Download Automated Metered Dose Inhaler

Automated Metered Dose Inhaler
Presentation #5 (04/07/04)
Presented By Group 11:
The “MDI Auto-Maniacs”
Maria del Carmen Carrillo
Jennifer B. Struble
Loyrirk Temiyakarn
Problem Definition

Automatic Metered Dose Inhalant (MDI)
delivery device:
 Electromechanical,
in-hospital inhalant drug
delivery system
 Patients are mechanically ventilated and
sedated
 Medication delivered automatically as
prescribed electronically
 Medication must be well shaken
(homogenized with propellant)
Background

What is a Metered
Dose Inhaler?

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
Who Uses Them?


pocket-sized handheld inhaler
delivers standardized dose of
medication for bronchodilation
Patients with asthma or
chronic obstructive pulmonary
disease (COPD)
Setting?

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Critical patients in hospitals
Prescriptions for outpatient or
in-home use
Current Issues

Recent Statistics
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1/25 patients are intubated and
mechanically ventilated (1997)
Methods in-use
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Manual administration
Patent Search

Automatic
methods are
NOT for
mechanically
ventilated
patients

Patent Number
6,095,141
QuickTime™ and a
TIFF (LZW) decompressor
are needed to see this picture.
Design Factors

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Integration with existing
endotracheal tubing
Homogenization with
propellant
Delivery of medication
into ventilation system
Tubing length
Synchronization of
delivery with breathing
Software/Automation


User interface
Prescription error
checking
Shaking = Homogenization

Key obstacle homogenization
 Actuators homogenize and
administer Albuterol

Pneumatic


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Simple singular
directional motion
Set stroke length
Controlled through
relays/valves by
computer
Experiment on Homogenization

1.
2.
3.
4.
Overall - Difficult to quantify
and so based on subjective
analysis
Soft vs. Vigorous Shakes Soft more effective
Various Vigorous Shakes One worked better than two
Various Soft Shakes - Five
better than three or ten
With the Spacer - ineffective,
has to be inhaled to leave the
spacer
Project Status

Research completed

Ventilators (Siemens Servo I)
 Ventilation circuits
 Albuterol canisters
 Homogenization

Parts obtained

Festo pneumatics

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Computer w/ DAQ card
Parts still needed



Cylinders
Valves
Tubing
Relays
Casing/Enclosure
Prototype in construction
Working Design:
Using Prefabricated Canisters

Integrated with existing
ventilation circuit


Homogenize


In-line using AeroChamber
Pneumatic Actuator
Computer-controlled


LabVIEW
Prescribe dosage by
timer/alarm
 Homogenization/actuation
sequence programmed
 Keeps track of actuations,
alerts user before new
canister is needed
Timeline

Completed Work


Research
Clearly defined design
factors


Through Innovation
Workbench

Testing with Albuterol

Obtained Festo parts

Timeline


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
Obtain parts ~ on-going
Prototype ~ next week
Testing ~ next week
Final prototype ~ mid-April

Poster creation ~ midlate-April
Current Work

Obtain more components
for prototype



Relays
Casing/Enclosure
Build prototype

Woo-hoo!
References
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http://familydoctor.org/040.xml
http://www.medlineplus.com/
http://www.alarismed.com/na/press/presskit_bkgd.sht
ml
http://www.drgreene.com/21_1377.html
http://www.med.umich.edu/anes/tcpub/glossary/anest
hesia_glossary-05.htm
http://www.rattus.com/catalogpagesearch5akent.asp?
page=5
Hudson RCI. AnaConDa™ Principles of Operation.
2003
http://www.ahrq.gov/data/hcup/factbk2/factbk2.htm