Download The Royal Gene Lab (Pedigree)

Name: _____________________
Date: ___________
Per. ______
The Royal Gene
Hemophilia- Disease of the “Bluebloods”
Queen Victoria of England ruled the United Kingdom from 1837 until 1901. She and her husband had 9
children who married into other royal families around the world. She introduced the mutant gene for hemophilia
into the royal family. Hemophilia is a genetic disorder that makes it hard for a person’s blood to clot. This
means a person with hemophilia will bleed for a lot longer than a normal person when they get hurt. It is a
recessive X-linked disorder.
I.
a.
b.
c.
d.
e.
Identify the hemophiliacs:
Shade the entire figure for the following:
Prince Leopold, Victoria’s youngest son
Prince Friedrich, Alice’s son
Prince Leopold, Beatrice’s son
Prince Maurice, Beatrice’s son
Prince Waldemar, Irene’s son
f. Czarevitch Alexis, Alix’s son
g. Prince Rupert, great-grandson of Victoria
h. Prince Maurice, great-grandson of Victoria
i. Prince Alphonso, son of Victoria Eugenie
j. Prince Gonzalo, son of Victoria Eugenie
II.
Now go through and Highlight the names of all the carriers, remember hemophilia is a
Sex-linked disorder.
III.
Analysis- Answer on the back of your pedigree chart.
1. What was Queen Victoria’s genotype?
2. What was Albert’s genotype?
3. Construct a Punnett square to determine the probability of their having a
son that was hemophiliac.
4. Why are there only female carriers for hemophilia?
5. When did Princess Alice discover she was a carrier?
6. Which granddaughter of Victoria was a carrier through her father, not her
mother?
7. Was there any possibility of Leopold and Helena having a hemophilia son?
Explain?
8. Why was the British royal family not affected by hemophilia?
9. Construct a Punnett square to predict the probability of hemophila in the
offspring of:
a. Gonzalo had married a carrier
b. Gonzalo had married a woman who did not carry the allele for
hemophilia.
10. How did Queen Victoria become a carrier when there was no family history
of hemophilia anywhere in her backgoround??????
Bonus: Why don’t we know if Alix’s daughters were carriers? (hint remember your history)