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Science for Global Health: Fostering International Collaboration IANAS Science Funding Workshop 26-28 July 2009 Norka Ruiz Bravo,PhD Special Advisor to the Director National Institutes of Health U.S. Department of Health and Human Services Outline •Global Burden of Disease •Biomedical Research Portfolio •NIH Structure, Function •Fogarty International Center Global Burden of Disease, Reported Mortality by Cause, 2004 World Pop. ~ 6 billion Region of the Americas Pop. ~ 874 million 10% 10% 14% 31% 59% 76% Communicable, Maternal, Perinatal, and Nutritional Conditions Non-Communicable Diseases Injuries Source: World Health Report, 2008; Disease Control Priorities Project, 2006 Global Burden of Disease, Reported Mortality by Cause, Non-Communicable Diseases, Region of the Americas, 2004 7% Malignant neoplasms 6% 25% 5% 6% Cardiovascular diseases Respiratory diseases Digestive diseases Diabetes mellitus 8% Neuropsychiatric conditions Other 43% Source: World Health Report, 2008; Disease Control Priorities Project, 2006 Balanced National Biomedical Research Portfolio Clinical Research Translational Research Basic Research NIH - $30 B Clinical Research Translational Research Basic Research Private Sector - $60B NIH Extramural Grants (FY 2008) •Supports > 150,000 PIs & Key Personnel •About 83% of NIH budget •Awards issued to > 3,000 institutions in > 100 countries •Clinical, Basic, & Translational Research National Institutes of Health, Bethesda, Maryland, Research Campus National Institutes of Health: The Steward of Biomedical and Behavioral Research for the Nation MISSION Science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. METHODS Supporting peer-reviewed scientific research at universities, medical schools, hospitals, and research institutions throughout United States and overseas Conducting research in its own laboratories Training research investigators Developing and disseminating credible health information based on scientific discovery Elias Zerhouni, M.D. DirectorNIH Director, National National Institute Institute on on Aging Aging National National Institute Institute on on Alcohol Alcohol Abuse Abuse and and Alcoholism Alcoholism National National Institute Institute of of Allergy Allergy and and Infectious Infectious Diseases Diseases National National Institute Institute of of Arthritis Arthritis and and Musculoskeletal Musculoskeletal and and Skin Skin Diseases Diseases National National Cancer Cancer Institute Institute National National Institute Institute of of Child Child Health Health and and Human Human Development Development National National Institute Institute on on Deafness Deafness and and Other Other Communication Communication Disorders Disorders National National Institute Institute of of Dental Dental and and Craniofacial Craniofacial Research Research National National Institute Institute of of Diabetes Diabetes and and Digestive Digestive and and Kidney Kidney Diseases Diseases National National Institute Institute on on Drug Drug Abuse Abuse National National Institute Institute of of Environmental Environmental Health Health Sciences Sciences National National Eye Eye Institute Institute National National Institute Institute of of General General Medical Medical Sciences Sciences National National Heart, Heart, Lung, Lung, and and Blood Blood Institute Institute National National Human Human Genome Genome Research Research Institute Institute National National Institute Institute of of Mental Mental Health Health National National Institute Institute of of Neurological Neurological Disorders Disorders and and Stroke Stroke National National Institute Institute of of Nursing Nursing Research Research National National Institute Institute of of Biomedical Biomedical Imaging Imaging and and Bioengineering Bioengineering National National Center Center for for Complementary Complementary and and Alternative Alternative Medicine Medicine Fogarty Fogarty International International Center Center National National Center Center for for Research Research Resources Resources National National Library Library of of Medicine Medicine National National Center Center on on Minority Minority Health Health and and Health Health Disparities Disparities Clinical Clinical Center Center Center Center for for Information Information Technology Technology = Institutes and Centers that award grants Center Center for for Scientific Scientific Review Review NIH Budget Total FY 2009 Budget: $30.4 Billion $4.7 84% Outside NIH > 3,000 Organizations Worldwide 16% Inside NIH $2.9 B Intramural Research (10%) $1.2 B Staff & Buildings (4%) $0.6 B Other (2%) Spending at NIH Spending Outside $24.7 NIH – Extramural and Other Grant Awards, by Type • • • • • • • • • Research Grant Programs New Investigators Program Multiple Principal Investigators Research Supplement Programs Ruth L. Kirschstein National Research Service Awards (NRSA) Research Ethics and Training Grant Programs NIH Career Development (K) Awards Small Business Awards Other Programs Source: http://grants2.nih.gov/grants/funding/funding_program.htm Mission • Address global health challenges through innovative and collaborative research and training programs • Support and advance the NIH mission through international partnerships • “Science for Global Health” • FY 2009 Appropriation $68.7 million Research and Research Training ~$50 million in grant awards • 1/3 Research, 2/3 Research Training • Awards range $10,000 - $1 million • Low and Middle Income Countries • Research Capacity Development and Sustainability Extramural Research Grants – 8 Programs Fogarty International Research Collaboration Award (FIRCA) International Cooperative Biodiversity Groups (ICBG) Ecology of Infectious Diseases (EID) International Studies on Health and Economic Development (ISHED) Int’l Tobacco and Health Research and Capacity Building Program Global Research Initiative Program for New Foreign Investigators (GRIP) Stigma and Global Health Research Program Brain Disorders in the Developing World: Research Across the Lifespan Extramural Training Grants – 14 Programs Fogarty International Collaborative Trauma and Injury Research Training Global Infectious Diseases Research Training International Clinical, Operational, and Health Services Research Training Awards for HIV/AIDS and Tuberculosis International Research Ethics Education and Career Development International Maternal and Child Health Research Training Fogarty International Clinical Scholars Research Training International Centers for Excellence in Clinical Research and Management Training International Training Program in Environmental and Occupational Health Informatics Training for Global Health Global Research Training in Population Health International Collaborative Genetics Research Training AIDS International Training and Research International Clinical, Operational, and Health Services Research Training Awards for Malaria Framework Programs for Global Health International Clinical, Operational, and Health Services Research Training Awards (ICOHRTA) Chronic Diseases: Goals and Objectives Bridge the training gap for clinical, operational and health services research in order to: Strengthen capacity to conduct clinical, operational, and health services research to measure incidence and prevalence of non-communicable disorders and diseases; characterize disease burdens; and devise, evaluate and implement practical and affordable therapeutic or preventive interventions; Help LMICs apply current knowledge and new discoveries to clinical and public health practice; and Support programs at research institutions to both train researchers and to communicate and disseminate knowledge in support of evidence-based policies. $2.5 million awarded to 12 institutions ($150k each in new awards and $200k each in competing renewals) under previous PA issued in FY 2006 New Program Announcement anticipated IC Partners: NCCAM, NIA, NIDA, NIDCR, NIMH, NINDS and OD/OD/Office of Dietary Supplements ICOHRTA Chronic Diseases: Current Foreign Research and Training Sites Poland Czech Republic Ukraine Turkey China India Bangladesh Thailand Vietnam Peru Brazil Argentina ICOHRTA Chronic: Current Research Training Areas • • • • • • • • • Evidence-based health care Maternal & child health and nutrition Suicide prevention and mental health Nutrition-related chronic disease prevention Finances and mental health Smoking cessation and substance abuse Oral health Mental health, developmental disabilities and behavioral disorders Community-based interventions to prevent drug use and HIV transmission Source: http://www.fic.nih.gov/programs/training_grants/icohrta/index.htm Thank you for your attention!