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ANN FRANCES RAMSDELL CURRICULUM VITAE OFFICE ADDRESS: Medical University of South Carolina Department of Regenerative Medicine and Cell Biology 173 Ashley Ave Suite 601 Charleston, SC 29425 PHONE: (843) 792-1620 FAX: (843) 792-0664 EMAIL: [email protected] University of South Carolina School of Medicine Department of Cell Biology and Anatomy 6439 Garners Ferry Road Bldg 1, B-22 Columbia, SC 29208 PHONE: (803) 216-3892 FAX: (803) 216-3846 EMAIL: [email protected] EDUCATION: 1988-1991 1991-1996 B.S. (Biology) Ph.D. (Cell Biology) (mentor: Dr. Roger Markwald) College of Charleston Charleston, SC 29424 Medical University of South Carolina POSTDOCTORAL TRAINING: 1997 Post-doctoral Fellow Harvard Medical School/MA (mentor: Dr. Mark Fishman) General Hospital 1997-2000 Post-doctoral Fellow University of Utah Huntsman (mentor: Dr. Joe Yost) Cancer Institute FACULTY APPOINTMENTS: 1997 Research Associate Medical University of South Carolina Dept. of Cell Biology and Anatomy 2000-2006 Assistant Professor University of South Carolina School of Medicine Dept. of Cell Biology and Anatomy and joint appointment with College of Arts and Sciences Program in Women’s and Gender Studies 2002-2007 Assistant Professor (dual appointment with USC) Medical University of South Carolina Dept. of Cell Biology and Anatomy 2006-present 2008-present Associate Professor (with tenure) University of South Carolina School of Medicine Dept. of Cell Biology and Anatomy and joint appointment with College of Arts and Sciences Program in Women’s and Gender Studies Associate Professor (dual appointment with USC) Medical University of South Carolina Dept. of Regenerative Medicine and Cell Biology EXTRAMURAL GRANTS: ACTIVE: 2011-2013 National Institutes of Health NICHD R21 ($275,000/2 yr direct) (NCE through 3/31/13) PD/PI: Ramsdell (3.6 calendar months) “Mammary Gland Laterality in Normal and Neoplastic Development” PAST EXTRAMURAL FUNDING: 2000-2002 National American Heart Association Scientist Development Grant ($65,000 yr/direct) PI: Ramsdell (3 calendar months) “Cellular and Molecular Mechanisms of Cardiac Left-Right Development” 2004-2007 National Science Foundation MCB-0421929 ($16,945/yr direct) PI: Darden (subcontract to Ramsdell, 1 calendar month) “Salamander Blue Cone/Green Rod Visual Pigment Gene Characterization” 2002-2006 National Institutes of Health R01 HL73270 ($200,000/yr direct) PI: Ramsdell (5.4 calendar months) “Left-Right Axis Determination and Cardiac Development” 2005-2008 National Institutes of Health R01 HL73190 ($225,000/yr direct) PI: Eisenberg (Co-investigator, Ramsdell 1 calendar month) “Non-Canonical WNT Signal Transduction and Cardiogenesis” 2007-2012 National Institutes of Health HLBI K02 86737 ($75,000/yr direct) PI: Ramsdell (1.2 calendar months) “Development of Xenopus as a Model of Human Congenital Heart Disease” INTRAMURAL GRANTS: ACTIVE: 2013-2014 USC School of Medicine Research and Development Funds ($15,000/1 yr direct) PI: Ramsdell (1.8 calendar months) “Laterality of Mammary Stem Cells and Microenvironment During Development and Neoplasia” PAST INTRAMURAL FUNDING: 2001-2002 USC Research and Productive Scholarship Award PI: Ramsdell “Identification of a Type I Activin-Like Kinase Receptor that Is Required for Cardiac Left-Right Development” 2003-2004 Medical University of South Carolina University Research Council Grant ($20,549 direct) PI: Ramsdell (1.8 calendar months) “Endoderm: A Molecular Regulator of Vertebrate Left-Right Asymmetry” 2008-2009 MUSC University Research Council Grant ($40,000 direct) PI: Ramsdell (2.4 calendar months) “Request for Interim Funding for NIH R01 HL-073270 Left-Right Axis Determination and Cardiac Development” AWARDS: 1990 1991 1995 1997 1998 1998-2000 2004 2006 2006 2006 Medical University of South Carolina Student Research Day, 1st place undergraduate platform Medical University of South Carolina Student Research Day, 1st place graduate platform American Association of Anatomists Jan Langman Award, 1st place national graduate platform American Association of Anatomists Outstanding Dissertation Award Honorable Mention NIH Individual National Research Service Award (declined because of move to Univ. UT) American Heart Association Western States Fellowship USC Women’s and Gender Studies Faculty Award for Teaching Excellence American Association of Anatomists Young Faculty Travel Award USC School of Medicine Research Advancement Award MUSC Health Science Foundation Developing Scholar Award COMMITTEE MEMBERSHIP: University 2013201220122012 2005-2012 USC WGST Awards Committee USC WGST Personnel Committee USC SOM Grade Change Committee USC SOM Women in Science and Medicine Committee Medical University of SC Women Scholars Initiative Steering Committee 2005-2010 2002 2001-2007 2001 2001 2000-2006 2000-2002 2000-2002 Medical University of SC Women Scholars Initiative Mentoring sub-committee (co-chair) USC Women’s Studies Conference Planning Committee USC Women’s Studies Graduate Committee USC LCME Basic Science Internal Review Committee USC Biomedical Sciences Graduate Admission Committee Committee on Women, USC School of Medicine (Chair 20012002) USC Cell Biology & Anatomy Seminar Committee USC Cell Biology & Anatomy Faculty Search Committee Hollings Cancer Center Service Activities MUSC “Changing What’s Possible” video interview, March 2010 MUSC “Changing What’s Possible” television commercial, April 2010 Presentation at the Hollings Cancer Center Monthly Staff Meeting, January 2011 Presentation at the Hollings Cancer Center Advisory Board, March 2011 Opening Remarks at the Hollings Cancer Center Clinical Trials Awareness Campaign Appreciation Lunch, March 2011 Presentation at the Hollings Cancer Center Citizen’s Advisory Council, April 2011 Hollings Cancer Center video interview, April 2011 MUSC “The Catalyst” print interview on clinical trials, April 2011 Hollings Cancer Center team member, May 2011 Dragon Boat Presentation at the Hollings Cancer Center Citizen’s Advisory Council New Member Orientation, August 2011 WTMA 1250 AM “The Morning Buzz” radio interview with Richard Todd (Hollings Cancer Center signature fundraising event, Gourmet and Grapes), October 2011 WCBD News 2 television interview with Carolyn Murray, October 2011 Hollings Cancer Center representative at the Brighton’s “Power of Pink” event, October 20, 2001, Charleston, SC Presentation at The Point Is” (a local fundraising group), November 2011, Johns Island, SC Hollings Cancer Center promotional photo shoot, Waterfront Park, September 14, 2012, Charleston, SC Speaker, “Pink Partini”, Tanger Outlet fundraiser for breast cancer research, September 27, 2012, North Charleston, SC Opening remarks, Susan G. Komen Lowcountry Race for the Cure Survivor Ceremony, October 2012, Daniel Island, SC Interviewee, Charelston Regional Business Journal “Clinical Trials”, September 2013 TEACHING: Undergraduate Education: 2000- Women’s Health (USC WGST 113), primary teaching assignment (35 contact hours/ fall or spring semester) 2002 Fundamentals of Scientific Inquiry (USC SCHC 285A), lecturer Graduate Studies Education: 2001-2002 Integrated Biomedical Systems (USC SOM BMSC 705), lecturer (4 contact hours/spring semester) 2002-2005 Developmental Biology (MUSC MCBP 762), lecturer (4 contact hours/fall semester; course is offered in alternate years) 2004-2006 Research in Cardiovascular Disease (USC SCCC 302D), lecturer (1 contact hour/fall semester) 2004-2007 Graduate Cell Biology (USC BMSC 702), lecturer primary teaching assignment (5 contact hours/spring semester) 2000-2002 Special Topics in Embryology (USC ANAT 715), primary teaching and 2004assignment (12 contact hours/ fall or spring semester) 2007 2014Cardiovascular Development (USC SOM BMSC 730), lecturer (2 contact hours) TRAINEES AND STUDENTS: 2013Huda Atiya, USC SOM Biomedical Sciences doctoral student 2011Jacqulyne Robichaux, MUSC MCBP doctoral student 2003-2004 Yumei Chen, Ph.D., postdoctoral fellow 2000-2003 Lisha Whitaker, masters student, USC Biomedical Sciences Program First Place winner of the 2002 USC School of Medicine Newton Graduate Student Research Symposium Graduated 12/2002 and enrolled in Univ. of GA Veterinary School 2001-2003 Ekaterina Mironova, doctoral student, USC Biomedical Sciences Program Second Place winner of the 2002 Medical University of SC Student Research Day graduate platform session (student remained at USC with a new mentor after my lab relocated) 2001-2003 Chris Wells, undergraduate, USC Biology/Pre-med major 2001-2003 Laura Edwards, undergraduate, USC Women’s Studies/Pre-Med Programs Recipient of the 2002 USC Arney Robinson Childs Award for undergraduate research. Graduated 2003 and enrolled at Northeastern University School of Law Summer Research Students 2003 Sidney Wong, Charleston Academic Magnet High School Senior Thesis 2004 Edreca Thompson, MUSC Summer Undergraduate Research Program 2004 Octavius Coleman, MUSC Summer Health Professionals Program 2005 John Johnson, MUSC Summer Undergraduate Research Program 2006 Ashley Procopio Allen, MUSC Summer Health Professionals Program 2007 Natalie Holder, MUSC Summer Undergraduate Research Program 2008 Megan Lee, MUSC Summer Health Professionals Program 2008 David Bowen, MUSC Summer Health Professionals Program PRESENTATIONS: Submitted: 1992 Platform session, 74th Annual Endocrine Society Meeting, San Antonio, TX “Activation of a TGF-a positive feedback loop results in growth inhibition of GH4 cells” 1996 Seminar, Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, SC “Homogenetic induction of endocardial cushion tissue in the embryonic chick heart” 1996 Platform session, Weinstein Cardiovascular Development Conference, Philadelphia, PA “Induction of endocardial cushion tissue is a progressive homogenetic event” 1998 Platform session, Weinstein Cardiovascular Development Conference, Nashville, TN “TGF-related signaling in left lateral vegetal cells initiates the vertebrate leftright axis” 2000 Platform session, 2000 Keystone Symposium on Molecular Biology of the Cardiovascular System, Salt Lake City, UT “Cardiac looping and the left-right axis: antagonism of left-side Vg1 activity by a right-side BMP/ALK2 pathway” 2001 Platform session, Minisymposium on Induction of Heart Development, 2001 Experimental Biology, Orlando, FL “Identification of novel genes and multiple signaling pathways that regulate cardiac left-right development” 2002 Platform session, Minisymposium on TGF in Heart and Vascular Development, 2002 Experimental Biology, New Orleans, LA “The activin-like kinase receptor-4 modulates left-right axis determination in Xenopus” 2006 Platform session, Minisymposium on Growth and Development, Experimental Biology, San Francisco, CA “Left-right lineage analysis in the embryonic Xenopus heart reveals a novel framework linking congenital cardiac defects and laterality disease” Invited: 1996 Invited short talk, Heart Development Spring Symposium, Medical College of Georgia “Homogenetic induction of endocardial cushion tissue” 1999 Invited seminar, University of South Carolina School of Medicine, Columbia, SC “Identification of multiple genes and signaling pathways in cardiac left-right development” 2001 Invited talk, Cardiovascular Developmental Biology Center Annual Spring Symposium, Medical University of South Carolina, Charleston, SC “Multiple pathways in cardiac left-right development” 2001 Invited seminar, Columbia College, Columbia, SC “How the body tells left from right” 2001 Invited seminar, South Carolina Cancer Center, University of South Carolina, Columbia, SC “Mechanisms of generating cardiac left-right asymmetry” 2001 2005 2006 2008 2008 2012 Invited seminar, University of North Carolina at Charlotte, Charlotte, NC “Mechanisms underlying the generation of cardiac left-right asymmetry” Invited talk, Cardiovascular Developmental Biology Center Spring Symposium, Medical University of South Carolina, Charleston, SC “Left-right axis determination and cardiac development in Xenopus” Invited talk, Southeastern American Association for Laboratory Animal Science, Charleston, SC. “Xenopus husbandry and care” Invited talk, Cardiovascular Developmental Biology Center Spring Symposium, Medical University of South Carolina, Charleston, SC “Left-right axis determination and cardiac development” Invited seminar, University of Kansas Medical Center School of Medicine, Department of Anatomy and Cell Biology, Kansas City, MO “The TGF paradox: Arbiter of cardiac left-right asymmetry and symmetry in vertebrate development” Invited symposium speaker, Gordon Research Conference on Mammary Gland Biology, Barga (Lucca), Italy “The laterality of breast cancer: Has embryonic patterning left one side more susceptible to disease?” EXTRAMURAL PROFESSIONAL ACTIVITIES 2002-present, Ad hoc reviewer for The Anatomical Record 2004-present, Ad hoc reviewer for Developmental Dynamics 2005-present, Ad hoc reviewer for Developmental Biology 2006-present, Ad hoc reviewer for Development 2008 Ad hoc reviewer for Science 2002-2003 2000-2003 2004 2005 2006 2006 2011-present PUBLICATIONS: Peer-reviewed journal articles Reviewer, American Association of Anatomists Outreach Grant Proposals (Chair 2003) American Association of Anatomists, National Advisory Board of Young Anatomists American Association of Anatomists Society Officer and Board Nominations Committee National American Heart Association Basic Cell and Molecular Biology 2 study section American Association of Anatomists Membership Committee Organizer and Chair, American Association of Anatomists Growth and Development Minisymposium, 2006 Experimental Biology meeting Reviewer, ZRG1F05 NIH study section Fuseler J.W., Robichaux J.P., Atiyah H.I., and Ramsdell A.F. (2014) Morphometric and fractal dimension analysis identifies early neoplastic changes in mammary epithelium of MMTV-cNeu mice. Anticancer Research in press. Veltmaat J.M., Ramsdell A.F., Sterneck E. (2013) Positional variations in mammary gland development and breast cancer. Journal of Mammary Gland Biology and Neoplasia 18:179-88 Martin L.K., Bratoeva M., Bernanke J.M., Redmond M.C., Ramsdell A.F., Eisenberg C.A., and Eisenberg L.M. (2012). Inhibition of heart formation by lithium is an indirect result of the disruption of tissue organization within the embryo. Development, Growth and Differentiation 54:153-66. Martin L.K., Mezentseva N.V., Bratoeva M., Ramsdell A.F., Eisenberg, C.A., and Eisenberg L.M. (2011) Canonical WNT signaling enhances stem cell expression in the developing heart without a corresponding inhibition of cardiogenic differentiation. Stem Cells and Development 20:1973-83. Ramsdell A. F., Bernanke, J. M., and Trusk, T. C. (2006) Left-right lineage analysis of the embryonic Xenopus heart reveals a novel framework linking congenital cardiac defects and laterality disease. Development 133:1399-1410. Ramsdell, A.F., Bernanke, J.M., Johnson, J., and Trusk, T.C. (2005) Left-right lineage analysis of AV cushion tissue in normal and laterality defective Xenopus hearts. The Anatomical Record 287:1176-1182. Ramsdell, A.F. (2005). Left-right asymmetry and congenital cardiac defects: getting to the heart of the matter in vertebrate left-right axis determination. Developmental Biology 288:1-20. Tiedeken J., Ramsdell J.S., and Ramsdell, A.F. (2005) Developmental toxicity of domoic acid in zebrafish (Danio rerio). Neurotoxicology and Teratology 27:711-717. 8. Chen, Y., Whitaker, L. L., and Ramsdell, A. F. (2005) Developmental analysis of activin-like kinase-4 (ALK4) expression in Xenopus laevis. Developmental Dynamics 232:393-398. Chen, Y., Mironova, E., Whitaker, L. L., Edwards, L., Yost, H. J., and Ramsdell, A. F. (2004) ALK4 functions as a receptor for multiple TGF-related ligands to regulate to left-right axis determination and mesoderm induction in Xenopus. Developmental Biology 268:280-294. Ramsdell, A.F. and Yost, H.J. (1999) Cardiac looping and the vertebrate left-right axis: antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway. Development 126: 5195-5205. Ramsdell, A.F. and Yost, H.J. (1998) Molecular mechanisms of vertebrate left-right development. Trends in Genetics 14:459-465. Ramsdell, A.F., Moreno-Rodriguez, R.A., Wienecke, M.M., Sugi, Y., Turner, D.K., Mjaatvedt, C.H. and Markwald, R.R. (1998) Identification of an autocrine signaling pathway that amplifies induction of endocardial cushion tissue in the avian heart. Acta Anatomica 162:1-15. Ramsdell, A.F. and Markwald, R.R. (1997) Induction of endocardial cushion tissue in the avian heart is regulated, in part, by TGF3-mediated autocrine signaling. Developmental Biology 188: 64-74. Book Chapters 1. Ramsdell, A.F. and Yost, H.J. (2001) Cardiac looping and the left-right axis: integrating morphological, molecular, and genetic analyses of vertebrate left-right asymmetry. In: Formation of the Heart and Its Regulation, (Tomanek, R. J. and Runyan, R. B., eds.) New York, NY: Springer-Verlag pp. 45-73. 2. Mjaatvedt, C.H., Yamamura, H., Wessels, A., Ramsdell, A., Turner, D. and Markwald, R.R. (1998) Mechanisms of segmentation, septation, and remodeling of the tubular heart: endocardial cushion fate and cardiac looping. In: Heart Development (Harvey, R. and Rosenthal, N., eds.) San Diego, CA: Adademic Press pp. 159-177. 3. Ramsdell, A.F., Krug, E.L. and Markwald, R.R. (1997) Regulation of valvuloseptal morphogenesis. In: Microscopy of Reproduction and Development: A Dynamic Approach, Volume I (Pietro M. Motta, ed.) Rome, Italy: Universita di Roma, pp. 307317. Book reviews and newsletter articles (not peer-reviewed) 1. Ramsdell, A.F. (2004) A laboratory guide to the mammalian embryo. The Quarterly Review of Biology 79:426. 2. Ramsdell, A.F. (2001) High Marks for Undergraduate Mentoring in Biomedical Research. In: American Association of Anatomists Quarterly Newsletter, Vol. 10, p. 3435. 3. Ramsdell, A.F. (2000) Women In Anatomy: The Challenges Continue. In: American Association of Anatomists Quarterly Newsletter, Vol. 9, p. 16-17.