogenization/actuation sequence programmed Keeps track of actuations, alerts user before new canister is needed Timeline Completed Work Research Clearly defined design factors Through Innovation Workbench Testing with Albuterol Obtained Festo parts Timeline Obtain parts ~ on-going Prototype ~ next week Testing ~ next week Final prototype ~ mid-April Poster creation ~ midlate-April Current Work Obtain more components for prototype Relays Casing/Enclosure Build prototype Woo-hoo! References http://familydoctor.org/040.xml http://www.medlineplus.com/ http://www.alarismed.com/na/press/presskit_bkgd.sht ml http://www.drgreene.com/21_1377.html http://www.med.umich.edu/anes/tcpub/glossary/anest hesia_glossary-05.htm http://www.rattus.com/catalogpagesearch5akent.asp? page=5 Hudson RCI. AnaConDa™ Principles of Operation. 2003 http://www.ahrq.gov/data/hcup/factbk2/factbk2.htm