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Name: _____________________ Date: ___________ Per. ______ The Royal Gene Hemophilia- Disease of the “Bluebloods” Queen Victoria of England ruled the United Kingdom from 1837 until 1901. She and her husband had 9 children who married into other royal families around the world. She introduced the mutant gene for hemophilia into the royal family. Hemophilia is a genetic disorder that makes it hard for a person’s blood to clot. This means a person with hemophilia will bleed for a lot longer than a normal person when they get hurt. It is a recessive X-linked disorder. I. a. b. c. d. e. Identify the hemophiliacs: Shade the entire figure for the following: Prince Leopold, Victoria’s youngest son Prince Friedrich, Alice’s son Prince Leopold, Beatrice’s son Prince Maurice, Beatrice’s son Prince Waldemar, Irene’s son f. Czarevitch Alexis, Alix’s son g. Prince Rupert, great-grandson of Victoria h. Prince Maurice, great-grandson of Victoria i. Prince Alphonso, son of Victoria Eugenie j. Prince Gonzalo, son of Victoria Eugenie II. Now go through and Highlight the names of all the carriers, remember hemophilia is a Sex-linked disorder. III. Analysis- Answer on the back of your pedigree chart. 1. What was Queen Victoria’s genotype? 2. What was Albert’s genotype? 3. Construct a Punnett square to determine the probability of their having a son that was hemophiliac. 4. Why are there only female carriers for hemophilia? 5. When did Princess Alice discover she was a carrier? 6. Which granddaughter of Victoria was a carrier through her father, not her mother? 7. Was there any possibility of Leopold and Helena having a hemophilia son? Explain? 8. Why was the British royal family not affected by hemophilia? 9. Construct a Punnett square to predict the probability of hemophila in the offspring of: a. Gonzalo had married a carrier b. Gonzalo had married a woman who did not carry the allele for hemophilia. 10. How did Queen Victoria become a carrier when there was no family history of hemophilia anywhere in her backgoround?????? Bonus: Why don’t we know if Alix’s daughters were carriers? (hint remember your history)