Download Table 1

Online supplementary material, Murphy, Biopharming review
Table S1 Examples of some biopharming companies, their products and plant
expression systems as of mid-2007.
Although small/medium-scale biopharming R&D companies can be found in much of the
developed world, the major focus of commercial manufacture is undoubtedly in North
America. Note also that this business sector is very dynamic with companies changing
hands or going out of business on a regular basis.
Agragen Inc, Grand Forks, North Dakota – docosahexaenoic acid and albumin in
flax/linseed: no website
Agrenvec SL, Madrid, Spain – various proteins in Brassica spp: www.agrenvec.es/eng/
Agrisoma Biosciences Inc, Burnaby, Canada – various in plants: www.agrisoma.com
Altor BioScience Corporation, Miramar, Florida - therapeutic antibodies in transgenic
lettuce: www.altorbioscience.com
Bayer Innovation GmbH, Munich, Germany – various unspecified therapeutics in plants:
http://www.phenostor.de
Biolex Therapeutics, Pittsboro, North Carolina – human therapeutic proteins in
duckweed: www.biolex.com
CIGB, Havana, Cuba – antibodies in tobacco: http://www.cigb.edu.cu/pages/
Chlorogen Inc, St. Louis, Missouri – cholera, anthrax, and plague vaccines, human serum
albumin, interferon for liver diseases including hepatitis C, elastin, 4HB, and insulinlike growth factor in tobacco chloroplasts: www.chlorogen.com
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Online supplementary material, Murphy, Biopharming review
Cobento A/S, Aarhus, Denmark - Human Intrinsic Factor and placental transcobalamin in
Arabidopsis thaliana: www.cobento.dk
Controlled Pharming Ventures LLC, McCordsville, Indiana – undisclosed products in
maize: www.controlledpharming.com
Dow AgroSciences, Indianapolis, Indiana – animal vaccines in plant cell cultures:
http://www.dowagro.com
[Epicyte Pharmaceutical, San Diego, California (acquired by Biolex in 2004) - human
interferons in maize]
Farmacule BioIndustries, Brisbane, Australia – edible vaccines, vitronectin, trypsin and
other proteins in tobacco, banana and sugar cane: www.farmacule.com
Greenovation Biotech GmbH, Freiburg, Germany – monoclonal antibodies in moss cell
cultures: http://www.greenovation.com/Projects_Production.htm
[Icon Genetics AG, Germany (acquired by Bayer Innovation GmbH in 2006) –
monoclonal antibodies in tobacco: www.icongenetics.com]
LemnaGene SA, Dardilly, France – recombinant proteins in duckweed:
www.lemnagene.com
[Large Scale Biology, Vacaville, California (bankrupt as of late 2005) - formerly
developing numerous animals and human vaccines in tobacco]
Maltagen Forschung GmbH, Andernach, Germany – various recombinant proteins in
barley: www.maltagen.de/index-english.htm
Mapp Biopharmaceutical, Inc, San Diego, California – monoclonal antibodies from
plants: www.mappbio.com
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Online supplementary material, Murphy, Biopharming review
Medicago Inc, Québec City, Canada - vaccines, monoclonal antibodies, and biogenerics
in alfalfa: www.medicago.com
Meristem Therapeutics, Clermont-Ferrand, France - Lipase, lactoferrin, plasma proteins,
collagen, antibodies (IgA, IgM), allergens and protease inhibitors in maize and
tobacco: www.meristem-therapeutics.com
[Monsanto Company, St. Louis, Missouri - abandoned development of pharmaceuticalproducing maize in 2003]
Novoplant GmbH, Gatersleben, Germany – various veterinary proteins in peas:
www.novoplant.com
ORF Genetics, Reykjavik, Iceland – growth factors, cytokines, enzymes and human
transcription factors in barley seeds: www.orfgenetics.com
PhycoBiologics Canada Inc, Charlottetown, Canada – recombinant proteins in
Chlamydomonas reinhardtii: www.phycotransgenics.com
Phytomedics Inc, Jamesburg, New Jersey - various recombinant proteins via root
secretion in hydroponic tobacco: www.phytomedics.com
Planet Biotechnology Inc, Hayward, California – antibody-based therapeutic agents in
tobacco: http://www.planetbiotechnology.com
Plantechno, Cremona, Italy – recombinant proteins in various plants, including poplar,
tobacco and barley: www.plantechno.com
Plantigen, London, Canada – human therapeutics in tobacco leaves:
www.lhsc.on.ca/plantigen
PLANTON GmbH, Kiel, Germany – various human/animal peptides and proteins in
potato tubers: www.planton.de
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Online supplementary material, Murphy, Biopharming review
ProdiGene Inc, College Station, Texas - aprotinin, trypsin and a veterinary TGE vaccine
in maize: www.prodigene.com
Protalix BioTherapeutics Inc, Karmiel, Israel – human therapeutic proteins in plant cell
cultures: www.protalix.com
Rincon Pharmaceuticals Inc, San Diego, California – human protein therapeutics in
eukaryotic algae: www.rinconpharma.com
ROOTec bioactives GmbH, Basel, Switzerland – recombinant proteins in tobacco hairy
root cultures: http://www.rootec.com
SemBioSys Genetics Inc, Calgary, Canada – human insulin in safflower:
www.sembiosys.com
UniCrop Ltd, Helsinki, Finland - recombinant proteins from biocontained
Camelina sativa seedlings: www.unicrop.fi
Ventria Bioscience, College Station, Texas - lactoferrin and lysozyme in rice:
http://www.ventria.com
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