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Week 1 An introduction to genetics and learning the lingo. Lecture 1 Biotechnology News Inheritance and Reproduction News DNA and Destiny Epigenetics Imprinting DNA Packaging Chromosomes Nucleosomes and Chromatin Human genes Normal Human Karyotype Human Genome Project The Central Dogma Gene Expression and Cell Differentiation The Structure of Proteins Four Levels of Protein Structure Hemoglobin Sickle-cell Disease Lecture 2 mRNA Has Specialized Regions with Important Functions mRNA Has Specialized Regions with Important Functions 2 The promoter Control of Gene Expression Control of Gene Expression 2 Control of Gene Expression 3 mRNA is Translated in the 5' to 3’ Direction DNA and Protein are Colinear Activators Activators 2 Amino Acids and Proteins Epigenetics Defined Epigenetics Defined 2 Epigenetics in Action Methylation Genomic Imprinting Genomic Imprinting 2 Genomic Imprinting 3 Genomic Imprinting 4 Lifestyle and Methylation Patterns: Nutrition Lifestyle and Methylation Patterns: Exercise Lifestyle and Methylation Patterns: Smoking Lifestyle and Methylation Patterns: Smoking 2 Lecture 3 What Causes Mutations DNA and Mutations Frame-shift Mutations Frame-shift Mutation 2 The Central Dogma In Detail For Proteins, Form Shapes Function Lecture 4 Allele Definition Allele Definition 2 Homologous Chromosomes Homologous Chromosomes 2 Variation In Gene Expression Penetrance and Expressivity Human Polygenic Traits Pleiotropy Pleiotropic and Polygenic Traits Epistasis Lecture 5 Hormone Action Serotonin Irritable Bowel Syndrome “The Violence Gene” “Warrior Gene” Neurons Neurotransmitters Alcoholic Flies Sexually Spurned Flies Turn to the Bottle Lecture 6 Comparative Genomics Knockout Mice Knockout Mice 2 The Human Genome Project Information Developmental Genetics Hox Genes Eyeless Gene PAX6 RNA Interference Drosophila as Human Disease Models: Drug Discovery