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Appendix 2: Papers screened for suitability Africa, C. W., Bayingana, C. & Yasin-Harnekar, S. (2009) The use of Perioscan as a potential screening test for mothers at risk for delivery of pre-term and low birth-weight infants. J Int.Acad.Periodontol 11, 193-199. Africa, C. W., Kayitenkore, J. & Bayingana, C. (2010) Examination of maternal gingival crevicular fluid for the presence of selected periodontopathogens implicated in the pre-term delivery of low birthweight infants. Virulence. 1, 254-259. Africa, C. W. (2011) Oral colonization of Gram-negative anaerobes as a risk factor for preterm delivery. Virulence. 2, 498-508. Agueda, A., Echeverria, A. & Manau, C. (2008) Association between periodontitis in pregnancy and preterm or low birth weight: Review of the literature. Med Oral Patol.Oral Cir.Bucal. 13, E609E615. Agueda, A., Ramon, J. M., Manau, C., Guerrero, A. & Echeverria, J. J. (2008) Periodontal disease as a risk factor for adverse pregnancy outcomes: a prospective cohort study. J Clin Periodontol 35, 16-22. Ahearne, J. (2005) What is scientific evidence? Br.Dent J 199, 315 Ahmadian, L., Monzavi, A., Arbabi, R. & Hashemi, H. M. (2011) Full-mouth rehabilitation of an edentulous patient with Papillon-Lefevre syndrome using dental implants: a clinical report. J Prosthodont. 20, 643-648. Aitchison, G. U. (1979) A method for the measurement of the gingival sulcus of sheep. Res Vet.Sci. 27, 381-383. Akl, E. A., Gaddam, S., Gunukula, S. K., Honeine, R., Jaoude, P. A. & Irani, J. (2010) The effects of waterpipe tobacco smoking on health outcomes: a systematic review. Int.J Epidemiol. 39, 834857. Al Habashneh, R., Aljundi, S. H. & Alwaeli, H. A. (2008) Survey of medical doctors' attitudes and knowledge of the association between oral health and pregnancy outcomes. Int.J Dent Hyg. 6, 214-220. Al Habashneh, R., Khader, Y. S., Jabali, O. A. & Alchalabi, H. (2012) Prediction of Preterm and Low Birth Weight Delivery by Maternal Periodontal Parameters: Receiver Operating Characteristic (ROC) Curve Analysis. Matern.Child Health J Al Jundi, S. H., Hammad, M. M. & Dabous, I. (2011) Case report: hypophosphatemic rickets and aggressive periodontitis: a review of the role of dentine matrix protein 1 in the pathogenesis. Eur.Arch.Paediatr.Dent 12, 46-50. Albandar, J. M. & Rams, T. E. (2002) Global epidemiology of periodontal diseases: an overview Periodontol 2000 29, 7-10. Albandar, J. M. (2007) Periodontal Disease Surveillance J Periodontol 78, 1179-1181. Albert, M. A. (2008) Race/ethnicity and inflammation: is there a link to periodontal disease? J Periodontol 79, 1121-1123. Ali, T. B. & Abidin, K. Z. (2012) Relationship of periodontal disease to pre-term low birth weight infants in a selected population--a prospective study. Community Dent Health 29, 100-105. Alves, R. T. & Ribeiro, R. A. (2006) Relationship between maternal periodontal disease and birth of preterm low weight babies. Braz.Oral Res 20, 318-323. Alwaeli, H. A. & Al Jundi, S. H. (2005) Periodontal disease awareness among pregnant women and its relationship with socio-demographic variables. Int.J Dent Hyg. 3, 74-82. Alzoubi, I. A., Hammad, M. M. & Abu Alhaija, E. S. (2008) Periodontal parameters in different dentofacial vertical patterns. Angle Orthod. 78, 1006-1014. Ambrina Qureshi, S. I. A. S. A. Q. A. A. K. (5 A.D.) Periodontal Infection: A Potential Risk Factor for Pre-term Delivery of Low Birth Weight (PLBW) Babies. J Pak Med Assoc 55, 448-451. Ancel, P. Y., Cubizolles, M. J. S., Di Renzo, G. C., Papiernik, E. & Bréart, G. (1999) Br J Obstet Gynaecol 106, 1162-1170 Anil, S. & Al Ghamdi, H. S. (2006) The impact of periodontal infections on systemic diseases. An update for medical practitioners. Saudi.Med J 27, 767-776. Arce, R. M., Barros, S. P., Wacker, B., Peters, B., Moss, K. & Offenbacher, S. (2009) Increased TLR4 expression in murine placentas after oral infection with periodontal pathogens. Placenta 30, 156-162. Arenas-Sordo, M. L., Hernandez-Zamora, E., Montoya-Perez, L. A. & Aldape-Barrios, B. C. (2006) Cockayne's syndrome: a case report. Literature review. Med Oral Patol.Oral Cir.Bucal. 11 , E236-E238. Armitage, G. C. (2001) Periodontal disease and pregnancy: discussion, conclusions, and recommendations. Ann Periodontol 6, 189-192. Arteaga-Guerra, J. J., Ceron-Souza, V. & Mafla, A. C. (2010) Dynamic among periodontal disease, stress, and adverse pregnancy outcomes. Rev Salud Publica (Bogota.) 12, 276-286. Avila, W. S., Timerman, L., Romito, G. A., Marcelino, S. L., Neves, I. L., Zugaib, M. & Grinberg, M. (2011) Periodontal disease in pregnant patients with rheumatic valvular disease: clinical and microbiological study. Arq Bras.Cardiol. 96, 307-311. Avula, H. & Avula, J. (2011) Periodontal Infections and Adverse Pregnancy Outcomes: The Oral HealthÇöFetal Connection. Journal of Gynecologic Surgery 27 , 1-4. Azarpazhooh, A. & Tenenbaum, H. C. (2012) Separating fact from fiction: use of high-level evidence from research syntheses to identify diseases and disorders associated with periodontal disease. J Can Dent Assoc. 78, c25 Baab, D. A., Page, R. C. & Morton, T. (1985) Studies of a family manifesting premature exfoliation of deciduous teeth. J Periodontol 56, 403-409. Baab, D. A., Page, R. C., Ebersole, J. L., Williams, B. L. & Scott, C. R. (1986) Laboratory studies of a family manifesting premature exfoliation of deciduous teeth. J Clin Periodontol 13, 677-683. Babalola, D. A. & Omole, F. (2010) Periodontal disease and pregnancy outcomes. J Pregnancy. 2010, 293439. 2 Baccaglini, L. (2011) A meta-analysis of randomized controlled trials shows no evidence that periodontal treatment during pregnancy prevents adverse pregnancy outcomes. The Journal of the American Dental Association 142, 1192-1193. Bachrach, G., Ianculovici, C., Naor, R. & Weiss, E. I. (2005) Fluorescence based measurements of Fusobacterium nucleatum coaggregation and of fusobacterial attachment to mammalian cells. FEMS Microbiol Lett. 248, 235-240. Barak, S., Oettinger-Barak, O., Machtei, E. E., Sprecher, H. & Ohel, G. (2007) Evidence of periopathogenic microorganisms in placentas of women with preeclampsia. J Periodontol 78, 670-676. Barber, S., Day, P., Judge, M., Toole, E. O. & Fayle, S. (2012) Variant Carvajal syndrome with additional dental anomalies. Int.J Paediatr.Dent 22, 390-6. Barden, A., Beilin, L. J., Ritchie, J., Croft, K. D., Walters, B. N. & Michael, C. A. (1996) Plasma and urinary 8-iso-prostane as an indicator of lipid peroxidation in pre-eclampsia and normal pregnancy. Clin Sci 91, 711-718. Barnes, C. M. (2007) Treatment of periodontal disease and the risk of preterm birth. Pract.Proced.Aesthet.Dent 19, 118 Baskaradoss, J. K., Geevarghese, A. & Kutty, V. R. (2011) Maternal periodontal status and preterm delivery: a hospital based case-control study. J Periodontal Res 46, 542-549. Baskaradoss, J.K., Geevarghese, A. & Al Farraj Al Dosari, A. (2012) Causes of Adverse Pregnancy Outcomes and the Role of Maternal Periodontal Status – A Review of the Literature. The Open Dentistry Journal 6, 79-84. Bassani, D. G., Olinto, M. T. & Kreiger, N. (2007) Periodontal disease and perinatal outcomes: a case-control study. J Clin Periodontol 34, 31-39. Battino, M., Ferreiro, M. S., Quiles, J. L., Bompadre, S., Leone, L. & Bullon, P. (2003) Alterations in the oxidation products, antioxidant markers, antioxidant capacity and lipid patterns in plasma of patients affected by Papillon-Lefevre syndrome. Free Radic.Res 37, 603-609. Bazopoulou-Kyrkanidou, E., Vrahopoulos, T. P., Eliades, G., Vastardis, H., Tosios, K. & Vrotsos, I. A. (2007) Periodontitis associated with Hajdu-Cheney syndrome. J Periodontol 78, 1831-1838. Beazley, D., Sundell, T., Patters, M., Carr, T., Blankenship, J. A. & Mercer, B. (2001) Correlation of periodontal disease, risk factors, and perinatal outcomes in a high risk population. American Journal of Obstetrics and Gynecology 185, S146 Beck, J. D., Offenbacher, S., Williams, R., Gibbs, P. & Garcia, R. (1998) Periodontitis: a risk factor for coronary heart disease? Ann Periodontol 3, 127-141. Beckett, H. (2005) Five-step definition. Br.Dent J 199, 547, 549 Belanger, M., Rodrigues, P. & Progulske-Fox, A. (2007) Genetic manipulation of Porphyromonas gingivalis. Curr.Protoc.Microbiol Chapter 13, Unit13CBerthelot, J. M. & Le Goff, B. (2010) Rheumatoid arthritis and periodontal disease. Joint Bone Spine 77 , 537-541. 3 Betleja-Gromada, K., Banach, J., Kaczmarek, A., Mnichowska-Polanowska, M. & GiedrysKalemba, S. (2008) [Anaerobic bacteria of periodontal pockets in course of periodontitis and premature labor]. Med Dosw.Mikrobiol. 60, 71-78. Bettiol, H., Rona, R. J., Chinnn, S., Goldani, M. & Barbieri, M. A. (2000) Factors associated with preterm births in southeast Brazil: a comparison of two birth cohorts born 15 years apart Paediatr Perinat Epidemiol 14, 30-38 Bey, A. (2011) Periodontitis: a significant risk factor for preterm low birth weight (PTLBW) babies. Biology and Medicine 3, 158-162. Block, M. S. & Kent, J. N. (1992) Prospective review of integral implants. Dent Clin North Am 36, 27-37. Bobetsis, Y. A., Barros, S. P. & Offenbacher, S. (2006) Exploring the relationship between periodontal disease and pregnancy complications. The Journal of the American Dental Association 137, 7S-13S. Bochniak, M. & Sadlak-Nowicka, J. (2004) [Periodontitis and cardiovascular diseases--review of publications]. Przegl.Lek. 61, 518-522. Boggess, K. A., Lieff, S., Murtha, A. P., Moss, K., Beck, J. & Offenbacher, S. (2003) Maternal periodontal disease is associated with an increased risk for preeclampsia. Obstet Gynecol 101, 227-231. Boggess, K. A. (2005) Pathophysiology of preterm birth: emerging concepts of maternal infection. Clin Perinatol. 32, 561-569. Boggess, K. A. & Edelstein, B. L. (2006) Oral health in women during preconception and pregnancy: implications for birth outcomes and infant oral health. Matern.Child Health J 10, S169S174. Boggess, K. A. (2010) Treatment of localized periodontal disease in pregnancy does not reduce the occurrence of preterm birth: results from the Periodontal Infections and Prematurity Study (PIPS). Am J Obstet Gynecol 202, 101-102. Boggess, K. A., Beck, J. D., Murtha, A. P., Moss, K. & Offenbacher, S. (2006) Maternal periodontal disease in early pregnancy and risk for a small-for-gestational-age infant. American Journal of Obstetrics and Gynecology 194, 1316-1322. Boggess, K. A., Berggren, E. K., Koskenoja, V., Urlaub, D. & Lorenz, C. (2012) Severe Preeclampsia and Maternal Self-Report of Oral Health, Hygiene, and Dental Care. Journal of Periodontology 1-14. Bokhari, S. A. & Khan, A. A. (2006) The relationship of periodontal disease to cardiovascular diseases--review of literature. J Pak.Med Assoc. 56, 177-181. Bonett, J. B. (2004) Exploring the link. Periodontitis and preterm birth. Penn.Dent J (Phila) 10-13. Borges, I., Moreira, E. A., Filho, D. W., de Oliveira, T. B., da Silva, M. B. & Fr+Âde, T. S. (2007) Mediators Inflamm 2007, 45794Bošnjak, A., Relja, T., Vučićević-Boras, V., Plasaj, H. & Plančak, D. (2006) Pre-term delivery and periodontal disease: a caseÇôcontrol study from Croatia. Journal of Clinical Periodontology 33, 710-716. 4 Boutigny, H., Boschin, F. & Delcourt-Debruyne, E. (2005) [Periodontal diseases, tobacco and pregnancy]. J Gynecol Obstet Biol Reprod.(Paris) 34 Spec No 1, 3S74-3S83. Boyd, D. L., Katz, V., Pertik, G. S. & Offenbacher, S. (1994) Relationship between periodontal disease status and birth outcome. Journal of Dental Research 73, 394 Boyer, R., Jame, F. & Arancibia, S. (1991) [A non-exocrine function of the submaxillary gland]. Ann Endocrinol (Paris) 52, 307-322. Branschofsky, M., Beikler, T., Schafer, R., Flemming, T. F. & Lang, H. (2011) Secondary trauma from occlusion and periodontitis. Quintessence.Int. 42, 515-522. Breedlove, G. (2004) Prioritizing oral health in pregnancy. Kans.Nurse 79, 4-6. Brogardh-Roth, S., Matsson, L. & Klingberg, G. (2011) Molar-incisor hypomineralization and oral hygiene in 10- to-12-yr-old Swedish children born preterm. Eur.J Oral Sci. 119, 33-39. Bryan, S. M., James, S. H., Michael, J. N., William, B., Anthony, J. D., Panos, N. P., Dennis, A. M., James, E. F., Virginia, R. L., James, B. & Stephen, M. (2009) Change in periodontitis during pregnancy and the risk of pre-term birth and low birthweight. SO: Journal of Clinical Periodontology 36, 308-314. Buduneli, N., Baylas, H., Buduneli, E., T++rko-lu, O., K+Âse, T. & Dahlen, G. (2005) Periodontal infections and pre-term low birth weight: a case-control study. Journal of Clinical Periodontology 32, 174-181. Bush, B. C. & Donley, T. G. (2002) A model for dental hygiene education concerning the relationship between periodontal health and systemic health. Educ.Health (Abingdon.) 15, 19-26. Cabala, A., Chomyszyn-Gajewska, M. & Drozdz, W. (2006) [Periodontitis and systemic disease relationships]. Przegl.Lek. 63, 773-777. Cakic, S. (2009) [Gingival crevicular fluid in the diagnosis of periodontal and systemic diseases]. Srp.Arh.Celok.Lek. 137, 298-303. Calabrese, N., Calabrese, A., Nibali, L., Rosati, A., Fiengo, S. & Di Renzo, G. C. (2010) Is there any association between periodontitis and preterm low birth weight? J Matern.Fetal Neonatal Med 23, 1288-1293. Caminiti, M. F., Sandor, G. K., Giambattistini, C. & Tompson, B. (1998) Outcomes of the surgical exposure, bonding and eruption of 82 impacted maxillary canines. J Can Dent Assoc. 64, 572579. Campbell, E. (2007) It's more than the mouth: the effects of periodontal disease on systemic health. Dent Assist. 76, 26. Canakci, C. F., Tatar, A., Canakci, V., Cicek, Y., Oztas, S. & Orbak, R. (2006) New evidence of premature oxidative DNA damage: mitochondrial DNA deletion in gingival tissue of patients with periodontitis. J Periodontol 77, 1894-1900. Canakci, C. F., Canakci, V., Tatar, A., Eltas, A., Sezer, U., Cicek, Y. & Oztas, S. (2009) Increased salivary level of 8-hydroxydeoxyguanosine is a marker of premature oxidative mitochondrial DNA damage in gingival tissue of patients with periodontitis. Arch.Immunol Ther.Exp.(Warsz.) 57, 205211. 5 Canakci, V., Canakci, C. F., Canakci, H., Canakci, E., Cicek, Y., Ingec, M., Ozgoz, M., Demir, T., Dilsiz, A. & Yagiz, H. (2004) Periodontal disease as a risk factor for pre-eclampsia: a case control study. Aust.N.Z.J Obstet Gynaecol. 44, 568-573. Canakci, V., Canakci, C. F., Yildirim, A., Ingec, M., Eltas, A. & Erturk, A. (2007) Periodontal disease increases the risk of severe pre-eclampsia among pregnant women. J Clin Periodontol 34, 639-645. Canakci, V., Yildirim, A., Canakci, C. F., Eltas, A., Cicek, Y. & Canakci, H. (2007) Total antioxidant capacity and antioxidant enzymes in serum, saliva, and gingival crevicular fluid of preeclamptic women with and without periodontal disease. Journal of Periodontology 78, 16021611. Carrillo-de-Albornoz, A., Figuero, E., Herrera, D. & Bascones-Mart+¡nez, A. (2010) Gingival changes during pregnancy: II. Influence of hormonal variations on the subgingival biofilm. Journal of Clinical Periodontology 37, 230-240. Carrillo-de-Albornoz, A., Figuero, E., Herrera, D., Cuesta, P. & Bascones-Mart+¡nez, A. (2012) Gingival changes during pregnancy: III. Impact of clinical, microbiological, immunological and socio-demographic factors on gingival inflammation. Journal of Clinical Periodontology 39, 272283. Carta, G., Persia, G., Falciglia, K. & Iovenitti, P. (2004) Periodontal disease and poor obstetrical outcome. Clin Exp.Obstet Gynecol 31, 47-49. Caruso, F., Nastri, L., Arienzo, M., Signoriello, G., Picardi, C., Mazza, C., Caruso, U. & Gallo, C. (2007) Association between threatened pre-term labour and periodontal disease: does a relationship exist? A matched case-control study. Minerva Stomatol 56, 415-426. Castaldi, J. L., Bertin, M. S., Gimenez, F. & Lede, R. (2006) [Periodontal disease: Is it a risk factor for premature labor, low birth weight or preeclampsia?]. Rev Panam.Salud Publica 19, 253-258. Cetin, I., Pileri, P., Villa, A., Calabrese, S., Ottolenghi, L. & Abati, S. (2012) Pathogenic Mechanisms Linking Periodontal Diseases With Adverse Pregnancy Outcomes. Reprod.Sci. 19:633-641. Chambrone, L., Pannuti, C. M., Guglielmetti, M. R. & Chambrone, L. A. (2011) Evidence grade associating periodontitis with preterm birth and/or low birth weight: II: a systematic review of randomized trials evaluating the effects of periodontal treatment. J Clin Periodontol 38, 902-914. Chambrone, L., Guglielmetti, M. R., Pannuti, C. M. & Chambrone, L. A. (2011) Evidence grade associating periodontitis to preterm birth and/or low birth weight: I. A systematic review of prospective cohort studies. J Clin Periodontol 38, 795-808. Champagne, C. M., Madianos, P. N., Lieff, S., Murtha, A. P., Beck, J. D. & Offenbacher, S. (2000) Periodontal medicine: emerging concepts in pregnancy outcomes. J Int.Acad.Periodontol 2, 9-13. Chan, H. C., Wu, C. T., Welch, K. B. & Loesche, W. J. (2010) Periodontal Disease Activity Measured by the Benzoyl-DL-Arginine-Naphthylamide Test Is Associated With Preterm Births. Journal of Periodontology 81, 982-991. Chappell, L. C., Seed, P. T. & Briley, A. (2002) A longitudinal study of biochemical variables in women at risk of preeclampsia. Am J Obstet Gynecol 187, 127- 6 Chappell, L. C., Seed, P. T. & Kelly, F. J. (2002) Vitamin C and E supplementation in women at risk of preeclampsia is associated with changes in indices of oxidative stress and placental function. Am J Obstet Gynecol 187, 777-784 Chapple, I. L. (1997) Reactive oxygen species and antioxidants in inflammatory diseases. J Clin Periodontol 24, 287-296. Chapple, I. L. (2004) Management of chronic periodontal diseases within the NHS. Br.Dent J 196, 505Chapple, I. L. & Matthews, J. B. (2007) The role of reactive oxygen and antioxidant species in periodontal tissue destruction Periodontol 2000 43, 160-232. Chen, Y., Ding, Y. & Liu, M. (2011) [Papillon-Lefevre syndrome: a case report]. Hua Xi.Kou Qiang.Yi.Xue.Za Zhi. 29, 660-662. Clemmens, D. A. & Kerr, A. R. (2008) Improving oral health in women: nurses' call to action. MCN Am J Matern.Child Nurs. 33, 10-14. Clothier, B., Stringer, M. & Jeffcoat, M. K. (2007) Periodontal disease and pregnancy outcomes: exposure, risk and intervention. Best.Pract.Res Clin Obstet Gynaecol. 21, 451-466. Conde-Agudelo, A. n., Villar, J. & Lindheimer, M. (2008) Maternal infection and risk of preeclampsia: Systematic review and metaanalysis. American Journal of Obstetrics and Gynecology 198, 7-22. Contreras, A., Herrera, J. A., Soto, J. E., Arce, R. M., Jaramillo, A. & Botero, J. E. (2006) Periodontitis is associated with preeclampsia in pregnant women. J Periodontol 77, 182-188. Coonrod, D. V., Jack, B. W., Stubblefield, P. G., Hollier, L. M., Boggess, K. A., Cefalo, R., Cox, S. N., Dunlop, A. L., Hunter, K. D., Prasad, M. R., Lu, M. C., Conry, J. A., Gibbs, R. S. & Hogan, V. K. (2008) The clinical content of preconception care: infectious diseases in preconception care. Am J Obstet Gynecol 199, S296-S309. Corbella, S., Del Fabbro, M., Taschieri, S. & Francetti, L. (2012) Periodontal disease and adverse pregnancy outcomes: a systematic review. Italian Oral Surgery 11, 132-146 Corbella, S., Taschieri, S., Francetti, L., De Siena, F. & Del Fabbro, M. (2011) Periodontal disease as a risk factor for adverse pregnancy outcomes: a systematic review and meta-analysis of case-control studies. Odontology 100, 232-40. Costa, M. C. (2006) [Low birth weight and periodontal disease association]. Rev Saude Publica 40, 353 Costerton, J. & Keller, D. (2007) Oral periopathogens and systemic effects. Gen Dent 55, 210215. Cota, L. O., Guimaraes, A. N., Costa, J. E., Lorentz, T. C. & Costa, F. O. (2006) Association between maternal periodontitis and an increased risk of preeclampsia. J Periodontol 77, 20632069. Cota, L. s. O. M., Guimar+úes, A. N., Costa, J. E., Lorentz, T. C. M. & Costa, F. O. (2006) Association Between Maternal Periodontitis and an Increased Risk of Preeclampsia. Journal of Periodontology 77, 2063-2069. 7 Cruz, S. S., Costa, M. C., Gomes, F., I, Vianna, M. I. & Santos, C. T. (2005) [Maternal periodontal disease as a factor associated with low birth weight]. Rev Saude Publica 39, 782-787. Cruz, S. S., Costa, M. C., Gomes-Filho, I. S., Rezende, E. J., Barreto, M. L., Dos Santos, C. A., Vianna, M. I., Passos, J. S. & Cerqueira, E. M. (2009) Contribution of periodontal disease in pregnant women as a risk factor for low birth weight. Community Dent Oral Epidemiol. 37, 527533. Cruz, S. S., Costa, M. C., Gomes-Filho, I. S., Barreto, M. L., Dos Santos, C. A., Martins, A. G., Passos, J. S., de Freitas, C. O., Sampaio, F. P. & Cerqueira, E. M. (2010) Periodontal therapy for pregnant women and cases of low birthweight: an intervention study. Pediatrics International 52, 57-64. Cullinan, M. P., Ford, P. J. & Seymour, G. J. (2009) Periodontal disease and systemic health: current status. Aust.Dent J 54 Suppl 1, S62-S69. D Gandhimadhi R Mythili (2010) Periodontal infection as a risk factor for preterm low birth weight. Journal of Indian Society of Periodontology 14, 114-120. Dörtbudak, O., Eberhardt, R., Ulm, M. & Persson, G. R. (2005) Periodontitis, a marker of risk in pregnancy for preterm birth. Journal of Clinical Periodontology 32, 45-52. Damare, S. M., Wells, S. & Offenbacher, S. (1997) Eicosanoids in periodontal diseases: potential for systemic involvement. Adv.Exp.Med Biol 433, 23-35. Dasanayake, A. P. (1998) Poor periodontal health of the pregnant woman as a risk factor for low birth weight. Ann Periodontol 3, 206-212. Dasanayake, A. P., Russell, S., Boyd, D., Madianos, P. N., Forster, T. & Hill, E. (2003) Preterm low birth weight and periodontal disease among African Americans. Dent Clin North Am 47, 1151xi. Dasanayake, A. P., Gennaro, S., Hendricks-Munoz, K. D. & Chhun, N. (2008) Maternal periodontal disease, pregnancy, and neonatal outcomes. MCN Am J Matern.Child Nurs. 33, 4549. Davenport, E. S., Williams, C. E. C. S., Sterne, J. A. C., Sivapathasundram, V., Fearne, J. M. & Curtis, M. A. (1998) The East London study of maternal chronic periodontal disease and preterm low birth weight infants: Study design and prevalence data. Annals of Periodontology 3, 213-221. Davenport, E. S., Williams, C. E. S., Sterne, J. A. C., Murad, S. & Sivapathasundram, V. (1999) No association between increased periodontal disease and premature low birth weight. Journal of Dental Research 78, 1045 Davenport, E. S., Williams, C. E. S., Sterne, J. A. C., Murad, S. & Sivapathasundram, V. (2000) Maternal periodontal disease and preterm low birthweight infants. Journal of Clinical Periodontology 27, Suppl 1 31. Davenport, E. S., Williams, C. E., Sterne, J. A., Murad, S., Sivapathasundram, V. & Curtis, M. A. (2002) Maternal periodontal disease and preterm low birthweight: case-control study. J Dent Res 81, 313-318. Davenport, E. S. (2001) Periodontology: A study of periodontal health in early pregnancy. Br Dent J 191 , 564-564. 8 Davenport, E. (2004) Treatment of periodontitis reduces the risk of spontaneous preterm birth. Journal of Evidence Based Dental Practice 4, 220-221. Davenport, E. S. (2010) Preterm low birthweight and the role of oral bacteria. Journal of Oral Microbiology; Vol 2 de Tejada, B. M., Gayet-Ageron, A., Combescure, C., Irion, O. & Baehni, P. (2012) Association between early preterm birth and periodontitis according to USA and European consensus definitions. J Matern.Fetal Neonatal Med Posted online May 29, 2012 (doi:10.3109/14767058.2012.663827) DeBowes, L. J. (1998) The effects of dental disease on systemic disease. Vet.Clin North Am Small Anim Pract. 28, 1057-1062. Deppe, H., Hohlweg-Majert, B., Holzle, F., Schneider, K. T. & Wagenpfeil, S. (2010) Pilot study for periodontal treatment and pregnancy outcome: a clinical prospective study. Quintessence.Int. 41, e101-e110. Devine, P., Perez-Delboy, A., D'Alton, M., Jarjoura, K. & Papapanou, P. N. (2001) Periodontal disease and preterm delivery: a case control study. American Journal of Obstetrics and Gynecology 185, 140. Dhanawade, S. S., Shah, S. D. & Kakade, G. M. (2009) Papillon-lefevre syndrome with liver abscess. Indian Pediatr. 46, 723-725. Di Mario, S., Spettoli, D., Alessandrini, C., Erenbourg, A., Ronfani, L. & Basevi, V. (2011) Periodontal infection and preterm birth: successful periodontal therapy reduces the risk of preterm birth. BJOG: An International Journal of Obstetrics & Gynaecology 118, 635-635. Dixon, N. G., Ebright, D., Defrancesco, M. A. & Hawkins, R. E. (1994) Orogenital contact: a cause of chorioamnionitis? Obstet Gynecol 84, 654-655. Dolapo A.Babalola and Folashade Omole (2010) Periodontal Disease and Pregnancy Outcomes. Journal of Pregnancy Donley, T. G. (1997) A modified placement technique to improve retention. Of tetracyclineimpregnated fibers. J Am Dent Assoc. 128, 465-468. Dortbudak, O., Eberhardt, R., Ulm, M. & Persson, G. R. (2005) Periodontitis, a marker of risk in pregnancy for preterm birth. Journal of Clinical Periodontology 32, 45-52. Douglas, J. D., Schmidt, R. E. & Prine, J. R. (1970) Vegetative endocarditis in a chimpanzee. J Am Vet.Med Assoc. 157, 736-741. Dror, D. K. (2011) Vitamin D status during pregnancy: maternal, fetal, and postnatal outcomes. Curr.Opin.Obstet Gynecol 23, 422-426. Durand, R., Gunselman, E. L., Hodges, J. S., DiAngelis, A. J. & Michalowicz, B. S. (2009) A pilot study of the association between cariogenic oral bacteria and preterm birth. Oral Dis 15, 400-406. Dye, B. A. (2010) The Relationship Between Periodontitis and Alcohol use is not Clear. Journal of Evidence Based Dental Practice 10, 225-227. Dyne, K. M., Vitellaro-Zuccarello, L., Bacchella, L., Lanzi, G. & Cetta, G. (1993) Ehlers-Danlos syndrome type VIII: biochemical, stereological and immunocytochemical studies on dermis from a 9 child with clinical signs of Ehlers-Danlos syndrome and a family history of premature loss of permanent teeth. Br.J Dermatol. 128, 458-463. Ebersole, J. L. (2003) Humoral immune responses in gingival crevice fluid: local and systemic implications. Periodontol 2000 31, 135-166. Ebersole, J. L., Novak, M. J., Michalowicz, B. S., Hodges, J. S., Steffen, M. J., Ferguson, J. E., DiAngelis, A., Buchanan, W., Mitchell, D. A. & Papapanou, P. N. (2009) Systemic immune responses in pregnancy and periodontitis: relationship to pregnancy outcomes in the Obstetrics and Periodontal Therapy (OPT) study. J Periodontol 80, 953-960. Ebersole, J. L., Stevens, J., Steffen, M. J., Dawson, I. D. & Novak, M. J. (2010) Systemic endotoxin levels in chronic indolent periodontal infections. J Periodontal Res 45, 1-7. EL Gharib, M. (2009) The association between chronic periodontitis & pre-term low birth weight infants. International Journal of Gynecology & Obstetrics 107, Supplement 2 , S563 Emmanuel, R. V. & Neelakantan, S. (2011) Perilous periodontitis: a clinical study. Pract.Midwife. 14, 28-31. Engebretson, S. P., Lalla, E. & Lamster, I. B. (1999) Periodontitis and systemic disease. N.Y.State Dent J 65, 30-32. Enwonwu, C. O., Phillips, R. S., Ibrahim, C. D. & Danfillo, I. S. (2004) Nutrition and oral health in Africa. Int.Dent J 54, 344-351. Ercan, E., Eratalay, K., Deren, O., Gur, D., Ozyuncu, O., Altun, B., Kanli, C., Ozdemir, P. & Akincibay, H. (2012) Evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight. Acta Odontologica Scandinavica 1-7. Erdem, A. P. & Sepet, E. (2008) Mineral trioxide aggregate for obturation of maxillary central incisors with necrotic pulp and open apices. Dent Traumatol. 24, e38-e41. Esposito, M., Hirsch, J. M., Lekholm, U. & Thomsen, P. (1998) Biological factors contributing to failures of osseointegrated oral implants. (II). Etiopathogenesis. Eur.J Oral Sci. 106 , 721-764. Etoz, O. A., Ulu, M. & Kesim, B. (2010) Treatment of patient with Papillon-Lefevre syndrome with short dental implants: a case report. Implant.Dent 19, 394-399. F Sayar , M Sadat Hoseini & S Abbaspour (2011) Effect of Periodontal Disease on Preeclampsia. Iranian Journal of Public Health 40, 122-127. Fahey, M. (2012) Periodontal Health Isn't Yet the Answer to Preterm Birth. J Can Dent Assoc 78, c31 Farrell, S., Ide, M. & Wilson, R. F. (2006) The relationship between maternal periodontitis, adverse pregnancy outcome and miscarriage in never smokers. J Clin Periodontol 33, 115-120. Farrell, S.& Ide, M (2005) Associations Between Maternal Periodontitis, Periodontal Treatment and Pregnancy Complications - Part 1: Potential Pathogenic Mechanisms and Risk Factors. PERIO - Periodontal Practice Today 2, 159-171. Fehder, W. P. (2008) Nursing care & management of pathological oral conditions among women and children. MCN Am J Matern.Child Nurs. 33, 38-44. 10 Felice, P., Pelliccioni, G. A. & Checchi, L. (2005) Periodontal disease as a risk factor in pregnancy. Minerva Stomatol 54, 255-264. Ferguson, J. E., Hansen, W. F., Novak, K. F. & Novak, M. J. (2007) Should we treat periodontal disease during gestation to improve pregnancy outcomes? Clin Obstet Gynecol 50, 454-467. Figuero, E., Carrillo-de-Albornoz, A., Herrera, D. & Bascones-Martinez, A. (2010) Gingival changes during pregnancy: I. Influence of hormonal variations on clinical and immunological parameters. Journal of Clinical Periodontology 37, 220-229. Fischer, J., Blanchet-Bardon, C., Prud'Homme, J. F., Pavek, S., Steijlen, P. M., Dubertret, L. & Weissenbach, J. (1997) Mapping of Papillon-Lefevre syndrome to the chromosome 11q14 region. Eur.J Hum.Genet. 5, 156-160. Fisher, M. A. & Taylor, G. W. (2009) A prediction model for chronic kidney disease includes periodontal disease. J Periodontol 80, 16-23. Fogacci, M. F., Leao, A., Vettore, M. V., Sheiham, A., Radnai, M., Pal, A., Novak, T., Urban, E., Eller, J. & Gorzo, I. (2010) Periodontal treatment completed before the 35th week of pregnancy appeared to have a beneficial effect on birthweight and time of delivery. Letter to the editor. J Dent Res 89, 101-102. Fogacci, M. F., Vettore, M. V. & Leao, A. T. (2011) The effect of periodontal therapy on preterm low birth weight: a meta-analysis. Obstetrics and Gynecology 117, 153-165. Ford, P. J. (2010) Immunological techniques: ELISA, flow cytometry, and immunohistochemistry. Methods Mol.Biol 666, 327-343. Fowler, E. B., Breault, L. G. & Cuenin, M. F. (2001) Periodontal disease and its association with systemic disease. Mil.Med 166, 85-89. Friedlander, A. H. & Mahler, M. E. (2001) Major depressive disorder. Psychopathology, medical management and dental implications. J Am Dent Assoc. 132, 629-638. Fritz, M. E., Lemons, J. E., Jeffcoat, M., Braswell, L. D. & Reddy, M. (1994) Evaluation of consecutively placed unloaded root-form and plate-form implants in adult Macaca mulatta monkeys. J Periodontol 65, 788-795. From, E., Philipsen, H. P. & Thormann, J. (1978) Dyskeratosis benigna intraepithelialis mucosae et cutis hereditaria. A report of this disorder in father and son. J Cutan.Pathol 5, 105-115. Gürsoy, M., Pajukanta, R., Sorsa, T. & Könönen, E. (2008) Clinical changes in periodontium during pregnancy and post-partum. Journal of Clinical Periodontology 35, 576-583. Gajendra, S. & Kumar, J. V. (2004) Oral health and pregnancy: a review. N.Y.State Dent J 70, 40-44. Galgut, P. N. (1995) Observations on the recurrence of destructive periodontal disease during a period of four years after treatment. J West Soc Periodontol Periodontal Abstr. 43, 137-145. Galvao, M. P., Rosing, C. K. & Ferreira, M. B. (2003) Effects of ligature-induced periodontitis in pregnant Wistar rats. Pesqui.Odontol Bras. 17, 51-55. Gandhimadhi, D. & Mythili, R. (2010) Periodontal infection as a risk factor for preterm low birth weight. Journal of Indian Society of Periodontology 14, 114-120. 11 Gangadhar, V., Ramesh, A. & Thomas, B. (2011) Correlation between leptin and the health of the gingiva: a predictor of medical risk. Indian J Dent Res 22, 537-541. Garcia, R. (2011) Scaling and root debridement in pregnant women did not result in fewer preterm births. Evid.Based Dent 12, 112. Garcia, R. I., Henshaw, M. M. & Krall, E. A. (2001) Relationship between periodontal disease and systemic health. Periodontology 2000 25, 21-36. Gard, P. R. (2010) Implications of the angiotensin converting enzyme gene insertion/deletion polymorphism in health and disease: a snapshot review. Int.J Mol.Epidemiol.Genet. 1, 145-157. Gazolla, C. M., Ribeiro, A., Moyses, M. R., Oliveira, L. A., Pereira, L. J. & Sallum, A. W. (2007) Evaluation of the incidence of preterm low birth weight in patients undergoing periodontal therapy. J Periodontol 78, 842-848. Gazolla, C. M., Ribeiro, A., Moys+®s, M. R., Oliveira, L. A. M., Pereira, L. J. & Sallum, A. n. W. (2007) Evaluation of the Incidence of Preterm Low Birth Weight in Patients Undergoing Periodontal Therapy. Journal of Periodontology 78, 842-848. Geatch, D. R., Harris, J. I., Heasman, P. A. & Taylor, J. J. (1999) In vitro studies of lymphocyte apoptosis induced by the periodontal pathogen Porphyromonas gingivalis. J Periodontal Res 34, 70-78. Gelmetti, C., Nazzaro, V., Cerri, D. & Fracasso, L. (1989) Long-term preservation of permanent teeth in a patient with Papillon-Lefevre syndrome treated with etretinate. Pediatr.Dermatol. 6, 222-225. Genc, G., Dursun, H., Sarac, A. & Dalgic, B. (2007) Papillon-lefevre syndrome with congenital hepatic fibrosis. Mymensingh.Med J 16, S63-S66. George, A., Shamim, S., Johnson, M., Ajwani, S., Bhole, S., Blinkhorn, A., Ellis, S. & Andrews, K. (2011) Periodontal treatment during pregnancy and birth outcomes: a meta-analysis of randomised trials. Int.J Evid.Based Healthc. 9, 122-147. Gernet, W. & Krekeler, G. (1979) [The value of functional analyses for systematic periodontal treatment (clinical study)]. Dtsch.Zahnarztl.Z. 34, 374-377. Ghandour, I. (1989) Hyperkeratosis palmoplantaris with premature periodontal destruction (Papillon Lefevre syndrome)--report of two cases. East Afr.Med J 66, 615-619. Giannella, L., Giulini, S., Cerami, L. B., La Marca, A., Forabosco, A. & Volpe, A. (2011) Periodontal disease and nitric oxide levels in low risk women with preterm labor. Eur.J Obstet Gynecol Reprod.Biol 158, 47-51. Gibbs, R. S., Romero, R., Hillier, S. L., Eshenbach, D. A. & Sweet, R. T. (1992) Am J Obstet Gynecol 166, 1515Gibbs, R. S. (2001) The Relationship Between Infections and Adverse Pregnancy Outcomes: An Overview. Annals of Periodontology 6, 153-163. Giglio, J. A., Lanni, S. M., Laskin, D. M. & Giglio, N. W. (2009) Oral health care for the pregnant patient. J Can Dent Assoc. 75, 43-48. 12 Giuliani, V., Baccetti, T., Pace, R. & Pagavino, G. (2002) The use of MTA in teeth with necrotic pulps and open apices. Dent Traumatol. 18, 217-221. Goepfert, A. R., Jeffcoat, M. K., Andrews, W. W., Faye-Petersen, O., Cliver, S. P., Goldenberg, R. L. & Hauth, J. C. (2004) Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth. Obstet Gynecol 104, 777-783. Goeppert, A. R., Jeffcoat, M., Andrews, W. W., Cliver, S., Hauth, J. C., Faye-Peterson, O. & Goldenberg, R. L. (2001) Upper genital tract inflammation is increased in women with early spontaneous preterm birth (SPTB) but not in women with periodontal disease with periodontal disease. American Journal of Obstetrics and Gynecology 185, Goldenberg, R. L. & Culhane, J. F. (2006) Preterm birth and periodontal disease. N.Engl.J Med 355, 1925-1927. Goldenberg, R. L., Culhane, J. F., Iams, J. D. & Romero, R. (2008) Epidemiology and causes of preterm birth. Lancet 371, 75-84. Goldenberg, R. L. & Culhane, J. F. (2006) Preterm Birth and Periodontal Disease. New England Journal of Medicine 355, 1925-1927. Goldie, M. P. (2006) Healthy mother, healthy baby. Int.J Dent Hyg. 4, 162-163. Gomes-Filho, I. S., da Cruz, S. S., Rezende, E. J., da Silveira, B. B., Trindade, S. C., Passos, J. S., de Freitas, C. O., Cerqueira, E. M. & de Souza Teles Santos CA (2006) Periodontal status as predictor of prematurity and low birth weight. J Public Health Dent 66, 295-298. Gomes-Filho, I. S., Cruz, S. S., Rezende, E. J., Dos Santos, C. A., Soledade, K. R., Magalhaes, M. A., de Azevedo, A. C., Trindade, S. C., Vianna, M. I., Passos, J. S. & Cerqueira, E. M. (2007) Exposure measurement in the association between periodontal disease and prematurity/low birth weight. J Clin Periodontol 34, 957-963. Gomes-Filho, I. S., Cruz, S. S., Costa, M. C., Passos, J. S., Cerqueira, E. M., Sampaio, F. P., Pereira, E. C. & Miranda, L. F. (2010) Periodontal therapy and low birth weight: preliminary results from an alternative methodologic strategy. J Periodontol 81, 1725-1733. Gomes-Silva, J. M., Ruviere, D. B., Segatto, R. A., de Queiroz, A. M. & de Freitas, A. C. (2006) Sotos syndrome: a case report. Spec.Care Dentist. 26, 257-262. Gonzales-Marin, C., Spratt, D. A., Millar, M. R., Simmonds, M., Kempley, S. T. & Allaker, R. P. (2011) Levels of periodontal pathogens in neonatal gastric aspirates and possible maternal sites of origin. Mol.Oral Microbiol 26, 277-290. Gottehrer, N. R. (2003) Managing risk factors in successful nonsurgical treatment of periodontal disease. Dent Today 22, 64-69. Graves, D. T., Jiang, Y. & Genco, C. (2000) Periodontal disease: bacterial virulence factors, host response and impact on systemic health. Curr.Opin.Infect Dis 13, 227-232. Greenstein, G., Greenstein, B. & Cavallaro, J. (2007) Prerequisite for treatment planning implant dentistry: periodontal prognostication of compromised teeth. Compend.Contin.Educ.Dent 28, 436446. Guilbeau, J. R. & Hurst, H. (2009) Brush up: periodontal disease and pregnancy. Nurs.Womens Health 13, 496-499. 13 Guimaraes, A. N., Silva-Mato, A., Miranda Cota, L. O., Siqueira, F. M. & Costa, F. O. (2010) Maternal periodontal disease and preterm or extreme preterm birth: an ordinal logistic regression analysis. J Periodontol 81, 350-358. Gur, A. & Majra, J. (2011) Awareness regarding the systemic effects of periodontal disease among medical interns in India. J Glob.Infect Dis 3, 123-127. Ha, J. E., Oh, K. J., Yang, H. J., Jun, J. K., Jin, B. H., Paik, D. I. & Bae, K. H. (2011) Oral Health Behaviors, Periodontal Disease, and Pathogens in Preeclampsia: A Case-Control Study in Korea. Journal of Periodontology 82, 1685-1692. Haas, R., Baron, M., Dortbudak, O. & Watzek, G. (2000) Lethal photosensitization, autogenous bone, and e-PTFE membrane for the treatment of peri-implantitis: preliminary results. Int.J Oral Maxillofac.Implants 15, 374-382. Hamilton, J. (2005) The link between periodontal disease and systemic diseases: state of the evidence 2005. J Calif.Dent Assoc. 33, 29-38. Han, Y. W., Redline, R. W., Li, M., Yin, L., Hill, G. B. & McCormick, T. S. (2004) Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. Infect Immun. 72, 2272-2279. Han, Y. W., Ikegami, A., Bissada, N. F., Herbst, M., Redline, R. W. & Ashmead, G. G. (2006) Transmission of an uncultivated Bergeyella strain from the oral cavity to amniotic fluid in a case of preterm birth. J Clin Microbiol 44, 1475-1483. Han, Y. W., Ikegami, A., Chung, P., Zhang, L. & Deng, C. X. (2007) Sonoporation is an efficient tool for intracellular fluorescent dextran delivery and one-step double-crossover mutant construction in Fusobacterium nucleatum. Appl.Environ.Microbiol 73, 3677-3683. Han, Y. W., Fardini, Y., Chen, C., Iacampo, K. G., Peraino, V. A., Shamonki, J. M. & Redline, R. W. (2010) Term stillbirth caused by oral Fusobacterium nucleatum. Obstet Gynecol 115, 442-445. Han, Y. W. (2011) Oral health and adverse pregnancy outcomes - what's next? J Dent Res 90, 289-293. Han, Y. W., Redline, R. W., Li, M., Yin, L., Hill, G. B. & McCormick, T. S. (2004) Fusobacterium nucleatum Induces Premature and Term Stillbirths in Pregnant Mice: Implication of Oral Bacteria in Preterm Birth. Infection and Immunity 72, 2272-2279. Harper, L. M., Parry, S., Stamilio, D. M., Odibo, A. O., Cahill, A. G., Strauss, J. F., III & Macones, G. A. (2012) The interaction effect of bacterial vaginosis and periodontal disease on the risk of preterm delivery. Am J Perinatol. 29, 347-352. Harrel, S. K. & Nunn, M. E. (2009) The association of occlusal contacts with the presence of increased periodontal probing depth. J Clin Periodontol 36, 1035-1042. Hart, R., Doherty, D. A., Pennell, C. E., Newnham, I. A. & Newnham, J. P. (2012) Periodontal disease: a potential modifiable risk factor limiting conception. Human Reproduction 27, 13321342. Hart, T. C., Hart, P. S., Bowden, D. W., Michalec, M. D., Callison, S. A., Walker, S. J., Zhang, Y. & Firatli, E. (1999) Mutations of the cathepsin C gene are responsible for Papillon-Lefevre syndrome. J Med Genet. 36, 881-887. 14 Hart, T. C., Hart, P. S., Michalec, M. D., Zhang, Y., Firatli, E., Van Dyke, T. E., Stabholz, A., Zlotogorski, A., Shapira, L. & Soskolne, W. A. (2000) Haim-Munk syndrome and Papillon-Lefevre syndrome are allelic mutations in cathepsin C. J Med Genet. 37, 88-94. Hartsfield, J. K., Jr. (1994) Premature exfoliation of teeth in childhood and adolescence. Adv.Pediatr. 41, 453-470. Hasegawa-Nakamura, K., Tateishi, F., Nakamura, T., Nakajima, Y., Kawamata, K., Douchi, T., Hatae, M. & Noguchi, K. (2011) The possible mechanism of preterm birth associated with periodontopathic Porphyromonas gingivalis. J Periodontal Res 46, 497-504. Hasegawa, K., Furuichi, Y., Shimotsu, A., Nakamura, M., Yoshinaga, M., Kamitomo, M., Hatae, M., Maruyama, I. & Izumi, Y. (2003) Associations between systemic status, periodontal status, serum cytokine levels, and delivery outcomes in pregnant women with a diagnosis of threatened premature labor. J Periodontol 74, 1764-1770. Hattab, F. N. & Amin, W. M. (2005) Papillon-Lefevre syndrome with albinism: a review of the literature and report of 2 brothers. Oral Surg Oral Med Oral Pathol Oral Radiol.Endod 100, 709716. Hayashi, C., Gudino, C. V., Gibson, F. C., III & Genco, C. A. (2010) Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. Mol.Oral Microbiol 25, 305-316. Heimonen, A., Rintamaki, H., Furuholm, J., Janket, S. J., Kaaja, R. & Meurman, J. H. (2008) Postpartum oral health parameters in women with preterm birth. Acta Odontologica Scandinavica 1-8. Heimonen, A., Janket, S. J., Meurman, J. H., Furuholm, J., Ackerson, L. K. & Kaaja, R. (2008) Oral health care patterns and the history of miscarriage. Oral Diseases 14, 734-740. Heimonen, A., Janket, S. J., Kaaja, R., Ackerson, L. K., Muthukrishnan, P. & Meurman, J. H. (2009) Oral Inflammatory Burden and Preterm Birth. Journal of Periodontology 80, 884-891. Hein, G. (1977) [Caries or fluoridation--a comparison between Hamburg and Vordingborg (Denmark)]. Monatsschr.Kinderheilkd. 125, 61-64. Herrera, J. A., Parra, B., Herrera, E., Botero, J. E., Arce, R. M., Contreras, A. & Lopez-Jaramillo, P. (2007) Periodontal disease severity is related to high levels of C-reactive protein in preeclampsia. J Hypertens. 25, 1459-1464. Herrera, J. A., Velez-Medina, S. & Molano, R. (2009) Periodontal intervention effects on pregnancy outcomes in women with preeclampsia Colomb Med 40, 177- 184. Hill, G. B. (1998) Preterm birth: associations with genital and possibly oral microflora. Ann Periodontol 3, 222-232. Hirano, E., Sugita, N., Kikuchi, A., Shimada, Y., Sasahara, J., Iwanaga, R., Tanaka, K. & Yoshie, H. (2010) Peroxisome proliferator-activated receptor gamma polymorphism and periodontitis in pregnant Japanese women. J Periodontol 81, 897-906. Hogg, N. (1998) Free radicals in disease Semin Reprod Endocrinol 16, 241-248. 15 Holbrook, W. P., Oskarsdottir, A., Fridjonsson, T., Einarsson, H., Hauksson, A. & Geirsson, R. T. (2004) No link between low-grade periodontal disease and preterm birth: a pilot study in a healthy Caucasian population. Acta Odontol Scand 62, 177-179. Holmes, J. & Tanner, M. S. (1976) Premature eruption and macrodontia associated with insulin resistant diabetes and pineal hyperplasia. Report of two cases. Br.Dent J 141, 280-284. Holmstrup, P., Poulsen, A. H., Andersen, L., Skuldbol, T. & Fiehn, N. E. (2003) Oral infections and systemic diseases. Dent Clin North Am 47, 575-598. Horton, A. L., Boggess, K. A., Moss, K. L., Jared, H. L., Beck, J. & Offenbacher, S. (2008) Periodontal disease early in pregnancy is associated with maternal systemic inflammation among African American women. J Periodontol 79, 1127-1132. Horton, A. L., Boggess, K. A., Moss, K. L., Beck, J. & Offenbacher, S. (2010) Periodontal disease, oxidative stress, and risk for preeclampsia. J Periodontol 81, 199-204. Horton, A. L. & Boggess, K. A. (2012) Periodontal disease and preterm birth. Obstet Gynecol Clin North Am 39, 17-23, vii. Hruska, A. (1968) [My practical and theoretical experiences on the nature of premature loosening of teeth]. DDZ. 22, 586-590. Huang, Z., Sha, Y. Q., Kang, J., Chen, Z. B., Miao, J. X. & Sun, Y. Y. (2010) [Association between preterm low birth weight and maternal cytokine levels of saliva and gingival crevicular fluid]. Zhonghua Kou Qiang.Yi.Xue.Za Zhi. 45, 260-264. Hubbard, S. & Shanks, A. (2004) Relationship between periodontal disease and preterm low birth weight infants. Tenn.Med 97, 81Hubel, C. A. (1999) Oxidative stress in the pathogenesis of preeclampsia. Proc Soc Exp Biol Med 222, 222-235. Huck, O., Tenebaum, H. & Davideau, J-L. (2011) Relationship between Periodontal Diseases and PretermBirth: Recent Epidemiological and Biological Data Journal of Pregnancy Article ID 164654, doi:10.1155/2011/164654 Hujoel, P. P., Lydon-Rochelle, M., Robertson, P. B. & del Aguila, M. A. (2006) Cessation of periodontal care during pregnancy: effect on infant birthweight. Eur.J Oral Sci. 114, 2-7. Hunter, J. M. & Arbona, S. I. (1995) The tooth as a marker of developing world quality of life: a field study in Guatemala. Soc Sci.Med 41, 1217-1240. Iacopino, A. M. (2010) Epigenetics: new explanations for old problems? J Can Dent Assoc. 76, a76 Ide, M., Wilson, R. F. & Ashley, F. P. (1998) Relationship between adverse pregnancy outcome and maternal periodontal disease. Journal of Dental Research 77, 648. Ide, M. & Farrell. S. (2005) Associations Between Maternal Periodontitis, Periodontal Treatment and Pregnancy Complications - Part 2: Analytical Epidemiology. PERIO - Periodontal Practice Today 2, 173-182. 16 Ikegami, A., Chung, P. & Han, Y. W. (2009) Complementation of the fadA mutation in Fusobacterium nucleatum demonstrates that the surface-exposed adhesin promotes cellular invasion and placental colonization. Infect Immun. 77, 3075-3079. Inaba, H. & Amano, A. (2010) Roles of oral bacteria in cardiovascular diseases--from molecular mechanisms to clinical cases: Implication of periodontal diseases in development of systemic diseases. J Pharmacol.Sci. 113, 103-109. Irwin, C., Mullally, B., Ziada, H., Byrne, P. J. & Allen, E. (2008) Periodontics: 9. Periodontitis and systemic conditions--is there a link? Dent Update 35, 92-8, 100. Ishigaki, S., Kurozumi, T., Morishige, E. & Yatani, H. (2006) Occlusal interference during mastication can cause pathological tooth mobility. J Periodontal Res 41, 189-192. Ishihara, O., Hayashi, M. & Osawa, H. (2004) Isoprostanes, prostaglandins and tocopherols in pre-eclampsia, normal pregnancy and non-pregnancy. Free Radic Res 38, 913-918. Iwanaga, R., Sugita, N., Hirano, E., Sasahara, J., Kikuchi, A., Tanaka, K. & Yoshie, H. (2011) FcgammaRIIB polymorphisms, periodontitis and preterm birth in Japanese pregnant women. J Periodontal Res 46, 292-302. Jain, N., Jain, G. K., Javed, S., Iqbal, Z., Talegaonkar, S., Ahmad, F. J. & Khar, R. K. (2008) Recent approaches for the treatment of periodontitis. Drug Discov.Today 13, 932-943. Jain, V., Gupta, R. & Parkash, H. (2005) Prosthodontic rehabilitation in Papillon-Lefevre syndrome: a case report. J Indian Soc Pedod.Prev.Dent 23, 96-98. Jarjoura, K., Devine, P., Perez-Delboy, A., D'Alton, M. & Papapanou, P. N. (2002) Periodontal disease and preterm birth: A case control study. Journal of Dental Research 81, 231Jarjoura, K., Devine, P. C., Perez-Delboy, A., Herrera-Abreu, M., D'Alton, M. & Papapanou, P. N. (2005) Markers of periodontal infection and preterm birth. American Journal of Obstetrics and Gynecology 192, 513-519. Jeffcoat, M., Parry, S., Gerlach, R. W. & Doyle, M. J. (2011) Use of alcohol-free antimicrobial mouth rinse is associated with decreased incidence of preterm birth in a high-risk population. Am J Obstet Gynecol 205, 382-386. Jeffcoat, M., Parry, S., Sammel, M., Clothier, B., Catlin, A. & Macones, G. (2011) Periodontal infection and preterm birth: successful periodontal therapy reduces the risk of preterm birth. BJOG 118, 250-256. Jeffcoat, M. K. (2000) Preterm birth, osteoporosis, and periodontal disease. Compend.Contin.Educ.Dent Suppl 5-11. Jeffcoat, M. K., Geurs, N. C., Reddy, M. S., Goldenberg, R. L. & Hauth, J. C. (2001) Current evidence regarding periodontal disease as a risk factor in preterm birth. Ann Periodontol 6, 183188. Jeffcoat, M. K., Geurs, N. C., Reddy, M. S., Cliver, S. P., Goldenberg, R. L. & Hauth, J. C. (2001) Periodontal infection and preterm birth: results of a prospective study. J Am Dent Assoc. 132, 875-880. 17 Jeffcoat, M. K., Hauth, J. C., Geurs, N. C., Reddy, M. S., Cliver, S. P., Hodgkins, P. M. & Goldenberg, R. L. (2003) Periodontal disease and preterm birth: results of a pilot intervention study. J Periodontol 74, 1214-1218. Jin, L. J. & Cao, C. F. (1992) Clinical diagnosis of trauma from occlusion and its relation with severity of periodontitis. J Clin Periodontol 19, 92-97. John, V. & Kim, S. J. (2002) Periodontal disease and systemic disease. Clinical information for the practicing dentist. J Indiana Dent Assoc. 81, 15-18. Jyoti Bansal , Abhishek Bansal , Navneet Kukreja & Urvashi Kukreja (2012) Periodontal diseases as an emerging potential risk factor for adverse pregnancy outcomes: A review of concepts. Journal of the Turkish-German Gynecological Association 12, 176-180. Kadowaki, T., Takii, R., Baba, A. & Yamamoto, K. (2003) [Gingipains as the determinants of periodontopathogenicity]. Nihon Yakurigaku Zasshi 122, 37-44. Kahn, S., Garcia, C. H., Galan, J. J., Namen, F. M., Machado, W. A., Silva Junior, J. A., Sardenberg, E. M. & Egreja, A. M. (2008) [Evaluating the existence of oral infection control in patients admitted in state hospitals in Rio de Janeiro]. Cien.Saude Colet. 13 , 1825-1831. Kalra, N., Sushma, K. & Mahapatra, G. K. (2000) Changes in developing succedaneous teeth as a consequence of infected deciduous molars. J Indian Soc Pedod.Prev.Dent 18, 90-94. Kamma, J. J., Lygidakis, N. A. & Nakou, M. (1998) Subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia. J Clin Periodontol 25, 759-765. Kassab, P., Colombier, M. L., Kaminski, M., Lelong, N., Sixou, M., Nabet, C. & for the EPIPAP (EPIdemiological study on the relation between Periodontitis and Adverse Pregnancy outcomes) group (2011) Impact of periodontitis definition in epidemiological research. Results from the EPIPAP study in postpartum women. European Journal of Oral Sciences 119, 156-162. Katz, J., Chaushu, G. & Sharabi, Y. (2001) On the association between hypercholesterolemia, cardiovascular disease and severe periodontal disease. J Clin Periodontol 28, 865-868. Katz, J., Orchard, A. B., Ortega, J., Lamont, R. J. & Bimstein, E. (2006) Oral health and preterm delivery education: a new role for the pediatric dentist. Pediatr.Dent 28, 494-498. Katz, J., Chegini, N., Shiverick, K. T. & Lamont, R. J. (2009) Localization of P. gingivalis in preterm delivery placenta. J Dent Res 88, 575-578. Katz, J., Wallet, S. & Cha, S. (2010) Periodontal disease and the oral-systemic connection: "is it all the RAGE?". Quintessence.Int. 41, 229-237. Katz, J., Onate, M. D., Pauley, K. M., Bhattacharyya, I. & Cha, S. (2011) Presence of Porphyromonas gingivalis in gingival squamous cell carcinoma. Int.J Oral Sci. 3, 209-215. Kawar, N. & Alrayyes, S. (2011) Periodontitis in pregnancy: the risk of preterm labor and low birth weight. Dis Mon. 57, 192-202. Kazmierczak, W., Fiegler, P., Fiegler-Mecik, H., Mecik, T. J. & Przybylek, B. (2004) [Influence of the prevention of maternal periodontitis on the risk of preterm delivery]. Wiad.Lek. 57 Suppl 1, 148-151. 18 Kazmierczak, W., Fiegler, P., Wegrzyn, P., Fiegler-Mecik, H., Przybylek, B. & Kaminski, K. (2005) [Risk assessment for preterm delivery in pregnant women with active periodontitis]. Ginekol.Pol. 76, 632-638. Keelan, J. A., Wong, P. M., Bird, P. S. & Mitchell, M. D. (2010) Innate inflammatory responses of human decidual cells to periodontopathic bacteria. Am J Obstet Gynecol 202, 471-11. Kerpen, S. J. (2005) The damn millimeter. N.Y.State Dent J 71, 19Khader, Y., Al shishani, L., Obeidat, B., Khassawneh, M., Burgan, S., Amarin, Z. O., Alomari, M. & Alkafajei, A. (2009) Maternal periodontal status and preterm low birth weight delivery: a casecontrol study. Arch.Gynecol Obstet 279, 165-169. Khader, Y. S. & Ta'ani, Q. (2005) Periodontal diseases and the risk of preterm birth and low birth weight: a meta-analysis. J Periodontol 76, 161-165. Khader, Y. S., Jibreal, M., Al Omiri, M. & Amarin, Z. (2006) Lack of association between periodontal parameters and preeclampsia. J Periodontol 77, 1681-1687. Khalili, J. (2010) Genetic test and periodontal disease. Lik.Sprava. 91-95. Kim, A. J., Lo, A. J., Pullin, D. A., Thornton-Johnson, D. S. & Karimbux, N. Y. (2012) Scaling and Root Planing Treatment for Periodontitis to Reduce Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Periodontol Kim, J. & Amar, S. (2006) Periodontal disease and systemic conditions: a bidirectional relationship. Odontology 94, 10-21. Kim, J., Yang, K. H., Nam, J. S., Choi, J. R., Song, J., Chang, M. & Lee, K. A. (2009) A novel PHEX mutation in a Korean patient with sporadic hypophosphatemic rickets. Ann Clin Lab Sci. 39, 182-187. Kinane, D. & Bouchard, P. (2008) Periodontal diseases and health: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol 35, 333-337. Kinane, D. F. (2001) Causation and pathogenesis of periodontal disease Periodontol 2000 25, 820. Klassen, J. T. & Krasko, B. M. (2002) The dental health status of dialysis patients. J Can Dent Assoc. 68, 34-38. Klebanoff, M. & Searle, K. (2006) The role of inflammation in preterm birth--focus on periodontitis. BJOG 113 Suppl 3, 43-45. Kloetzel, M. K., Huebner, C. E. & Milgrom, P. (2011) Referrals for dental care during pregnancy. J Midwifery Womens Health 56, 110-117. Konopka, T., Rutkowska, M., Hirnle, L., Kopec, W. & Karolewska, E. (2003) The secretion of prostaglandin E2 and interleukin 1-beta in women with periodontal diseases and preterm lowbirth-weight. Bull.Group Int.Rech.Sci.Stomatol Odontol 45, 18-28. Konopka, T. (2004) [Periodontitis and preterm low birth weight]. Ginekol.Pol. 75, 397-403. 19 Konopka, T., Rutkowska, M., Hirnle, L. & Kopec, W. (2004) [IL-1beta and PGE2 production in whole blood and gingival fluid in women with periodontitis and preterm low birth weight]. Ginekol.Pol. 75, 352-360. Kostadinov, S. & Pinar, H. (2005) Amniotic fluid infection syndrome and neonatal mortality caused by Eikenella corrodens. Pediatr.Dev.Pathol 8, 489-492. Kothiwale, S. V. & Mathur, S. (2008) Partial expression of Papillon-Lefevre Syndrome. Indian J Dent Res 19, 264-266. Kothiwale, S. & Panwar, V. (2011) Poor periodontal health of pregnant women as a risk factor for preterm and low birth weight. Indian Journal of Dentistry 2, 129-133. Kramer, M., Demissie, K., Yang, H., Platt, R. W., Sauvé, R. & Liston, R. (2000) The contribution of mild and moderate preterm birth to infant mortality. Fetal and Infant Health Study Group of the Canadian Perinatal Surveillance System JAMA 284, 843-849. Krejci, C. B. & Bissada, N. F. (2002) Women's health issues and their relationship to periodontitis. J Am Dent Assoc. 133, 323-329. Kressin, S., Herforth, A., Preis, S., Wahn, V. & Lenard, H. G. (1995) Papillon-Lefevre syndrome-successful treatment with a combination of retinoid and concurrent systematic periodontal therapy: case reports. Quintessence.Int. 26, 795-803. Kumar, J. & Samelson, R. (2009) Oral health care during pregnancy recommendations for oral health professionals. N.Y.State Dent J 75, 29-33. Kunnen, A., Blaauw, J., van Doormaal, J. J., van Pampus, M. G., van der Schans, C. P., Aarnoudse, J. G., van Winkelhoff, A. J. & Abbas, F. (2007) Women with a recent history of earlyonset pre-eclampsia have a worse periodontal condition. J Clin Periodontol 34, 202-207. Kunnen, A., van Doormaal, J. J., Abbas, F., Aarnoudse, J. G., van Pampus, M. G. & Faas, M. M. (2010) Periodontal disease and pre-eclampsia: a systematic review. J Clin Periodontol 37, 10751087. Kurnatowska, A. & Stankiewicz, A. (2006) [Clinical evaluation of periodontium in pregnant women with risk of preterm birth]. Ginekol.Pol. 77, 366-5. Kushtagi, P., Kaur, G., Kukkamalla, M. A. & Thomas, B. (2008) Periodontal infection in women with low birth weight neonates. Int.J Gynaecol.Obstet 101, 296-298. López, N. J., Smith, P. C. & Gutierrez, J. (2002) Higher Risk of Preterm Birth and Low Birth Weight in Women with Periodontal Disease. Journal of Dental Research 81, 58-63. López, N. s. J., Smith, P. C. & Gutierrez, J. (2002) Periodontal Therapy May Reduce the Risk of Preterm Low Birth Weight in Women With Peridotal Disease: A randomized Controlled Trial. Journal of Periodontology 73, 911-924. López, N. s. J., Da Silva, I., Ipinza, J. n. & Guti+®rrez, J. (2005) Periodontal Therapy Reduces the Rate of Preterm Low Birth Weight in Women With Pregnancy-Associated Gingivitis. Journal of Periodontology 76, 2144-2153. Laass, M. W., Hennies, H. C., Preis, S., Stevens, H. P., Jung, M., Leigh, I. M., Wienker, T. F. & Reis, A. (1997) Localisation of a gene for Papillon-Lefevre syndrome to chromosome 11q14-q21 by homozygosity mapping. Hum.Genet. 101, 376-382. 20 Laine, M. A. (2002) Effect of pregnancy on periodontal and dental health. Acta Odontol Scand 60, 257-264. Lamont, R. J. & Jenkinson, H. F. (1998) Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol.Biol Rev 62, 1244-1263. Lawn, J., Yakoob, M., Haws, R., Soomro, T., Darmstadt, G. & Bhutta, Z. (2009) 3.2 million stillbirths: epidemiology and overview of the evidence review. BMC Pregnancy and Childbirth 9 , S2 Le Borgne, H., Soueidan, A., Caroit-Cambazard, Y., Boutigny, H., Jean-Baptiste, K., Nguyen, J. M. & Philippe, H. J. (2011) [Periodontal diseases and preterm birth: a pilot study]. Gynecol Obstet Fertil. 39, 399-401. Le, H. T., Jareinpituk, S., Kaewkungwal, J. & Pitiphat, W. (2007) Increased risk of preterm birth among non- smoking, non- alcohol drinking women with maternal periodontitis. Southeast Asian J Trop.Med Public Health 38, 586-593. León, R., Silva, N., Ovalle, A., Chaparro, A., Ahumada, A., Gajardo, M., Martinez, M. & Gamonal, J. (2007) Detection of Porphyromonas gingivalis in the Amniotic Fluid in Pregnant Women With a Diagnosis of Threatened Premature Labor. Journal of Periodontology 78, 1249-1255. Leal, J. B. & Carracho, J. L. (1968) [Considerations on dental treatments during pregnancy]. Rev Stomatol Chir Maxillofac. 69, 703-708. Lefevre, C., Blanchet-Bardon, C., Jobard, F., Bouadjar, B., Stalder, J. F., Cure, S., Hoffmann, A., Prud'Homme, J. F. & Fischer, J. (2001) Novel point mutations, deletions, and polymorphisms in the cathepsin C gene in nine families from Europe and North Africa with Papillon-Lefevre syndrome. J Invest Dermatol. 117, 1657-1661. Leon, R., Silva, N., Ovalle, A., Chaparro, A., Ahumada, A., Gajardo, M., Martinez, M. & Gamonal, J. (2007) Detection of Porphyromonas gingivalis in the amniotic fluid in pregnant women with a diagnosis of threatened premature labor. J Periodontol 78, 1249-1255. Leone, C. R. (2001) [Maternal periodontal disease and premature birth or low birth weight]. J Pediatr.(Rio J) 77, 6-7. Li, X., Kolltveit, K. M., Tronstad, L. & Olsen, I. (2000) Systemic diseases caused by oral infection. Clin Microbiol Rev 13, 547-558. Li, X. J., Sha, Y. Q. & He, J. (2004) [Advances research of periodontal disease and preterm low birth weight deliveries]. Zhonghua Kou Qiang.Yi.Xue.Za Zhi. 39, 341-343. Li, X. J., Kong, J. J., Liang, F. B., Chen, H. & He, J. (2006) [Analysis of periodontal status in pregnant women with a diagnosis of threatened premature labor]. Shanghai Kou Qiang.Yi.Xue. 15, 478-481. Li, X. J., Kong, J. J., Chen, H., Liang, F. B. & He, J. (2006) [Associations between periodontal status and delivery outcomes in pregnant women with a diagnosis of threatened premature labor]. Zhonghua Kou Qiang.Yi.Xue.Za Zhi. 41, 599-601. Li, X. J., Kong, J. J., Liang, F. B., Chen, H. & He, J. (2007) [A pilot study on relationship of periodontal status, serum level of interleukin-1beta and delivery outcomes in pregnant women]. Hua Xi.Kou Qiang.Yi.Xue.Za Zhi. 25, 61-63. 21 Lieff, S., Boggess, K., Madianos, P., Murtha, A., McKaig, R., Moss, K., Worley, M., Smith, F., Beck, J. & Offenbacher, S. (2001) Clinical periodontal disease in a pregnant cohort: racial disparity at enrollment and delivery. American Journal of Obstetrics and Gynecology 185, 156Lieff, S., Boggess, K. A., Murtha, A. P., Jared, H., Madianos, P. N., Moss, K., Beck, J. & Offenbacher, S. (2004) The oral conditions and pregnancy study: Periodontal status of a cohort of pregnant women. Journal of Periodontology , 116-126. Lin, D., Moss, K., Beck, J. D., Hefti, A. & Offenbacher, S. (2007) Persistently high levels of periodontal pathogens associated with preterm pregnancy outcome. J Periodontol 78, 833-841. Lin, Y., Tian, Z. R., Chen, H. B., Tai, B. J., Jiang, H. & Du, M. Q. (2009) [Study on maternal periodontal diseases of the relationships between porphyromonas gingivalis, serum proimmflamatory mediators and preterm low birth weight]. Hua Xi.Kou Qiang.Yi.Xue.Za Zhi. 27, 595598. Liu, J., Zhong, L. J., Shi, F. C., Zhang, L., Zhang, Q. & Sun, D. L. (2011) [Expression of tumor necrosis factor in placenta tissue of pregnant rats with chronic peridontitis]. Zhonghua Kou Qiang.Yi.Xue.Za Zhi. 46, 276-279. Loesche, W. J. (1997) Association of the oral flora with important medical diseases. Curr.Opin.Periodontol 4, 21-28. Loesche, W. J. (1999) Anaerobic Periodontal Infections as Risk Factors for Medical Diseases. Curr.Infect Dis Rep. 1, 33-38. Lohsoonthorn, V., Kungsadalpipob, K., Chanchareonsook, P., Limpongsanurak, S., Vanichjakvong, O., Sutdhibhisal, S., Sookprome, C., Wongkittikraiwan, N., Kamolpornwijit, W., Jantarasaengaram, S., Manotaya, S., Siwawej, V., Barlow, W. E., Fitzpatrick, A. L. & Williams, M. A. (2009) Maternal periodontal disease and risk of preeclampsia: a case-control study. Am J Hypertens. 22, 457-463. Lohsoonthorn, V., Kungsadalpipob, K., Chanchareonsook, P., Limpongsanurak, S., Vanichjakvong, O., Sutdhibhisal, S., Wongkittikraiwan, N., Sookprome, C., Kamolpornwijit, W., Jantarasaengaram, S., Manotaya, S., Siwawej, V., Barlow, W. E., Fitzpatrick, A. L. & Williams, M. A. (2009) Is maternal periodontal disease a risk factor for preterm delivery? Am J Epidemiol. 169, 731-739. Looney, S. W. (2008) Re: Treatment of periodontal disease and the risk of preterm birth. J Periodontol 79, 1-2. Looney, S. W. (2008) Letter to the Editor: Re: Treatment of Periodontal Disease and the Risk of Preterm Birth. Journal of Periodontology 79, 1-2. Lopes, F. F., Lima, L. L., Rodrigues, M. C. d. A., Cruz, M. C. F. N. d., Oliveira, A. E. l. F. d. & Alves, C. M. C. (2005) A condição periodontal materna e o nascimento de prematuro de baixo peso: estudo caso-controle [Maternal periodontal status and preterm low birth weight: a casecontrol study]. Revista Brasileira de Ginecologia e Obstetricia 27, 382-386. Lopez-Jaramillo, P., Gomez-Arbelaez, D. & Lopez-Lopez, J. (2011) Periodontal disease and hypertension: the pre-eclampsia model in Hispanic population. J Hypertens. 29, 1020-1021. Lopez, N. J., Smith, P., Pavez, V. & Gutierrez, J. (2000) Periodontal disease: a risk factor for low birth weight and preterm delivery. Journal of Clinical Periodontology 27, 31- 22 Lopez, N. J., Smith, P. C. & Gutierrez, J. (2002) Periodontal therapy may reduce the risk of preterm low birth weight in women with periodontal disease: a randomized controlled trial. J Periodontol 73, 911-924. Lopez, N. J., Smith, P. C. & Gutierrez, J. (2002) Higher risk of preterm birth and low birth weight in women with periodontal disease. J Dent Res 81, 58-63. Lopez, N. J., Da, S., I, Ipinza, J. & Gutierrez, J. (2005) Periodontal therapy reduces the rate of preterm low birth weight in women with pregnancy-associated gingivitis. J Periodontol 76, 21442153. Lopez, R. (2005) Periodontal disease, preterm birth and low birthweight. Evid.Based Dent 6, 9091. Lopez, R. (2007) Is periodontal disease associated with poor pregnancy outcomes? What is the strength of association between periodontal disease in mothers and birth of their infants preterm or with low birthweights? Evid.Based Dent 8, 114-115. Lopez, R. (2007) Periodontal treatment in pregnant women improves periodontal disease but does not alter rates of preterm birth. Evid.Based Dent 8, 38Lopez, R. (2008) Periodontal disease and adverse pregnancy outcomes. Evid.Based Dent 9, 48Louro, P. M., Fiori, H. H., Filho, P. L., Steibel, J. & Fiori, R. M. (2001) [Periodontal disease in pregnancy and low birth weight]. J Pediatr.(Rio J) 77, 23-28. Lunardelli, A. N. & Peres, M. A. l. (2005) Is there an association between periodontal disease, prematurity and low birth weight? A population-based study. Journal of Clinical Periodontology 32, 938-946. Lundgren, T., Crossner, C. G., Twetman, S. & Ullbro, C. (1996) Systemic retinoid medication and periodontal health in patients with Papillon-Lefevre syndrome. J Clin Periodontol 23, 176-179. Macones, G. A., Parry, S., Nelson, D. B., Strauss, J. F., Ludmir, J., Cohen, A. W., Stamilio, D. M., Appleby, D., Clothier, B., Sammel, M. D. & Jeffcoat, M. (2010) Treatment of localized periodontal disease in pregnancy does not reduce the occurrence of preterm birth: results from the Periodontal Infections and Prematurity Study (PIPS). Am J Obstet Gynecol 202, 147-148. Madianos, P. N., Lieff, S., Beck, J., Patel, T. & Offenbacher, S. (2000) Periodontitis, serum Creactive protein, and antibodies against periodontal pathogens in mothers with normal and preterm low birth weight babies. Journal of Clinical Periodontology 27, 31. Madianos, P. N., Lieff, S., Murtha, A. P., Boggess, K. A., Auten, R. L., Jr., Beck, J. D. & Offenbacher, S. (2001) Maternal periodontitis and prematurity. Part II: Maternal infection and fetal exposure. Ann Periodontol 6, 175-182. Madianos, P. N., Bobetsis, G. A. & Kinane, D. F. (2002) Is periodontitis associated with an increased risk of coronary heart disease and preterm and/or low birth weight births? J Clin Periodontol 29 Suppl 3, 22-36. Madrigal-Martinez-Pereda, C., Guerrero-Rodriguez, V., Guisado-Moya, B. & Meniz-Garcia, C. (2009) Langerhans cell histiocytosis: literature review and descriptive analysis of oral manifestations. Med Oral Patol.Oral Cir.Bucal. 14, E222-E228. 23 Majorana, A., Notarangelo, L. D., Savoldi, E., Gastaldi, G. & Lozada-Nur, F. (1999) Leukocyte adhesion deficiency in a child with severe oral involvement. Oral Surg Oral Med Oral Pathol Oral Radiol.Endod 87, 691-694. Manau, C., Echeverria, A., Agueda, A., Guerrero, A. & Echeverria, J. J. (2008) Periodontal disease definition may determine the association between periodontitis and pregnancy outcomes. Journal of Clinical Periodontology 35, 385-397. Mangini, F., Santacroce, L. & Bottalico, L. (2006) [Periodontitis and systemic diseases]. Clin Ter. 157 , 541-548. Manjunath, B. C., Praveen, K., Chandrashekar, B. R., Rani, R. M. & Bhalla, A. (2011) Periodontal infections: a risk factor for various systemic diseases. Natl.Med J India 24, 214-219. Mannem, S. & Chava, V. K. (2011) The relationship between maternal periodontitis and preterm low birth weight: A case-control study. Contemp.Clin Dent 2, 88-93. Mansur, A. T., Goktay, F. & Demirok, N. (2006) A case of Papillon-Lefevre syndrome associated with xanthogranulomatous pyelonephritis and hepatitis. J Dermatol. 33, 59-63. Marakoglu, I., Gursoy, U. K., Marakoglu, K., Cakmak, H. & Ataoglu, T. (2008) Periodontitis as a risk factor for preterm low birth weight. Yonsei Med J 49, 200-203. Mariggio, M. A., Guida, L., Laforgia, A., Santacroce, R., Curci, E., Montemurro, P. & Fumarulo, R. (2001) Nicotine effects on polymorphonuclear cell apoptosis and lipopolysaccharide-induced monocyte functions. A possible role in periodontal disease? J Periodontal Res 36, 32-39. Mariggio, M. A., Vinella, A., Pasquetto, N., Curci, E., Cassano, A. & Fumarulo, R. (2004) In vitro effects of polyamines on polymorphonuclear cell apoptosis and implications in the pathogenesis of periodontal disease. Immunopharmacol.Immunotoxicol. 26, 93-101. Marin, C., Segura-Egea, J. J., Martínez-Sahuquillo, A.. & Bullón, P. (2005) Correlation between infant birth weight and mother's periodontal status. Journal of Clinical Periodontology 32, 299304. Martins Moliterno, L. F., Monteiro, B., Da Silva Figueredo, C. M. & Fischer, R. G. (2005) Association between periodontitis and low birth weight: a caseÇôcontrol study. Journal of Clinical Periodontology 32, 886-890. Martos, R. & Marton, I. (2008) [Correlations between dental-oral infections and cardiovascular disease]. Fogorv.Sz 101, 101-105. Marwick, C. (2000) Periodontal disease may pose one risk for premature birth. JAMA 283, 2922Matevosyan, N. R. (2011) Periodontal disease and perinatal outcomes. Arch.Gynecol Obstet 283, 675-686. Mayer, Y., Levin, L., Oettinger-Barak, O. & Machtei, E. (2008) [Pregnancy and periodontal disease--is there a relation?]. Refuat.Hapeh.Vehashinayim. 25, 24-33, 82. McClanahan, J. R., Peyyala, R., Mahajan, R., Montelaro, R. C., Novak, K. F. & Puleo, D. A. (2011) Bioactivity of WLBU2 peptide antibiotic in combination with bioerodible polymer. Int.J Antimicrob.Agents 38, 530-533. 24 McClure, H. M., Alford, P. & Swenson, B. (1976) Nonenteric Shigella infections in nonhuman primates. J Am Vet.Med Assoc. 169, 938-939. McCullagh, P. (1980) Regression models for ordinal data (with discussion). J R Stat Soc [Ser B] 42, 109-142. McGaw, T. (2002) Periodontal disease and preterm delivery of low-birth-weight infants. J Can Dent Assoc. 68, 165-169. McKinney, E. T., Shouri, R., Hunt, R. S., Ahokas, R. A. & Sibai, B. M. (2000) Am J Obstet Gynecol 183, 874-877. McLeod, D. E. (2000) A practical approach to the diagnosis and treatment of periodontal disease. J Am Dent Assoc. 131, 483-491. Mealey, B. L. & Rose, L. F. (2008) Diabetes mellitus and inflammatory periodontal diseases. Curr.Opin.Endocrinol.Diabetes Obes. 15, 135-141. Mealey, B. L. (1999) Influence of periodontal infections on systemic health. Periodontology 2000 21, 197-209. Meffert, R. M. (1996) Periodontitis vs. peri-implantitis: the same disease? The same treatment? Crit Rev Oral Biol Med 7, 278-291. Meneghini, C., Battaglia, T. & Niccoli, A. (2003) [Periodontal pathology during pregnancy]. Clin Ter. 154, 105-109. Menezes Esme , Yakoob Mohammad , Soomro Tanya , Haws Rachel , Darmstadt Gary & Bhutta Zulfiqar (2007) Reducing stillbirths: prevention and management of medical disorders and infections during pregnancy. BMC Pregnancy and Childbirth 9 suppl 1, s4 Menon, R., Dunlop, A. L., Kramer, M. R., Fortunato, S. J. & Hogue, C. J. (2011) An overview of racial disparities in preterm birth rates: caused by infection or inflammatory response? Acta Obstet Gynecol Scand 90, 1325-1331. Meurman, J. H., Furuholm, J., Kaaja, R., Rintamaki, H. & Tikkanen, U. (2006) Oral health in women with pregnancy and delivery complications. Clin Oral Investig. 10, 96-101. Meyer, M. S., Joshipura, K., Giovannucci, E. & Michaud, D. S. (2008) A review of the relationship between tooth loss, periodontal disease, and cancer. Cancer Causes Control 19, 895-907. Meyle, J. & Gonzales, J. R. (2001) Influences of systemic diseases on periodontitis in children and adolescents. Periodontol 2000 26, 92-112. Michalowicz, B. S., Hodges, J. S., DiAngelis, A. J., Lupo, V. R., Novak, M. J., Ferguson, J. E., Buchanan, W., Bofill, J., Papapanou, P. N., Mitchell, D. A., Matseoane, S. & Tschida, P. A. (2006) Treatment of periodontal disease and the risk of preterm birth. N.Engl.J Med 355, 1885-1894. Michalowicz, B. S. & Durand, R. (2007) Maternal periodontal disease and spontaneous preterm birth. Periodontol 2000 44, 103-112. Michalowicz, B. S., DiAngelis, A. J., Novak, M. J., Buchanan, W., Papapanou, P. N., Mitchell, D. A., Curran, A. E., Lupo, V. R., Ferguson, J. E., Bofill, J., Matseoane, S., Deinard, A. S., Jr. & Rogers, T. B. (2008) Examining the safety of dental treatment in pregnant women. J Am Dent Assoc. 139, 685-695. 25 Michalowicz, B. S., Novak, M. J., Hodges, J. S., DiAngelis, A., Buchanan, W., Papapanou, P. N., Mitchell, D. A., Ferguson, J. E., Lupo, V., Bofill, J., Matseoane, S., Steffen, M. & Ebersole, J. L. (2009) Serum inflammatory mediators in pregnancy: changes after periodontal treatment and association with pregnancy outcomes. J Periodontol 80, 1731-1741. Michalowicz, B. S., Hodges, J. S., Novak, M. J., Buchanan, W., DiAngelis, A. J., Papapanou, P. N., Mitchell, D. A., Ferguson, J. E., Lupo, V. R., Bofill, J. & Matseoane, S. (2009) Change in periodontitis during pregnancy and the risk of pre-term birth and low birthweight. J Clin Periodontol 36, 308-314. Mikamo, H., Kawazoe, K., Sato, Y., Izumi, K. & Tamaya, T. (1996) Intra-amniotic infection caused by capnocytophaga species. Infect Dis Obstet Gynecol 4, 301-302. Mills, L. W. & Moses, D. T. (2002) Oral health during pregnancy. MCN Am J Matern.Child Nurs. 27, 275-280. Milne, G. L., Yin, H., Brooks, J. D., Sanchez, S., Jackson, R. L. & Morrow, J. D. (2007) Methods Enzymol. 433, 113Mitchell-Lewis, D., Engebretson, S. P., Chen, J., Lamster, I. B. & Papapanou, P. N. (2001) Periodontal infections and pre-term birth: early findings from a cohort of young minority women in New York. European Journal of Oral Sciences 109, 34-39. Mobeen, N., Jehan, I., Banday, N., Moore, J., McClure, E. M., Pasha, O., Wright, L. L. & Goldenberg, R. L. (2008) Periodontal disease and adverse birth outcomes: a study from Pakistan. Am J Obstet Gynecol 198, 514-518. Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G. & The PRISMA Group (2009) Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement. PLoS Med 6, e1000097Mokeem, S. A., Molla, G. N. & Al Jewair, T. S. (2004) The prevalence and relationship between periodontal disease and pre-term low birth weight infants at King Khalid University Hospital in Riyadh, Saudi Arabia. J Contemp.Dent Pract. 5, 40-56. Moliterno, L. F., Monteiro, B., Figueredo, C. M. & Fischer, R. G. (2005) Association between periodontitis and low birth weight: a case-control study. J Clin Periodontol 32, 886-890. Mommaerts, M. Y., Michiels, M. L. & De Pauw, G. A. (2005) A 2-year outcome audit of a versatile orthodontic bone anchor. J Orthod. 32, 175-181. Monnerat, A. B. L., Medeiros, U. V., Kahn, S., Vasconcelos, M., Vianna, M., Micelli, V. & Borrego, J. (2001) Periodontal disease and preterm birth birth in a Brazilian pregnant population. Journal of Dental Research Montuschi, P., Barnes, P. J. & Roberts, L. J. (2004) Isoprostanes: markers and mediators of oxidative stress. FASEB J 18, 1791-1800. Moore, S., Ide, M., Wilson, R. F., Coward, P. Y., Borkowska, E., Baylis, R., Bewley, S., Maxwell, D. J., Mulhair, L. & Ashley, F. P. (2001) Periodontology: Periodontal health of London women during early pregnancy. Br Dent J 191, 570-573. Moore, S., Ide, M., Coward, P. Y., Randhawa, M., Borkowska, E., Baylis, R. & Wilson, R. F. (2004) A prospective study to investigate the relationship between periodontal disease and adverse pregnancy outcome. British Dental Journal 197, 251-258. 26 Moore, S., Ide, M., Randhawa, M., Walker, J. J., Reid, J. G. & Simpson, N. A. B. (2004) An investigation into the association among preterm birth, cytokine gene polymorphisms and periodontal disease. British Journal of Obstetrics and Gynaecology 111, 125-132. Moore, S., Randhawa, M. & Ide, M. (2005) A case-control study to investigate an association between adverse pregnancy outcome and periodontal disease. J Clin Periodontol 32, 1-5. Moorhead, K. & Guiahi, M. (2010) Pregnancy complicated by Ludwig's angina requiring delivery. Infect Dis Obstet Gynecol 2010, 158264. Moreu, G., Tellez, L. & Gonzalez-Jaranay, M. (2005) Relationship between maternal periodontal disease and low-birth-weight pre-term infants. J Clin Periodontol 32, 622-627. Morris, J. M., Gopaul, N. K. & Endresen, M. J. (1998) Circulating markers of oxidative stress are raised in normal pregnancy and pre-eclampsia. Br J Obstet Gynaecol 105, 1195-1199. Moss, K. L., Mauriello, S., Ruvo, A. T., Offenbacher, S., White, R. P., Jr. & Beck, J. D. (2006) Reliability of third molar probing measures and the systemic impact of third molar periodontal pathology. J Oral Maxillofac.Surg 64, 652-658. Moss, K. L., Serlo, A. D., Offenbacher, S., Beck, J. D., Mauriello, S. M. & White, R. P., Jr. (2007) The oral and systemic impact of third molar periodontal pathology. J Oral Maxillofac.Surg 65, 1739-1745. Moss, K. L., Ruvo, A. T., Offenbacher, S., Beck, J. D., Mauriello, S. M. & White, R. P., Jr. (2007) Third molars and progression of periodontal pathology during pregnancy. J Oral Maxillofac.Surg 65, 1065-1069. Moss, K. L., Beck, J. D. & Offenbacher, S. (2005) Clinical risk factors associated with incidence and progression of periodontal conditions in pregnant women. Journal of Clinical Periodontology 32, 492-498. Moutsopoulos, N. M. & Madianos, P. N. (2006) Low-grade inflammation in chronic infectious diseases: paradigm of periodontal infections. Ann N.Y.Acad.Sci. 1088, 251-264. Mufalo, P. S., Kaizer, R. O., Dalben, G. S. & de Almeida, A. L. (2009) Comparison of periodontal parameters in individuals with syndromic craniosynostosis. J Appl.Oral Sci. 17, 13-20. Muglia, L. J. & Katz, M. (2010) The Enigma of Spontaneous Preterm Birth. New England Journal of Medicine 362, 529-535. Muller, H. P. (2002) [Does chronic periodontitis play a role in the pathogenesis of cardiovascular and cerebrovascular diseases?]. Gesundheitswesen 64, 89-98. Mumghamba, E. G. & Manji, K. P. (2007) Maternal oral health status and preterm low birth weight at Muhimbili National Hospital, Tanzania: a case-control study. BMC.Oral Health 7, 8Myers, D. R., O'Dell, N. L., Clark, J. W. & Cross, R. L. (1989) Localized prepubertal periodontitis: literature review and report of case. ASDC J Dent Child 56, 107-111. Nabet, C., Lelong, N., Colombier, M. L., Sixou, M., Musset, A. M., Goffinet, F. & Kaminski, M. (2010) Maternal periodontitis and the causes of preterm birth: the case-control Epipap study. Journal of Clinical Periodontology 37, 37-45. 27 Nagarakanti, S. (2012) Knowledge, attitude and practice towards periodontal diseases among gynaecologists: a pilot study. J Obstet Gynaecol. 32, 62-63. Nagaveni, N. B., Suma, R., Shashikiran, N. D. & Subba, R., V (2008) Papillon-Lefevre syndrome: Report of two cases in the same family. J Indian Soc Pedod.Prev.Dent 26, 78-81. Nakashima, M. & Akamine, A. (2005) The application of tissue engineering to regeneration of pulp and dentin in endodontics. J Endod 31, 711-718. Neely, A. L. (2009) Periodontitis May Not Have Been Associated with Adverse Pregnancy Outcomes. Journal of Evidence Based Dental Practice 9, 77-80. Nesse, W., Spijkervat, F. K., Abbis, F. & Vissink, A. (2006) [Links between periodontal disease and general health. 2. Preterm birth, diabetes and autoimmune diseases]. Ned.Tijdschr.Tandheelkd. 113, 191-196. Newman, H. N. (1998) Periodontal therapeutics--a viable option? Int.Dent J 48, 173-179. Newnham, J. P., Shub, A., Jobe, A. H., Bird, P. S., Ikegami, M., Nitsos, I. & Moss, T. J. (2005) The effects of intra-amniotic injection of periodontopathic lipopolysaccharides in sheep. Am J Obstet Gynecol 193, 313-321. Newnham, J. P., Newnham, I. A., Ball, C. M., Wright, M., Pennell, C. E., Swain, J. & Doherty, D. A. (2009) Treatment of periodontal disease during pregnancy: a randomized controlled trial. Obstetrics and Gynecology 114, 1239-1248. Nickles, K., Schacher, B., Schuster, G., Valesky, E. & Eickholz, P. (2011) Evaluation of two siblings with Papillon-Lefevre syndrome 5 years after treatment of periodontitis in primary and mixed dentition. J Periodontol 82, 1536-1547. Niederman, R. (2010) Periodontal treatment did not prevent complications of pregnancy. Evid.Based Dent 11, 18-19. Nikolaos, P. P., Ilias, P. P., Apostolos, Z., Antonis, V., Davide, M., Evangelos, G. P., Spyridon, T., Daniel, W. & Ioannis E Messinis (2010) Obstetric outcomes after treatment of periodontal disease during pregnancy: systematic review and meta-analysis. BMJ 341, Nithianantham, S., Xu, M., Wu, N., Han, Y. W. & Shoham, M. (2006) Crystallization and preliminary X-ray data of the FadA adhesin from Fusobacterium nucleatum. Acta Crystallogr.Sect.F.Struct.Biol Cryst.Commun. 62, 1215-1217. Noack, B., Klingenberg, J., Weigelt, J. & Hoffmann, T. (2005) Periodontal status and preterm low birth weight: a case control study. J Periodontal Res 40, 339-345. Novak, M. J. & Donley, T. G. (2002) Using host response modifiers in the treatment of periodontal disease. Pract.Proced.Aesthet.Dent 14, suppl-10. Novak, M. J., Novak, K. F., Hodges, J. S., Kirakodu, S., Govindaswami, M., DiAngelis, A., Buchanan, W., Papapanou, P. N. & Michalowicz, B. S. (2008) Periodontal bacterial profiles in pregnant women: response to treatment and associations with birth outcomes in the obstetrics and periodontal therapy (OPT) study. J Periodontol. 79, 1870-1879. Novak, T., Radnai, M., Gorzo, I., Urban, E., Orvos, H., Eller, J. & Pal, A. (2009) Prevention of preterm delivery with periodontal treatment. Fetal Diagn Ther. 25, 230-233. 28 Nugent, J. L. & Baker, P. N. (2006) Periodontal disease and adverse pregnancy outcomes: a systematic review. BJOG 113, 848-849. Nunn, J. H., Welbury, R. R., Gordon, P. H., Stretton-Downes, S. & Green-Abate, C. (1992) Dental health of children in an integrated urban development programme for destitute mothers with twins in Addis Ababa. Int.Dent J 42, 445-450. Nussbaum, G. & Shapira, L. (2011) How has neutrophil research improved our understanding of periodontal pathogenesis? J Clin Periodontol 38 Suppl 11, 49-59. Nutalapati, R., Ramisetti, A., Mutthineni, R. B., Jampani, N. D. & Kasagani, S. K. (2011) Awareness of association between periodontitis and PLBW among selected population of practising gynecologists in Andhra Pradesh. Indian J Dent Res 22, 735O'Mahony, A., MacNeill, S. R. & Cobb, C. M. (2000) Design features that may influence bacterial plaque retention: a retrospective analysis of failed implants. Quintessence.Int. 31, 249-256. Oertling, K. M. & Barsley, R. (2003) The relationship between periodontal disease and preterm low birth weight and a new Medicaid dental program intervention for pregnant women. LDA.J 62, 10-13. Oettinger-Barak, O., Barak, S., Ohel, G., Oettinger, M., Kreutzer, H., Peled, M. & Machtei, E. E. (2005) Severe Pregnancy Complication (Preeclampsia) Is Associated With Greater Periodontal Destruction. Journal of Periodontology 76, 134-137. Offenbacher, S., Beck, J., McKaig, R., Pertik, G. S., Maynor, G. & Katz, V. (1995) Multivariate analyses of periodontal disease as risk factor for preterm low birth weight. Journal of Dental Research 74, 158. Offenbacher, S., Katz, V., Fertik, G., Collins, J., Boyd, D., Maynor, G., McKaig, R. & Beck, J. (1996) Periodontal infection as a possible risk factor for preterm low birth weight. J Periodontol 67, 1103-1113. Offenbacher, S., Beck, J. D., Lieff, S. & Slade, G. (1998) Role of periodontitis in systemic health: spontaneous preterm birth. J Dent Educ. 62, 852-858. Offenbacher, S., Jared, H. L., O'Reilly, P. G., Wells, S. R., Salvi, G. E., Lawrence, H. P., Socransky, S. S. & Beck, J. D. (1998) Potential pathogenic mechanisms of periodontitis associated pregnancy complications. Ann Periodontol 3, 233-250. Offenbacher, S. (1999) The link between periodontal disease and systemic health: a scientific update. Interview by Phillip Bonner. Dent Today 18, 88-89. Offenbacher, S., Madianos, P. N., Suttle, M., Beck, J. D., Wells, S., Lieff, S., Jared, H. L., Murtha, A. P., Boggess, K. A., Livingston, E. G. & Herbert, W. N. P. (1999) Elevated human fetal IgM suggests in utero exposure to periodontal pathogens. Journal of Dental Research 78, 379Offenbacher, S., Lieff, S., Boggess, K. A., Murtha, A. P., Madianos, P. N., Champagne, C. M., McKaig, R. G., Jared, H. L., Mauriello, S. M., Auten, R. L., Jr., Herbert, W. N. & Beck, J. D. (2001) Maternal periodontitis and prematurity. Part I: Obstetric outcome of prematurity and growth restriction. Ann Periodontol 6, 164-174. Offenbacher, S. & Beck, J. D. (2001) Periodontitis: a potential risk factor for spontaneous preterm birth. Compend.Contin.Educ.Dent 22, 17-20. 29 Offenbacher, S., Lieff, S., Boggess, K. A., Murtha, A. P., Madianos, P. N., Champagne, C. M. E., McKaig, R. G., Jared, H. L., Mauriello, S. M., Auten, R. L., Herbert, W. N. P. & Beck, J. D. (2001) Maternal Periodontitis and Prematurity. Part I: Obstetric Outcome of Prematurity and Growth Restriction. Annals of Periodontology 6, 164-174. Offenbacher, S. (2004) Maternal periodontal infections, prematurity, and growth restriction. Clin Obstet Gynecol 47, 808-821. Offenbacher, S., Lin, D., Strauss, R., McKaig, R., Irving, J., Barros, S. P., Moss, K., Barrow, D. A., Hefti, A. & Beck, J. D. (2006) Effects of periodontal therapy during pregnancy on periodontal status, biologic parameters, and pregnancy outcomes: a pilot study. J Periodontol 77, 2011-2024. Offenbacher, S., Boggess, K. A., Murtha, A. P., Jared, H. L., Lieff, S., McKaig, R. G., Mauriello, S. M., Moss, K. L. & Beck, J. D. (2006) Progressive periodontal disease and risk of very preterm delivery. Obstet Gynecol 107, 29-36. Offenbacher, S., Beck, J. D., Jared, H. L., Mauriello, S. M., Mendoza, L. C., Couper, D. J., Stewart, D. D., Murtha, A. P., Cochran, D. L., Dudley, D. J., Reddy, M. S., Geurs, N. C. & Hauth, J. C. (2009) Effects of periodontal therapy on rate of preterm delivery: a randomized controlled trial. Obstet Gynecol 114, 551-559. Offenbacher, S., Katz, V., Fertik, G., Collins, J., Boyd, D., Maynor, G., McKaig, R. & Beck, J. (1996) Periodontal Infection as a Possible Risk Factor for Preterm Low Birth Weight. Journal of Periodontology 67, 1103-1113. Offenbacher, S. & Beck, J. (2007) Has Periodontal Treatment Failed to Reduce Adverse Pregnancy Outcomes? The Answer May Be Premature. Journal of Periodontology 78, 195-197. Ogawa, T., Mori, H., Yasuda, K. & Hasegawa, M. (1994) Molecular cloning and characterization of the genes encoding the immunoreactive major cell-surface proteins of Porphyromonas gingivalis. FEMS Microbiol Lett. 120, 23-30. Oittinen, J., Kurki, T., Kekki, M., Kuusisto, M., Pussinen, P., Vilkuna-Rautiainen, T., Nieminen, A., Asikainen, S. & Paavonen, J. (2005) Periodontal disease and bacterial vaginosis increase the risk for adverse pregnancy outcome. Infect Dis Obstet Gynecol 13, 213-216. Oliveira Diniz, C. K., Correa, M. G., Casati, M. Z., Nociti, F. H., Jr., Ruiz, K. G., Brosi Ambrosano, G. M. & Sallum, E. A. (2012) Diabetes Mellitus May Increase Bone Loss After Occlusal Trauma and Experimental Periodontitis. J Periodontol Feb 6. [Epub ahead of print] Oliveira, A. M., de Oliveira, P. A., Cota, L. O., Magalhaes, C. S., Moreira, A. N. & Costa, F. O. (2010) Periodontal therapy and risk for adverse pregnancy outcomes. Clinical Oral Investigations online DOI 10.1007/s00784-012-0679-3. Otomo-Corgel, J. & Merin, R. L. (2002) Periodontal disease and systemic health--what you and your patients need to know. J Calif.Dent Assoc. 30, 307-311. Otsuka, Y., Ito, M., Yamaguchi, M., Saito, S., Uesu, K., Kasai, K., Abiko, Y. & Mega, J. (2002) Enhancement of lipopolysaccharide-stimulated cyclooxygenase-2 mRNA expression and prostaglandin E2 production in gingival fibroblasts from individuals with Down syndrome. Mech.Ageing Dev. 123, 663-674. Ovalle, A., Gamonal, J., Martinez, M. A., Silva, N., Kakarieka, E., Fuentes, A., Chaparro, A., Gajardo, M., Leon, R., Ahumada, A. & Cisternas, C. (2009) [Relationship between periodontal diseases and ascending bacterial infection with preterm delivery]. Rev Med Chil. 137, 504-514. 30 Page, R. C. (1998) The pathobiology of periodontal diseases may affect systemic diseases: inversion of a paradigm. Ann Periodontol 3, 108-120. Panjamurthy, K., Manoharan, S. & Ramachandran, C. R. (2005) Lipid peroxidation and antioxidant status in patients with periodontitis. Cell Mol Biol Lett 10, 255-264. Papapanou, P. N. (1996) Periodontal diseases: epidemiology. Ann Periodontol 1, 1-36. Paquette, D. W., Madianos, P., Offenbacher, S., Beck, J. D. & Williams, R. C. (1999) The concept of "risk" and the emerging discipline of periodontal medicine. J Contemp.Dent Pract. 1 , 1-8. Paquette, D. W. (2002) The periodontal infection-systemic disease link: a review of the truth or myth. J Int.Acad.Periodontol 4, 101-109. Passini Junior, R., Nomura, M. L. & Politano, G. T. (2007) Doença periodontal e complicações obstétricas: há relação de risco? [Periodontal disease and obstetrical complications: is there a risk relationship?. ]. Revista Brasileira de Ginecologia e Obstetricia 29, 370-375. Passini, R., Tedesco, R., Marba, S., Cecatti, J., Guinsburg, R., Martinez, F., Nomura, M. & the Brazilian Network of Studies on Reproductive and Perinatal Health (2010) Brazilian multicenter study on prevalence of preterm birth and associated factors. BMC Pregnancy and Childbirth 10, 22. Pattrapornnan, P., Derouen, T. A. & Songpaisan, Y. (2012) Increased Risks of Preterm Birth and Low Birthweight Baby in Thai HIV-Pregnant Women With Periodontitis. J Periodontol online 2012 DOI: 10.1902/jop.2012.110500 Peretz, B. (2005) Preterm low birthweight (PLBW) and maternal periodontal disease: a debate in the literature. Refuat.Hapeh.Vehashinayim. 22, 88. Persson, R., Hitti, J., Verhelst, R., Vaneechoutte, M., Persson, R., Hirschi, R., Weibel, M., Rothen, M., Temmerman, M., Paul, K. & Eschenbach, D. (2009) The vaginal microflora in relation to gingivitis. BMC.Infect Dis 9, 6 Pihlstrom, B. L., Michalowicz, B. S. & Johnson, N. W. (2005) Periodontal diseases Lancet 366, 1809-1820. Pimentel Lopes De Oliveira GJ, Amaral, F. L., Chaves De Souza, J. A., Ribeiro, C. M. & Cirelli, J. A. (2010) Effect of periodontal treatment on the incidence of preterm delivery: a systematic review. Minerva Stomatol 59, 543-550. Piscoya, M. D., Ximenes, R. A., Silva, G. M., Jamelli, S. R. & Coutinho, S. B. (2012) Maternal periodontitis as a risk factor for prematurity. Pediatrics International 54, 68-75. Pitiphat, W., Joshipura, K. J., Gillman, M. W., Williams, P. L., Douglass, C. W. & Rich-Edwards, J. W. (2008) Maternal periodontitis and adverse pregnancy outcomes. Community Dent Oral Epidemiol. 36, 3-11. Pitiphat, W., Joshipura, K. J., Rich-Edwards, J. W., Williams, P. L., Douglass, C. W. & Gillman, M. W. (2006) Periodontitis and Plasma C-Reactive Protein During Pregnancy. Journal of Periodontology 77, 821-825. Pizzo, G., La Cara, M., Conti, N. M. & Guiglia, R. (2005) Periodontitis and preterm delivery. A review of the literature. Minerva Stomatol 54, 1-14. 31 Pizzo, G., Guiglia, R., Lo, R. L. & Campisi, G. (2010) Dentistry and internal medicine: from the focal infection theory to the periodontal medicine concept. Eur.J Intern.Med 21, 496-502. Politano, G. T., Passini, R., Nomura, M. L., Velloso, L., Morari, J. & Couto, E. (2011) Correlation between periodontal disease, inflammatory alterations and pre-eclampsia. Journal of Periodontal Research 46, 505-511. Polyzos, N. P., Polyzos, I. P., Mauri, D., Tzioras, S., Tsappi, M., Cortinovis, I. & Casazza, G. (2009) Effect of periodontal disease treatment during pregnancy on preterm birth incidence: a metaanalysis of randomized trials. Am J Obstet Gynecol 200, 225-232. Polyzos, N. P., Polyzos, I. P., Zavos, A., Valachis, A., Mauri, D., Papanikolaou, E. G., Tzioras, S., Weber, D. & Messinis, I. E. (2010) Obstetric outcomes after treatment of periodontal disease during pregnancy: systematic review and meta-analysis. BMJ 341, c7017 Posteraro, A. F. (1992) Papillon-Lefevre syndrome. J Ala Dent Assoc. 76, 16-19. Pratchyapruit, W. O. & Kullavanijaya, P. (2002) Papillon-Lefevre syndrome: a case report. J Dermatol. 29, 329-335. Pretorius, C., Jagatt, A. & Lamont, R. F. (2007) The relationship between periodontal disease, bacterial vaginosis, and preterm birth. J Perinat.Med. 35, 93-99. Proff, P., Steinmetz, I., Bayerlein, T., Dietze, S., Fanghanel, J. & Gedrange, T. (2006) Bacterial colonisation of interior implant threads with and without sealing. Folia Morphol.(Warsz.) 65, 75-77. Pussinen, P. J., Paju, S., Mantyla, P. & Sorsa, T. (2007) Serum microbial- and host-derived markers of periodontal diseases: a review. Curr.Med Chem. 14, 2402-2412. Qureshi, A., Ijaz, S., Syed, A., Qureshi, A. & Khan, A. A. (2005) Periodontal infection: a potential risk factor for pre-term delivery of low birth weight (PLBW) babies. J Pak.Med Assoc. 55, 448452. Raber-Durlacher, J. E., van Steenbergen, T. J. M., van der Velden, U., de Graaff, J. & AbrahamInpijn, L. (1994) Experimental gingivitis during pregnancy and post-partum: clinical, endocrinological, and microbiological aspects. Journal of Clinical Periodontology 21, 549-558. Radnai, M. & Gorzo, I. (2002) [Periodontal disease as a potential risk factor for preterm birth and low birth weight (Literature review)]. Fogorv.Sz 95, 241-244. Radnai, M., Gorzo, I., Nagy, E., Urban, E., Novak, T. & Pal, A. (2004) A possible association between preterm birth and early periodontitis. A pilot study. J Clin Periodontol 31, 736-741. Radnai, M., Gorzo, I., Nagy, E., Urban, E., Eller, J., Novak, T. & Pal, A. (2005) [Caries and periodontal state of pregnant women. Part II. Periodontal state]. Fogorv.Sz 98, 101-106. Radnai, M., Gorzo, I., Urban, E., Eller, J., Novak, T. & Pal, A. (2006) Possible association between mother's periodontal status and preterm delivery. J Clin Periodontol 33, 791-796. Radnai, M., Pal, A., Novak, T., Urban, E., Eller, J., Heffter, N., Horvath, G. & Gorzo, I. (2008) [The possible effect of basic periodontal treatment on the outcome of pregnancy]. Fogorv.Sz 101, 179185. Radnai, M., Pal, A., Novak, T., Urban, E., Eller, J. & Gorzo, I. (2009) Benefits of periodontal therapy when preterm birth threatens. J Dent Res 88, 280-284. 32 Raijmakers, M. T., Dechend, R. & Poston, L. (2004) Hypertension 44, 374Rajapakse, P. S., Nagarathne, M., Chandrasekra, K. B. & Dasanayake, A. P. (2005) Periodontal disease and prematurity among non-smoking Sri Lankan women. J Dent Res 84, 274-277. Rakoto-Alson, S., Tenenbaum, H. & Davideau, J. L. (2010) Periodontal diseases, preterm births, and low birth weight: findings from a homogeneous cohort of women in Madagascar. J Periodontol 81, 205-213. Ramchandani, M., Siddiqui, M., Kanwar, R., Lakha, M., Phi, L., Giacomelli, L. & Chiappelli, F. (2010) Proteomic signature of periodontal disease in pregnancy: Predictive validity for adverse outcomes. Bioinformation. 5, 300-303. Ramesh, A., Sharma, A. & Thomas, B. (2009) Evaluation of plasma C-reactive protein levels in pregnant women with and without periodontal disease: A comparative study. Journal of Indian Society of Periodontology 13, 145-149. Ranalli, D. N. & Studen-Pavlovich, D. (2002) Women's oral health across the lifespan. Part One: Historical perspectives. Northwest.Dent 81, 19-21, 24, 70. Ratcliff, P. A. & O'Hehir, T. (1997) A risk to expectant mothers? RDH 17, 24-6, 50. Rateitschak-Pluss, E. M. & Schroeder, H. E. (1984) History of periodontitis in a child with Papillon-Lefevre syndrome. A case report. J Periodontol 55, 35-46. Rautemaa, R., Lauhio, A., Cullinan, M. P. & Seymour, G. J. (2007) Oral infections and systemic disease--an emerging problem in medicine. Clin Microbiol Infect 13, 1041-1047. Redman, C. W., Sacks, G. P. & Sargent, I. L. (1999) Am J Obstet Gynecol 180, 499Reinstein, E., Wang, R. Y., Zhan, L., Rimoin, D. L. & Wilcox, W. R. (2011) Ehlers-Danlos type VIII, periodontitis-type: further delineation of the syndrome in a four-generation pedigree. Am J Med Genet.A 155A, 742-747. Rethman, M. P. (2011) Pregnancy and periodontal disease. J Am Dent Assoc. 142, 484-485. Riche, E. L., Boggess, K. A., Lieff, S., Murtha, A. P., Auten, R. L., Beck, J. D. & Offenbacher, S. (2002) Periodontal disease increases the risk of preterm delivery among preeclamptic women. Ann Periodontol 7, 95-101. Rivera-Hidalgo, F. (2001) Systemic disease and periodontal disease. Tex.Dent J 118, 944-953. Roberts, G. L. (2000) Fusobacterial infections: an underestimated threat. Br.J Biomed.Sci. 57, 156-162. Robson, S. J. & Leader, L. R. (2010) Management of subsequent pregnancy after an unexplained stillbirth. J Perinatol 30, 305-310. Rocha, J. M., Chaves, V. R., Urbanetz, A. A., Baldissera, R. S. & Rosing, C. K. (2011) Obstetricians' knowledge of periodontal disease as a potential risk factor for preterm delivery and low birth weight. Braz.Oral Res 25, 248-254. Rogers, M. S., Wang, C. C., Tam, W. H., Li, C. Y., Chu, K. O. & Chu, C. Y. (2006) Oxidative stress in midpregnancy as a predictor of gestational hypertension and pre-eclampsia. BJOG 113, 1053-1059. 33 Romero, B. C., Chiquito, C. S., Elejalde, L. E. & Bernardoni, C. B. (2002) Relationship between periodontal disease in pregnant women and the nutritional condition of their newborns. J Periodontol 73, 1177-1183. Rose, L. F., Steinberg, B. J. & Minsk, L. (2000) The relationship between periodontal disease and systemic conditions. Compend.Contin.Educ.Dent 21, 870-877. Ruiz, R. J., Jallo, N., Murphey, C., Marti, C. N., Godbold, E. & Pickler, R. H. (2012) Second trimester maternal plasma levels of cytokines IL-1Ra, Il-6 and IL-10 and preterm birth. J Perinatol Ruma, M., Boggess, K., Moss, K., Jared, H., Murtha, A., Beck, J. & Offenbacher, S. (2008) Maternal periodontal disease, systemic inflammation, and risk for preeclampsia. Am J Obstet Gynecol 198, 389-5. Russell, S. & Dasanayake, A. P. (2006) Maternal periodontal disease is related to preterm low birth weight delivery in a group of Brazilian women. J Evid.Based Dent Pract. 6, 236-237. Ryalat, S., Sawair, F., Baqain, Z., Barghout, N., Amin, W., Badran, D. & Badran, E. (2011) Effect of Oral Diseases on Mothers Giving Birth to Preterm Infants. Medical Principles and Practice 20, 556-561. Ryu, J. I., Oh, K., Yang, H., Choi, B. K., Ha, J. E., Jin, B. H., Kim, H. D. & Bae, K. H. (2010) Health behaviors, periodontal conditions, and periodontal pathogens in spontaneous preterm birth: a case-control study in Korea. J Periodontol 81, 855-863. Sacco, G., Carmagnola, D., Abati, S., Luglio, P. F., Ottolenghi, L., Villa, A., Maida, C. & Campus, G. (2008) Periodontal disease and preterm birth relationship: a review of the literature. Minerva Stomatol 57, 233-250. Sadatmansouri, S., Sedighpoor, N. & Aghaloo, M. (2006) Effects of periodontal treatment phase I on birth term and birth weight. J Indian Soc Pedod.Prev.Dent 24, 23-26. Saddki, N., Bachok, N., Hussain, N. H., Zainudin, S. L. & Sosroseno, W. (2008) The association between maternal periodontitis and low birth weight infants among Malay women. Community Dent Oral Epidemiol. 36, 296-304. Sadeghi, R., Rabiee, M., Saderi, H. & Jafari, M. (2011) [ The relationship between salivary bacterial flora and adverse pregnancy outcomes ] [Article in Persian]. Tehran University Medical Journal 69, 49-54. Safirstein, J. J., Owens, B. M. & Swords, R. L. (2001) The resin retained natural tooth pontic: a transitional esthetic solution. J Tenn.Dent Assoc. 81, 31-33. Saini, R., Saini, S. & Saini, S. R. (2010) Periodontitis: A risk for delivery of premature labor and low-birth-weight infants. J Nat.Sci.Biol Med 1, 40-42. Saito, S., Hayakawa, M., Takiguchi, H. & Abiko, Y. (1999) Opsonophagocytic effect of antibody against recombinant conserved 40-kDa outer membrane protein of Porphyromonas gingivalis. J Periodontol 70, 610-617. Sanchez, A. R., Kupp, L. I., Sheridan, P. J. & Sanchez, D. R. (2004) Maternal chronic infection as a risk factor in preterm low birth weight infants: the link with periodontal infection. J Int.Acad.Periodontol 6, 89-94. 34 Sanchez, A. R., Bagniewski, S., Weaver, A. L. & Vallejos, N. (2007) Correlations between maternal periodontal conditions and preterm low birth weight infants. J Int.Acad.Periodontol 9 , 34-41. Sant'Ana, A. C., Campos, M. R., Passanezi, S. C., Rezende, M. L., Greghi, S. L. & Passanezi, E. (2011) Periodontal treatment during pregnancy decreases the rate of adverse pregnancy outcome: a controlled clinical trial. J Appl.Oral Sci. 19, 130-136. Santacroce, L., Carlaio, R. G. & Bottalico, L. (2010) Does it make sense that diabetes is reciprocally associated with periodontal disease? Endocr.Metab Immune.Disord.Drug Targets. 10 , 57-70. Santos-Pereira, S. A., Giraldo, P. C., Saba-Chujfi, E., Amaral, R. L., Morais, S. S., Fachini, A. M. & Goncalves, A. K. (2007) Chronic periodontitis and pre-term labour in Brazilian pregnant women: an association to be analysed. J Clin Periodontol 34, 208-213. Sanu, O. & Lamont, R. F. (2011) Periodontal disease and bacterial vaginosis as genetic and environmental markers for the risk of spontaneous preterm labor and preterm birth. J Matern.Fetal Neonatal Med 24, 1476-1485. Sasahara, J., Kikuchi, A., Takakuwa, K., Sugita, N., Abiko, Y., Yoshie, H. & Tanaka, K. (2009) Antibody responses to Porphyromonas gingivalis outer membrane protein in the first trimester. Aust.N.Z.J Obstet Gynaecol. 49, 137-141. Sánchez AR, B. S. W. A. V. N. (2007) Correlations between maternal periodontal conditions and preterm low birth weight infants. J Int Acad Periodontol 9, 34-41. Sánchez AR, K. L. S. P. S. D. (2004) Maternal chronic infection as a risk factor in preterm low birth weight infants: the link with periodontal infection. J Int Acad Periodontol 6, 89-94. Sant'Ana, A. C. P. et al (2011) Periodontal treatment during pregnancy decreases the rate of adverse pregnancy outcome: a controlled clinical trial. J. Appl. Oral Sci. 19, 130-136. Scannapieco, F. A. (1998) Position paper of The American Academy of Periodontology: periodontal disease as a potential risk factor for systemic diseases. J Periodontol 69, 841-850. Scannapieco, F. A., Bush, R. B. & Paju, S. (2003) Periodontal disease as a risk factor for adverse pregnancy outcomes. A systematic review. Ann Periodontol 8, 70-78. Scannapieco, F. A. (2004) Periodontal inflammation: from gingivitis to systemic disease? Compend.Contin.Educ.Dent 25, 16-25. Scannapieco, F. A., Dasanayake, A. P. & Chhun, N. (2010) "Does periodontal therapy reduce the risk for systemic diseases?". Dent Clin North Am 54, 163-181. Schacher, B., Baron, F., Ludwig, B., Valesky, E., Noack, B. & Eickholz, P. (2006) Periodontal therapy in siblings with Papillon-Lefevre syndrome and tinea capitis: a report of two cases. J Clin Periodontol 33, 829-836. Schenkein, H. A., Best, A. M., Brooks, C. N., Burmeister, J. A., Arrowood, J. A., Kontos, M. C. & Tew, J. G. (2007) Anti-cardiolipin and increased serum adhesion molecule levels in patients with aggressive periodontitis. J Periodontol 78, 459-466. Schenkein, H. A., Koertge, T. E., Sabatini, R., Brooks, C. N. & Gunsolley, J. C. (2012) Birth weight of infants of mothers with aggressive periodontitis. J Periodontol 83, 279-286. 35 Scholl, T. O., Leskiw, M., Chen, X., Sims, M. & Stein, T. P. (2005) Oxidative stress, diet, and the etiology of preeclampsia. Am J Clin Nutr 81, 1390-1396. Schroder, W. A., Le, T. T., Major, L., Street, S., Gardner, J., Lambley, E., Markey, K., MacDonald, K. P., Fish, R. J., Thomas, R. & Suhrbier, A. (2010) A physiological function of inflammationassociated SerpinB2 is regulation of adaptive immunity. J Immunol 184 , 2663-2670. Schroeder, H. E., Seger, R. A., Keller, H. U. & Rateitschak-Pluss, E. M. (1983) Behavior of neutrophilic granulocytes in a case of Papillon-Lefevre syndrome. J Clin Periodontol 10, 618-635. Schulhof, R. J. (2009) Connecting the dots: can your practice be in the lifesaving business? Dent Today 28, 104, 106-104, 107. Segura-Egea, J. J., Jimenez-Rubio, A., Velasco-Ortega, E. & Rios-Santos, J. V. (2003) Talon cusp causing occlusal trauma and acute apical periodontitis: report of a case. Dent Traumatol. 19, 55-59. Sembene, M., Moreau, J. C., Mbaye, M. M., Diallo, A., Diallo, P. D., Ngom, M. & Benoist, H. M. (2000) [Periodontal infection in pregnant women and low birth weight babies]. Odontostomatol.Trop. 23, 19-22. Senel, F. C., Altintas, N. Y., Bagis, B., Cankaya, M., Pampu, A. A., Satiroglu, I. & Senel, A. C. (2012) A 3-year follow-up of the rehabilitation of Papillon-Lefevre syndrome by dental implants. J Oral Maxillofac.Surg 70, 163-167. Sert, T., Kirzioglu, F. Y., Fentoglu, O., Aylak, F. & Mungan, T. (2011) Serum placental growth factor, vascular endothelial growth factor, soluble vascular endothelial growth factor receptor-1 and -2 levels in periodontal disease, and adverse pregnancy outcomes. J Periodontol 82, 17351748. Seymour, G. J., Ford, P. J., Cullinan, M. P., Leishman, S. & Yamazaki, K. (2007) Relationship between periodontal infections and systemic disease. Clin Microbiol Infect 13 Suppl 4, 3-10. Seymour, R. A. (2010) Does periodontal treatment improve general health? Dent Update 37, 2062. Sha, Y. Q., Huang, Z., Chen, Z. B., Kang, J., He, L. & Yu, X. Q. (2009) [Association between periodontitis and preterm low birth weight]. Beijing Da.Xue.Xue.Bao. 41, 117-120. Shah, J. & Goel, S. (2007) Papillon-Lefevre syndrome: two case reports. Indian J Dent Res 18, 210-213. Sharma, A., Ramesh, A. & Thomas, B. (2009) Evaluation of plasma C-reactive protein levels in pregnant women with and without periodontal disease: A comparative study. Journal of Indian Society of Periodontology 13, 145-149. Sharma, G. & Whatling, R. (2011) Case report: premature exfoliation of primary teeth in a 4-yearold child, a diagnostic dilemma. Eur.Arch.Paediatr.Dent 12, 312-317. Sharma, R., Maimanuku, L. R., Morse, Z. & Pack, A. R. (2007) Preterm low birth weights associated with periodontal disease in the Fiji Islands. Int.Dent J 57, 257-260. Shenoy, R. P., Nayak, D. G. & Sequeira, P. S. (2009) Periodontal disease as a risk factor in preterm low birth weight--an assessment of gynecologists' knowledge: a pilot study. Indian J Dent Res 20, 13-16. 36 Shetty, M., Shetty, P. K., Ramesh, A., Thomas, B., Prabhu, S. & Rao, A. (2010) Periodontal disease in pregnancy is a risk factor for preeclampsia. Acta Obstet Gynecol Scand 89, 718-721. Shi, Y., Wang, J. & Cao, C. (1997) [Clinical studies on pulpitis and periapical periodontitis caused by traumatic occlusion]. Zhonghua Kou Qiang.Yi.Xue.Za Zhi. 32, 23-25. Shub, A., Swain, J. R. & Newnham, J. P. (2006) Periodontal disease and adverse pregnancy outcomes. J Matern.Fetal Neonatal Med 19, 521-528. Shub, A., Wong, C., Jennings, B., Swain, J. R. & Newnham, J. P. (2009) Maternal periodontal disease and perinatal mortality. Aust.N.Z.J Obstet Gynaecol. 49, 130-136. Sibai, B., Dekker, G. & Kupferminc, M. (2005) Pre-eclampsia Lancet 365, 785-799 Silk, H., Douglass, A. B., Douglass, J. M. & Silk, L. (2008) Oral health during pregnancy. Am Fam.Physician 77, 1139-1144. Silva, G. M., Coutinho, S. B., Piscoya, M. D., Ximenes, R. A. & Jamelli, S. R. (2012) Periodontitis as a Risk Factor for Pre-Eclampsia. J Periodontol Feb 6. [Epub ahead of print] Silva, G. M., Coutinho, S. B., Piscoya, M. D., Ximenes, R. A. A. & Jamelli, S. R. (2012) Periodontitis as a Risk Factor for Pre-Eclampsia. Journal of Periodontology 1-12. Silveira, L. B., Prates, R. A., Novelli, M. D., Marigo, H. A., Garrocho, A. A., Amorim, J. C., Sousa, G. R., Pinotti, M. & Ribeiro, M. S. (2008) Investigation of mast cells in human gingiva following low-intensity laser irradiation. Photomed.Laser Surg 26, 315-321. Siqueira, F. M., Cota, L. O., Costa, J. E., Haddad, J. P., Lana, A. M. & Costa, F. O. (2007) Intrauterine growth restriction, low birth weight, and preterm birth: adverse pregnancy outcomes and their association with maternal periodontitis. J Periodontol 78, 2266-2276. Siqueira, F. M., Cota, L. O., Costa, J. E., Haddad, J. P., Lana, A. M. & Costa, F. O. (2008) Maternal periodontitis as a potential risk variable for preeclampsia: a case-control study. J Periodontol 79, 207-215. Siristatidis, C., Nisiotakis, C., Zokaris, N., Chrelias, C., Iakovidou, H. & Salamalekis, E. (2006) Hormonal alterations in gum disease leading to preterm labor. Arch.Gynecol Obstet 274, 13-18. Sixou, J. L., Robert, J. C. & Bonnaure-Mallet, M. (1997) Loss of deciduous teeth and germs of permanent incisors in a 4-year-old child. An atypic prepubertal periodontitis? A clinical, microbiological, immunological and ultrastructural study. J Clin Periodontol 24, 836-843. Skuldbol, T., Johansen, K. H., Dahlen, G., Stoltze, K. & Holmstrup, P. (2006) Is pre-term labour associated with periodontitis in a Danish maternity ward? J Clin Periodontol 33, 177-183. Slavkin, H. C. (1997) First encounters: transmission of infectious oral diseases from mother to child. J Am Dent Assoc. 128, 773-778. Slots, J. & Kamma, J. J. (2001) General health risk of periodontal disease. Int.Dent J 51, 417427. Slots, J. (2010) Human viruses in periodontitis. Periodontol 2000 53, 89-110. Smith, G. L. (1994) Diagnosis of periodontal disease activity by detection of key microbial antigens. J Clin Periodontol 21, 615-620. 37 Soder, B., Jin, L. J., Klinge, B. & Soder, P. O. (2007) Periodontitis and premature death: a 16year longitudinal study in a Swedish urban population. J Periodontal Res 42, 361-366. Soder, B. (2009) Periodontitis and premature death: a longitudinal, prospective clinical trial. J Dent Hyg. 83, 184-185. Soleymani-e- Shayesteh Y & Kamali-Nia Z (2002) The relationship between pregnancy, preterm and premature delivery. Journal of Dental Medicine 15, 65-72. Solmi, R., Rossetti, A., Talassi, O., Tomasini, G. L., Fato, R., Estornell, E., Lucarini, G., Lenaz, G., Simonelli, L., Brunelli, M. A. & Biagini, G. (1993) Gingival fibroblasts "in vitro" and Down's Syndrome. Cytotechnology 11, S59-S61. Souccar, N. M., Chakhtoura, M., Ghafari, J. G. & Abdelnoor, A. M. (2010) Porphyromonas gingivalis in dental plaque and serum C-reactive protein levels in pregnancy. J Infect Dev.Ctries. 4, 362-366. Spence, J. A., Aitchison, G. U., Sykes, A. R. & Atkinson, P. J. (1980) Broken mouth (premature incisor loss) in sheep: the pathogenesis of periodontal disease. J Comp Pathol 90, 275-292. Srinivas, S. K., Sammel, M. D., Stamilio, D. M., Clothier, B., Jeffcoat, M. K., Parry, S., Macones, G. A., Elovitz, M. A. & Metlay, J. (2009) Periodontal disease and adverse pregnancy outcomes: is there an association? Am J Obstet Gynecol 200, 497-498. Srinivas, S. K. & Parry, S. (2012) Periodontal disease and pregnancy outcomes: time to move on? J Womens Health (Larchmt.) 21, 121-125. Srinivasan, U., Misra, D., Marazita, M. L. & Foxman, B. (2009) Vaginal and oral microbes, host genotype and preterm birth. Med Hypotheses 73, 963-975. Stamilio, D. M., Chang, J. J. & Macones, G. A. (2007) Periodontal disease and preterm birth: do the data have enough teeth to recommend screening and preventive treatment? Am J Obstet Gynecol 196, 93-94. Straka, M. (2011) Pregnancy and periodontal tissues. Neuro.Endocrinol Lett. 32, 34-38. Subramaniam, P., Mathew, S. & Gupta, K. K. (2008) Papillon-Lefevre syndrome: a case report. J Indian Soc Pedod.Prev.Dent 26, 171-174. Sugita, N., Kobayashi, T., Kikuchi, A., Shimada, Y., Hirano, E., Sasahara, J., Tanaka, K. & Yoshie, H. (2012) Immunoregulatory gene polymorphisms in Japanese women with preterm births and periodontitis. Journal of Reproductive Immunology 93, 94-101. Sundell, T. M., Beazley, D., Patters, M. R., Carr, T. L., Blankenship, J. A. & Mercer, B. M. (2002) Periodontal disease status and preterm birth in high risk women. Journal of Dental Research 81, 230Suzuki, K., Tanaka, T., Kondo, N., Minai, J., Sato, M. & Yamagata, Z. (2008) Is maternal smoking during early pregnancy a risk factor for all low birth weight infants? J Epidemiol. 18 , 89-96. Tabanella, G., Nowzari, H. & Slots, J. (2009) Clinical and microbiological determinants of ailing dental implants. Clin Implant.Dent Relat Res 11, 24-36. Taghzouti, N., Xiong, X., Gornitsky, M., Chandad, F., Voyer, R., Gagnon, G., Leduc, L., Xu, H., Tulandi, T., Wei, B., S+®n+®cal, J., Velly, A. M., Salah, M. H. & Fraser, W. D. (2011) Periodontal 38 Disease is Not Associated With Preeclampsia in Canadian Pregnant Women. Journal of Periodontology 83, 871-877. Takahashi, K., Nishida, H., Takeda, H. & Shin, K. (2004) Telomere length in leukocytes and cultured gingival fibroblasts from patients with aggressive periodontitis. J Periodontol 75, 84-90. Takinami, H., Goseki-Sone, M., Watanabe, H., Orimo, H., Hamatani, R., Fukushi-Irie, M. & Ishikawa, I. (2004) The mutant (F310L and V365I) tissue-nonspecific alkaline phosphatase gene from hypophosphatasia. J Med Dent Sci. 51, 67-74. Tar, I. & Martos, R. (2002) [Periodontal disease and general health--literature review]. Fogorv.Sz 95, 73-77. Tarannum, F. & Faizuddin, M. (2007) Effect of periodontal therapy on pregnancy outcome in women affected by periodontitis. Journal of Periodontology 78, 2095-2103. Tarannum, F., Faizuddin, M. & Madaiah, H. (2011) Gingival crevicular fluid prostaglandin E2 level as a predictor of preterm low birth weight: a pilot investigation. J Oral Sci. 53, 293-300. Tateishi, F., Hasegawa-Nakamura, K., Nakamura, T., Oogai, Y., Komatsuzawa, H., Kawamata, K., Douchi, T., Hatae, M. & Noguchi, K. (2012) Detection of Fusobacterium nucleatum in chorionic tissues of high-risk pregnant women. Journal of Clinical Periodontology 39, 417-424. Teel, R. (2002) Protecting the next generation. The dental hygienist's role in managing periodontal disease as a risk factor for low-birth-weight babies. Dent Today 21, 46-49. Teng, Y. T., Taylor, G. W., Scannapieco, F., Kinane, D. F., Curtis, M., Beck, J. D. & Kogon, S. (2002) Periodontal health and systemic disorders. J Can Dent Assoc. 68, 188-192. Tewari, S., Tewari, S., Sharma, R. K., Abrol, P. & Sen, R. (2009) Necrotizing stomatitis: a possible periodontal manifestation of deferiprone-induced agranulocytosis. Oral Surg Oral Med Oral Pathol Oral Radiol.Endod 108, e13-e19. Thomas, N., Middleton, P. & Crowther, C. (2008) Oral and dental health care practices in pregnant women in Australia: a postnatal survey. BMC Pregnancy and Childbirth 8, 13Thomson, A. & Kahler, B. (2010) Regenerative endodontics--biologically-based treatment for immature permanent teeth: a case report and review of the literature. Aust.Dent J 55, 446-452. Tilakaratne, A., Soory, M., Ranasinghe, A. W., Corea, S. M. X., Ekanayake, S. L. & De Silva, M. (2000) Periodontal disease status during pregnancy and 3 months post-partum, in a rural population of Sri-Lankan women. Journal of Clinical Periodontology 27, 787-792. Tinti, C. & Parma-Benfenati, S. (2001) Treatment of peri-implant defects with the vertical ridge augmentation procedure: a patient report. Int.J Oral Maxillofac.Implants 16, 572-577. Tomar, S. L. (2001) Dentistry's role in tobacco control. J Am Dent Assoc. 132 Suppl, 30S-35S. Tonetti, M. S. & Mombelli, A. (1999) Early-onset periodontitis. Ann Periodontol 4, 39-53. Toomes, C., James, J., Wood, A. J., Wu, C. L., McCormick, D., Lench, N., Hewitt, C., Moynihan, L., Roberts, E., Woods, C. G., Markham, A., Wong, M., Widmer, R., Ghaffar, K. A., Pemberton, M., Hussein, I. R., Temtamy, S. A., Davies, R., Read, A. P., Sloan, P., Dixon, M. J. & Thakker, N. S. (1999) Loss-of-function mutations in the cathepsin C gene result in periodontal disease and palmoplantar keratosis. Nat.Genet. 23, 421-424. 39 Toto, P. D., Kollar, J. A. & Gargiulo, A. W. (1981) Gingivitis induced by gingival impaction in monkeys. Oral Surg Oral Med Oral Pathol 52, 333-338. Toygar, H. U., Seydaoglu, G., Kurklu, S., Guzeldemir, E. & Arpak, N. (2007) Periodontal health and adverse pregnancy outcome in 3,576 Turkish women. J Periodontol 78, 2081-2094. Toygar, H. U., Kircelli, C., Firat, E. & Guzeldemir, E. (2007) Combined therapy in a patient with Papillon-Lefevre syndrome: a 13-year follow-up. J Periodontol 78, 1819-1824. Toygar, H. U., Seydaoglu, G., Kurklu, S., Guzeldemir, E. & Arpak, N. (2007) Periodontal Health and Adverse Pregnancy Outcome in 3,576 Turkish Women. Journal of Periodontology 78, 20812094. Tucker, R. (2006) Periodontitis and pregnancy. J R.Soc Promot.Health 126, 24-27. Ullbro, C., Kinnby, B., Lindberg, P. & Matsson, L. (2004) Tissue plasminogen activator (t-PA) and placental plasminogen activator inhibitor (PAI-2) in gingival crevicular fluid from patients with Papillon-Lefevre syndrome. J Clin Periodontol 31, 708-712. Underner, M. & Perriot, J. (2011) [Smokeless tobacco]. Rev Mal Respir. 28, 978-994. Uotila, J., Tuimala, R., Pyykk, K. & Ahotupa, M. (1993) Pregnancy-induced hypertension is associated with changes in maternal and umbilical blood antioxidants. Gynecol Obstet Invest 36, 153-157 Uppal, A., Uppal, S., Pinto, A., Dutta, M., Shrivatsa, S., Dandolu, V. & Mupparapu, M. (2010) The effectiveness of periodontal disease treatment during pregnancy in reducing the risk of experiencing preterm birth and low birth weight: a meta-analysis. J Am Dent Assoc. 141, 14231434. Urban, E., Radnai, M., Novak, T., Gorzo, I., Pal, A. & Nagy, E. (2006) Distribution of anaerobic bacteria among pregnant periodontitis patients who experience preterm delivery. Anaerobe. 12, 52-57. Valdez, I. H., Katz, R. W. & Travis, W. D. (1990) Premature alveolar bone loss in ErdheimChester disease. Oral Surg Oral Med Oral Pathol 70, 294-296. Valentini, P., Abensur, D. & Missika, P. (1993) Membrane exposure during bone regeneration before implant placement: management and results. A report of two cases. J Oral Implantol. 19, 364-368. van Dijk, L. J. (2002) [How threatening is periodontitis? Effects of periodontitis on the human body]. Ned.Tijdschr.Tandheelkd. 109, 449-453. van Steenbergen, T. J. & de Soet, J. J. (1998) [Transmission of infectious oral diseases from mother to child]. Ned.Tijdschr.Tandheelkd. 105, 404-407. van Winkelhoff, A. J., Winkel, E. G. & Vandenbroucke-Grauls, C. M. (2001) [Periodontitis: a hidden chronic infection]. Ned.Tijdschr.Geneeskd. 145, 557-563. Vandana, K. L. & Redy, B. V. (2003) Prepubertal periodontitis: a report of 2 cases. J Dent Child (Chic.) 70, 82-85. Vergnes, J. N. & Sixou, M. (2007) Preterm low birth weight and maternal periodontal status: a meta-analysis. Am J Obstet Gynecol 196, 135-137. 40 Vergnes, J. N. (2008) Studies suggest an association between maternal periodontal disease and pre-eclampsia. Evid.Based Dent 9, 46-47. Vergnes, J. N., Kaminski, M., Lelong, N., Musset, A. M., Sixou, M. & Nabet, C. (2011) Maternal dental caries and pre-term birth: results from the EPIPAP study. Acta Odontol Scand 69, 248256. Verlinden, C. R., Gooris, P. G. & Becking, A. G. (2011) Complications in transpalatal distraction osteogenesis: a retrospective clinical study. J Oral Maxillofac.Surg 69, 899-905. Vettore, M. V., Lamarca, G. A., Leao, A. T., Thomaz, F. B., Sheiham, A. & Leal, M. C. (2006) Periodontal infection and adverse pregnancy outcomes: a systematic review of epidemiological studies. Cad.Saude Publica 22, 2041-2053. Vettore, M. V., Leao, A. T., Leal, M. C., Feres, M. & Sheiham, A. (2008) The relationship between periodontal disease and preterm low birthweight: clinical and microbiological results. J Periodontal Res 43, 615-626. Vettore, M. V., Leal, M., Leao, A. T., da Silva, A. M., Lamarca, G. A. & Sheiham, A. (2008) The relationship between periodontitis and preterm low birthweight. J Dent Res 87, 73-78. Villa, A., Abati, S., Strohmenger, L., Cargnel, M. & Cetin, I. (2011) Self-reported oral hygiene habits and periodontal symptoms among postpartum women. Arch.Gynecol Obstet 284, 245-249. Vogt, M., Sallum, A., Cecatti, J. & Morais, S. (2010) Periodontal disease and some adverse perinatal outcomes in a cohort of low risk pregnant women. Reproductive Health 7, 29Wald, N. J. & Hackshaw, A. K. (1996) Cigarette smoking: an epidemiological overview. Br.Med Bull. 52, 3-11. Waldrop, T. C., Anderson, D. C., Hallmon, W. W., Schmalstieg, F. C. & Jacobs, R. L. (1987) Periodontal manifestations of the heritable Mac-1, LFA-1, deficiency syndrome. Clinical, histopathologic and molecular characteristics. J Periodontol 58, 400-416. Wan, A. K., Seow, W. K., Purdie, D. M., Bird, P. S., Walsh, L. J. & Tudehope, D. I. (2001) Oral colonization of Streptococcus mutans in six-month-old predentate infants. J Dent Res 80 , 20602065. Wani, A. A., Devkar, N., Patole, M. S. & Shouche, Y. S. (2006) Description of two new cathepsin C gene mutations in patients with Papillon-Lefevre syndrome. J Periodontol 77, 233-237. Warnakulasuriya, S. (2011) Waterpipe smoking, oral cancer and other oral health effects. Evid.Based Dent 12, 44-45. Watanabe, H., Iida, M., Zhang, Y. J., Seki, T. & Ishikawa, I. (1991) [A case of severe periodontal disease in adolescence associated with hypophosphatasia]. Kokubyo Gakkai Zasshi 58, 613-623. Watanabe, H., Umeda, M., Seki, T. & Ishikawa, I. (1993) Clinical and laboratory studies of severe periodontal disease in an adolescent associated with hypophosphatasia. A case report. J Periodontol 64, 174-180. Watanabe, H., Goseki-Sone, M., Iimura, T., Oida, S., Orimo, H. & Ishikawa, I. (1999) Molecular diagnosis of hypophosphatasia with severe periodontitis. J Periodontol 70, 688-691. 41 Watanabe, H., Hashimoto-Uoshima, M., Goseki-Sone, M., Orimo, H. & Ishikawa, I. (2001) A novel point mutation (C571T) in the tissue-non-specific alkaline phosphatase gene in a case of adult-type hypophosphatasia. Oral Dis 7, 331-335. Watanabe, H., Takinami, H., Goseki-Sone, M., Orimo, H., Hamatani, R. & Ishikawa, I. (2005) Characterization of the mutant (A115V) tissue-nonspecific alkaline phosphatase gene from adulttype hypophosphatasia. Biochem.Biophys.Res Commun. 327, 124-129. Watts, T. (2002) Maternal periodontal disease and preterm low birthweight: case-control study. Br.Dent J 193, 267. Wener, M. E. & Lavigne, S. E. (2004) Can periodontal disease lead to premature delivery? How the mouth affects the body. AWHONN.Lifelines. 8, 422-431. White, S. J. & McLean, W. H. (2005) Kindler surprise: mutations in a novel actin-associated protein cause Kindler syndrome. J Dermatol.Sci. 38, 169-175. Wilder, R., Robinson, C., Jared, H. L., Lieff, S. & Boggess, K. (2007) Obstetricians' knowledge and practice behaviors concerning periodontal health and preterm delivery and low birth weight. J Dent Hyg. 81, 81. Wilder, R. S., Thomas, K. M. & Jared, H. (2008) Periodontal-systemic disease education in United States dental hygiene programs. J Dent Educ. 72, 669-679. Williams, C. A. & Aller, M. S. (1992) Gingivitis/stomatitis in cats. Vet.Clin North Am Small Anim Pract. 22, 1361-1383. Williams, C. E., Davenport, E. S., Sterne, J. A., Sivapathasundaram, V., Fearne, J. M. & Curtis, M. A. (2000) Mechanisms of risk in preterm low-birthweight infants. Periodontol 2000 23, 142150. Wimmer, G. & Pihlstrom, B. L. (2008) A critical assessment of adverse pregnancy outcome and periodontal disease. Journal of Clinical Periodontology 35, 380-397. Wood, S., Frydman, A., Cox, S., Brant, R., Needoba, S., Eley, B. & Sauve, R. (2006) Periodontal disease and spontaneous preterm birth: a case control study. BMC.Pregnancy.Childbirth. 6, 24Wright, K. B., Holan, G., Casamassimo, P. S. & King, D. R. (1991) Alveolar bone loss in two children with short-bowel syndrome receiving total parenteral nutrition. J Periodontol 62, 272-275. Xiong, X., Buekens, P., Vastardis, S. & Wu, T. (2006) Periodontal disease as one possible explanation for the Mexican paradox. Med Hypotheses 67, 1348-1354. Xiong, X., Buekens, P., Fraser, W. D., Beck, J. & Offenbacher, S. (2006) Periodontal disease and adverse pregnancy outcomes: a systematic review. BJOG 113, 135-143. Xiong, X., Buekens, P., Vastardis, S. & Yu, S. M. (2007) Periodontal disease and pregnancy outcomes: state-of-the-science. Obstet Gynecol Surv. 62, 605-615. Xiong, X., Buekens, P., Goldenberg, R. L., Offenbacher, S. & Qian, X. (2011) Optimal timing of periodontal disease treatment for prevention of adverse pregnancy outcomes: before or during pregnancy? Am J Obstet Gynecol 205, 111-116. Yang, Y., Bai, X., Liu, H., Li, L., Cao, C. & Ge, L. (2007) Novel mutations of cathepsin C gene in two Chinese patients with Papillon-Lefevre syndrome. J Dent Res 86, 735-738. 42 Yeo, B. K., Lim, L. P., Paquette, D. W. & Williams, R. C. (2005) Periodontal disease -- the emergence of a risk for systemic conditions: pre-term low birth weight. Ann Acad.Med Singapore 34, 111-116. Yokoyama, M., Hinode, D., Masuda, K., Yoshioka, M. & Grenier, D. (2005) Effect of female sex hormones on Campylobacter rectus and human gingival fibroblasts. Oral Microbiol Immunol 20 , 239-243. Zachariasen, R. D. & Dennison, D. K. (1998) Periodontal disease and preterm low birth weight deliveries. J Gt.Houst.Dent Soc 70, 16-19. Zadeh-Modarres, S., Amooian, B., Bayat-Movahed, S. & Mohamadi, M. (2007) Periodontal health in mothers of preterm and term infants. Taiwan.J Obstet Gynecol 46, 157-161. Zadeh Modarres Sh., Amooian B., Bayat Movahed S., Mohammadi M., Sheikholeslam L. & Sheikholeslam F (2007) Comparison of gingival health between mothers with preterm and term labor at Mahdieh Hospital between 2001 and 2002. Journal of Dental Medicine 20, 53-58. Zadik, Y., Chapnik, L. & Goldstein, L. (2007) In-flight barodontalgia: analysis of 29 cases in military aircrew. Aviat.Space Environ.Med 78, 593-596. Zanata, R. L., Fernandes, K. B. & Navarro, P. S. (2008) Prenatal dental care: evaluation of professional knowledge of obstetricians and dentists in the cities of Londrina/PR and Bauru/SP, Brazil, 2004. J Appl.Oral Sci. 16, 194-200. Zeeman, G. G., Veth, E. O. & Dennison, D. K. (2001) Focus on primary care: periodontal disease: implications for women's health. Obstet Gynecol Surv. 56, 43-49. Zermeño, N., Flores, A., Saldívar, R., Soria, L., Garza, R. & Iglesias, B. (2011) Enfermedad periodontal como factor de riesgo para presentar resultados perinatales adversos. Revista chilena de obstetricia y ginecología 76, 338-343. Zhang, Y., Hart, P. S., Moretti, A. J., Bouwsma, O. J., Fisher, E. M., Dudlicek, L., Pettenati, M. J. & Hart, T. C. (2002) Biochemical and mutational analyses of the cathepsin c gene (CTSC) in three North American families with Papillon Lefevre syndrome. Hum.Mutat. 20, 75Zhang, Z. K. (2010) [Strengthen research on the relationship between oral diseases and systemic diseases]. Zhongguo Yi.Xue.Ke.Xue.Yuan Xue.Bao. 32, 245-248. 43